SHP-1 phosphatase activity counteracts increased T cell receptor affinity.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 3582132)

Published in J Clin Invest on February 08, 2013

Authors

Michael Hebeisen1, Lukas Baitsch, Danilo Presotto, Petra Baumgaertner, Pedro Romero, Olivier Michielin, Daniel E Speiser, Nathalie Rufer

Author Affiliations

1: Department of Oncology, Lausanne University Hospital Center and University of Lausanne, Lausanne, Switzerland.

Articles citing this

T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy. Proc Natl Acad Sci U S A (2013) 1.14

Re-adapting T cells for cancer therapy: from mouse models to clinical trials. Immunol Rev (2014) 0.94

Monitoring the Dynamics of T Cell Clonal Diversity Using Recombinant Peptide:MHC Technology. Front Immunol (2013) 0.93

T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells. Clin Exp Immunol (2015) 0.88

TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu. Front Immunol (2013) 0.87

Control of T cell antigen reactivity via programmed TCR downregulation. Nat Immunol (2016) 0.87

The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation. J Leukoc Biol (2014) 0.84

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression. Front Immunol (2016) 0.83

Specific increase in potency via structure-based design of a TCR. J Immunol (2014) 0.82

The effect of adjuvanting cancer vaccines with herpes simplex virus glycoprotein D on melanoma-driven CD8+ T cell exhaustion. J Immunol (2014) 0.80

Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response. Front Immunol (2015) 0.80

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens. Front Immunol (2015) 0.80

Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation. J Immunol (2015) 0.78

The advantages of PD1 activating chimeric receptor (PD1-ACR) engineered lymphocytes for PDL1(+) cancer therapy. Am J Transl Res (2015) 0.77

Molecular insights for optimizing T cell receptor specificity against cancer. Front Immunol (2013) 0.77

SHP-1: the next checkpoint target for cancer immunotherapy? Biochem Soc Trans (2016) 0.77

Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells. Curr Opin Immunol (2013) 0.77

CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells. Sci Rep (2016) 0.77

Identification of human leukemia antigen A*0201-restricted epitopes derived from epidermal growth factor pathway substrate number 8. Mol Med Rep (2015) 0.75

Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1. Immunol Cell Biol (2016) 0.75

Molecular Pathways: Breaking the Epithelial Cancer Barrier for Chimeric Antigen Receptor and T-cell Receptor Gene Therapy. Clin Cancer Res (2016) 0.75

T cell activation is reduced by the catalytically inactive form of protein tyrosine phosphatase SHP-2. Int J Clin Exp Med (2015) 0.75

Low-affinity CD4+ T cells are major responders in the primary immune response. Nat Commun (2016) 0.75

Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis. Cell Cycle (2015) 0.75

Recent advances in T-cell engineering for use in immunotherapy. F1000Res (2016) 0.75

Articles cited by this

Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med (2012) 35.24

PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol (2008) 19.24

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science (2011) 15.79

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood (2009) 9.24

Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol (2011) 9.19

miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell (2007) 9.08

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science (2001) 8.31

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol (2012) 7.26

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol (2003) 4.56

Complete but curtailed T-cell response to very low-affinity antigen. Nature (2009) 4.31

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nat Immunol (2003) 4.17

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Genet (2002) 4.03

T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC. Cell Immunol (2002) 3.57

B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science (2012) 3.03

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat Immunol (2001) 2.83

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med (2012) 2.58

Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions. J Immunol (2008) 2.54

TCRs with high affinity for foreign pMHC show self-reactivity. Nat Immunol (2002) 2.12

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity. Immunology (2009) 1.85

High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines. J Immunol (2007) 1.85

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. Immunol Rev (2009) 1.78

Sodium stibogluconate is a potent inhibitor of protein tyrosine phosphatases and augments cytokine responses in hemopoietic cell lines. J Immunol (2001) 1.73

Immunotherapy earns its spot in the ranks of cancer therapy. J Exp Med (2012) 1.71

The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Ann N Y Acad Sci (2011) 1.67

A PD-1 polymorphism is associated with disease progression in multiple sclerosis. Ann Neurol (2005) 1.50

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell. Proc Natl Acad Sci U S A (2005) 1.49

Strength of TCR-peptide/MHC interactions and in vivo T cell responses. J Immunol (2011) 1.47

Dynamics of cell surface molecules during T cell recognition. Annu Rev Biochem (2003) 1.46

Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines. J Clin Invest (2006) 1.40

The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. J Biol Chem (2002) 1.34

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function. J Immunol (2010) 1.33

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein Sci (2006) 1.31

Comparison between computational alanine scanning and per-residue binding free energy decomposition for protein-protein association using MM-GBSA: application to the TCR-p-MHC complex. Proteins (2007) 1.25

Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Proc Natl Acad Sci U S A (2012) 1.16

Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness. J Biol Chem (2012) 1.16

Attenuated T cell responses to a high-potency ligand in vivo. PLoS Biol (2010) 1.15

Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets. J Transl Med (2011) 1.13

Challenges in T cell receptor gene therapy. J Gene Med (2012) 1.09

MM-GBSA binding free energy decomposition and T cell receptor engineering. J Mol Recognit (2010) 1.01

SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells. J Immunol (2010) 0.99

Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen. Blood (2011) 0.97

Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors. J Cancer (2011) 0.95

The Serial Engagement Model 17 Years After: From TCR Triggering to Immunotherapy. Front Immunol (2012) 0.94

Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo. J Immunol (2012) 0.91

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects. Oncotarget (2011) 0.90

Articles by these authors

The Pathway Tools software. Bioinformatics (2002) 14.89

TLR3 deficiency in patients with herpes simplex encephalitis. Science (2007) 5.86

Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J (2005) 5.36

Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97

Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res (2004) 3.59

Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. J Clin Invest (2011) 3.28

Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol (2004) 3.20

Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI). Cancer Immunol Immunother (2007) 3.16

Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest (2005) 3.11

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat Genet (2011) 3.10

Tumour immunity: effector response to tumour and role of the microenvironment. Lancet (2008) 2.94

Coupled folding and binding with alpha-helix-forming molecular recognition elements. Biochemistry (2005) 2.94

"MIATA"-minimal information about T cell assays. Immunity (2009) 2.90

Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood (2002) 2.88

The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat Immunol (2008) 2.87

SwissParam: a fast force field generation tool for small organic molecules. J Comput Chem (2011) 2.74

The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72

Four functionally distinct populations of human effector-memory CD8+ T lymphocytes. J Immunol (2007) 2.59

SwissDock, a protein-small molecule docking web service based on EADock DSS. Nucleic Acids Res (2011) 2.46

Inhibition of the shade avoidance response by formation of non-DNA binding bHLH heterodimers. EMBO J (2009) 2.20

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum (2008) 2.15

Mining alpha-helix-forming molecular recognition features with cross species sequence alignments. Biochemistry (2007) 1.93

EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming. J Biol Chem (2006) 1.91

The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J Biol Chem (2007) 1.89

Harmonization of immune biomarker assays for clinical studies. Sci Transl Med (2011) 1.84

Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression. Eur J Immunol (2009) 1.81

Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR. Immunity (2005) 1.81

Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions. Blood (2003) 1.78

Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. PLoS One (2012) 1.77

D²P²: database of disordered protein predictions. Nucleic Acids Res (2012) 1.75

New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J Immunol (2006) 1.74

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. J Clin Invest (2009) 1.71

Melan-A/MART-1-specific CD8 T cells: from thymus to tumor. Trends Immunol (2002) 1.68

In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A (2007) 1.65

Harmonization guidelines for HLA-peptide multimer assays derived from results of a large scale international proficiency panel of the Cancer Vaccine Consortium. Cancer Immunol Immunother (2009) 1.63

Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses. Proc Natl Acad Sci U S A (2009) 1.61

Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen. Proc Natl Acad Sci U S A (2008) 1.59

Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma. Immunol Rev (2002) 1.58

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion. Nat Immunol (2013) 1.57

Rational drug design via intrinsically disordered protein. Trends Biotechnol (2006) 1.57

Toll-like receptor 3 expressed by melanoma cells as a target for therapy? Clin Cancer Res (2007) 1.55

MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity (2013) 1.51

Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators. Biochim Biophys Acta (2007) 1.50

Improving protein order-disorder classification using charge-hydropathy plots. BMC Bioinformatics (2014) 1.50

Early prediction of response to sunitinib after imatinib failure by 18F-fluorodeoxyglucose positron emission tomography in patients with gastrointestinal stromal tumor. J Clin Oncol (2008) 1.50

Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance. J Exp Med (2002) 1.48

RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses. Blood (2007) 1.47

Transcriptional profiling of Caulobacter crescentus during growth on complex and minimal media. J Bacteriol (2004) 1.46

Thymic selection generates a large T cell pool recognizing a self-peptide in humans. J Exp Med (2002) 1.44

Matrix metalloproteinase 9 (MMP-9/gelatinase B) proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity. Oncogene (2002) 1.42

Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab. Cancer Immunol Immunother (2013) 1.42

Conservation of intrinsic disorder in protein domains and families: I. A database of conserved predicted disordered regions. J Proteome Res (2006) 1.42

Abdominal obesity, insulin resistance, and metabolic syndrome in a southern European population. Eur J Intern Med (2003) 1.41

Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. J Clin Endocrinol Metab (2003) 1.41

Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities. J Virol (2010) 1.40

The three main stumbling blocks for anticancer T cells. Trends Immunol (2012) 1.38

Heat shock cognate protein 70 is involved in rotavirus cell entry. J Virol (2002) 1.37

Rotavirus gene silencing by small interfering RNAs. EMBO Rep (2002) 1.36

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function. J Immunol (2010) 1.33

Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples. J Immunol Methods (2005) 1.33

Structural prediction of peptides bound to MHC class I. J Mol Biol (2005) 1.33

The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. J Immunol (2009) 1.32

Toll-like receptors' two-edged sword: when immunity meets apoptosis. Eur J Immunol (2007) 1.32

Dramatic response induced by vemurafenib in a BRAF V600E-mutated lung adenocarcinoma. J Clin Oncol (2013) 1.31

Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells. Cancer Res (2012) 1.30

Ex vivo detectable activation of Melan-A-specific T cells correlating with inflammatory skin reactions in melanoma patients vaccinated with peptides in IFA. Cancer Immun (2004) 1.29

Human effector CD8+ T lymphocytes express TLR3 as a functional coreceptor. J Immunol (2006) 1.28

Ex vivo analysis of human antigen-specific CD8+ T-cell responses: quality assessment of fluorescent HLA-A2 multimer and interferon-gamma ELISPOT assays for patient immune monitoring. J Immunother (2004) 1.27

Efficient transduction of dendritic cells and induction of a T-cell response by third-generation lentivectors. Hum Gene Ther (2002) 1.27

Conservation of intrinsic disorder in protein domains and families: II. functions of conserved disorder. J Proteome Res (2006) 1.27

Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression. Cancer Res (2011) 1.25