Published in Exp Gerontol on December 10, 2012
Reliability of a Frailty Index Based on the Clinical Assessment of Health Deficits in Male C57BL/6J Mice. J Gerontol A Biol Sci Med Sci (2014) 2.20
Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff (Millwood) (2013) 2.03
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell (2015) 1.88
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice. Aging (Albany NY) (2014) 1.15
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol (2015) 1.10
Battery of behavioral tests in mice that models age-associated changes in human motor function. Age (Dordr) (2014) 1.09
You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda) (2014) 1.04
Life-long spontaneous exercise does not prolong lifespan but improves health span in mice. Longev Healthspan (2013) 1.02
Cognitive effects of cancer and its treatments at the intersection of aging: what do we know; what do we need to know? Semin Oncol (2013) 0.99
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity. Diabetes (2015) 0.98
Clinical strategies and animal models for developing senolytic agents. Exp Gerontol (2014) 0.96
Translational physiology: from molecules to public health. J Physiol (2013) 0.96
Inorganic nitrite supplementation for healthy arterial aging. J Appl Physiol (1985) (2014) 0.91
Cognitive effects of cancer systemic therapy: implications for the care of older patients and survivors. J Clin Oncol (2014) 0.91
Gait Speed Predicts Incident Disability: A Pooled Analysis. J Gerontol A Biol Sci Med Sci (2015) 0.89
Translational geroscience: emphasizing function to achieve optimal longevity. Aging (Albany NY) (2014) 0.83
Obesity and related consequences to ageing. Age (Dordr) (2016) 0.83
Infrastructure and resources for an aging population: embracing complexity in translational research. Transl Res (2013) 0.77
The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda. J Gerontol A Biol Sci Med Sci (2016) 0.77
Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice. J Appl Physiol (1985) (2014) 0.76
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty. Physiology (Bethesda) (2017) 0.75
Building for the future: essential infrastructure for rodent ageing studies. Mamm Genome (2016) 0.75
Comparative Approaches to Understanding the Relation Between Aging and Physical Function. J Gerontol A Biol Sci Med Sci (2015) 0.75
Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan. Aging Cell (2017) 0.75
Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci (2001) 42.21
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA (2001) 15.85
Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature (2005) 11.23
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med (2010) 8.77
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45
Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci (2006) 8.00
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med (2009) 7.06
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med (1999) 6.92
Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc (2006) 6.81
Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med (2004) 5.86
Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med (2002) 4.97
Serum IL-6 level and the development of disability in older persons. J Am Geriatr Soc (1999) 4.84
Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes (2004) 4.67
Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med (2011) 4.38
Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study. Arch Intern Med (2005) 4.24
In search of Methuselah: estimating the upper limits to human longevity. Science (1990) 3.99
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis (2009) 3.40
Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci (2009) 3.14
Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc (2006) 2.91
Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am (2003) 2.73
Inflammation and frailty in older women. J Am Geriatr Soc (2007) 2.66
Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study). Am J Cardiol (2003) 2.49
C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population-based, prospective study. Thromb Haemost (2006) 2.25
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature (2011) 1.97
Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell (2008) 1.71
Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia (2009) 1.66
JAK inhibitor therapy for myelofibrosis: critical assessment of value and limitations. Leukemia (2010) 1.63
Elevated levels of tumor necrosis factor alpha and mortality in centenarians. Am J Med (2003) 1.49
Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell (2012) 1.43
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun (2012) 1.37
White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort. J Clin Epidemiol (2001) 1.29
Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models? J Gerontol A Biol Sci Med Sci (2009) 1.28
Inflammation, coagulation, and the pathway to frailty. Am J Med (2009) 1.26
Single-gene mutations and healthy ageing in mammals. Philos Trans R Soc Lond B Biol Sci (2011) 1.25
The basics of preclinical drug development for neurodegenerative disease indications. BMC Neurol (2009) 1.23
The caloric restriction paradigm: implications for healthy human aging. Am J Hum Biol (2012) 1.22
Healthspan, translation, and new outcomes for animal studies of aging. J Gerontol A Biol Sci Med Sci (2009) 1.21
Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflamm Bowel Dis (2010) 1.12
Measuring systemic inflammatory regulation in older adults: evidence and utility. Rejuvenation Res (2009) 1.09
Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-gamma, and IP3R activation. Aging Cell (2010) 1.08
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell (2012) 1.08
Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults. Mech Ageing Dev (2008) 1.08
JAK inhibitors in myeloproliferative neoplasms: rationale, current data and perspective. Blood Rev (2011) 1.03
Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. Exp Gerontol (2009) 1.00
Exceptional parental longevity associated with lower risk of Alzheimer's disease and memory decline. J Am Geriatr Soc (2010) 0.96
Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells. Bone (2009) 0.96
Sources of life strengths as predictors of late-life mortality and survivorship. Int J Aging Hum Dev (2006) 0.89
Whose quality of life is it anyway? Why not ask seniors to tell us about it? Int J Aging Hum Dev (2000) 0.88
An index of self-rated health deficits in relation to frailty and adverse outcomes in older adults. Aging Clin Exp Res (2009) 0.85