Published in Nat Rev Cancer on December 13, 2012
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer (2013) 3.23
Serine and glycine metabolism in cancer. Trends Biochem Sci (2014) 1.70
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53
A chemical probe toolbox for dissecting the cancer epigenome. Nat Rev Cancer (2017) 1.40
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science (2016) 1.31
Protein methylation at the surface and buried deep: thinking outside the histone box. Trends Biochem Sci (2013) 1.25
Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep (2013) 1.22
Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell (2014) 1.15
Readers of histone methylarginine marks. Biochim Biophys Acta (2014) 1.08
Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway. Nat Commun (2014) 1.06
PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Nat Commun (2015) 1.04
Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol (2015) 1.03
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. J Biol Chem (2013) 1.02
The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond. Cell Mol Life Sci (2015) 1.02
Selective inhibitors of protein methyltransferases. J Med Chem (2014) 1.01
Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing. J Biol Chem (2013) 1.01
Protein arginine methylation of non-histone proteins and its role in diseases. Cell Cycle (2013) 1.00
Chemical biology of protein arginine modifications in epigenetic regulation. Chem Rev (2015) 0.99
Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11. Br J Pharmacol (2014) 0.94
Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria. J Biol Chem (2014) 0.92
Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev (2014) 0.92
Global proteomic analysis in trypanosomes reveals unique proteins and conserved cellular processes impacted by arginine methylation. J Proteomics (2013) 0.91
N-alpha-terminal acetylation of histone H4 regulates arginine methylation and ribosomal DNA silencing. PLoS Genet (2013) 0.89
Small Molecule Inhibitors of Protein Arginine Methyltransferases. Expert Opin Investig Drugs (2016) 0.89
Chemical and biological methods to detect post-translational modifications of arginine. Biopolymers (2014) 0.88
Diversity of clinical implication of B-cell translocation gene 1 expression by histopathologic and anatomic subtypes of gastric cancer. Dig Dis Sci (2014) 0.88
Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate. BMC Syst Biol (2013) 0.87
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol (2015) 0.87
Functional Role of G9a Histone Methyltransferase in Cancer. Front Immunol (2015) 0.87
The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. Leukemia (2015) 0.86
Dynamic Arginine Methylation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6 Regulates Toll-like Receptor Signaling. J Biol Chem (2015) 0.86
PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest (2015) 0.86
A gain-of-function mouse model identifies PRMT6 as a NF-κB coactivator. Nucleic Acids Res (2014) 0.86
Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. J Biol Chem (2015) 0.86
Tumor necrosis factor (TNF)-α induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-κB p65 methylation. J Biol Chem (2014) 0.86
Emerging technologies to map the protein methylome. J Mol Biol (2014) 0.86
Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression. Oncotarget (2015) 0.86
Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget (2015) 0.86
A metabolomic approach to identifying platinum resistance in ovarian cancer. J Ovarian Res (2015) 0.85
Therapeutic targeting of splicing in cancer. Nat Med (2016) 0.85
Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing. Proc Natl Acad Sci U S A (2014) 0.85
Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. J Clin Invest (2015) 0.84
Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells. Mol Oncol (2014) 0.84
Signaling pathways that control mRNA turnover. Cell Signal (2013) 0.84
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. Elife (2015) 0.84
A journey toward Bioorthogonal Profiling of Protein Methylation inside living cells. Curr Opin Chem Biol (2013) 0.84
Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma. PLoS One (2015) 0.84
TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells. Prostate (2013) 0.84
A chemical proteomics approach for global analysis of lysine monomethylome profiling. Mol Cell Proteomics (2014) 0.84
Structural biology and chemistry of protein arginine methyltransferases. Medchemcomm (2014) 0.83
Proteomic analysis of arginine methylation sites in human cells reveals dynamic regulation during transcriptional arrest. Mol Cell Proteomics (2014) 0.83
PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents. Oncotarget (2015) 0.83
Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy. Cancer Sci (2016) 0.82
Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS Med Chem Lett (2015) 0.82
Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation. Proc Natl Acad Sci U S A (2015) 0.82
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP. Oncotarget (2015) 0.81
Protein Arginine Methylation and Citrullination in Epigenetic Regulation. ACS Chem Biol (2015) 0.81
Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta-catenin. J Transl Med (2015) 0.81
Histone methylation modifiers in cellular signaling pathways. Cell Mol Life Sci (2015) 0.81
Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro. J Neurooncol (2014) 0.81
Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation. Nucleic Acids Res (2014) 0.81
A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase. Proc Natl Acad Sci U S A (2016) 0.81
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners. Oxid Med Cell Longev (2015) 0.81
Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies? Mol Oncol (2016) 0.81
Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia. J Clin Invest (2016) 0.81
Role of PRMTs in cancer: Could minor isoforms be leaving a mark? World J Biol Chem (2014) 0.80
A HIERARCHICAL BAYESIAN MODEL FOR INFERENCE OF COPY NUMBER VARIANTS AND THEIR ASSOCIATION TO GENE EXPRESSION. Ann Appl Stat (2014) 0.80
Epigenetic modulation of insulin-like growth factor-II overexpression by hepatitis B virus X protein in hepatocellular carcinoma. Am J Cancer Res (2015) 0.80
Role of JMJD6 in Breast Tumourigenesis. PLoS One (2015) 0.80
Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues. ACS Chem Biol (2013) 0.80
Arginine increases development of in vitro-produced porcine embryos and affects the protein arginine methyltransferase-dimethylarginine dimethylaminohydrolase-nitric oxide axis. Reprod Fertil Dev (2015) 0.80
A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression. Oncogene (2016) 0.79
Roles of protein arginine methyltransferases in the control of glucose metabolism. Endocrinol Metab (Seoul) (2014) 0.79
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer. J Biol Chem (2015) 0.79
Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly. J Biol Chem (2016) 0.79
Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop. J Biol Chem (2014) 0.79
Interactions affected by arginine methylation in the yeast protein-protein interaction network. Mol Cell Proteomics (2013) 0.79
Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1. Mol Biol Cell (2014) 0.78
Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun (2015) 0.78
Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem (2016) 0.78
Mapping of Post-translational Modifications of Transition Proteins, TP1 and TP2, and Identification of Protein Arginine Methyltransferase 4 and Lysine Methyltransferase 7 as Methyltransferase for TP2. J Biol Chem (2015) 0.77
MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling. J Invest Dermatol (2016) 0.77
A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs. Neurotox Res (2014) 0.77
Exploration of cyanine compounds as selective inhibitors of protein arginine methyltransferases: synthesis and biological evaluation. J Med Chem (2015) 0.77
Effect of methylation on the side-chain pKa value of arginine. Protein Sci (2015) 0.77
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells. Nat Commun (2016) 0.77
Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev (2017) 0.76
Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cells. Oncoimmunology (2016) 0.76
The Role of Protein Arginine Methyltransferases in Inflammatory Responses. Mediators Inflamm (2016) 0.76
Mutations of Chromatin Structure Regulating Genes in Human Malignancies. Curr Protein Pept Sci (2016) 0.76
Enhanced levels of asymmetric dimethylarginine in a serum of middle age patients with myelodysplastic syndrome. J Hematol Oncol (2013) 0.76
Prmt7 is dispensable in tissue culture models for adipogenic differentiation. F1000Res (2013) 0.76
PRMT4-mediated arginine methylation negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation. Mol Cell Biol (2014) 0.76
Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage. Sci Rep (2015) 0.76
Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Sci Rep (2016) 0.75
Protein Arginine Methyltransferase Product Specificity Is Mediated by Distinct Active-site Architectures. J Biol Chem (2016) 0.75
aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism. Mol Cell Proteomics (2016) 0.75
Methylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression. J Biol Chem (2015) 0.75
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res (2010) 25.55
Selective inhibition of BET bromodomains. Nature (2010) 18.79
BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell (2011) 14.34
Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90
Non-coding RNAs in human disease. Nat Rev Genet (2011) 11.40
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature (2011) 8.29
Protein arginine methylation in mammals: who, what, and why. Mol Cell (2009) 7.44
Regulation of transcription by a protein methyltransferase. Science (1999) 7.22
Global histone modification patterns predict risk of prostate cancer recurrence. Nature (2005) 7.03
Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proc Natl Acad Sci U S A (2011) 6.30
Stress granules: the Tao of RNA triage. Trends Biochem Sci (2008) 6.27
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell (2004) 5.30
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science (2001) 5.25
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev (2010) 4.75
A transcriptional switch mediated by cofactor methylation. Science (2001) 4.32
Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr Biol (2001) 4.17
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes. Mol Cell Biol (2004) 3.90
Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature (2007) 3.68
Purification of proteins associated with specific genomic Loci. Cell (2009) 3.53
JMJD6 is a histone arginine demethylase. Science (2007) 3.48
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol (2009) 3.46
The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem (1996) 3.04
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nat Cell Biol (2008) 3.04
SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets. Mol Cell (2001) 2.95
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev (2009) 2.95
The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell (2007) 2.94
Arginine methylation regulates the p53 response. Nat Cell Biol (2008) 2.94
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol (2005) 2.83
Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr Biol (2002) 2.78
Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Biochemistry (2001) 2.74
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins. J Biol Chem (2001) 2.67
The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem (2001) 2.63
Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency. Genes Dev (2010) 2.59
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol Cell (2008) 2.58
JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. Cancer Cell (2011) 2.56
Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A (2003) 2.50
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. EMBO Rep (2009) 2.50
beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev Cell (2010) 2.44
The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation. PLoS Biol (2006) 2.43
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat Cell Biol (2009) 2.42
Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A (2005) 2.40
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res (2010) 2.39
Negative regulation of transcription by the type II arginine methyltransferase PRMT5. EMBO Rep (2002) 2.38
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (2009) 2.37
The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies. J Biol Chem (2000) 2.36
PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev (2007) 2.34
PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells. J Biol Chem (2000) 2.26
Tudor domains bind symmetrical dimethylated arginines. J Biol Chem (2005) 2.23
A novel WD repeat protein component of the methylosome binds Sm proteins. J Biol Chem (2001) 2.22
Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. J Biol Chem (2000) 2.20
The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol Cell (2009) 2.18
Protein arginine-methyltransferase-dependent oncogenesis. Nat Cell Biol (2007) 2.14
PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep (2002) 2.11
Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. EMBO J (2007) 2.08
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol (2008) 2.00
Regulation of estrogen rapid signaling through arginine methylation by PRMT1. Mol Cell (2008) 1.97
Histone arginine methylation. FEBS Lett (2010) 1.95
Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol (2006) 1.94
Control of CBP co-activating activity by arginine methylation. EMBO J (2002) 1.91
Arginine N-methyltransferase 1 is required for early postimplantation mouse development, but cells deficient in the enzyme are viable. Mol Cell Biol (2000) 1.90
Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. Sci Signal (2011) 1.90
Survival motor neuron protein facilitates assembly of stress granules. FEBS Lett (2004) 1.86
CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Cancer Res (2008) 1.83
Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer (2011) 1.81
TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell (2010) 1.80
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell (2010) 1.76
Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. Blood (2001) 1.74
Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. Mol Cell Biol (2008) 1.73
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A (2009) 1.73
The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science (2011) 1.72
Current chemical biology approaches to interrogate protein methyltransferases. ACS Chem Biol (2012) 1.70
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A (2006) 1.69
Deciphering arginine methylation: Tudor tells the tale. Nat Rev Mol Cell Biol (2011) 1.69
Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem (2007) 1.68
Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival. Mol Cell (2008) 1.67
PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem (2005) 1.67
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Cancer Res (2007) 1.66
O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins. J Biol Chem (2008) 1.64
Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance. Nat Struct Mol Biol (2012) 1.64
Drugging Wnt signalling in cancer. EMBO J (2012) 1.63
Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells. Clin Cancer Res (2005) 1.63
A methylation-mediator complex in hormone signaling. Genes Dev (2004) 1.61
Arginine methylation regulates DNA polymerase beta. Mol Cell (2006) 1.57
Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. EMBO J (2007) 1.55
The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol (2006) 1.55
The cold-inducible RNA-binding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor. Exp Cell Res (2007) 1.47
Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status. Cancer (2004) 1.45
Alternative splicing yields protein arginine methyltransferase 1 isoforms with distinct activity, substrate specificity, and subcellular localization. J Biol Chem (2007) 1.44
Arginine methylation controls growth regulation by E2F-1. EMBO J (2012) 1.44
Coactivator-associated arginine methyltransferase 1, CARM1, affects pre-mRNA splicing in an isoform-specific manner. J Biol Chem (2005) 1.42
A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol (2009) 1.40
Distribution of NG, NG,-dimethylarginine in nuclear protein fractions. Biochem Biophys Res Commun (1977) 1.40
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol (2011) 1.40
Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis. Breast Cancer Res Treat (2008) 1.40
Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A (2007) 1.40
Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A (2010) 1.37
Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J Biol Chem (2002) 1.36
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. Hum Mol Genet (2008) 1.36
Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep (2006) 5.19
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. J Biol Chem (2006) 3.14
The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell (2007) 2.94
The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem (2001) 2.63
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50
Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A (2003) 2.50
PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. EMBO Rep (2002) 2.11
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol (2010) 2.07
Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. J Virol (2005) 2.02
Small molecule regulators of protein arginine methyltransferases. J Biol Chem (2004) 1.99
Histone arginine methylation. FEBS Lett (2010) 1.95
Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell (2003) 1.87
TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell (2010) 1.80
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol (2012) 1.77
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J (2004) 1.74
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol (2013) 1.72
Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A (2006) 1.69
Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem (2007) 1.68
PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem (2005) 1.67
Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PLoS One (2009) 1.66
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res (2009) 1.49
WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene (2004) 1.47
Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett (2002) 1.46
Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol (2010) 1.42
A protein-domain microarray identifies novel protein-protein interactions. Biochem J (2002) 1.42
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol (2011) 1.40
Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). Biochem J (2005) 1.40
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol (2010) 1.37
Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem (2007) 1.35
Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J Biol Chem (2004) 1.35
Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. J Cell Sci (2009) 1.33
14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Cancer Res (2002) 1.33
Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J (2010) 1.27
Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol (2009) 1.26
Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell (2012) 1.23
Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo. J Biol Chem (2005) 1.22
Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep (2013) 1.22
The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem (2005) 1.21
Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem (2007) 1.21
CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep (2008) 1.21
Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One (2009) 1.18
Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol (2008) 1.17
Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem (2009) 1.16
WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer (2007) 1.13
epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem (2008) 1.13
Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell (2013) 1.12
IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis (2009) 1.12
Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res (2010) 1.10
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat Struct Mol Biol (2012) 1.09
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun (2011) 1.04
Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J Mol Biol (2011) 1.04
Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem (2009) 1.02
Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Rep (2011) 1.02
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. J Biol Chem (2013) 1.02
Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes Dev (2011) 1.00
Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. PLoS One (2012) 0.99
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development (2010) 0.99
Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. J Proteome Res (2010) 0.98
Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. J Biol Chem (2011) 0.98
Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem (2007) 0.97
Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol (2009) 0.94
Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem (2011) 0.94
Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY) (2012) 0.93
Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem (2011) 0.93
Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem (2010) 0.90
AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog (2010) 0.89
Protein methylation and DNA repair. Mutat Res (2007) 0.88
Techniques in protein methylation. Methods Mol Biol (2004) 0.88
Methods applied to the study of protein arginine methylation. Methods Enzymol (2012) 0.88
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chem Sci (2011) 0.88
Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Mol Biosyst (2011) 0.88
Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem (2011) 0.87
Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. PLoS One (2012) 0.85
A TR-FRET-based functional assay for screening activators of CARM1. Chembiochem (2013) 0.83
Xenoestrogens regulate the activity of arginine methyltransferases. Chembiochem (2010) 0.82
Protein-domain microarrays. Methods Mol Biol (2004) 0.80
Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. J Mol Biol (2009) 0.79
Titivated for destruction: the methyl degron. Mol Cell (2012) 0.79
Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. J Biol Chem (2014) 0.78
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. J Med Chem (2012) 0.78
Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol (2012) 0.78
Reprogramming the histone code. Chem Biol (2007) 0.75
Correction: Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS Pathog (2017) 0.75