Published in Ann Intern Med on November 13, 2012
The impact of diet and lifestyle on gut microbiota and human health. Nutrients (2014) 1.40
Addressing dichotomous data for participants excluded from trial analysis: a guide for systematic reviewers. PLoS One (2013) 1.40
Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents. Clin Microbiol Rev (2014) 1.17
Breakthroughs in the treatment and prevention of Clostridium difficile infection. Nat Rev Gastroenterol Hepatol (2016) 1.13
The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med (2016) 1.08
Probiotics for the prevention of Clostridium difficile-associated diarrhea. Ann Intern Med (2013) 0.97
Probiotics for the prevention of Clostridium difficile-associated diarrhea. Ann Intern Med (2013) 0.96
Microbial and metabolic interactions between the gastrointestinal tract and Clostridium difficile infection. Gut Microbes (2013) 0.94
Risk and safety of probiotics. Clin Infect Dis (2015) 0.92
Clostridium difficile Infection: Epidemiology, Pathogenesis, Risk Factors, and Therapeutic Options. Scientifica (Cairo) (2014) 0.91
Faecal microbiota transplantation for the treatment of recurrent Clostridium difficile infection: current promise and future needs. Curr Opin Gastroenterol (2013) 0.89
Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections. World J Gastroenterol (2016) 0.86
A checklist designed to aid consistency and reproducibility of GRADE assessments: development and pilot validation. Syst Rev (2014) 0.86
Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial. Open Forum Infect Dis (2016) 0.86
C. difficile Infection: Changing Epidemiology and Management Paradigms. Clin Transl Gastroenterol (2015) 0.85
Probiotics for the prevention of Clostridium difficile. Can Fam Physician (2013) 0.84
Assessing worldwide research activity on probiotics in pediatrics using Scopus database: 1994-2014. World Allergy Organ J (2016) 0.83
Probiotics are effective at preventing Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Int J Gen Med (2016) 0.83
Probiotics for antibiotic-associated diarrhea: do we have a verdict? World J Gastroenterol (2014) 0.83
Treatment Strategies for Recurrent Clostridium difficile Infection. Can J Hosp Pharm (2013) 0.82
Antibiotics-related adverse events in the infectious diseases department of a French teaching hospital: a prospective study. Eur J Clin Microbiol Infect Dis (2013) 0.81
Clinical update for the diagnosis and treatment of Clostridium difficile infection. World J Gastrointest Pharmacol Ther (2014) 0.81
Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury. Shock (2016) 0.80
Multi-institution case-control and cohort study of risk factors for the development and mortality of Clostridium difficile infections in Japan. BMJ Open (2014) 0.80
Diet and nutrition in cancer survivorship and palliative care. Evid Based Complement Alternat Med (2013) 0.80
Epidemiology, Diagnosis, and Management of Clostridium difficile Infection in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis (2016) 0.79
Emerging therapies for Clostridium difficile infection - focus on fidaxomicin. Infect Drug Resist (2013) 0.79
Overview of Clostridium difficile infection: implications for China. Gastroenterol Rep (Oxf) (2013) 0.79
Clinical Characteristics of Symptomatic Clostridium difficile Infection in Children: Conditions as Infection Risks and Whether Probiotics Is Effective. Pediatr Gastroenterol Hepatol Nutr (2014) 0.79
Preclinical studies of amixicile, a systemic therapeutic developed for treatment of Clostridium difficile infections that also shows efficacy against Helicobacter pylori. Antimicrob Agents Chemother (2014) 0.79
Progress in the discovery of treatments for C. difficile infection: A clinical and medicinal chemistry review. Curr Top Med Chem (2014) 0.79
Infection prevention and control of Clostridium difficile: a global review of guidelines, strategies, and recommendations. J Glob Health (2016) 0.79
Incidence and outcomes of bloodstream infections among hematopoietic cell transplant recipients from species commonly reported to be in over-the-counter probiotic formulations. Transpl Infect Dis (2016) 0.78
Learning Data-Driven Patient Risk Stratification Models for Clostridium difficile. Open Forum Infect Dis (2014) 0.78
Live probiotic cultures and the gastrointestinal tract: symbiotic preservation of tolerance whilst attenuating pathogenicity. Front Cell Infect Microbiol (2014) 0.77
Probiotics for the prevention of Clostridium difficile-associated diarrhea. In response. Ann Intern Med (2013) 0.77
Development of Streptococcus pneumoniae Vaccines Using Live Vectors. Vaccines (Basel) (2014) 0.77
Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. Antibiotics (Basel) (2015) 0.77
Probiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for? Anaerobe (2016) 0.77
The Role of Probiotics in the Treatment of Dysentery: a Randomized Double-Blind Clinical Trial. Probiotics Antimicrob Proteins (2017) 0.76
Probiotics for the treatment of Clostridium difficile associated disease. World J Gastrointest Pathophysiol (2013) 0.76
Isolation of C. difficile Carriers Alone and as Part of a Bundle Approach for the Prevention of Clostridium difficile Infection (CDI): A Mathematical Model Based on Clinical Study Data. PLoS One (2016) 0.76
Practicing prevention with probiotics. JAMA Dermatol (2013) 0.75
Clostridium difficile in Children: To Treat or Not to Treat? Pediatr Gastroenterol Hepatol Nutr (2014) 0.75
ACP Journal Club. Review: probiotics reduce Clostridium difficile-associated diarrhea in patients receiving antibiotics. Ann Intern Med (2013) 0.75
Efficacy of Electrical Stimulators for Bone Healing: A Meta-Analysis of Randomized Sham-Controlled Trials. Sci Rep (2016) 0.75
Lactobacillus probiotics in the prevention of diarrhea associated with Clostridium difficile: a systematic review and Bayesian hierarchical meta-analysis. CMAJ Open (2016) 0.75
Advances in the Microbiome: Applications to Clostridium difficile Infection. J Clin Med (2016) 0.75
Integrating naturopathy: can we move forward? Perm J (2013) 0.75
Effect of Metronidazole in Infants with Bowel Habit Change: Irrelative to the Clostridium difficile Colonization. Pediatr Gastroenterol Hepatol Nutr (2017) 0.75
Enhanced Probiotic Potential of Lactobacillus reuteri When Delivered as a Biofilm on Dextranomer Microspheres That Contain Beneficial Cargo. Front Microbiol (2017) 0.75
Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea. Gastroenterol Clin North Am (2017) 0.75
Community-acquired Clostridium difficile infection. Can Fam Physician (2017) 0.75
Fermented Milk Consumption and Common Infections in Children Attending Day-Care Centers: A Randomized Trial. J Pediatr Gastroenterol Nutr (2016) 0.75
PURLs: prescribing an antibiotic? Pair it with probiotics. J Fam Pract (2013) 0.75
Tracking Inhibitory Alterations during Interstrain Clostridium difficile Interactions by Monitoring Cell Envelope Capacitance. ACS Infect Dis (2016) 0.75
[Not Available]. Praxis (Bern 1994) (2013) 0.75
A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated Lactobacillus LB. Therap Adv Gastroenterol (2016) 0.75
Critical care medicine 2013: a review and prospect. J Thorac Dis (2013) 0.75
Disruption of the Gut Ecosystem by Antibiotics. Yonsei Med J (2018) 0.75
Clostridium Difficile Infection in Acute Care Hospitals: Systematic Review and Best Practices for Prevention. Infect Control Hosp Epidemiol (2017) 0.75
The role of single-shot metronidazole in the prevention of Clostridium difficile infection following ileostomy reversal surgery. Int J Colorectal Dis (2016) 0.75
Grading quality of evidence and strength of recommendations. BMJ (2004) 26.08
Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA (2006) 11.71
GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol (2011) 10.02
Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43
Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group. BMC Health Serv Res (2004) 7.20
High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90
Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis. JAMA (2002) 5.57
A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds. N Engl J Med (2015) 5.28
Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ (2008) 5.16
A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals. CMAJ (2002) 4.84
Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA (2012) 4.58
The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med (2015) 4.49
Internet versus mailed questionnaires: a randomized comparison (2). J Med Internet Res (2004) 4.45
The diabetes mellitus medication choice decision aid: a randomized trial. Arch Intern Med (2009) 4.41
Need for expertise based randomised controlled trials. BMJ (2005) 4.34
An observational study of orthopaedic abstracts and subsequent full-text publications. J Bone Joint Surg Am (2002) 4.25
Peginterferon alpha-2a is associated with higher sustained virological response than peginterferon alfa-2b in chronic hepatitis C: systematic review of randomized trials. Hepatology (2010) 4.19
Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol (2007) 4.06
Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med (2014) 3.96
Combined corticosteroid and antiviral treatment for Bell palsy: a systematic review and meta-analysis. JAMA (2009) 3.81
Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis (2006) 3.80
A new 'mechanistic-practical" framework for designing and interpreting randomized trials. J Clin Epidemiol (2008) 3.75
The reporting of methodological factors in randomized controlled trials and the association with a journal policy to promote adherence to the Consolidated Standards of Reporting Trials (CONSORT) checklist. Control Clin Trials (2002) 3.62
Physicians' and patients' choices in evidence based practice. BMJ (2002) 3.57
GRADE guidelines 6. Rating the quality of evidence--imprecision. J Clin Epidemiol (2011) 3.54
Is a subgroup effect believable? Updating criteria to evaluate the credibility of subgroup analyses. BMJ (2010) 3.54
Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev (2011) 3.44
Longer- Versus Shorter-Duration Dual-Antiplatelet Therapy After Drug-Eluting Stent Placement: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 3.41
Barriers to full-text publication following presentation of abstracts at annual orthopaedic meetings. J Bone Joint Surg Am (2003) 3.36
Can we individualize the 'number needed to treat'? An empirical study of summary effect measures in meta-analyses. Int J Epidemiol (2002) 3.36
Validity of composite end points in clinical trials. BMJ (2005) 3.26
Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22
Male sex and the risk of mortality among individuals enrolled in antiretroviral therapy programs in Africa: a systematic review and meta-analysis. AIDS (2013) 3.17
Internal fixation compared with arthroplasty for displaced fractures of the femoral neck. A meta-analysis. J Bone Joint Surg Am (2003) 3.14
Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. CMAJ (2010) 3.13
Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ (2007) 3.06
Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 2.95
Does ratification of human-rights treaties have effects on population health? Lancet (2009) 2.93
Telecare for patients with type 1 diabetes and inadequate glycemic control: a randomized controlled trial and meta-analysis. Diabetes Care (2004) 2.93
Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system. BMC Health Serv Res (2005) 2.91
Oral direct Factor Xa inhibitors versus low-molecular-weight heparin to prevent venous thromboembolism in patients undergoing total hip or knee replacement: a systematic review and meta-analysis. Ann Intern Med (2012) 2.91
Helping patients with type 2 diabetes mellitus make treatment decisions: statin choice randomized trial. Arch Intern Med (2007) 2.82
Progress in evidence-based medicine. JAMA (2008) 2.77
Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis. CMAJ (2004) 2.76
Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis. BMJ (2013) 2.73
Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis. Circulation (2013) 2.73
Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ (2012) 2.69
Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid. J Clin Epidemiol (2011) 2.69
A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med (2004) 2.68
Operative management of displaced femoral neck fractures in elderly patients. An international survey. J Bone Joint Surg Am (2005) 2.68
Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol (2008) 2.66
Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol (2008) 2.61
Internet versus mailed questionnaires: a controlled comparison (2). J Med Internet Res (2004) 2.59
Clinical expertise in the era of evidence-based medicine and patient choice. ACP J Club (2002) 2.58
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev (2013) 2.58
An observational study found that authors of randomized controlled trials frequently use concealment of randomization and blinding, despite the failure to report these methods. J Clin Epidemiol (2004) 2.58
Users' guide to detecting misleading claims in clinical research reports. BMJ (2004) 2.55
Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial. JAMA (2013) 2.55
The minimal detectable change cannot reliably replace the minimal important difference. J Clin Epidemiol (2009) 2.55
Cooling for neonatal hypoxic ischemic encephalopathy: do we have the answer? Pediatrics (2007) 2.51
Long-term exposure to ambient air pollution and risk of hospitalization with community-acquired pneumonia in older adults. Am J Respir Crit Care Med (2009) 2.50
Risk prediction models for mortality in ambulatory patients with heart failure: a systematic review. Circ Heart Fail (2013) 2.50
Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 2.50
Estimating required information size by quantifying diversity in random-effects model meta-analyses. BMC Med Res Methodol (2009) 2.39
Induction of epitope-specific neutralizing antibodies against West Nile virus. J Virol (2007) 2.30
Swine outbreak of pandemic influenza A virus on a Canadian research farm supports human-to-swine transmission. Clin Infect Dis (2011) 2.28
How to use an article reporting a multiple treatment comparison meta-analysis. JAMA (2012) 2.28
A systematic review of studies comparing health outcomes in Canada and the United States. Open Med (2007) 2.26
Ethical issues in stopping randomized trials early because of apparent benefit. Ann Intern Med (2007) 2.21
Systematic reviewers neglect bias that results from trials stopped early for benefit. J Clin Epidemiol (2007) 2.20
Does duration of perioperative antibiotic prophylaxis matter in cardiac surgery? A systematic review and meta-analysis. Ann Surg (2011) 2.16
Surveillance definitions of infections in long-term care facilities: revisiting the McGeer criteria. Infect Control Hosp Epidemiol (2012) 2.15
Low intensity pulsed ultrasonography for fractures: systematic review of randomised controlled trials. BMJ (2009) 2.15
Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials. Am J Respir Crit Care Med (2012) 2.15
Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ (2008) 2.15
Measurement properties and interpretability of the Chronic respiratory disease questionnaire (CRQ). COPD (2005) 2.12
Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer. Gastroenterology (2010) 2.10
Effect of bisphosphonates on periprosthetic bone mineral density after total joint arthroplasty. A meta-analysis. J Bone Joint Surg Am (2005) 2.05
Molecular detection of tumor cells in regional lymph nodes is associated with disease recurrence and poor survival in node-negative colorectal cancer: a systematic review and meta-analysis. J Clin Oncol (2011) 2.02
Design, analysis, and presentation of crossover trials. Trials (2009) 2.01
Patient-important outcomes in registered diabetes trials. JAMA (2008) 2.00
A practical approach to evidence-based dentistry: IX: how to appraise and use an article about economic analysis. J Am Dent Assoc (2015) 1.99
Prevalence and underdiagnosis of chronic obstructive pulmonary disease among patients at risk in primary care. CMAJ (2010) 1.95
Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis. BMC Med (2013) 1.94
Are the recommendations to use perioperative beta-blocker therapy in patients undergoing noncardiac surgery based on reliable evidence? CMAJ (2004) 1.92