Published in Protein Sci on March 01, 2013
Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission. J Am Chem Soc (2013) 1.04
Helical membrane protein conformations and their environment. Eur Biophys J (2013) 0.99
The styrene-maleic acid copolymer: a versatile tool in membrane research. Eur Biophys J (2015) 0.98
Ab initio calculations and validation of the pH-dependent structures of the His37-Trp41 quartet, the heart of acid activation and proton conductance in the M2 protein of Influenza A virus. Chem Sci (2013) 0.90
Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers. Proc Natl Acad Sci U S A (2014) 0.85
Solid state NMR: The essential technology for helical membrane protein structural characterization. J Magn Reson (2013) 0.85
Solid state NMR and protein-protein interactions in membranes. Curr Opin Struct Biol (2013) 0.82
Binding of MgtR, a Salmonella transmembrane regulatory peptide, to MgtC, a Mycobacterium tuberculosis virulence factor: a structural study. J Mol Biol (2013) 0.82
Dynamic Short Hydrogen Bonds in Histidine Tetrad of Full-Length M2 Proton Channel Reveal Tetrameric Structural Heterogeneity and Functional Mechanism. Structure (2015) 0.81
Assignment of oriented sample NMR resonances from a three transmembrane helix protein. J Magn Reson (2014) 0.80
Membrane protein structural validation by oriented sample solid-state NMR: diacylglycerol kinase. Biophys J (2014) 0.80
Chemical ligation of the influenza M2 protein for solid-state NMR characterization of the cytoplasmic domain. Protein Sci (2015) 0.79
Proton release from the histidine-tetrad in the M2 channel of the influenza A virus. J Phys Chem B (2014) 0.77
Magic angle spinning NMR of viruses. Prog Nucl Magn Reson Spectrosc (2015) 0.76
Viroporins, Examples of the Two-Stage Membrane Protein Folding Model. Viruses (2015) 0.75
EmrE dimerization depends on membrane environment. Biochim Biophys Acta (2014) 0.75
Why bound amantadine fails to inhibit proton conductance according to simulations of the drug-resistant influenza A M2 (S31N). J Phys Chem B (2014) 0.75
Principles that govern the folding of protein chains. Science (1973) 23.40
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32
Influenza virus M2 protein has ion channel activity. Cell (1992) 8.52
Structure and mechanism of the M2 proton channel of influenza A virus. Nature (2008) 6.79
Structural basis for the function and inhibition of an influenza virus proton channel. Nature (2008) 5.69
Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. J Virol (1988) 5.31
The GxxxG motif: a framework for transmembrane helix-helix association. J Mol Biol (2000) 5.09
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J Virol (1993) 4.76
Influenza virus M2 protein mediates ESCRT-independent membrane scission. Cell (2010) 4.33
A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc Natl Acad Sci U S A (1997) 4.03
Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature (2010) 3.95
The M2 proton channels of influenza A and B viruses. J Biol Chem (2005) 3.49
Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins. J Virol (2000) 3.39
Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science (2010) 3.32
Structure of the transmembrane region of the M2 protein H(+) channel. Protein Sci (2001) 3.31
Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape. EMBO J (1997) 3.23
Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity. Proc Natl Acad Sci U S A (2006) 3.22
Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue. Biophys J (1995) 3.06
Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells. J Physiol (1996) 3.03
The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc Natl Acad Sci U S A (2001) 2.97
Influenza virus assembly and budding. Virology (2011) 2.90
Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature (2012) 2.88
Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Biophys J (2007) 2.68
The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR. Biochemistry (2002) 2.56
Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology (1998) 2.54
Helix packing in polytopic membrane proteins: role of glycine in transmembrane helix association. Biophys J (1999) 2.49
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc Natl Acad Sci U S A (2010) 2.43
Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers. Protein Sci (2003) 2.43
Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc Natl Acad Sci U S A (2009) 2.32
Lipid bilayer pressure profiles and mechanosensitive channel gating. Biophys J (2004) 2.30
Experimentally based orientational refinement of membrane protein models: A structure for the Influenza A M2 H+ channel. J Mol Biol (1999) 2.28
Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus. J Virol (2001) 2.22
Structure of amantadine-bound M2 transmembrane peptide of influenza A in lipid bilayers from magic-angle-spinning solid-state NMR: the role of Ser31 in amantadine binding. J Mol Biol (2008) 2.15
pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry (2000) 2.14
Mechanism for proton conduction of the M(2) ion channel of influenza A virus. J Biol Chem (2000) 2.13
Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel. Proc Natl Acad Sci U S A (2008) 2.07
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine. J Phys Chem B (2008) 1.97
Proton transport behavior through the influenza A M2 channel: insights from molecular simulation. Biophys J (2007) 1.96
Prediction of solvent accessibility and sites of deleterious mutations from protein sequence. Nucleic Acids Res (2005) 1.95
Conformational heterogeneity of the M2 proton channel and a structural model for channel activation. Proc Natl Acad Sci U S A (2009) 1.94
The influenza A virus M2 channel: a molecular modeling and simulation study. Virology (1997) 1.94
Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2009) 1.93
Comparison of helix interactions in membrane and soluble alpha-bundle proteins. Biophys J (2002) 1.88
Influence of solubilizing environments on membrane protein structures. Trends Biochem Sci (2010) 1.74
Differences in conductance of M2 proton channels of two influenza viruses at low and high pH. J Physiol (2003) 1.67
Influenza virus M2 protein: a molecular modelling study of the ion channel. Protein Eng (1993) 1.66
Analysis of the posttranslational modifications of the influenza virus M2 protein. J Virol (1995) 1.65
The influenza virus M2 ion channel protein: probing the structure of the transmembrane domain in intact cells by using engineered disulfide cross-linking. Virology (1999) 1.59
Influences of membrane mimetic environments on membrane protein structures. Annu Rev Biophys (2013) 1.58
The influenza virus ion channel and maturation cofactor M2 is a cholesterol-binding protein. Eur Biophys J (2004) 1.54
NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel. J Am Chem Soc (2011) 1.53
The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Sci (2005) 1.52
A novel method of resistance for influenza against a channel-blocking antiviral drug. Proteins (2004) 1.48
Structure determination of a membrane protein in proteoliposomes. J Am Chem Soc (2012) 1.37
Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc (2011) 1.37
Solution structure and functional analysis of the influenza B proton channel. Nat Struct Mol Biol (2009) 1.37
Structural basis for proton conduction and inhibition by the influenza M2 protein. Protein Sci (2012) 1.36
Magic angle spinning NMR investigation of influenza A M2(18-60): support for an allosteric mechanism of inhibition. J Am Chem Soc (2010) 1.36
Transmembrane helix uniformity examined by spectral mapping of torsion angles. Structure (2008) 1.35
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel. Biochem Biophys Res Commun (2010) 1.35
Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein. J Am Chem Soc (2011) 1.29
Proton and cation transport activity of the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A (2010) 1.24
A computational study of the closed and open states of the influenza a M2 proton channel. Biophys J (2005) 1.21
A theory for the proton transport of the influenza virus M2 protein: extensive test against conductance data. Biophys J (2011) 1.20
Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses. Structure (2011) 1.18
Diffusion-Influenced Transport of Ions across a Transmembrane Channel with an Internal Binding Site. J Phys Chem Lett (2010) 1.12
M2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes. Angew Chem Int Ed Engl (2012) 1.12
Magic angle spinning and oriented sample solid-state NMR structural restraints combine for influenza a M2 protein functional insights. J Am Chem Soc (2012) 1.11
How pH opens a H+ channel: the gating mechanism of influenza A M2. Structure (2005) 1.11
Kinetic analysis of the M2 proton conduction of the influenza virus. J Am Chem Soc (2010) 1.10
Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus. J Virol (1996) 1.09
Recent progress in structure-based anti-influenza drug design. Drug Discov Today (2012) 1.06
Tolerance to changes in membrane lipid composition as a selected trait of membrane proteins. Biochemistry (2011) 1.04
M2 protein from influenza A: from multiple structures to biophysical and functional insights. Curr Opin Virol (2012) 1.03
Glycines: role in α-helical membrane protein structures and a potential indicator of native conformation. Biochemistry (2012) 1.01
Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus. Biochim Biophys Acta (2010) 0.96
Functional reconstitution of influenza A M2(22-62). Biochim Biophys Acta (2010) 0.90
Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins. Biochim Biophys Acta (2010) 0.87
Mechanistic insight into the h(2)o/d (2)o isotope effect in the proton transport of the influenza virus m2 protein. J Membr Biol (2011) 0.85
Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science (2010) 3.32
Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity. Proc Natl Acad Sci U S A (2006) 3.22
Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Biophys J (2007) 2.68
Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers. Protein Sci (2003) 2.43
Solid-state NMR characterization of conformational plasticity within the transmembrane domain of the influenza A M2 proton channel. Biochim Biophys Acta (2007) 1.98
A secondary gate as a mechanism for inhibition of the M2 proton channel by amantadine. J Phys Chem B (2008) 1.97
Conformational heterogeneity of the M2 proton channel and a structural model for channel activation. Proc Natl Acad Sci U S A (2009) 1.94
Influences of membrane mimetic environments on membrane protein structures. Annu Rev Biophys (2013) 1.58
Proton transport through influenza A virus M2 protein reconstituted in vesicles. Biophys J (2007) 1.47
The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain. Biophys J (2007) 1.44
Cloning and expression of multiple integral membrane proteins from Mycobacterium tuberculosis in Escherichia coli. Protein Sci (2005) 1.40
Transmembrane helix uniformity examined by spectral mapping of torsion angles. Structure (2008) 1.35
Solid-state NMR and MD simulations of the antiviral drug amantadine solubilized in DMPC bilayers. Biophys J (2007) 1.29
Uniformity, ideality, and hydrogen bonds in transmembrane alpha-helices. Biophys J (2002) 1.27
Proton conductance of influenza virus M2 protein in planar lipid bilayers. Biophys J (2004) 1.25
Lipid bilayers: an essential environment for the understanding of membrane proteins. Magn Reson Chem (2007) 1.16
Solid-state 19F NMR spectroscopy reveals that Trp41 participates in the gating mechanism of the M2 proton channel of influenza A virus. J Am Chem Soc (2007) 1.15
Construction of a series of vectors for high throughput cloning and expression screening of membrane proteins from Mycobacterium tuberculosis. BMC Biotechnol (2008) 1.12
M2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes. Angew Chem Int Ed Engl (2012) 1.12
Magic angle spinning and oriented sample solid-state NMR structural restraints combine for influenza a M2 protein functional insights. J Am Chem Soc (2012) 1.11
Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry. J Proteome Res (2005) 1.11
Analysis of RF heating and sample stability in aligned static solid-state NMR spectroscopy. J Magn Reson (2006) 1.10
In support of the BMRB. Nat Struct Mol Biol (2012) 1.09
Comprehensive evaluation of solution nuclear magnetic resonance spectroscopy sample preparation for helical integral membrane proteins. J Struct Funct Genomics (2006) 1.06
Recent progress in structure-based anti-influenza drug design. Drug Discov Today (2012) 1.06
Solid state NMR strategy for characterizing native membrane protein structures. Acc Chem Res (2013) 1.04
Structural biology of transmembrane domains: efficient production and characterization of transmembrane peptides by NMR. Protein Sci (2007) 1.02
Glycines: role in α-helical membrane protein structures and a potential indicator of native conformation. Biochemistry (2012) 1.01
Uniformly aligned full-length membrane proteins in liquid crystalline bilayers for structural characterization. J Am Chem Soc (2007) 0.97
Lipid bilayer preparations of membrane proteins for oriented and magic-angle spinning solid-state NMR samples. Nat Protoc (2013) 0.95
Structural genomics of membrane proteins. Genome Biol (2004) 0.95
15N and 31P solid-state NMR study of transmembrane domain alignment of M2 protein of influenza A virus in hydrated cylindrical lipid bilayers confined to anodic aluminum oxide nanopores. J Magn Reson (2005) 0.95
Backbone structure of a small helical integral membrane protein: A unique structural characterization. Protein Sci (2009) 0.94
Towards quantitative measurements in solid-state CPMAS NMR: A Lee-Goldburg frequency modulated cross-polarization scheme. J Magn Reson (2004) 0.93
High-resolution heteronuclear correlation spectroscopy in solid state NMR of aligned samples. J Magn Reson (2007) 0.90
A large volume flat coil probe for oriented membrane proteins. J Magn Reson (2006) 0.90
Functional reconstitution of influenza A M2(22-62). Biochim Biophys Acta (2010) 0.90
Flow-through lipid nanotube arrays for structure-function studies of membrane proteins by solid-state NMR spectroscopy. Biophys J (2006) 0.90
Ab initio calculations and validation of the pH-dependent structures of the His37-Trp41 quartet, the heart of acid activation and proton conductance in the M2 protein of Influenza A virus. Chem Sci (2013) 0.90
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A. J Med Chem (2014) 0.90
The role of Trp side chains in tuning single proton conduction through gramicidin channels. Biophys J (2002) 0.89
Ligand binding in the conserved interhelical loop of CorA, a magnesium transporter from Mycobacterium tuberculosis. J Biol Chem (2009) 0.88
Ion-binding study by 17O solid-state NMR spectroscopy in the model peptide Gly-Gly-Gly at 19.6 T. J Am Chem Soc (2006) 0.88
Drug sensitivity, drug-resistant mutations, and structures of three conductance domains of viral porins. Biochim Biophys Acta (2010) 0.87
Noncontact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents. Biophys J (2002) 0.87
Solid-state 19F-NMR analysis of 19F-labeled tryptophan in gramicidin A in oriented membranes. Biophys J (2002) 0.87
Atomic refinement with correlated solid-state NMR restraints. J Magn Reson (2003) 0.87
Modeling the membrane environment for membrane proteins. Biophys J (2011) 0.85
Mathematical aspects of protein structure determination with NMR orientational restraints. Bull Math Biol (2004) 0.83
Recent developments in membrane-protein structural genomics. Genome Biol (2006) 0.82
Solid state NMR and protein-protein interactions in membranes. Curr Opin Struct Biol (2013) 0.82
A systematic assessment of mature MBP in membrane protein production: overexpression, membrane targeting and purification. Protein Expr Purif (2011) 0.82
Ion solvation by channel carbonyls characterized by 17O solid-state NMR at 21 T. J Am Chem Soc (2005) 0.81
Identifying inter-residue resonances in crowded 2D (13)C- (13)C chemical shift correlation spectra of membrane proteins by solid-state MAS NMR difference spectroscopy. J Biomol NMR (2013) 0.81
The effect of Hartmann-Hahn mismatching on polarization inversion spin exchange at the magic angle. J Magn Reson (2002) 0.81
Cross-polarization schemes for peptide samples oriented in hydrated phospholipid bilayers. J Magn Reson (2004) 0.80
Seeking higher resolution and sensitivity for NMR of quadrupolar nuclei at ultrahigh magnetic fields. J Am Chem Soc (2002) 0.79
Gramicidin channels are internally gated. Biophys J (2010) 0.79
Molecular dynamics simulations of Trp side-chain conformational flexibility in the gramicidin A channel. Biopolymers (2003) 0.78
NMR spin locking of proton magnetization under a frequency-switched Lee-Goldburg pulse sequence. J Magn Reson (2002) 0.77
Detergent optimized membrane protein reconstitution in liposomes for solid state NMR. Biochemistry (2014) 0.77
14N Polarization Inversion Spin Exchange at Magic Angle (PISEMA). J Magn Reson (2008) 0.76
1H, 15N and 13C backbone resonance assignment of Rv1567c, an integral membrane protein from Mycobacterium tuberculosis. Biomol NMR Assign (2008) 0.75
Chemical cleavage of fusion proteins for high-level production of transmembrane peptides and protein domains containing conserved methionines. Biochim Biophys Acta (2008) 0.75