Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study.

PubWeight™: 11.47‹?› | Rank: Top 0.1%

🔗 View Article (PMC 3563251)

Published in Lancet Neurol on January 03, 2013

Authors

Maarten J Titulaer1, Lindsey McCracken, Iñigo Gabilondo, Thaís Armangué, Carol Glaser, Takahiro Iizuka, Lawrence S Honig, Susanne M Benseler, Izumi Kawachi, Eugenia Martinez-Hernandez, Esther Aguilar, Núria Gresa-Arribas, Nicole Ryan-Florance, Abiguei Torrents, Albert Saiz, Myrna R Rosenfeld, Rita Balice-Gordon, Francesc Graus, Josep Dalmau

Author Affiliations

1: Department of Neurology and Neurosciences, Hospital of the University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.

Associated clinical trials:

Immunotherapy in Intractable Cryptogenic Epilepsy Patients With Autoimmune Antibody | NCT02695797

Efficacy of Ocrelizumab in Autoimmune Encephalitis | NCT03835728

Articles citing this

(truncated to the top 100)

Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis (2013) 4.51

Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol (2013) 4.18

Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis. Ann Neurol (2014) 3.40

A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol (2016) 2.86

Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies. Lancet Neurol (2014) 2.53

Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients. Neurology (2013) 2.32

Frequency and characteristics of isolated psychiatric episodes in anti–N-methyl-d-aspartate receptor encephalitis. JAMA Neurol (2013) 2.12

Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol (2014) 2.07

Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry (2013) 2.02

Status epilepticus of inflammatory etiology: a cohort study. Neurology (2015) 2.02

Fact or fiction? Examining a role for N-methyl-D-aspartate receptor autoantibodies in psychiatric illness. Biol Psychiatry (2015) 2.01

Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients. Neurology (2015) 1.96

Utility and safety of rituximab in pediatric autoimmune and inflammatory CNS disease. Neurology (2014) 1.87

Autoimmune post-herpes simplex encephalitis of adults and teenagers. Neurology (2015) 1.83

Acute mechanisms underlying antibody effects in anti-N-methyl-D-aspartate receptor encephalitis. Ann Neurol (2014) 1.73

Autoimmune encephalopathies. Ann N Y Acad Sci (2014) 1.65

Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice. Brain (2014) 1.59

A novel treatment-responsive encephalitis with frequent opsoclonus and teratoma. Ann Neurol (2013) 1.50

Autoimmune Encephalitis in Postpartum Psychosis. Am J Psychiatry (2015) 1.50

A case of NMDAR encephalitis misdiagnosed as postpartum psychosis and neuroleptic malignant syndrome. Neurol Sci (2014) 1.47

Neuroinflammation and psychiatric illness. J Neuroinflammation (2013) 1.42

Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. Lancet Psychiatry (2015) 1.29

GABAB receptor autoantibody frequency in service serologic evaluation. Neurology (2013) 1.28

Autoimmune encephalitis update. Neuro Oncol (2014) 1.27

Prevalence and treatment of anti-NMDA receptor encephalitis. Lancet Neurol (2013) 1.22

N-methyl-D-aspartate receptor antibody-mediated neurological disease: results of a UK-based surveillance study in children. Arch Dis Child (2015) 1.22

NMDA receptor antibodies associated with distinct white matter syndromes. Neurol Neuroimmunol Neuroinflamm (2014) 1.22

Diagnosis and management of paraneoplastic neurologic disorders. Curr Treat Options Oncol (2013) 1.15

Autoimmune encephalitis as differential diagnosis of infectious encephalitis. Curr Opin Neurol (2014) 1.13

Paraneoplastic neurological syndromes. Clin Exp Immunol (2014) 1.12

Anti-N-methyl-D-aspartate-receptor encephalitis: diagnosis, optimal management, and challenges. Ther Clin Risk Manag (2014) 1.11

Cell-surface central nervous system autoantibodies: clinical relevance and emerging paradigms. Ann Neurol (2014) 1.08

Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica. J Neurol Neurosurg Psychiatry (2016) 1.08

Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin-4 channelopathies: a decade later. Ann N Y Acad Sci (2015) 1.07

Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas. Blood (2014) 1.06

Anti-N-methyl-d-aspartate receptor encephalitis in Korea: clinical features, treatment, and outcome. J Clin Neurol (2014) 1.06

Autoimmunity, seizures, and status epilepticus. Epilepsia (2013) 1.03

Antibody-Mediated Autoimmune Encephalopathies and Immunotherapies. Neurotherapeutics (2016) 1.02

Late-onset anti-NMDA receptor encephalitis. Neurology (2013) 1.01

Prevalence and treatment of anti-NMDA receptor encephalitis. Lancet Neurol (2013) 1.01

Cerebellar ataxia and glutamic acid decarboxylase antibodies: immunologic profile and long-term effect of immunotherapy. JAMA Neurol (2014) 1.01

Anti-NMDA Receptor Encephalitis in the Polar Bear (Ursus maritimus) Knut. Sci Rep (2015) 1.00

Investigations on CXCL13 in anti-N-methyl-D-aspartate receptor encephalitis: a potential biomarker of treatment response. JAMA Neurol (2015) 1.00

Clinical spectrum and diagnostic value of antibodies against the potassium channel related protein complex. Neurologia (2014) 0.97

Predictors of outcome in acute encephalitis. Neurology (2013) 0.97

The clinical spectrum of Caspr2 antibody-associated disease. Neurology (2016) 0.97

Human neurexin-3α antibodies associate with encephalitis and alter synapse development. Neurology (2016) 0.96

Anti-NMDA receptor encephalitis, autoimmunity, and psychosis. Schizophr Res (2014) 0.96

Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization. Neurology (2015) 0.95

Anti-N-methyl-d-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment. BJPsych Bull (2015) 0.95

Autoimmune encephalitis: A potentially reversible cause of status epilepticus, epilepsy, and cognitive decline. Ann Indian Acad Neurol (2013) 0.94

New-onset refractory status epilepticus: Etiology, clinical features, and outcome. Neurology (2015) 0.94

Neuronal autoantibodies in epilepsy patients with peri-ictal autonomic findings. J Neurol (2016) 0.94

Neuroimmunology: an expanding frontier in autoimmunity. Front Immunol (2015) 0.93

Neuroinflammation: Ways in Which the Immune System Affects the Brain. Neurotherapeutics (2015) 0.93

High prevalence of NMDA receptor IgA/IgM antibodies in different dementia types. Ann Clin Transl Neurol (2014) 0.93

The Diagnosis and Treatment of Autoimmune Encephalitis. J Clin Neurol (2016) 0.92

Antigenic and mechanistic characterization of anti-AMPA receptor encephalitis. Ann Clin Transl Neurol (2014) 0.92

Treatment and outcome of children and adolescents with N-methyl-D-aspartate receptor encephalitis. J Neurol (2015) 0.92

Anti-LGI1-associated cognitive impairment: Presentation and long-term outcome. Neurology (2016) 0.91

Authors' reply. Lancet Neurol (2013) 0.91

Update on neurological paraneoplastic syndromes. Curr Opin Oncol (2015) 0.90

Encephalitis hospitalization rates and inpatient mortality in the United States, 2000-2010. PLoS One (2014) 0.90

Ovarian teratoma-associated anti-NMDAR encephalitis: a systematic review of reported cases. Orphanet J Rare Dis (2014) 0.89

Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography. BMC Neurol (2014) 0.88

Hypoglutamatergic state is associated with reduced cerebral glucose metabolism in anti-NMDA receptor encephalitis: a case report. BMC Psychiatry (2015) 0.87

Anti-N-methyl-D-aspartate receptor encephalitis: a patient with refractory illness after 25 months of intensive immunotherapy. JAMA Neurol (2013) 0.87

Clinical Neuropathology practice guide 4-2013: post-herpes simplex encephalitis: N-methyl-Daspartate receptor antibodies are part of the problem. Clin Neuropathol (2013) 0.86

Comparison of diagnostic accuracy of microscopy and flow cytometry in evaluating N-methyl-D-aspartate receptor antibodies in serum using a live cell-based assay. PLoS One (2015) 0.86

Autoimmune epilepsies. Neurotherapeutics (2014) 0.86

Autoantibodies and the immune hypothesis in psychotic brain diseases: challenges and perspectives. Clin Dev Immunol (2013) 0.85

Autoimmune causes of encephalitis syndrome in Thailand: prospective study of 103 patients. BMC Neurol (2013) 0.85

Pathologically confirmed autoimmune encephalitis in suspected Creutzfeldt-Jakob disease. Neurol Neuroimmunol Neuroinflamm (2015) 0.85

Tocilizumab in Autoimmune Encephalitis Refractory to Rituximab: An Institutional Cohort Study. Neurotherapeutics (2016) 0.84

Immunoadsorption therapy in autoimmune encephalitides. Neurol Neuroimmunol Neuroinflamm (2016) 0.83

High-throughput flow cytometry cell-based assay to detect antibodies to N-methyl-D-aspartate receptor or dopamine-2 receptor in human serum. J Vis Exp (2013) 0.83

Current and emergent treatments for symptoms and neurocognitive impairment in schizophrenia. Curr Treat Options Psychiatry (2015) 0.83

Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications. Psychopharmacology (Berl) (2015) 0.82

Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis. J Pediatric Infect Dis Soc (2014) 0.82

Autoimmune synaptopathies. Nat Rev Neurosci (2016) 0.82

Neuronal surface antibody-mediated autoimmune encephalitis. Semin Neurol (2014) 0.82

White matter changes in childhood NMDA receptor encephalitis: Bringing new light to an old phenotype. Neurol Neuroimmunol Neuroinflamm (2014) 0.82

Efficacy of Intravenous Immunoglobulin in Neurological Diseases. Neurotherapeutics (2016) 0.82

Earlier treatment of NMDAR antibody encephalitis in children results in a better outcome. Neurol Neuroimmunol Neuroinflamm (2015) 0.82

Is it time for immunopsychiatry in psychotic disorders? Psychopharmacology (Berl) (2016) 0.82

Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. Transl Psychiatry (2015) 0.82

Antibody-associated epilepsies: Clinical features, evidence for immunotherapies and future research questions. Seizure (2016) 0.81

A case of inflammatory peripheral nerve destruction antedating anti-NMDA receptor encephalitis. Neurol Neuroimmunol Neuroinflamm (2014) 0.81

Clinical characteristics and outcomes between children and adults with anti-N-Methyl-D-Aspartate receptor encephalitis. J Neurol (2016) 0.81

Association of Progressive Cerebellar Atrophy With Long-term Outcome in Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis. JAMA Neurol (2016) 0.81

Dazed, confused, and asystolic: possible signs of anti-N-methyl-D-aspartate receptor encephalitis. Tex Heart Inst J (2015) 0.81

CSF herpes virus and autoantibody profiles in the evaluation of encephalitis. Neurol Neuroimmunol Neuroinflamm (2016) 0.81

Anti-NMDA Receptor Encephalitis During Pregnancy: A Case Report. Medicine (Baltimore) (2015) 0.81

Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application. Expert Rev Neurother (2015) 0.80

Neuroleptic intolerance in patients with anti-NMDAR encephalitis. Neurol Neuroimmunol Neuroinflamm (2016) 0.80

Specific Roles of NMDA Receptor Subunits in Mental Disorders. Curr Mol Med (2015) 0.80

Young girl with abnormal behavior: Anti-N-Methyl-D-Aspartate receptor immune encephalitis. Ann Indian Acad Neurol (2013) 0.80

Transient anti-NMDAR encephalitis in a newborn infant due to transplacental transmission. Neurol Neuroimmunol Neuroinflamm (2015) 0.80

Autoimmune Encephalitis. Eur Neurol Rev (2013) 0.80

Acute psychosis in a pregnant patient with Graves' hyperthyroidism and anti-NMDA receptor encephalitis. BMJ Case Rep (2015) 0.80

Articles cited by this

Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol (2008) 21.53

Interobserver agreement for the assessment of handicap in stroke patients. Stroke (1988) 20.14

Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol (2007) 16.81

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol (2009) 9.25

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry (1994) 8.88

Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis (2010) 7.60

N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain (2010) 6.84

Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci (2010) 6.44

Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol (2005) 5.89

Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell (1999) 4.93

Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma. Acta Neuropathol (2009) 3.97

The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis (2012) 3.63

Neuronal autoantigens--pathogenesis, associated disorders and antibody testing. Nat Rev Neurol (2012) 3.20

IgA NMDA receptor antibodies are markers of synaptic immunity in slow cognitive impairment. Neurology (2012) 2.78

Screening for tumours in paraneoplastic syndromes: report of an EFNS task force. Eur J Neurol (2010) 2.77

Disrupted surface cross-talk between NMDA and Ephrin-B2 receptors in anti-NMDA encephalitis. Brain (2012) 2.39

Analysis of relapses in anti-NMDAR encephalitis. Neurology (2011) 1.98

Anti-NMDA receptor encephalitis: diagnosis, psychiatric presentation, and treatment. Am J Psychiatry (2011) 1.96

Case records of the Massachusetts General Hospital. Case 26-2008. A 26-year-old woman with headache and behavioral changes. N Engl J Med (2008) 1.60

The emerging link between autoimmune disorders and neuropsychiatric disease. J Neuropsychiatry Clin Neurosci (2011) 1.54

Ovarian teratoma associated with anti-N-methyl D-aspartate receptor encephalitis: a report of 5 cases documenting prominent intratumoral lymphoid infiltrates. Int J Gynecol Pathol (2012) 1.25

Articles by these authors

Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol (2008) 21.53

Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol (2007) 16.81

Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol (2011) 10.82

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol (2009) 9.25

Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol (2010) 7.97

Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain (2005) 6.81

Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med (2014) 6.50

Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci (2010) 6.44

Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol (2005) 5.89

Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol (2009) 5.75

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. Neuron (2013) 4.67

A patient with encephalitis associated with NMDA receptor antibodies. Nat Clin Pract Neurol (2007) 4.63

Paraneoplastic syndromes of the CNS. Lancet Neurol (2008) 4.62

AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol (2009) 4.49

Neuropathological changes in essential tremor: 33 cases compared with 21 controls. Brain (2007) 4.36

Pediatric anti-N-methyl-D-aspartate receptor encephalitis-clinical analysis and novel findings in a series of 20 patients. J Pediatr (2012) 4.12

Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma. Acta Neuropathol (2009) 3.97

Clinical analysis of anti-Ma2-associated encephalitis. Brain (2004) 3.89

The frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis (2012) 3.63

Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain (2008) 3.51

Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis. Ann Neurol (2014) 3.40

Neuronal autoantigens--pathogenesis, associated disorders and antibody testing. Nat Rev Neurol (2012) 3.20

Limbic encephalitis and variants: classification, diagnosis and treatment. Neurologist (2007) 3.06

Investigations of caspr2, an autoantigen of encephalitis and neuromyotonia. Ann Neurol (2011) 2.99

N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol (2012) 2.91

Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology (2012) 2.83

Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report. Neurology (2013) 2.82

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol (2012) 2.75

Tonic seizures: a diagnostic clue of anti-LGI1 encephalitis? Neurology (2011) 2.70

EFA6A-like antibodies in paraneoplastic encephalitis associated with immature ovarian teratoma: a case report. J Neurooncol (2006) 2.67

Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology (2011) 2.57

Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic. J Infect Dis (2008) 2.54

Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Acta Neuropathol (2002) 2.48

Antibodies and neuronal autoimmune disorders of the CNS. J Neurol (2009) 2.40

Anti-NMDA-receptor encephalitis: a severe, multistage, treatable disorder presenting with psychosis. J Neuroimmunol (2010) 2.36

A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurol (2013) 2.32

Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients. Neurology (2013) 2.32

Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy. Arch Neurol (2009) 2.25

Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition. J Neurol Neurosurg Psychiatry (2012) 2.21

Case records of the Massachusetts General Hospital. Case 34-2011: A 75-year-old man with memory loss and partial seizures. N Engl J Med (2011) 2.21

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis. Brain (2012) 2.17

Frequency and characteristics of isolated psychiatric episodes in anti–N-methyl-d-aspartate receptor encephalitis. JAMA Neurol (2013) 2.12

Glycine receptor autoimmune spectrum with stiff-man syndrome phenotype. JAMA Neurol (2013) 2.10

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A (2008) 2.09

Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08

Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol (2014) 2.07

Association of glucocerebrosidase mutations with dementia with lewy bodies. Arch Neurol (2009) 2.06

Autoantigen diversity in the opsoclonus-myoclonus syndrome. Ann Neurol (2003) 2.05

Voltage-gated potassium channel antibodies in limbic encephalitis. Ann Neurol (2003) 2.02

Cognitive deficits following anti-NMDA receptor encephalitis. J Neurol Neurosurg Psychiatry (2011) 2.01

Reduced Purkinje cell number in essential tremor: a postmortem study. Arch Neurol (2008) 1.99

Anti-NMDA receptor encephalitis causing prolonged nonconvulsive status epilepticus. Neurology (2010) 1.98

Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents. Curr Opin Pediatr (2010) 1.91

MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells. Cancer Biol Ther (2004) 1.90

Interplay of LRRK2 with chaperone-mediated autophagy. Nat Neurosci (2013) 1.88

Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain. J Neurosci (2012) 1.82

Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels. Ann Neurol (2012) 1.80

Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis. Ann Neurol (2009) 1.75

Acute mechanisms underlying antibody effects in anti-N-methyl-D-aspartate receptor encephalitis. Ann Neurol (2014) 1.73