Published in Nat Cell Biol on November 25, 2012
Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06
Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science (2014) 1.99
Tracing the cellular origin of cancer. Nat Cell Biol (2013) 1.75
A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science (2016) 1.64
Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog. Genes Dev (2016) 1.39
Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17
Heterogeneity and plasticity of epidermal stem cells. Development (2014) 1.08
Function of oncogenes in cancer development: a changing paradigm. EMBO J (2013) 1.02
EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers. Int J Mol Sci (2013) 1.02
Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. EMBO J (2014) 1.01
Tracking cells in their native habitat: lineage tracing in epithelial neoplasia. Nat Rev Cancer (2013) 1.00
Signaling involved in hair follicle morphogenesis and development. Int J Mol Sci (2014) 0.97
Cell-state transitions regulated by SLUG are critical for tissue regeneration and tumor initiation. Stem Cell Reports (2014) 0.97
Wnt7b is an important intrinsic regulator of hair follicle stem cell homeostasis and hair follicle cycling. Stem Cells (2014) 0.96
SLUG: Critical regulator of epithelial cell identity in breast development and cancer. Cell Adh Migr (2014) 0.94
Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer. Cancer Growth Metastasis (2015) 0.90
Defining the clonal dynamics leading to mouse skin tumour initiation. Nature (2016) 0.88
The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition. Semin Cancer Biol (2014) 0.87
Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision. Science (2016) 0.85
Sonic hedgehog signaling in Basal cell nevus syndrome. Cancer Res (2014) 0.83
Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget (2015) 0.82
Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. J Invest Dermatol (2014) 0.81
Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity. Cell Rep (2016) 0.80
Diverse cells at the origin of lung adenocarcinoma. Proc Natl Acad Sci U S A (2014) 0.80
The protective role of vitamin d signaling in non-melanoma skin cancer. Cancers (Basel) (2013) 0.79
Cell competition: winning out by losing notch. Cell Cycle (2015) 0.78
Tissue-specific tumorigenesis: context matters. Nat Rev Cancer (2017) 0.77
Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia. EMBO Mol Med (2013) 0.76
Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. Front Physiol (2016) 0.76
Developing senescence to remodel the embryo. Commun Integr Biol (2014) 0.75
Stem cell reprogramming as a driver of basal cell carcinoma. Nat Cell Biol (2012) 0.75
Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers. J Invest Dermatol (2016) 0.75
Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer. Cell Rep (2016) 0.75
Cell Fate Decisions During Breast Cancer Development. J Dev Biol (2016) 0.75
Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo. PLoS One (2017) 0.75
Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer (2017) 0.75
INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene (2017) 0.75
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J (1999) 10.82
Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell (2004) 10.79
Capturing and profiling adult hair follicle stem cells. Nat Biotechnol (2004) 10.35
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development (1999) 9.82
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell (2001) 8.41
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell (1998) 7.95
Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell (2008) 7.69
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67
Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A (2003) 7.60
Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell (2010) 6.00
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Frozen robust multiarray analysis (fRMA). Biostatistics (2010) 5.57
Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell (2001) 5.01
Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer (2003) 4.86
Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer (2008) 4.34
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27
Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol (2005) 4.04
Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev (2005) 3.67
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
Lhx2 maintains stem cell character in hair follicles. Science (2006) 2.78
Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells. Dev Cell (2005) 2.71
beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell (2010) 2.60
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet (2008) 2.45
Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell (2011) 2.38
A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs. Genesis (2008) 2.10
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci U S A (2011) 1.89
Basal cell carcinoma: biology, morphology and clinical implications. Mod Pathol (2006) 1.82
The magnitude of hedgehog signaling activity defines skin tumor phenotype. EMBO J (2003) 1.72
Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci U S A (2011) 1.68
G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. Am J Pathol (2008) 1.60
The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Genes Dev (2001) 1.50
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin. Development (2011) 1.43
Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation. Development (2008) 1.41
The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood (2007) 1.35
SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. J Cutan Pathol (2008) 1.33
Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching. Proc Natl Acad Sci U S A (2010) 1.19
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation. Br J Dermatol (2004) 1.18
Keratin expression in basal cell carcinomas. Br J Dermatol (1992) 1.06
Expression of beta-catenin in basal cell carcinoma. Br J Dermatol (2003) 1.04
Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol (2011) 0.99
Biochemical and immunohistochemical analyses of keratin expression in basal cell carcinoma. J Dermatol Sci (1998) 0.91
Basal cell carcinoma and pilomatrixoma mirror human follicular embryogenesis as reflected by their differential expression patterns of SOX9 and β-catenin. Br J Dermatol (2010) 0.85
E- and P-cadherin expression in tumor tissues and soluble E-cadherin levels in sera of patients with skin cancer. J Dermatol Sci (1996) 0.83
LEF-1 expression in basal cell carcinomas. Br J Dermatol (2009) 0.78
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Distinct stem cells contribute to mammary gland development and maintenance. Nature (2011) 6.32
Defining the mode of tumour growth by clonal analysis. Nature (2012) 5.02
RSAT: regulatory sequence analysis tools. Nucleic Acids Res (2008) 3.93
Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med (2003) 3.91
ORegAnno: an open-access community-driven resource for regulatory annotation. Nucleic Acids Res (2007) 3.80
Distinct contribution of stem and progenitor cells to epidermal maintenance. Nature (2012) 3.44
A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature (2011) 3.25
Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Cell Stem Cell (2008) 3.07
Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. Nat Genet (2012) 2.64
Comparison and meta-analysis of microarray data: from the bench to the computer desk. Trends Genet (2003) 2.54
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat Cell Biol (2010) 2.48
ENDEAVOUR update: a web resource for gene prioritization in multiple species. Nucleic Acids Res (2008) 2.31
Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci U S A (2011) 2.24
Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis. J Cell Biol (2009) 2.24
Multipotent and unipotent progenitors contribute to prostate postnatal development. Nat Cell Biol (2012) 1.89
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev (2007) 1.86
Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up. Am J Kidney Dis (2008) 1.71
Bosentan for the prevention of overcirculation-induced experimental pulmonary arterial hypertension. Circulation (2003) 1.71
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1. Neuron (2013) 1.67
Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma. Gastroenterology (2012) 1.67
Post mortem examination in the intensive care unit: still useful? Intensive Care Med (2004) 1.66
Acute transient thyroid swelling after fine-needle aspiration biopsy: rare complication of unknown origin. Clin Endocrinol (Oxf) (2011) 1.64
Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma. Clin Cancer Res (2009) 1.62
DNA damage response in adult stem cells: pathways and consequences. Nat Rev Mol Cell Biol (2011) 1.57
Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. J Cell Biol (2011) 1.56
INCLUSive: A web portal and service registry for microarray and regulatory sequence analysis. Nucleic Acids Res (2003) 1.55
Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med (2013) 1.54
Prevalence of metabolic syndrome increases with the increase in blood levels of gamma glutamyltransferase and alanine aminotransferase in Japanese men and women. Intern Med (2009) 1.52
Constitutive agonist-independent CCR5 oligomerization and antibody-mediated clustering occurring at physiological levels of receptors. J Biol Chem (2002) 1.44
Mesp1: a key regulator of cardiovascular lineage commitment. Circ Res (2010) 1.43
The majority of multipotent epidermal stem cells do not protect their genome by asymmetrical chromosome segregation. Stem Cells (2008) 1.37
Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line. Hum Mutat (2010) 1.37
Comparison of 18F-FDG and 11C-methionine for PET-guided stereotactic brain biopsy of gliomas. J Nucl Med (2004) 1.35
p63: revving up epithelial stem-cell potential. Nat Cell Biol (2007) 1.32
Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B. Dev Cell (2011) 1.29
Binaural and cochlear disparities. Proc Natl Acad Sci U S A (2006) 1.28
Imaging infection with 18F-FDG-labeled leukocyte PET/CT: initial experience in 21 patients. J Nucl Med (2006) 1.24
i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules. Nucleic Acids Res (2012) 1.24
A splicing variant of the androgen receptor detected in a metastatic prostate cancer exhibits exclusively cytoplasmic actions. Endocrinology (2007) 1.21
Tracing epithelial stem cells during development, homeostasis, and repair. J Cell Biol (2012) 1.16
Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration. Int J Cancer (2003) 1.15
Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases. J Neuropathol Exp Neurol (2002) 1.14
Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3. J Biol Chem (2002) 1.13
Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis. Mol Pharmacol (2005) 1.12
Gene profiling of hippocampal neuronal culture. J Neurochem (2003) 1.12
Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. EMBO J (2012) 1.11
Curcumin ameliorates macrophage infiltration by inhibiting NF-κB activation and proinflammatory cytokines in streptozotocin induced-diabetic nephropathy. Nutr Metab (Lond) (2011) 1.10
NK cell regulation of CD4 T cell-mediated graft-versus-host disease. J Immunol (2010) 1.10
Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem (2009) 1.10
Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. Mol Cancer (2007) 1.09
Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma. Cancer (2010) 1.09
The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. PLoS Biol (2009) 1.08
High accuracy mutation detection in leukemia on a selected panel of cancer genes. PLoS One (2012) 1.08
Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway. Eur J Pharm Sci (2012) 1.07
Mechanisms regulating epidermal stem cells. EMBO J (2012) 1.07
Comparison of clinical and post-mortem findings in intensive care unit patients. Virchows Arch (2007) 1.06
Prognostic values of galectin-3 and the macrophage migration inhibitory factor (MIF) in human colorectal cancers. Mod Pathol (2003) 1.05
A simplified approach for the molecular classification of glioblastomas. PLoS One (2012) 1.05
Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting. Cancer (2003) 1.04
Characterization and clinical evaluation of CD10+ stroma cells in the breast cancer microenvironment. Clin Cancer Res (2012) 1.03
Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy. Curr Cardiol Rev (2010) 1.03
Expression profiling of ependymomas unravels localization and tumor grade-specific tumorigenesis. Cancer (2009) 1.03
Positron emission tomography-guided volumetric resection of supratentorial high-grade gliomas: a survival analysis in 66 consecutive patients. Neurosurgery (2009) 1.03
Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats. Mol Nutr Food Res (2011) 1.03
ARDS: a clinicopathological confrontation. Chest (2008) 1.02
Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. J Immunol (2009) 1.02
Single-center experience with ipilimumab in an expanded access program for patients with pretreated advanced melanoma. J Immunother (2013) 1.01
ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues? Genome Biol (2008) 0.99
VEGFR1 and VEGFR2 involvement in extracellular galectin-1- and galectin-3-induced angiogenesis. PLoS One (2013) 0.99
Integrated positron emission tomography and magnetic resonance imaging-guided resection of brain tumors: a report of 103 consecutive procedures. J Neurosurg (2006) 0.99
Stem cells: Skin regeneration and repair. Nature (2010) 0.98
Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients. BMC Cancer (2010) 0.98
Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles. J Neuropathol Exp Neurol (2006) 0.98
Up-regulation of galectin-3 and its ligands by Trypanosoma cruzi infection with modulation of adhesion and migration of murine dendritic cells. Glycobiology (2004) 0.98
Gene expression profiling of the hedgehog signaling pathway in human meningiomas. Mol Med (2010) 0.97
Interleukin-3 and interferon beta cooperate to induce differentiation of monocytes into dendritic cells with potent helper T-cell stimulatory properties. Blood (2002) 0.97
Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy. Int J Cancer (2014) 0.96
Uric acid is positively associated with metabolic syndrome but negatively associated with diabetes in Japanese men. Intern Med (2009) 0.96
Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implications. Mod Pathol (2002) 0.95
Clustering methods applied in the detection of Ki67 hot-spots in whole tumor slide images: an efficient way to characterize heterogeneous tissue-based biomarkers. Cytometry A (2012) 0.95
aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation. J Cell Biol (2013) 0.94
TIMP-4 and CD63: new prognostic biomarkers in human astrocytomas. Mod Pathol (2010) 0.93
Select screening in a specific high-risk population of patients suggests a stage migration toward detection of non-muscle-invasive bladder cancer. Eur Urol (2011) 0.93
TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila. Cell Rep (2013) 0.93