The influence of hyaluronic acid hydrogel crosslinking density and macromolecular diffusivity on human MSC chondrogenesis and hypertrophy.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMC 3578381)

Published in Biomaterials on October 22, 2012

Authors

Liming Bian1, Chieh Hou, Elena Tous, Reena Rai, Robert L Mauck, Jason A Burdick

Author Affiliations

1: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Articles citing this

A fibrin/hyaluronic acid hydrogel for the delivery of mesenchymal stem cells and potential for articular cartilage repair. J Biol Eng (2014) 1.44

Mechanism of regulation of stem cell differentiation by matrix stiffness. Stem Cell Res Ther (2015) 0.93

Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate. Biomaterials (2013) 0.86

Spontaneous cardiomyocyte differentiation of mouse embryoid bodies regulated by hydrogel crosslink density. Biomater Sci (2013) 0.82

Visible light crosslinking of methacrylated hyaluronan hydrogels for injectable tissue repair. J Biomed Mater Res B Appl Biomater (2015) 0.82

Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment. J Tissue Eng (2014) 0.80

The effects of secretion factors from umbilical cord derived mesenchymal stem cells on osteogenic differentiation of mesenchymal stem cells. PLoS One (2015) 0.80

Cell-mediated degradation regulates human mesenchymal stem cell chondrogenesis and hypertrophy in MMP-sensitive hyaluronic acid hydrogels. PLoS One (2014) 0.79

Cell morphology and focal adhesion location alters internal cell stress. J R Soc Interface (2014) 0.79

Engineering the matrix microenvironment for cell delivery and engraftment for tissue repair. Curr Opin Biotechnol (2013) 0.79

Cell-laden microfluidic microgels for tissue regeneration. Lab Chip (2016) 0.78

Photocrosslinked layered gelatin-chitosan hydrogel with graded compositions for osteochondral defect repair. J Mater Sci Mater Med (2015) 0.77

Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche. Adv Mater (2016) 0.76

Effects of Hydrogel Stiffness and Extracellular Compositions on Modulating Cartilage Regeneration by Mixed Populations of Stem Cells and Chondrocytes In Vivo. Tissue Eng Part A (2016) 0.75

Comparative effect of physicomechanical and biomolecular cues on zone-specific chondrogenic differentiation of mesenchymal stem cells. Biomaterials (2016) 0.75

Hyaluronic acid in the management of osteoarthritis: injection therapies innovations. Clin Cases Miner Bone Metab (2016) 0.75

Application of Extrusion-Based Hydrogel Bioprinting for Cartilage Tissue Engineering. Int J Mol Sci (2017) 0.75

Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation. Stem Cell Res Ther (2017) 0.75

Thermosensitive Poly(N-vinylcaprolactam) Injectable Hydrogels for Cartilage Tissue Engineering. Tissue Eng Part A (2017) 0.75

Articles cited by this

Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell (2004) 16.89

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta (1986) 13.69

The extracellular matrix: not just pretty fibrils. Science (2009) 8.52

Biphasic creep and stress relaxation of articular cartilage in compression? Theory and experiments. J Biomech Eng (1980) 7.76

Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum (2006) 4.16

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (2004) 3.45

Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J Clin Invest (1994) 3.30

Functions of hyaluronan in wound repair. Wound Repair Regen (1999) 3.11

FEBio: finite elements for biomechanics. J Biomech Eng (2012) 2.81

Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds. Biotechnol Bioeng (2003) 2.17

Photocrosslinkable polysaccharides for in situ hydrogel formation. J Biomed Mater Res (2001) 2.12

Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis. Tissue Eng Part A (2009) 2.12

Molecular biology of matrix vesicles. Clin Orthop Relat Res (1995) 2.09

The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix. Stem Cells (2005) 1.97

Matrix remodeling during endochondral ossification. Trends Cell Biol (2004) 1.97

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering. Proc Natl Acad Sci U S A (2010) 1.96

Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage. Tissue Eng Part A (2008) 1.95

Biochemical quantification of DNA in human articular and septal cartilage using PicoGreen and Hoechst 33258. Osteoarthritis Cartilage (2002) 1.84

Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. Arthritis Rheum (2008) 1.83

Endochondral bone tissue engineering using embryonic stem cells. Proc Natl Acad Sci U S A (2008) 1.70

Materials as morphogenetic guides in tissue engineering. Curr Opin Biotechnol (2003) 1.69

Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: influence of collagen type II extracellular matrix on MSC chondrogenesis. Biotechnol Bioeng (2006) 1.67

Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells. Matrix Biol (2007) 1.58

Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks. J Biomed Mater Res A (2006) 1.51

Coculture of human mesenchymal stem cells and articular chondrocytes reduces hypertrophy and enhances functional properties of engineered cartilage. Tissue Eng Part A (2011) 1.49

Enhanced MSC chondrogenesis following delivery of TGF-β3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials (2011) 1.43

Macromer density influences mesenchymal stem cell chondrogenesis and maturation in photocrosslinked hyaluronic acid hydrogels. Osteoarthritis Cartilage (2009) 1.43

The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells. Biomaterials (2009) 1.32

Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage. J Biomech (2009) 1.29

RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation. J Biol Chem (2004) 1.12

Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. J Cell Physiol (2006) 1.09

Effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: dynamic pore reduction promotes cartilage formation. Tissue Eng (2006) 1.08

Reduced hydraulic permeability of three-dimensional collagen scaffolds attenuates gel contraction and promotes the growth and differentiation of mesenchymal stem cells. Acta Biomater (2010) 1.06

Differential effects of designed scaffold permeability on chondrogenesis by chondrocytes and bone marrow stromal cells. Biomaterials (2009) 1.00

The inhibitory effect of cartilage proteoglycans on hydroxyapatite growth. Calcif Tissue Int (1984) 0.99

Dynamic compressive loading enhances cartilage matrix synthesis and distribution and suppresses hypertrophy in hMSC-laden hyaluronic acid hydrogels. Tissue Eng Part A (2011) 0.98

The effects of crosslinking density on cartilage formation in photocrosslinkable hydrogels. Biomed Sci Instrum (1999) 0.95

Promotion of articular cartilage matrix vesicle mineralization by type I collagen. Arthritis Rheum (2008) 0.95

Cross-linking affects cellular condensation and chondrogenesis in type II collagen-GAG scaffolds seeded with bone marrow-derived mesenchymal stem cells. J Orthop Res (2010) 0.93

Fundamental studies of biodegradable hydrogels as cartilage replacement materials. Biomed Sci Instrum (1999) 0.91

The role of extracellular matrix components in dentin mineralization. Crit Rev Oral Biol Med (1991) 0.88

Validation of theoretical framework explaining active solute uptake in dynamically loaded porous media. J Biomech (2010) 0.86

The role of bFGF in down-regulating α-SMA expression of chondrogenically induced BMSCs and preventing the shrinkage of BMSC engineered cartilage. Biomaterials (2011) 0.83

Contraction-induced Mmp13 and -14 expression by goat articular chondrocytes in collagen type I but not type II gels. J Tissue Eng Regen Med (2011) 0.78

Articles by these authors

Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.19

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nat Mater (2013) 2.84

Review: photopolymerizable and degradable biomaterials for tissue engineering applications. Tissue Eng (2007) 2.46

The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers. Biomaterials (2008) 2.44

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics. Nat Commun (2012) 2.23

Fabrication and characterization of six electrospun poly(alpha-hydroxy ester)-based fibrous scaffolds for tissue engineering applications. Acta Biomater (2006) 2.14

Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis. Tissue Eng Part A (2009) 2.12

The effect of nanofiber alignment on the maturation of engineered meniscus constructs. Biomaterials (2007) 2.11

Engineering cartilage tissue. Adv Drug Deliv Rev (2007) 2.08

Patterning network structure to spatially control cellular remodeling and stem cell fate within 3-dimensional hydrogels. Biomaterials (2010) 1.95

Transient exposure to transforming growth factor beta 3 under serum-free conditions enhances the biomechanical and biochemical maturation of tissue-engineered cartilage. Tissue Eng Part A (2008) 1.95

Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix. Blood (2011) 1.91

Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering. J Orthop Res (2007) 1.90

A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading. Ann Biomed Eng (2004) 1.89

Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration. Tissue Eng Part B Rev (2009) 1.88

Injectable hydrogel properties influence infarct expansion and extent of postinfarction left ventricular remodeling in an ovine model. Proc Natl Acad Sci U S A (2010) 1.87

Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nat Mater (2009) 1.83

Differential maturation and structure-function relationships in mesenchymal stem cell- and chondrocyte-seeded hydrogels. Tissue Eng Part A (2009) 1.81

Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir (2004) 1.76

Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo. Chem Biol (2011) 1.76

Global analysis of posttranslational protein arginylation. PLoS Biol (2007) 1.75

Modification of infarct material properties limits adverse ventricular remodeling. Ann Thorac Surg (2011) 1.72

Micromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment. J Biomed Mater Res A (2006) 1.71

Anatomically shaped osteochondral constructs for articular cartilage repair. J Biomech (2003) 1.64

Cartilage tissue engineering: its potential and uses. Curr Opin Rheumatol (2006) 1.59

Micro-bioreactor array for controlling cellular microenvironments. Lab Chip (2007) 1.52

Influence of gel properties on neocartilage formation by auricular chondrocytes photoencapsulated in hyaluronic acid networks. J Biomed Mater Res A (2006) 1.51

Coculture of human mesenchymal stem cells and articular chondrocytes reduces hypertrophy and enhances functional properties of engineered cartilage. Tissue Eng Part A (2011) 1.49

Tissue engineering for articular cartilage repair--the state of the art. Eur Cell Mater (2013) 1.48

Controlling stem cell fate with material design. Adv Mater (2010) 1.44

Hydrolytically degradable hyaluronic acid hydrogels with controlled temporal structures. Biomacromolecules (2008) 1.44

Enhanced MSC chondrogenesis following delivery of TGF-β3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Biomaterials (2011) 1.43

Mechanically robust and bioadhesive collagen and photocrosslinkable hyaluronic acid semi-interpenetrating networks. Tissue Eng Part A (2009) 1.43

Transient exposure to transforming growth factor beta 3 improves the mechanical properties of mesenchymal stem cell-laden cartilage constructs in a density-dependent manner. Tissue Eng Part A (2009) 1.43

A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs. J Orthop Res (2005) 1.42

Hydrogel design for cartilage tissue engineering: a case study with hyaluronic acid. Biomaterials (2011) 1.40

Molded polyethylene glycol microstructures for capturing cells within microfluidic channels. Lab Chip (2004) 1.38

Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds. Eur Spine J (2007) 1.37

Tissue engineering and regenerative medicine: recent innovations and the transition to translation. Tissue Eng Part B Rev (2013) 1.34

Materials science. Smart biomaterials. Science (2004) 1.33

The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells. Biomaterials (2009) 1.32

Effects of auricular chondrocyte expansion on neocartilage formation in photocrosslinked hyaluronic acid networks. Tissue Eng (2006) 1.30

Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage. J Biomech (2009) 1.29

Cartilage interstitial fluid load support in unconfined compression following enzymatic digestion. J Biomech Eng (2004) 1.26

Neurotrophin-induced differentiation of human embryonic stem cells on three-dimensional polymeric scaffolds. Tissue Eng (2005) 1.25

Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogel. Eur Cell Mater (2010) 1.25

Sacrificial nanofibrous composites provide instruction without impediment and enable functional tissue formation. Proc Natl Acad Sci U S A (2012) 1.23

Injectable acellular hydrogels for cardiac repair. J Cardiovasc Transl Res (2011) 1.19

Photoinitiated crosslinked degradable copolymer networks for tissue engineering applications. Biomaterials (2003) 1.19

Fabrication and modeling of dynamic multipolymer nanofibrous scaffolds. J Biomech Eng (2009) 1.19

Engineered disc-like angle-ply structures for intervertebral disc replacement. Spine (Phila Pa 1976) (2010) 1.19

ISSLS prize winner: integrating theoretical and experimental methods for functional tissue engineering of the annulus fibrosus. Spine (Phila Pa 1976) (2008) 1.19

The influence of an aligned nanofibrous topography on human mesenchymal stem cell fibrochondrogenesis. Biomaterials (2010) 1.18

Injectable shear-thinning hydrogels engineered with a self-assembling Dock-and-Lock mechanism. Biomaterials (2011) 1.18

Synergistic effects of SDF-1α chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium. Biomaterials (2012) 1.18

Electrospun fibrous scaffolds with multiscale and photopatterned porosity. Macromol Biosci (2010) 1.14

Evaluation of the complex transcriptional topography of mesenchymal stem cell chondrogenesis for cartilage tissue engineering. Tissue Eng Part A (2010) 1.14

Differential behavior of auricular and articular chondrocytes in hyaluronic acid hydrogels. Tissue Eng Part A (2008) 1.14

Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis. Proc Natl Acad Sci U S A (2013) 1.12

The control of stem cell morphology and differentiation by hydrogel surface wrinkles. Biomaterials (2010) 1.12

High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties. Acta Biomater (2012) 1.12

Electrospinning of photocrosslinked and degradable fibrous scaffolds. J Biomed Mater Res A (2008) 1.12

Suprapharmacologic doses of intravenous dexamethasone followed by cyclosporine in the treatment of toxic epidermal necrolysis. Indian J Dermatol Venereol Leprol (2008) 1.12

Homologous structure-function relationships between native fibrocartilage and tissue engineered from MSC-seeded nanofibrous scaffolds. Biomaterials (2010) 1.12

Rational design of network properties in guest-host assembled and shear-thinning hyaluronic acid hydrogels. Biomacromolecules (2013) 1.09

Mechanical design criteria for intervertebral disc tissue engineering. J Biomech (2010) 1.09

Hydrophilic elastomeric biomaterials based on resilin-like polypeptides. Soft Matter (2009) 1.08

Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction. Sci Transl Med (2014) 1.08

Influence of injectable hyaluronic acid hydrogel degradation behavior on infarction-induced ventricular remodeling. Biomacromolecules (2011) 1.08

Mechano-topographic modulation of stem cell nuclear shape on nanofibrous scaffolds. Acta Biomater (2010) 1.07

Functional tissue engineering of chondral and osteochondral constructs. Biorheology (2004) 1.07

Enhanced release of small molecules from near-infrared light responsive polymer-nanorod composites. ACS Nano (2011) 1.06

Photocrosslinkable hydrogel for myocyte cell culture and injection. J Biomed Mater Res B Appl Biomater (2007) 1.06

Engineering synthetic hydrogel microenvironments to instruct stem cells. Curr Opin Biotechnol (2013) 1.05

Acellular biomaterials: an evolving alternative to cell-based therapies. Sci Transl Med (2013) 1.05

Dermatitis artefacta. Indian Dermatol Online J (2012) 1.05

High-throughput and combinatorial technologies for tissue engineering applications. Tissue Eng Part B Rev (2009) 1.04

Spatial control of cell-mediated degradation to regulate vasculogenesis and angiogenesis in hyaluronan hydrogels. Biomaterials (2012) 1.02

Maturation state-dependent alterations in meniscus integration: implications for scaffold design and tissue engineering. Tissue Eng Part A (2010) 1.02

Synthesis and orthogonal photopatterning of hyaluronic acid hydrogels with thiol-norbornene chemistry. Biomaterials (2013) 1.01

Osteocyte viability and regulation of osteoblast function in a 3D trabecular bone explant under dynamic hydrostatic pressure. J Bone Miner Res (2004) 1.01

Light-responsive biomaterials: development and applications. Macromol Biosci (2010) 1.01

Dynamic tensile loading improves the functional properties of mesenchymal stem cell-laden nanofiber-based fibrocartilage. Tissue Eng Part A (2011) 1.01

Influence of macromer molecular weight and chemistry on poly(beta-amino ester) network properties and initial cell interactions. J Biomed Mater Res A (2008) 1.01

Fiber stretch and reorientation modulates mesenchymal stem cell morphology and fibrous gene expression on oriented nanofibrous microenvironments. Ann Biomed Eng (2011) 1.00