Published in Am J Respir Cell Mol Biol on November 29, 2012
β-Blockers have differential effects on the murine asthma phenotype. Br J Pharmacol (2015) 0.95
Adverse effects of long-acting beta-agonists on airway hyperresponsiveness. Am J Respir Cell Mol Biol (2013) 0.85
Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma. Curr Opin Pharmacol (2014) 0.84
Ligand bias prevents class equality among beta-blockers. Curr Opin Pharmacol (2014) 0.81
Assessment of murine lung mechanics outcome measures: alignment with those made in asthmatics. Front Physiol (2013) 0.80
Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway. Curr Opin Pharmacol (2014) 0.79
Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. PLoS One (2015) 0.78
Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model. Am J Respir Cell Mol Biol (2015) 0.78
Phosphodiesterase 4 Inhibitors Attenuate the Asthma Phenotype Produced by β2-Adrenoceptor Agonists in Phenylethanolamine N-Methyltransferase-Knockout Mice. Am J Respir Cell Mol Biol (2016) 0.77
Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update. Br J Pharmacol (2016) 0.77
Epinephrine Activation of the β2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells. PLoS One (2015) 0.77
Reply: Adverse effects of long-acting beta-agonists on airway hyperresponsiveness. Am J Respir Cell Mol Biol (2013) 0.75
β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro. Sci Rep (2017) 0.75
β2 Agonists. Handb Exp Pharmacol (2016) 0.75
Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones. Pharmacol Ther (2016) 0.75
Effects of β-blockers on house dust mite-driven murine models pre- and post-development of an asthma phenotype. Pulm Pharmacol Ther (2017) 0.75
Targeting acetylcholine receptor M3 prevents the progression of airway hyperreactivity in a mouse model of childhood asthma. FASEB J (2017) 0.75
Differentiation of receptor systems activated by sympathomimetic amines. Nature (1967) 11.46
Regular inhaled beta-agonist treatment in bronchial asthma. Lancet (1990) 9.93
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Guide to Receptors and Channels (GRAC), 4th Edition. Br J Pharmacol (2009) 8.07
Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med (2006) 7.83
Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med (1996) 4.03
Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. Am J Respir Cell Mol Biol (2004) 2.50
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. J Clin Invest (2009) 2.28
Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol (2007) 2.24
Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma. Proc Natl Acad Sci U S A (2004) 1.85
Beta-arrestin-2 regulates the development of allergic asthma. J Clin Invest (2003) 1.85
The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study. Pulm Pharmacol Ther (2007) 1.61
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A (2009) 1.53
Asthma exacerbations. 5: assessment and management of severe asthma in adults in hospital. Thorax (2007) 1.49
New perspectives regarding β(2) -adrenoceptor ligands in the treatment of asthma. Br J Pharmacol (2011) 1.46
The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle. Endocrinology (2008) 1.38
Airway subsensitivity with long-acting beta 2-agonists. Is there cause for concern? Drug Saf (1997) 1.35
Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulm Pharmacol Ther (2007) 1.30
Targeted insertion of the Cre-recombinase gene at the phenylethanolamine n-methyltransferase locus: a new model for studying the developmental distribution of adrenergic cells. Dev Dyn (2004) 1.25
Is paradoxical pharmacology a strategy worth pursuing? Trends Pharmacol Sci (2001) 1.21
Beta-agonists and asthma: too much of a good thing? J Clin Invest (2003) 1.20
Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue. Neuromuscul Disord (2006) 1.16
Adverse effects of beta-agonists: are they clinically relevant? Am J Respir Med (2003) 1.14
Cellular mechanisms underlying temporal changes in skeletal muscle protein synthesis and breakdown during chronic {beta}-adrenoceptor stimulation in mice. J Physiol (2010) 1.11
Response to salbutamol in patients with mild asthma treated with nadolol. Eur Respir J (2010) 1.07
Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization. Am J Respir Cell Mol Biol (2006) 1.06
Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant? Curr Opin Pharmacol (2007) 1.01
Regular use of inhaled albuterol and the allergen-induced late asthmatic response. J Allergy Clin Immunol (1995) 1.00
Regular treatment with formoterol for chronic asthma: serious adverse events. Cochrane Database Syst Rev (2012) 0.98
Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma. J Appl Physiol (1985) (2003) 0.96
Assessment of intracellular mucin content in vivo. Methods Mol Biol (2012) 0.96
Can intellectualism stifle scientific discovery? Nat Rev Drug Discov (2002) 0.94
Current issues with beta2-adrenoceptor agonists: historical background. Clin Rev Allergy Immunol (2006) 0.92
Endogenous epinephrine protects against obesity induced insulin resistance. Auton Neurosci (2011) 0.90
Chronic formoterol administration reduces cardiac mitochondrial protein synthesis and oxidative capacity in mice. Int J Cardiol (2010) 0.89
Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue. Mol Cell Endocrinol (2010) 0.87
Mitochondrial dysfunction in the striatum of aged chronic mouse model of Parkinson's disease. Front Aging Neurosci (2009) 0.87
Inhaled adrenergic bronchodilators: historical development and clinical application. Respir Care (2000) 0.85
Epinephrine regulation of hemodynamics in catecholamine knockouts and the pithed mouse. Ann N Y Acad Sci (2008) 0.81
A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med (2011) 6.40
Airway mucus function and dysfunction. N Engl J Med (2010) 4.41
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med (2005) 4.00
Allergen-induced airway disease is mouse strain dependent. Am J Physiol Lung Cell Mol Physiol (2003) 2.56
Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. Am J Respir Cell Mol Biol (2004) 2.50
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet (2008) 2.48
The role of Toll-like receptor 4 in environmental airway injury in mice. Am J Respir Crit Care Med (2004) 2.43
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci (2006) 2.42
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem (2003) 2.31
Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol (2007) 2.24
Regulated airway goblet cell mucin secretion. Annu Rev Physiol (2008) 1.97
Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med (2011) 1.88
Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma. Proc Natl Acad Sci U S A (2004) 1.85
Morphine side effects in beta-arrestin 2 knockout mice. J Pharmacol Exp Ther (2005) 1.79
Airway mucus: From production to secretion. Am J Respir Cell Mol Biol (2006) 1.73
Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Am J Respir Cell Mol Biol (2007) 1.68
The safety and effects of the beta-blocker, nadolol, in mild asthma: an open-label pilot study. Pulm Pharmacol Ther (2007) 1.61
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation (2003) 1.55
Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A (2009) 1.53
Pneumonia during remission induction chemotherapy in patients with acute leukemia. Ann Am Thorac Soc (2013) 1.51
Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm Med (2009) 1.49
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci (2007) 1.48
Augmented lung inflammation protects against influenza A pneumonia. PLoS One (2009) 1.47
Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med (2008) 1.44
Retracted Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice. Am J Respir Cell Mol Biol (2010) 1.44
Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. Am J Respir Cell Mol Biol (2008) 1.44
Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype. Am J Respir Cell Mol Biol (2007) 1.41
Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. J Cell Sci (2004) 1.38
Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol (2009) 1.36
Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010) 1.34
Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways. J Physiol (2008) 1.33
Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. J Biol Chem (2006) 1.33
Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulm Pharmacol Ther (2007) 1.30
Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells. Cancer Res (2004) 1.29
Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. FASEB J (2008) 1.24
Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Dev Cell (2002) 1.22
Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356. Br J Pharmacol (2006) 1.20
Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice. J Immunol (2011) 1.16
Characterization of beta2-adrenergic receptor dephosphorylation: Comparison with the rate of resensitization. Mol Pharmacol (2006) 1.13
Both hematopoietic-derived and non-hematopoietic-derived {beta}-arrestin-2 regulates murine allergic airway disease. Am J Respir Cell Mol Biol (2009) 1.12
Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer. Int J Chron Obstruct Pulmon Dis (2011) 1.11
A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge. Am J Respir Cell Mol Biol (2006) 1.07
Exoskeletons and exhalation. N Engl J Med (2007) 1.07
Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization. Am J Respir Cell Mol Biol (2006) 1.06
Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice. Br J Pharmacol (2012) 1.06
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem (2003) 1.04
The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNgamma-induced cell death. J Cell Biol (2008) 1.04
Small airway mucous metaplasia and inflammation in chronic obstructive pulmonary disease. COPD (2008) 1.03
β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway. Proc Natl Acad Sci U S A (2012) 1.03
Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant? Curr Opin Pharmacol (2007) 1.01
Synergistic TLR2/6 and TLR9 activation protects mice against lethal influenza pneumonia. PLoS One (2012) 1.00
Cre-mediated recombination in mouse Clara cells. Genesis (2008) 1.00
Beta-agonist intrinsic efficacy: measurement and clinical significance. Am J Respir Crit Care Med (2002) 0.99
Exercise and the aging immune system. Ageing Res Rev (2012) 0.99
In vivo demonstration and quantification of intracellular Bacillus anthracis in lung epithelial cells. Infect Immun (2008) 0.99
Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide. Am J Physiol Lung Cell Mol Physiol (2005) 0.98
Rapid recycling of beta-adrenergic receptors is dependent on the actin cytoskeleton and myosin Vb. Traffic (2008) 0.98
Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum. J Biol Chem (2009) 0.97
Inhaled innate immune ligands to prevent pneumonia. Br J Pharmacol (2011) 0.97
Frequency dependence of respiratory system mechanics during induced constriction in a murine model of asthma. J Appl Physiol (1985) (2003) 0.96
Assessment of intracellular mucin content in vivo. Methods Mol Biol (2012) 0.96
Regulated mucin secretion from airway epithelial cells. Front Endocrinol (Lausanne) (2013) 0.95
Interleukin 6, but not T helper 2 cytokines, promotes lung carcinogenesis. Cancer Prev Res (Phila) (2010) 0.95
Can exercise training improve immune function in the aged? Ann N Y Acad Sci (2002) 0.95
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis (2009) 0.94
Inflammatory gene polymorphisms influence risk of postoperative morbidity after lung resection. Ann Thorac Surg (2005) 0.92
Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells. J Biol Chem (2009) 0.92
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins. J Biol Chem (2012) 0.91
Regulation of G-protein-coupled receptor activity by rab GTPases. Receptors Channels (2002) 0.91
Performance of a standardized bronchoalveolar lavage protocol in a comprehensive cancer center: a prospective 2-year study. Cancer (2011) 0.89
Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase. Mol Cancer (2013) 0.89
Inhaled therapeutics for prevention and treatment of pneumonia. Expert Opin Drug Saf (2009) 0.89
Endosome sorting of beta 2-adrenoceptors is GRK5 independent. Br J Pharmacol (2003) 0.88
In vivo phosphorylation of the somatostatin 2A receptor in human tumors. J Clin Endocrinol Metab (2003) 0.88
Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin. Am J Respir Cell Mol Biol (2006) 0.87