Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy.

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Published in Immunity on January 24, 2013

Authors

Wei Liao1, Jian-Xin Lin, Warren J Leonard

Author Affiliations

1: Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.

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Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat Immunol (2012) 1.41

Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism. J Immunol (2010) 1.39

The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements. EMBO J (2002) 1.36

Thymic stromal lymphopoietin: a new cytokine in asthma. Curr Opin Pharmacol (2008) 1.35

Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. J Immunol (2008) 1.32

Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection. J Immunol (2008) 1.30

Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J Immunol (2011) 1.30

Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma. J Exp Med (2003) 1.29

Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol (2011) 1.28

Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling. J Biol Chem (2002) 1.28

Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral infection. J Immunol (2011) 1.26

Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood (2006) 1.25

IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol (2011) 1.25

The transcription factor GABP is a critical regulator of B lymphocyte development. Immunity (2007) 1.24

The role of thymic stromal lymphopoietin in CD8+ T cell homeostasis. J Immunol (2008) 1.23

Defective B cell responses in the absence of SH2D1A. Proc Natl Acad Sci U S A (2005) 1.21

Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells. J Virol (2013) 1.18

Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood (2011) 1.12

T-cell development and function are modulated by dual specificity phosphatase DUSP5. J Biol Chem (2008) 1.10

Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. Int Immunol (2005) 1.10

Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling. J Immunol (2008) 1.08

IL-21 promotes the pathologic immune response to pneumovirus infection. J Immunol (2012) 1.06

Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med (2013) 1.06

The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells. Immunity (2013) 1.06

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression. Proc Natl Acad Sci U S A (2014) 1.05

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog (2013) 1.03

Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol (2012) 1.03

Excessive Th1 responses due to the absence of TGF-β signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis. Proc Natl Acad Sci U S A (2013) 1.02

Critical role for Rsk2 in T-lymphocyte activation. Blood (2007) 1.02

Angiostatic activity of the antitumor cytokine interleukin-21. Blood (2008) 0.98

Cytokine mediators of Th17 function. Eur J Immunol (2009) 0.97

Interleukin-21 receptor gene induction in human T cells is mediated by T-cell receptor-induced Sp1 activity. Mol Cell Biol (2005) 0.96

Key role for IL-21 in experimental autoimmune uveitis. Proc Natl Acad Sci U S A (2011) 0.94

Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory. J Immunol (2004) 0.94

Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2. Int Immunol (2002) 0.93

Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev (2014) 0.93

IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response. Diabetes (2011) 0.92

IL-21 is an immune activator that also mediates suppression via IL-10. Crit Rev Immunol (2010) 0.90

Overexpression of interleukin 21 induces expansion of hematopoietic progenitor cells. Int J Hematol (2006) 0.89

GA-binding protein regulates KIS gene expression, cell migration, and cell cycle progression. FASEB J (2007) 0.87

Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease. J Immunol (2010) 0.85

The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation. Blood (2008) 0.85

Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function. Mol Cell Biol (2008) 0.84

Th17 cell-derived IL-17 is dispensable for B cell antibody production. Cytokine (2012) 0.84

A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis. Ann Rheum Dis (2013) 0.83

A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. Blood (2007) 0.83

p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia. Blood (2011) 0.83

The comparative efficacy of ezetimibe added to atorvastatin 10 mg versus uptitration to atorvastatin 40 mg in subgroups of patients aged 65 to 74 years or greater than or equal to 75 years. J Geriatr Cardiol (2011) 0.82