Published in Dermatol Clin on October 23, 2012
What causes alopecia areata? Exp Dermatol (2013) 1.14
Transient Efficacy of Tofacitinib in Alopecia Areata Universalis. Case Rep Dermatol (2016) 0.81
Treatment of an alopecia areata patient with tofacitinib results in regrowth of hair and changes in serum and skin biomarkers. Exp Dermatol (2016) 0.76
A Rare Association of Childhood Alopecia Areata and Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome: Successfully Treated with Diphenylcyclopropenone. Int J Trichology (2015) 0.75
Hair follicle characteristics as early marker of Type 2 Diabetes. Med Hypotheses (2016) 0.75
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature (2007) 144.95
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet (2010) 9.90
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 6.11
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature (2007) 6.10
Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature (2000) 5.86
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity (2007) 5.67
Probing genetic overlap among complex human phenotypes. Proc Natl Acad Sci U S A (2007) 3.79
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med (1992) 3.77
Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial. Arthritis Rheum (2005) 3.64
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood (2008) 3.52
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet (2009) 3.36
Vitiligo, thyroid disease and autoimmunity. Br J Dermatol (1968) 3.18
Effect of NKG2D ligand expression on host immune responses. Immunol Rev (2010) 3.08
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature (2010) 2.85
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76
Treatment of murine lupus with CTLA4Ig. Science (1994) 2.69
ALOPECIA AREATA. AN EVALUATION OF 736 PATIENTS. Arch Dermatol (1963) 2.67
CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest (1999) 2.58
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. J Allergy Clin Immunol (2010) 2.51
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat Genet (2008) 2.13
Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc (1995) 1.99
History of atopy or autoimmunity increases risk of alopecia areata. J Am Acad Dermatol (2009) 1.96
Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway. J Immunol (2006) 1.73
Variants in the 5q31 cytokine gene cluster are associated with psoriasis. Genes Immun (2007) 1.59
Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest (2007) 1.56
Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet (2007) 1.55
Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol (2009) 1.55
Interventions for alopecia areata. Cochrane Database Syst Rev (2008) 1.55
Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol (2002) 1.55
Epidemiology and genetics of alopecia areata. Clin Exp Dermatol (2002) 1.45
Alopecia areata. Int J Dermatol (2007) 1.45
Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model. J Invest Dermatol (2004) 1.38
The pattern and profile of alopecia areata in Singapore--a study of 219 Asians. Int J Dermatol (2002) 1.33
Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig. J Clin Invest (1995) 1.27
Alopecia areata and cytomegalovirus infection in twins: genes versus environment? J Am Acad Dermatol (1998) 1.27
CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J Immunol (1995) 1.25
Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey. Arch Dermatol (1992) 1.23
Alopecia areata, thyroid disease and autoimmunity. Br J Dermatol (1969) 1.19
Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol (2007) 1.18
Gene array profiling and immunomodulation studies define a cell-mediated immune response underlying the pathogenesis of alopecia areata in a mouse model and humans. J Invest Dermatol (2002) 1.17
Sudden whitening of the hair. Bull N Y Acad Med (1972) 1.15
The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. J Investig Dermatol Symp Proc (1999) 1.13
Alopecia areata and auto-immunity. Br J Dermatol (1981) 1.11
Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice. Antioxid Redox Signal (2010) 1.07
Celiac disease and alopecia areata: report of a new association. Gastroenterology (1995) 1.06
Profile of alopecia areata: a questionnaire analysis of patient and family. Int J Dermatol (1992) 1.06
IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). PLoS One (2009) 1.04
B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes. J Immunol (1992) 1.04
CTLA4-Ig plus bone marrow induces long-term allograft survival and donor specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism. Transplantation (1996) 1.02
Serum levels of soluble interleukin-2 receptor alpha (sIL-2Ralpha) as a predictor of outcome in brucellosis. J Infect (2004) 1.02
Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis. BMC Med Genet (2009) 1.01
Cytokines and other mediators in alopecia areata. Mediators Inflamm (2010) 0.99
Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopy. Clin Exp Dermatol (2009) 0.99
T cell subpopulations in alopecia areata. J Am Acad Dermatol (1984) 0.97
Generalized vitiligo and associated autoimmune diseases in Japanese patients and their families. Allergol Int (2011) 0.97
Familial aggregation of alopecia areata. J Am Acad Dermatol (2006) 0.96
An evolutionary perspective on C-type lectins in infection and immunity. Ann N Y Acad Sci (2012) 0.95
Alopecia areata: immunohistochemistry and ultrastructure of infiltrate and identification of adhesion molecule receptors. Int J Dermatol (1996) 0.94
Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses. Pigment Cell Melanoma Res (2011) 0.94
The Autoimmune Disease Database: a dynamically compiled literature-derived database. BMC Bioinformatics (2006) 0.94
TAT-mediated peroxiredoxin 5 and 6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes. Life Sci (2009) 0.93
Increased soluble interleukin-2 receptor levels in the sera of type 1 diabetic patients. Diabetes Res (1988) 0.92
The genetic risk for alopecia areata in first degree relatives of severely affected patients. An estimate. Acta Derm Venereol (1992) 0.92
Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance. J Invest Dermatol (2012) 0.91
Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study. Arthritis Res Ther (2009) 0.90
Alopecia areata in families: association with the HLA locus. J Investig Dermatol Symp Proc (1999) 0.90
Investigation of the HLA-DRB1 locus in alopecia areata. Eur J Dermatol (2006) 0.89
Genetic variants in CTLA4 are strongly associated with alopecia areata. J Invest Dermatol (2011) 0.89
MHC class I chain-related gene B promoter polymorphisms and celiac disease. Hum Immunol (2006) 0.87
Hypothesis testing: CTLA4 co-stimulatory pathways critical in the pathogenesis of human and mouse alopecia areata. J Invest Dermatol (2011) 0.86
IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways? Invest Ophthalmol Vis Sci (2011) 0.86
Family history and risk of type 1 diabetes mellitus. Acta Diabetol (2002) 0.85
MICA gene polymorphism in the pathogenesis of type 1 diabetes. Ann N Y Acad Sci (2007) 0.84
The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. Genes Immun (2011) 0.84
A clinical study of childhood alopecia areata in Singapore. Pediatr Dermatol (2002) 0.83
Alopecia areata. Recent Pat Inflamm Allergy Drug Discov (2011) 0.83
IL-13 in asthma. The successful integration of lessons from mice and humans. Am J Respir Crit Care Med (2011) 0.83
MICB0106 gene polymorphism is associated with ulcerative colitis in central China. Int J Colorectal Dis (2009) 0.81
Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility. Tissue Antigens (2008) 0.78
[Treatment of alopecia areata: modern principles and perspectives]. Lijec Vjesn (2011) 0.77
Increased risk for type I (insulin-dependent) diabetes in relatives of patients with alopecia areata (AA). Am J Med Genet (1994) 0.77
Identical twins with identical alopecia areata. J Am Acad Dermatol (1992) 0.77
Alopecia areata. Dermatol Clin (1987) 0.77
Requirements for T cell recognition and elimination of retrovirally-transformed cells. Princess Takamatsu Symp (1988) 0.76
Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature (2010) 2.85
The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nat Genet (2006) 2.81
Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity (2005) 2.57
Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med (2011) 2.41
Augmented HER-2 specific immunity during treatment with trastuzumab and chemotherapy. Clin Cancer Res (2007) 2.20
Immune complex-mediated antigen presentation induces tumor immunity. J Clin Invest (2002) 2.13
Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell (2003) 2.06
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nat Genet (2008) 2.00
Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis. J Invest Dermatol (2008) 1.96
Antigenic targeting of the human mannose receptor induces tumor immunity. J Immunol (2007) 1.93
Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. J Immunol (2008) 1.83
Germline fumarate hydratase mutations in families with multiple cutaneous and uterine leiomyomata. J Invest Dermatol (2003) 1.72
Therapeutic targeting of Syk in autoimmune diabetes. J Immunol (2010) 1.69
Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells. Blood (2008) 1.62
Clinical and pathologic correlations in genetically distinct forms of atrichia. Arch Dermatol (2003) 1.57
Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet (2007) 1.55
Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells. Proc Natl Acad Sci U S A (2011) 1.54
Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance. J Clin Invest (2007) 1.51
CD8+ T cell concentration determines their efficiency in killing cognate antigen-expressing syngeneic mammalian cells in vitro and in mouse tissues. J Exp Med (2010) 1.48
FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis. J Immunol (2006) 1.42
RAGE ligation affects T cell activation and controls T cell differentiation. J Immunol (2008) 1.41
Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis. Exp Dermatol (2013) 1.39
Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress. J Leukoc Biol (2007) 1.36
Clinical and molecular diagnostic criteria of congenital atrichia with papular lesions. J Invest Dermatol (2002) 1.35
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature (2010) 1.35
Receptor for advanced glycation end products expression on T cells contributes to antigen-specific cellular expansion in vivo. J Immunol (2007) 1.26
Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis). J Invest Dermatol (2004) 1.24
P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle. Development (2008) 1.20
Hair follicle stem cells. J Investig Dermatol Symp Proc (2003) 1.19
The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis. Dev Biol (2007) 1.18
Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily. J Biol Chem (2005) 1.17
Activation of Notch1 in the hair follicle leads to cell-fate switch and Mohawk alopecia. Differentiation (2004) 1.17
Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas. J Clin Invest (2003) 1.17
Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis. Ann N Y Acad Sci (2008) 1.17
Compound heterozygosity for non-sense and mis-sense mutations in desmoplakin underlies skin fragility/woolly hair syndrome. J Invest Dermatol (2002) 1.15
Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle. Differentiation (2006) 1.14
A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice. Hum Mol Genet (2008) 1.14
Founder mutations in the lipase h gene in families with autosomal recessive woolly hair/hypotrichosis. J Invest Dermatol (2009) 1.13
Fc gamma receptor IIB on dendritic cells enforces peripheral tolerance by inhibiting effector T cell responses. J Immunol (2007) 1.13
RAGE expression in human T cells: a link between environmental factors and adaptive immune responses. PLoS One (2012) 1.09
The effect of inbreeding on the distribution of compound heterozygotes: a lesson from Lipase H mutations in autosomal recessive woolly hair/hypotrichosis. Hum Hered (2009) 1.09
Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy. Am J Hum Genet (2005) 1.07
Niche crosstalk: intercellular signals at the hair follicle. Cell (2011) 1.06
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases. Exp Dermatol (2006) 1.06
Nonsense mutations in the hairless gene underlie APL in five families of Pakistani origin. J Dermatol Sci (2007) 1.06
Whole-exome sequencing in a single proband reveals a mutation in the CHST8 gene in autosomal recessive peeling skin syndrome. Genomics (2012) 1.04
Novel molecular therapies for heritable skin disorders. J Invest Dermatol (2011) 1.03
Generation of 3D skin equivalents fully reconstituted from human induced pluripotent stem cells (iPSCs). PLoS One (2013) 1.03
KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development (2009) 1.03
Prenatal diagnosis for epidermolysis bullosa: a study of 144 consecutive pregnancies at risk. Prenat Diagn (2003) 1.02
Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth. Proc Natl Acad Sci U S A (2013) 1.02
Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia. J Invest Dermatol (2007) 1.01
Mutations in the desmoglein 4 gene underlie localized autosomal recessive hypotrichosis with monilethrix hairs and congenital scalp erosions. J Invest Dermatol (2006) 1.00
Broken hearts, woolly hair, and tattered skin: when desmosomal adhesion goes awry. Curr Opin Cell Biol (2007) 0.99
Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion. Am J Hum Genet (2011) 0.98
Biology and genetics of hair. Annu Rev Genomics Hum Genet (2010) 0.97
The hairless promoter is differentially regulated by thyroid hormone in keratinocytes and neuroblastoma cells. Exp Dermatol (2004) 0.96
Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression. Dev Dyn (2007) 0.96
De novo mutations in monilethrix. Exp Dermatol (2003) 0.96
Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture. Am J Hum Genet (2010) 0.95
Mutations in the LIPH gene in three Japanese families with autosomal recessive woolly hair/hypotrichosis. J Dermatol Sci (2009) 0.95
Hereditary leukonychia, or porcelain nails, resulting from mutations in PLCD1. Am J Hum Genet (2011) 0.95
Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling. PLoS One (2012) 0.94
Multiple cutaneous and uterine leiomyomas: refinement of the genetic locus for multiple cutaneous and uterine leiomyomas on chromosome 1q42.3-43. J Invest Dermatol (2002) 0.93
Strategies for genotyping: Effectiveness of tailing primers to increase accuracy in short tandem repeat determinations. J Biomol Tech (2002) 0.93
The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling. J Invest Dermatol (2004) 0.92
Genome-wide linkage analysis of an autosomal recessive hypotrichosis identifies a novel P2RY5 mutation. Genomics (2008) 0.92
Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis. PLoS Genet (2012) 0.92
Evidence for extensive locus heterogeneity in Naxos disease. J Invest Dermatol (2002) 0.91
Germline fumarate hydratase mutations and evidence for a founder mutation underlying multiple cutaneous and uterine leiomyomata. J Am Acad Dermatol (2005) 0.91
Loci controlling plasma non-HDL and HDL cholesterol levels in a C57BL /6J x CASA /Rk intercross. J Lipid Res (2003) 0.91
Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. Development (2011) 0.90
Atrichia with papular lesions resulting from mutations in the rhesus macaque (Macaca mulatta) hairless gene. Lab Anim (2002) 0.90
Reprogramming of human hair follicle dermal papilla cells into induced pluripotent stem cells. J Invest Dermatol (2012) 0.90
Differential structural properties and expression patterns suggest functional significance for multiple mouse desmoglein 1 isoforms. Differentiation (2004) 0.89
Genetics of structural hair disorders. J Invest Dermatol (2012) 0.89
Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity. Dev Biol (2008) 0.89
The role of BMP signalling in the control of ID3 expression in the hair follicle. Exp Dermatol (2004) 0.88
The spectrum of hair loss in patients with mycosis fungoides and Sézary syndrome. J Am Acad Dermatol (2010) 0.88
Mutations in the keratin 85 (KRT85/hHb5) gene underlie pure hair and nail ectodermal dysplasia. J Invest Dermatol (2009) 0.88
Compound heterozygous mutations in the hairless gene in atrichia with papular lesions. J Invest Dermatol (2003) 0.88
Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling. Gene Expr Patterns (2007) 0.88
Expression patterns of the transcription factor AP-2alpha during hair follicle morphogenesis and cycling. J Invest Dermatol (2003) 0.88
Position effect on FGF13 associated with X-linked congenital generalized hypertrichosis. Proc Natl Acad Sci U S A (2013) 0.88
Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene. Exp Dermatol (2008) 0.87
A nonsense mutation in the desmoglein 1 gene underlies striate keratoderma. Exp Dermatol (2003) 0.87
Striate palmoplantar keratoderma resulting from a frameshift mutation in the desmoglein 1 gene. J Dermatol Sci (2006) 0.87
Localized autosomal recessive hypotrichosis due to a frameshift mutation in the desmoglein 4 gene exhibits extensive phenotypic variability within a Pakistani family. J Invest Dermatol (2007) 0.87
Health-Related Quality of Life (HRQoL) in alopecia areata patients-a secondary analysis of the National Alopecia Areata Registry Data. J Investig Dermatol Symp Proc (2013) 0.87
Atrichia with papular lesions resulting from compound heterozygous mutations in the hairless gene: A lesson for differential diagnosis of alopecia universalis. J Am Acad Dermatol (2002) 0.86
Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation. Differentiation (2009) 0.86
Hairless contains a novel nuclear matrix targeting signal and associates with histone deacetylase 3 in nuclear speckles. Differentiation (2004) 0.86