In tight junctions, claudins regulate the interactions between occludin, tricellulin and marvelD3, which, inversely, modulate claudin oligomerization.

PubWeight™: 1.06‹?› | Rank: Top 10%

🔗 View Article (PMID 23203797)

Published in J Cell Sci on November 30, 2012

Authors

Jimmi Cording1, Johanna Berg, Nadja Käding, Christian Bellmann, Christian Tscheik, Julie K Westphal, Susanne Milatz, Dorothee Günzel, Hartwig Wolburg, Jörg Piontek, Otmar Huber, Ingolf Ernst Blasig

Author Affiliations

1: Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin, Germany.

Articles citing this

Architecture of tight junctions and principles of molecular composition. Semin Cell Dev Biol (2014) 1.21

Tight junction proteins: from barrier to tumorigenesis. Cancer Lett (2013) 1.14

Claudin interactions in and out of the tight junction. Tissue Barriers (2013) 1.08

Molecular organization of tricellular tight junctions. Tissue Barriers (2014) 1.04

Differential pathways of claudin oligomerization and integration into tight junctions. Tissue Barriers (2013) 0.99

Claudins: Gatekeepers of lung epithelial function. Semin Cell Dev Biol (2015) 0.94

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. Mol Biol Cell (2015) 0.87

Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration. Tissue Barriers (2015) 0.87

Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol (2016) 0.87

Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments. J Biol Chem (2014) 0.86

Microbes, Immunity, and Behavior: Psychoneuroimmunology Meets the Microbiome. Neuropsychopharmacology (2016) 0.86

Protein kinase D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1. J Biol Chem (2013) 0.85

Redox-sensitive structure and function of the first extracellular loop of the cell-cell contact protein claudin-1: lessons from molecular structure to animals. Antioxid Redox Signal (2015) 0.85

Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection. Sci Rep (2015) 0.84

JNK inhibitor SP600125 protects against lipopolysaccharide-induced acute lung injury via upregulation of claudin-4. Exp Ther Med (2014) 0.81

Pasiflora proteins are novel core components of the septate junction. Development (2015) 0.80

Junctional proteins of the blood-brain barrier: New insights into function and dysfunction. Tissue Barriers (2016) 0.80

Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair. Gastroenterology (2016) 0.79

Systems Proteomics View of the Endogenous Human Claudin Protein Family. J Proteome Res (2016) 0.79

Conceptual barriers to understanding physical barriers. Semin Cell Dev Biol (2015) 0.78

Hippo pathway elements Co-localize with Occludin: A possible sensor system in pancreatic epithelial cells. Tissue Barriers (2015) 0.78

The intestinal epithelial barrier: a therapeutic target? Nat Rev Gastroenterol Hepatol (2016) 0.78

Trends in drug delivery through tissue barriers containing tight junctions. Tissue Barriers (2013) 0.78

Highly conserved cysteines are involved in the oligomerization of occludin-redox dependency of the second extracellular loop. Antioxid Redox Signal (2013) 0.77

Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1. Mol Biol Cell (2016) 0.77

MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus. Biol Open (2016) 0.75

The mucosal barrier at a glance. J Cell Sci (2017) 0.75

Cross-over endocytosis of claudins is mediated by interactions via their extracellular loops. PLoS One (2017) 0.75

Maresin 1 Maintains the Permeability of Lung Epithelial Cells In Vitro and In Vivo. Inflammation (2016) 0.75

Tricellular junctions: how to build junctions at the TRICkiest points of epithelial cells. Mol Biol Cell (2017) 0.75

Articles by these authors

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep (2006) 4.06

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science (2010) 3.98

Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22

Structure and function of claudins. Biochim Biophys Acta (2007) 2.98

Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci (2009) 2.85

The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol (2003) 2.77

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J (2005) 2.72

Viscoelastic properties of individual glial cells and neurons in the CNS. Proc Natl Acad Sci U S A (2006) 2.64

Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature (2005) 2.43

Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J (2007) 2.43

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum Mol Genet (2005) 2.28

Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc Natl Acad Sci U S A (2011) 2.11

Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house? Eur J Immunol (2004) 2.03

Mutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization. Nat Genet (2010) 2.00

A survey of public knowledge and awareness related to antibiotic use and resistance in Sweden. J Antimicrob Chemother (2010) 1.91

Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J Gen Physiol (2009) 1.91

Peeling of the basal membrane in the human retina: ultrastructural effects. Ophthalmology (2004) 1.80

Transferrin receptor upregulation: in vitro labeling of rat mesenchymal stem cells with superparamagnetic iron oxide. Radiology (2007) 1.79

Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development. J Cell Sci (2005) 1.79

Development of the zebrafish lymphatic system requires VEGFC signaling. Curr Biol (2006) 1.78

Claudin-2, a component of the tight junction, forms a paracellular water channel. J Cell Sci (2010) 1.70

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB J (2007) 1.63

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One (2010) 1.62

Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol (2002) 1.55

Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1. J Biol Chem (2008) 1.55

Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood (2006) 1.50

The specific fates of tight junction proteins in apoptotic epithelial cells. J Cell Sci (2004) 1.49

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Hum Mol Genet (2008) 1.47

Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol Biol Cell (2009) 1.46

A transmembrane tight junction protein selectively expressed on endothelial cells and platelets. J Biol Chem (2002) 1.45

The tight junction protein occludin and the adherens junction protein alpha-catenin share a common interaction mechanism with ZO-1. J Biol Chem (2004) 1.42

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep (2006) 1.35

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence. J Neurosci (2007) 1.34

Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16. J Clin Invest (2006) 1.33

The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity. J Biol Chem (2006) 1.32

The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. J Cell Sci (2005) 1.31

A nonredundant human protein chip for antibody screening and serum profiling. Mol Cell Proteomics (2003) 1.31

Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim Biophys Acta (2010) 1.30

Current concepts of blood-brain barrier development. Int J Dev Biol (2011) 1.29

A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo. Blood (2007) 1.29

Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta Neuropathol (2004) 1.25

Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles. J Invest Dermatol (2002) 1.25

A potassium channel-linked mechanism of glial cell swelling in the postischemic retina. Mol Cell Neurosci (2004) 1.23

Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proc Natl Acad Sci U S A (2010) 1.21

CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia. Am J Hum Genet (2011) 1.20

Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. Biochem Biophys Res Commun (2004) 1.19

Estrogen receptor alpha up-regulation and redistribution in human heart failure. FASEB J (2006) 1.18

Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/β-catenin signaling pathway in human lung cancer. Carcinogenesis (2012) 1.17

Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion. Proc Natl Acad Sci U S A (2010) 1.17

Microbial butyrate and its role for barrier function in the gastrointestinal tract. Ann N Y Acad Sci (2012) 1.17

Astrocytic autoantibody of neuromyelitis optica (NMO-IgG) binds to aquaporin-4 extracellular loops, monomers, tetramers and high order arrays. J Autoimmun (2012) 1.16

CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood (2010) 1.16

Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport. J Biol Chem (2010) 1.15

Labeling of human mesenchymal stromal cells with superparamagnetic iron oxide leads to a decrease in migration capacity and colony formation ability. Cytotherapy (2009) 1.14

Expression pattern of the water channel aquaporin-4 in human gliomas is associated with blood-brain barrier disturbance but not with patient survival. J Neurosci Res (2007) 1.14

Functional investigations on human mesenchymal stem cells exposed to magnetic fields and labeled with clinically approved iron nanoparticles. BMC Cell Biol (2010) 1.13

Oral and fecal Campylobacter concisus strains perturb barrier function by apoptosis induction in HT-29/B6 intestinal epithelial cells. PLoS One (2011) 1.13

Elucidating the principles of the molecular organization of heteropolymeric tight junction strands. Cell Mol Life Sci (2011) 1.12

Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences. J Cell Sci (2004) 1.12

Modulation of tight junction structure and function by kinases and phosphatases targeting occludin. J Biomed Biotechnol (2012) 1.12

Extracellular matrix and the blood-brain barrier in glioblastoma multiforme: spatial segregation of tenascin and agrin. Acta Neuropathol (2002) 1.11

Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J Biol Chem (2009) 1.11

The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity. Proc Natl Acad Sci U S A (2007) 1.11

TRPV4-mediated regulation of epithelial permeability. FASEB J (2006) 1.10

Redistribution of the water channel protein aquaporin-4 and the K+ channel protein Kir4.1 differs in low- and high-grade human brain tumors. Acta Neuropathol (2005) 1.10

Zona occludens-2 inhibits cyclin D1 expression and cell proliferation and exhibits changes in localization along the cell cycle. Mol Biol Cell (2008) 1.09

Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell Tissue Res (2003) 1.09

Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation. Biochem Biophys Res Commun (2008) 1.07

Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules. Cell Mol Life Sci (2010) 1.07

Cell polarity-determining proteins Par-3 and PP-1 are involved in epithelial tight junction defects in coeliac disease. Gut (2011) 1.07

Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3. Hum Mol Genet (2009) 1.07

Reactive glial cells: increased stiffness correlates with increased intermediate filament expression. FASEB J (2010) 1.06

Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys J (2009) 1.06

EpCAM, a human tumor-associated antigen promotes Th2 development and tumor immune evasion. Blood (2009) 1.06

Claudin-17 forms tight junction channels with distinct anion selectivity. Cell Mol Life Sci (2012) 1.06

Effects of agrin on the expression and distribution of the water channel protein aquaporin-4 and volume regulation in cultured astrocytes. Eur J Neurosci (2007) 1.05

Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. Acta Neuropathol (2009) 1.05

Occludin protein family: oxidative stress and reducing conditions. Antioxid Redox Signal (2011) 1.04

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. Exp Cell Res (2010) 1.03

Intestinal expression of TFF and related genes during postnatal development in a piglet probiotic trial. Cell Physiol Biochem (2009) 1.03

Evidence for a role of dystroglycan regulating the membrane architecture of astroglial endfeet. Eur J Neurosci (2011) 1.02

The different structures containing tight junction proteins in epidermal and other stratified epithelial cells, including squamous cell metaplasia. Eur J Cell Biol (2007) 1.02

Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol (2010) 1.01

Structure and function of extracellular claudin domains. Ann N Y Acad Sci (2009) 0.97

Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity. EMBO J (2009) 0.97

Agrin defines polarized distribution of orthogonal arrays of particles in astrocytes. Cell Tissue Res (2009) 0.97

Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death. Cancer Res (2004) 0.97

Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2. J Pathol (2009) 0.97

ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. J Biol Chem (2008) 0.96

The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. Oncol Rep (2008) 0.96

Transient opening of the perineurial barrier for analgesic drug delivery. Proc Natl Acad Sci U S A (2012) 0.95

Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms. Int J Biochem Cell Biol (2005) 0.95

Ectopic vesicular neurotransmitter release along sensory axons mediates neurovascular coupling via glial calcium signaling. Proc Natl Acad Sci U S A (2010) 0.95