β2-Adrenergic receptor solutions for structural biology analyzed with microscale NMR diffusion measurements.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 3729229)

Published in Angew Chem Int Ed Engl on October 24, 2012

Authors

Reto Horst1, Pawel Stanczak, Raymond C Stevens, Kurt Wüthrich

Author Affiliations

1: Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Articles cited by this

Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74

A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (2008) 6.01

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature (2010) 3.19

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR. Science (2012) 3.07

Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci (2011) 2.89

Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure. J Mol Biol (2007) 1.63

Characterization of phospholipid mixed micelles by translational diffusion. J Biomol NMR (2004) 1.58

Size and shape of detergent micelles determined by small-angle X-ray scattering. J Phys Chem B (2007) 1.49

Structural insights into adrenergic receptor function and pharmacology. Trends Pharmacol Sci (2011) 1.42

Lipid composition of Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) insect cells used for baculovirus infection. FEBS Lett (1998) 1.38

Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy. Proc Natl Acad Sci U S A (2002) 1.32

GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles. Methods (2011) 1.09

NMR characterization of membrane protein-detergent micelle solutions by use of microcoil equipment. J Am Chem Soc (2009) 1.07

Translational diffusion of macromolecular assemblies measured using transverse-relaxation-optimized pulsed field gradient NMR. J Am Chem Soc (2011) 1.02

Toward rational design of protein detergent complexes: determinants of mixed micelles that are critical for the in vitro stabilization of a G-protein coupled receptor. Biophys J (2011) 0.94

Translational diffusion measurements by microcoil NMR in aqueous solutions of the Fos-10 detergent-solubilized membrane protein OmpX. J Phys Chem B (2012) 0.87

Rotational and translational self-diffusion of interacting spherical Brownian particles. Phys Rev B Condens Matter (1990) 0.87

Articles by these authors

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (2007) 11.74

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science (2008) 11.74

Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA. J Mol Biol (2002) 11.20

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (2010) 10.30

Structure of an agonist-bound human A2A adenosine receptor. Science (2011) 6.21

A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (2008) 6.01

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86

Structure of the human κ-opioid receptor in complex with JDTic. Nature (2012) 5.18

Protein NMR structure determination with automated NOE-identification in the NOESY spectra using the new software ATNOS. J Biomol NMR (2002) 4.55

An EB1-binding motif acts as a microtubule tip localization signal. Cell (2009) 4.08

Structure-function of the G protein-coupled receptor superfamily. Annu Rev Pharmacol Toxicol (2012) 3.83

Crystal structure of a lipid G protein-coupled receptor. Science (2012) 3.78

Serial femtosecond crystallography of G protein-coupled receptors. Science (2013) 3.58

Structure of the human histamine H1 receptor complex with doxepin. Nature (2011) 3.48

Structural basis for allosteric regulation of GPCRs by sodium ions. Science (2012) 3.40

Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17

Structure of the human smoothened receptor bound to an antitumour agent. Nature (2013) 3.08

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR. Science (2012) 3.07

Metabolic flux responses to pyruvate kinase knockout in Escherichia coli. J Bacteriol (2002) 3.06

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature (2012) 2.96

Microscale fluorescent thermal stability assay for membrane proteins. Structure (2008) 2.95

Automated projection spectroscopy (APSY). Proc Natl Acad Sci U S A (2005) 2.91

Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci (2011) 2.89

Structure of the human glucagon class B G-protein-coupled receptor. Nature (2013) 2.86

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol (2009) 2.82

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. J R Soc Interface (2009) 2.69

Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin. Nat Biotechnol (2006) 2.66

Prion strain discrimination using luminescent conjugated polymers. Nat Methods (2007) 2.62

Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography. J Am Chem Soc (2010) 2.62

Structural features for functional selectivity at serotonin receptors. Science (2013) 2.60

Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. Structure (2005) 2.55

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science (2002) 2.50

Effective rotational correlation times of proteins from NMR relaxation interference. J Magn Reson (2005) 2.37

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature (2008) 2.36

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme. Proc Natl Acad Sci U S A (2006) 2.28

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008. Nat Rev Drug Discov (2009) 2.23

NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure (2003) 2.15

NMR analysis of a 900K GroEL GroES complex. Nature (2002) 2.12

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure (2011) 2.11

De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A (2008) 2.10

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure (2012) 2.08

Discovery of new GPCR biology: one receptor structure at a time. Structure (2009) 2.08

Prion protein NMR structures of elk and of mouse/elk hybrids. Proc Natl Acad Sci U S A (2005) 2.01

Automated sample mounting and alignment system for biological crystallography at a synchrotron source. Structure (2004) 2.00

Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature (2006) 1.97

Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome. Acta Crystallogr D Biol Crystallogr (2003) 1.92

Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. J Med Chem (2010) 1.88

The JCSG high-throughput structural biology pipeline. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.87

Structural basis for molecular recognition at serotonin receptors. Science (2013) 1.86

Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell (2013) 1.83

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science (2014) 1.81

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. Proc Natl Acad Sci U S A (2004) 1.70

Prion protein NMR structures of cats, dogs, pigs, and sheep. Proc Natl Acad Sci U S A (2005) 1.66

Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure. J Mol Biol (2007) 1.63

Membrane protein-lipid interactions in mixed micelles studied by NMR spectroscopy with the use of paramagnetic reagents. Chembiochem (2004) 1.62

Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin. Biochemistry (2002) 1.59

A structural perspective of the sequence variability within botulinum neurotoxin subtypes A1-A4. J Mol Biol (2006) 1.59

Automated sequence-specific protein NMR assignment using the memetic algorithm MATCH. J Biomol NMR (2008) 1.59

Designing facial amphiphiles for the stabilization of integral membrane proteins. Angew Chem Int Ed Engl (2007) 1.55

Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX. Structure (2011) 1.54

Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction. PLoS Pathog (2008) 1.54

Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins (2006) 1.51

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov (2012) 1.50

NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH. FEBS Lett (2002) 1.49

Automated amino acid side-chain NMR assignment of proteins using (13)C- and (15)N-resolved 3D [ (1)H, (1)H]-NOESY. J Biomol NMR (2008) 1.49

Direct NMR observation of a substrate protein bound to the chaperonin GroEL. Proc Natl Acad Sci U S A (2005) 1.47

Structural plasticity and the evolution of antibody affinity and specificity. J Mol Biol (2003) 1.47

NMR structure of the integral membrane protein OmpX. J Mol Biol (2004) 1.46

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins (2002) 1.45

Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl (2006) 1.45

NMR structure of the bovine prion protein isolated from healthy calf brains. EMBO Rep (2004) 1.43

Amyloid formation by recombinant full-length prion proteins in phospholipid bicelle solutions. J Mol Biol (2006) 1.43

Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD. EMBO J (2005) 1.42

In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr (2005) 1.42

A molecular switch controls interspecies prion disease transmission in mice. J Clin Invest (2010) 1.41

Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc Natl Acad Sci U S A (2008) 1.41

NMR in drug discovery. Nat Rev Drug Discov (2002) 1.40

Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics. J Mol Biol (2004) 1.40

Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein. J Biol Chem (2006) 1.40

Solution NMR structure determination of proteins revisited. J Biomol NMR (2008) 1.39

The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure (2011) 1.39

Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange. Anal Chem (2010) 1.38

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. J Biol Chem (2010) 1.37

APSY-NMR with proteins: practical aspects and backbone assignment. J Biomol NMR (2008) 1.35

Structural basis of ligand binding and release in insect pheromone-binding proteins: NMR structure of Antheraea polyphemus PBP1 at pH 4.5. J Mol Biol (2007) 1.35

Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog. J Mol Biol (2007) 1.35

Prion protein NMR structures of chickens, turtles, and frogs. Proc Natl Acad Sci U S A (2005) 1.34

Metabolic-flux profiling of the yeasts Saccharomyces cerevisiae and Pichia stipitis. Eukaryot Cell (2003) 1.33

The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Structure (2005) 1.33

Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy. Proc Natl Acad Sci U S A (2002) 1.32

In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels. Acta Crystallogr D Biol Crystallogr (2008) 1.32

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. J Med Chem (2011) 1.30

Crystallization data mining in structural genomics: using positive and negative results to optimize protein crystallization screens. Methods (2004) 1.30

Novel beta-barrel fold in the nuclear magnetic resonance structure of the replicase nonstructural protein 1 from the severe acute respiratory syndrome coronavirus. J Virol (2007) 1.30

The J-UNIO protocol for automated protein structure determination by NMR in solution. J Biomol NMR (2012) 1.28

Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc Natl Acad Sci U S A (2004) 1.28

NMR structure of a KlbA intein precursor from Methanococcus jannaschii. Protein Sci (2007) 1.27