Published in Trends Biochem Sci on January 23, 2013
Function and information content of DNA methylation. Nature (2015) 3.09
Common DNA methylation alterations in multiple brain regions in autism. Mol Psychiatry (2013) 1.51
Cross-talk between site-specific transcription factors and DNA methylation states. J Biol Chem (2013) 1.24
Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides? Trends Biochem Sci (2013) 1.07
Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes Dev (2014) 1.02
ZBTB33 binds unmethylated regions of the genome associated with actively expressed genes. Epigenetics Chromatin (2013) 0.93
Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1. FEBS Lett (2015) 0.91
Evolving insights on how cytosine methylation affects protein-DNA binding. Brief Funct Genomics (2014) 0.90
Structural basis for Klf4 recognition of methylated DNA. Nucleic Acids Res (2014) 0.89
Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family. Mob DNA (2015) 0.85
New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217. J Biol Chem (2013) 0.85
Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks. Biochim Biophys Acta (2014) 0.85
DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å. Biochemistry (2013) 0.84
The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations. J Biol Chem (2015) 0.83
Quantitative Analysis of the DNA Methylation Sensitivity of Transcription Factor Complexes. Cell Rep (2017) 0.80
DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications. Adv Exp Med Biol (2016) 0.78
Distinctive Klf4 mutants determine preference for DNA methylation status. Nucleic Acids Res (2016) 0.78
Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol Cell (2017) 0.77
Zinc finger protein 382 is downregulated by promoter hypermethylation in pediatric acute myeloid leukemia patients. Int J Mol Med (2014) 0.76
DNA methylation of a GC repressor element in the smooth muscle myosin heavy chain promoter facilitates binding of the Notch-associated transcription factor, RBPJ/CSL1. Arterioscler Thromb Vasc Biol (2014) 0.75
Measurement of DNA Length Changes Upon CpG Hypermethylation by Microfluidic Molecular Stretching. Cell Med (2016) 0.75
Characterization of How DNA Modifications Affect DNA Binding by C2H2 Zinc Finger Proteins. Methods Enzymol (2016) 0.75
Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline. Oncotarget (2015) 0.75
The Methylcytosine Dioxygenase Ten-Eleven Translocase-2 (tet2) Enables Elevated GnRH Gene Expression and Maintenance of Male Reproductive Function. Endocrinology (2016) 0.75
Response to mackay et Al. Trends Biochem Sci (2013) 0.75
Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation. Int J Mol Sci (2017) 0.75
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet (1998) 7.52
DNA recognition by Cys2His2 zinc finger proteins. Annu Rev Biophys Biomol Struct (2000) 6.61
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One (2010) 6.38
High-resolution analysis of parent-of-origin allelic expression in the mouse brain. Science (2010) 5.91
A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science (2008) 5.35
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol (1988) 5.24
Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science (2011) 4.12
Sex-specific parent-of-origin allelic expression in the mouse brain. Science (2010) 3.89
SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell Mol Life Sci (1998) 3.78
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell (2011) 3.67
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism. Nature (2008) 3.62
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1. Nature (2008) 3.39
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature (2008) 3.28
ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. PLoS One (2010) 3.15
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57. Nat Genet (2008) 3.06
The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes Dev (2001) 2.91
The role of MeCP2 in the brain. Annu Rev Cell Dev Biol (2011) 2.84
Embryonic stem cells use ZFP809 to silence retroviral DNAs. Nature (2009) 2.80
A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors. Genome Res (2006) 2.71
Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA. Cell (2001) 2.64
All in the family: the BTB/POZ, KRAB, and SCAN domains. Mol Cell Biol (2001) 2.56
MeCP2 binding to DNA depends upon hydration at methyl-CpG. Mol Cell (2008) 2.48
Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res (2011) 2.36
The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. Nucleic Acids Res (2002) 2.02
Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem (2011) 1.88
Trim28 is required for epigenetic stability during mouse oocyte to embryo transition. Science (2012) 1.84
5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Nat Struct Mol Biol (2012) 1.74
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74
Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes. Genome Res (2006) 1.54
Coevolution of retroelements and tandem zinc finger genes. Genome Res (2011) 1.46
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics (2009) 1.45
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43
Sequence-specific recognition of methylated DNA by human zinc-finger proteins. Nucleic Acids Res (2010) 1.41
An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev (2012) 1.38
The MBD protein family-reading an epigenetic mark? Mutat Res (2008) 1.38
Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. J Biol Chem (1995) 1.30
The KRAB-ZFP/KAP1 system contributes to the early embryonic establishment of site-specific DNA methylation patterns maintained during development. Cell Rep (2012) 1.28
Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence. Nucleic Acids Res (2011) 1.26
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proc Natl Acad Sci U S A (2012) 1.18
Recognition of methylated DNA through methyl-CpG binding domain proteins. Nucleic Acids Res (2011) 1.16
SysZNF: the C2H2 zinc finger gene database. Nucleic Acids Res (2008) 1.13
Gain, loss and divergence in primate zinc-finger genes: a rich resource for evolution of gene regulatory differences between species. PLoS One (2011) 1.08
Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development (2008) 1.06
Evolution of C2H2-zinc finger genes revisited. BMC Evol Biol (2009) 1.02
Recognition of 5'-YpG-3' sequences by coupled stacking/hydrogen bonding interactions with amino acid residues. J Mol Biol (2004) 1.01
A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing. BMC Genomics (2011) 0.96
Recruitment of Dnmt1 roles of the SRA protein Np95 (Uhrf1) and other factors. Prog Mol Biol Transl Sci (2011) 0.89
The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration. Mol Cell Biol (2012) 0.87
Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes. Structure (2006) 0.85
Human more complex than mouse at cellular level. PLoS One (2012) 0.82
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature (2007) 8.33
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res (2003) 7.56
Many paths to methyltransfer: a chronicle of convergence. Trends Biochem Sci (2003) 5.65
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature (2007) 4.49
Structural basis for the product specificity of histone lysine methyltransferases. Mol Cell (2003) 4.42
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15
The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol (2005) 3.93
Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol (2008) 3.53
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature (2008) 3.28
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat Struct Mol Biol (2008) 3.20
Structural and sequence motifs of protein (histone) methylation enzymes. Annu Rev Biophys Biomol Struct (2005) 3.17
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell (2002) 2.94
Measuring the thermal conductivity of a single carbon nanotube. Phys Rev Lett (2005) 2.94
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87
In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. J Biol Chem (2004) 2.86
Mammalian DNA methyltransferases: a structural perspective. Structure (2008) 2.72
Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM. Proc Natl Acad Sci U S A (2009) 2.65
Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation. Nucleic Acids Res (2012) 2.55
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol Cell Biol (2002) 2.51
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol (2009) 2.50
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell (2008) 2.35
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem (2007) 2.34
Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure (2003) 2.30
The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat Struct Biol (2002) 2.24
Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc Natl Acad Sci U S A (2002) 2.20
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol (2010) 2.07
Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem (2002) 2.06
Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J Biol Chem (2002) 1.99
Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP. J Biol Chem (2002) 1.94
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74
Structure of the SET domain histone lysine methyltransferase Clr4. Nat Struct Biol (2002) 1.70
Putative autocleavage of outer capsid protein micro1, allowing release of myristoylated peptide micro1N during particle uncoating, is critical for cell entry by reovirus. J Virol (2004) 1.69
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med (2007) 1.69
Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. J Mol Evol (2002) 1.68
Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry (2007) 1.55
Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ-coupled two-dimensional LC-MS/MS. Proteomics (2014) 1.55
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability. Nat Struct Mol Biol (2010) 1.52
Antiapoptotic effect of serum and glucocorticoid-inducible protein kinase is mediated by novel mechanism activating I{kappa}B kinase. Cancer Res (2005) 1.48
Comprehensive alanine-scanning mutagenesis of Escherichia coli CsrA defines two subdomains of critical functional importance. J Biol Chem (2006) 1.47
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res (2008) 1.46
A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol Pharmacol (2012) 1.46
A nearly modern amphibious bird from the Early Cretaceous of northwestern China. Science (2006) 1.45
UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications. Epigenetics (2009) 1.45
Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells. Acta Pharmacol Sin (2008) 1.43
Simultaneous measurements of the specific heat and thermal conductivity of suspended thin samples by transient electrothermal method. Rev Sci Instrum (2009) 1.43
Molecular coupling of DNA methylation and histone methylation. Epigenomics (2010) 1.43
Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation. Mol Endocrinol (2007) 1.42
Insulin alleviates posttrauma cardiac dysfunction by inhibiting tumor necrosis factor-α-mediated reactive oxygen species production. Crit Care Med (2013) 1.42
Potential role of α-synuclein in neurodegeneration: studies in a rat animal model. J Neurochem (2012) 1.41
Activation of antioxidant pathways in ras-mediated oncogenic transformation of human surface ovarian epithelial cells revealed by functional proteomics and mass spectrometry. Cancer Res (2004) 1.41
Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog (2010) 1.40
Reduced expression of NDUFS3 and its clinical significance in serous ovarian cancer. Int J Gynecol Cancer (2013) 1.40
High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells. Cell Rep (2013) 1.40
Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A (2007) 1.40
An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev (2012) 1.38
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem (2004) 1.38
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol (2010) 1.37
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase. Cell (2005) 1.36
Nature of the promoter activated by C.PvuII, an unusual regulatory protein conserved among restriction-modification systems. J Bacteriol (2005) 1.36
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. Nucleic Acids Res (2012) 1.35
Improvement of antibiotic activity of Xenorhabdus bovienii by medium optimization using response surface methodology. Microb Cell Fact (2011) 1.35
An antibody to the putative aphid recognition site on cucumber mosaic virus recognizes pentons but not hexons. J Virol (2002) 1.35
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chem Biol (2008) 1.34
A Structural-informatics approach for tracing beta-sheets: building pseudo-C(alpha) traces for beta-strands in intermediate-resolution density maps. J Mol Biol (2004) 1.34
The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer. J Transl Med (2010) 1.33
The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site. J Biol Chem (2004) 1.33
Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res (2011) 1.32
Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem (2011) 1.32
Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol (2008) 1.31
The Magnaporthe oryzae avirulence gene AvrPiz-t encodes a predicted secreted protein that triggers the immunity in rice mediated by the blast resistance gene Piz-t. Mol Plant Microbe Interact (2009) 1.30
A model-based parallel origin and orientation refinement algorithm for cryoTEM and its application to the study of virus structures. J Struct Biol (2005) 1.29