Published in PLoS One on January 31, 2013
Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting. J Orthop Res (2015) 1.04
Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro. PLoS One (2013) 0.88
Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene. Proc Natl Acad Sci U S A (2015) 0.86
Notochordal cell-derived therapeutic strategies for discogenic back pain. Global Spine J (2013) 0.81
Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun (2016) 0.78
A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw. Proc Biol Sci (2017) 0.77
The generation and functional characterization of induced pluripotent stem cells from human intervertebral disc nucleus pulposus cells. Oncotarget (2017) 0.76
Targeting the annulus fibrosus of the intervertebral disc: Col1a2-Cre(ER)T mice show specific activity of Cre recombinase in the outer annulus fibrosus. J Cell Commun Signal (2016) 0.75
Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT. Proc Natl Acad Sci U S A (2016) 0.75
Implications for a Stem Cell Regenerative Medicine Based Approach to Human Intervertebral Disk Degeneration. Front Cell Dev Biol (2017) 0.75
Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. J Urol (2016) 0.75
Investigating microenvironmental regulation of human chordoma cell behaviour. PLoS One (2014) 0.75
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet (2000) 9.54
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell (1993) 7.41
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01
A myocardial lineage derives from Tbx18 epicardial cells. Nature (2008) 6.15
Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. J Bone Joint Surg Am (2006) 5.56
Expression pattern of the mouse T gene and its role in mesoderm formation. Nature (1990) 4.97
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev (1996) 4.94
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol Cell Biol (1989) 4.47
Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine (Phila Pa 1976) (2002) 4.39
Cloning of the T gene required in mesoderm formation in the mouse. Nature (1990) 4.20
HNF-3 beta is essential for node and notochord formation in mouse development. Cell (1994) 4.08
The initiation of liver development is dependent on Foxa transcription factors. Nature (2005) 3.88
Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J (1991) 3.85
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
A somitic compartment of tendon progenitors. Cell (2003) 3.77
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell (1994) 3.71
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development (1993) 3.63
Nutrition of the intervertebral disc. Spine (Phila Pa 1976) (2004) 3.27
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development (1993) 3.25
In situ hybridization analysis of chick embryos in whole mount and tissue sections. Methods Cell Biol (1996) 2.54
Observations on the postnatal structure of the intervertebral disc in man. J Anat (1952) 2.51
Structure and function of the notochord: an essential organ for chordate development. Development (2005) 2.38
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev (1999) 2.34
Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A (1993) 2.27
A homeobox gene essential for zebrafish notochord development. Nature (1995) 2.25
Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell (1994) 2.23
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem (2005) 2.15
Differential staining of collagens type I, II and III by Sirius Red and polarization microscopy. Arch Histol Jpn (1978) 2.12
Cloning and expression analysis of the mouse T-box gene Tbx18. Mech Dev (2001) 1.93
Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn (2008) 1.91
Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol (2005) 1.90
Trends in health care expenditures, utilization, and health status among US adults with spine problems, 1997-2006. Spine (Phila Pa 1976) (2009) 1.89
Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev (1999) 1.86
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development (1998) 1.85
The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development (2001) 1.83
Cre activity causes widespread apoptosis and lethal anemia during embryonic development. Genesis (2007) 1.79
Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol (2000) 1.78
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr Patterns (2004) 1.75
The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Genomics (1994) 1.74
Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech (2010) 1.69
The FoxA factors in organogenesis and differentiation. Curr Opin Genet Dev (2010) 1.69
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev (2001) 1.67
Intervertebral disc: anatomy-physiology-pathophysiology-treatment. Pain Pract (2008) 1.59
Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. Dev Cell (2007) 1.59
Induction of a second neural axis by the mouse node. Development (1994) 1.58
Pax1 and Pax9 synergistically regulate vertebral column development. Development (1999) 1.53
Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development (1999) 1.52
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes Dev (2010) 1.51
The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev (2004) 1.46
The influence of tissue section thickness on the study of collagen by the Picrosirius-polarization method. Histochemistry (1982) 1.30
The vertebral endplate: disc degeneration, disc regeneration. Eur Spine J (2006) 1.30
Cell fate and morphogenetic movement in the late mouse primitive streak. Mech Dev (1996) 1.29
Control of anteroposterior and dorsoventral domains of Nkx-6.1 gene expression relative to other Nkx genes during vertebrate CNS development. Mech Dev (1998) 1.22
Rescue of the tail defect of Brachyury mice. Genes Dev (1993) 1.22
The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev (2004) 1.17
Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A (2011) 1.15
Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulation. Gene Expr Patterns (2006) 1.13
Postnatal growth, differentiation, and aging of the mouse intervertebral disc. Spine (Phila Pa 1976) (2009) 1.03
Shh signaling from the nucleus pulposus is required for the postnatal growth and differentiation of the mouse intervertebral disc. PLoS One (2012) 1.00
Lumbar vertebral endplate lesions: prevalence, classification, and association with age. Spine (Phila Pa 1976) (2012) 0.94
Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc. Dev Dyn (2012) 0.93
Genetic patterning of the developing mouse tail at the time of posterior neuropore closure. Dev Dyn (1997) 0.93
Anatomy and examination of the spine. Neurol Clin (2007) 0.91
Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev (2009) 0.90
Histochemistry of the developing notochord, perichordal sheath and vertebrae in Danforth's short-tail (sd) and normal C57BL/6 mice. J Embryol Exp Morphol (1980) 0.89
Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Dev Biol (2011) 0.88
Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity. Mech Dev (2010) 0.88
Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs. Mech Dev (2012) 0.85
Staining of sulphated polysaccharides by means of alcian blue. Nature (1963) 0.78
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell (2005) 3.98
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet (2006) 3.79
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33
Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet (2006) 3.27
Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol (2009) 3.02
Epidermal stem cells arise from the hair follicle after wounding. FASEB J (2007) 2.81
MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80
Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol (2008) 2.61
Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem (2009) 2.59
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98
Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93
Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn (2008) 1.91
TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem (2009) 1.89
Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech (2010) 1.69
The microRNA-processing enzyme dicer maintains juxtaglomerular cells. J Am Soc Nephrol (2010) 1.60
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol (2009) 1.55
Dicer1 is required for differentiation of the mouse male germline. Biol Reprod (2008) 1.52
Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum. Dev Biol (2008) 1.51
Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron (2012) 1.50
Base composition of mononucleotide runs affects DNA polymerase slippage and removal of frameshift intermediates by mismatch repair in Saccharomyces cerevisiae. Mol Cell Biol (2002) 1.49
A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning. Dev Cell (2003) 1.48
The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science (2004) 1.40
Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37
Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol (2011) 1.32
Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell (2007) 1.31
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome (2009) 1.31
Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn (2008) 1.30
Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans. FASEB J (2004) 1.28
Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development (2005) 1.27
Multiphasic and tissue-specific roles of sonic hedgehog in cloacal septation and external genitalia development. Development (2009) 1.23
BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am (2008) 1.20
Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A (2011) 1.15
Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development (2004) 1.13
Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb. Dev Biol (2006) 1.13
Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation. Dev Biol (2005) 1.11
Expression patterns of the Tmem16 gene family during cephalic development in the mouse. Gene Expr Patterns (2008) 1.04
In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth. Dev Biol (2009) 1.01
Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn (2005) 1.00
MicroRNAs in mammalian development and tumorigenesis. Birth Defects Res C Embryo Today (2006) 0.97
Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration. J Orthop Res (2013) 0.97
Electrical slow waves in the mouse oviduct are dependent upon a calcium activated chloride conductance encoded by Tmem16a. Biol Reprod (2012) 0.95
Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc. Dev Dyn (2012) 0.93
The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness. Am J Respir Crit Care Med (2012) 0.93
Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A (2010) 0.92
Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet (2012) 0.89
Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev (2012) 0.89
The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol (2011) 0.89
Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns (2007) 0.88
Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs. Mech Dev (2012) 0.85
Notochord to Nucleus Pulposus Transition. Curr Osteoporos Rep (2015) 0.84
Aberrant FGF signaling, independent of ectopic hedgehog signaling, initiates preaxial polydactyly in Dorking chickens. Dev Biol (2009) 0.82
Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis (2014) 0.81
Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth. PLoS One (2012) 0.80
The sonic hedgehog pathway in chordoid tumours. Histopathology (2010) 0.80
Retracted Phylogenetic, expression, and functional analyses of anoctamin homologs in Caenorhabditis elegans. Am J Physiol Regul Integr Comp Physiol (2013) 0.79
Nuclei pulposi formation from the embryonic notochord occurs normally in GDF-5-deficient mice. Spine (Phila Pa 1976) (2011) 0.76