Published in Biotechniques on April 01, 1990
Aggresomes: a cellular response to misfolded proteins. J Cell Biol (1998) 11.24
A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother (2000) 8.54
Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J (1997) 5.52
Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism. Proc Natl Acad Sci U S A (1998) 3.31
An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol. BMC Biotechnol (2008) 3.27
A new crystal structure, Ca2+ dependence and mutational analysis reveal molecular details of E-cadherin homoassociation. EMBO J (1999) 3.20
A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol (1995) 3.18
Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci U S A (1996) 2.63
Site-directed, Ligase-Independent Mutagenesis (SLIM): a single-tube methodology approaching 100% efficiency in 4 h. Nucleic Acids Res (2004) 2.54
Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ. Proc Natl Acad Sci U S A (1998) 2.44
Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo. EMBO J (1992) 2.42
Rapid and efficient site-directed mutagenesis by single-tube 'megaprimer' PCR method. Nucleic Acids Res (1997) 2.38
An improved PCR-mutagenesis strategy for two-site mutagenesis or sequence swapping between related genes. Nucleic Acids Res (1998) 2.37
A rapid and efficient one-tube PCR-based mutagenesis technique using Pfu DNA polymerase. Nucleic Acids Res (1994) 2.35
Voltage-dependent structural interactions in the Shaker K(+) channel. J Gen Physiol (2000) 2.31
Sequences directing C to U editing of the plastid psbL mRNA are located within a 22 nucleotide segment spanning the editing site. EMBO J (1996) 2.21
Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I. J Cell Biol (1996) 2.16
The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter. EMBO J (1994) 2.13
Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion. Mol Biol Cell (1999) 2.10
The receptor for the fungal elicitor ethylene-inducing xylanase is a member of a resistance-like gene family in tomato. Plant Cell (2004) 2.09
Identification of a non-basic domain in the histone H4 N-terminus required for repression of the yeast silent mating loci. EMBO J (1992) 2.03
Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression. Nucleic Acids Res (1994) 1.93
Matrix protein and another viral component contribute to induction of apoptosis in cells infected with vesicular stomatitis virus. J Virol (2001) 1.92
Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region. Proc Natl Acad Sci U S A (1994) 1.92
Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cells. J Cell Biol (1998) 1.89
Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol (1996) 1.81
Efficient amplification using 'megaprimer' by asymmetric polymerase chain reaction. Nucleic Acids Res (1995) 1.80
Amino acid substitutions at position 190 of human immunodeficiency virus type 1 reverse transcriptase increase susceptibility to delavirdine and impair virus replication. J Virol (2003) 1.79
Deposition-related sites K5/K12 in histone H4 are not required for nucleosome deposition in yeast. Proc Natl Acad Sci U S A (1998) 1.77
Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes. J Physiol (1999) 1.76
Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-rRNA processing predominantly at site A3. Mol Cell Biol (1997) 1.74
Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene. PLoS Genet (2007) 1.67
Effect of rearrangements and duplications of the Cys-His motifs of Rous sarcoma virus nucleocapsid protein. J Virol (1993) 1.65
Low HLA-C expression at cell surfaces correlates with increased turnover of heavy chain mRNA. J Exp Med (1995) 1.63
A three-hybrid system for detecting small ligand-protein receptor interactions. Proc Natl Acad Sci U S A (1996) 1.61
Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol (2008) 1.61
Splicing efficiency of human immunodeficiency virus type 1 tat RNA is determined by both a suboptimal 3' splice site and a 10 nucleotide exon splicing silencer element located within tat exon 2. Nucleic Acids Res (1997) 1.61
The S4-S5 linker couples voltage sensing and activation of pacemaker channels. Proc Natl Acad Sci U S A (2001) 1.60
Overlapping PCR for bidirectional PCR amplification of specific alleles: a rapid one-tube method for simultaneously differentiating homozygotes and heterozygotes. Genome Res (1997) 1.60
Identification of a sequence within U5 required for human immunodeficiency virus type 1 to stably maintain a primer binding site complementary to tRNA(Met). J Virol (1997) 1.60
Structural conservation of ion conduction pathways in K channels and glutamate receptors. Proc Natl Acad Sci U S A (1995) 1.57
prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. J Mol Biol (2007) 1.57
Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands. Proc Natl Acad Sci U S A (1995) 1.57
Cooperative Pho2-Pho4 interactions at the PHO5 promoter are critical for binding of Pho4 to UASp1 and for efficient transactivation by Pho4 at UASp2. Mol Cell Biol (1998) 1.57
Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis. J Cell Biol (2002) 1.56
Antibody-ribosome-mRNA (ARM) complexes as efficient selection particles for in vitro display and evolution of antibody combining sites. Nucleic Acids Res (1997) 1.56
Ribosome stalling is responsible for arginine-specific translational attenuation in Neurospora crassa. Mol Cell Biol (1997) 1.56
Highly conserved NIKS tetrapeptide is functionally essential in eukaryotic translation termination factor eRF1. RNA (2002) 1.56
Transient translocation of the cytoplasmic (endo) domain of a type I membrane glycoprotein into cellular membranes. J Cell Biol (1993) 1.55
Site-directed mutagenesis using a double-stranded DNA fragment as a PCR primer. Nucleic Acids Res (1990) 1.54
Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J (2002) 1.53
Identification of adult mouse neurovirulence determinants of the Sindbis virus strain AR86. J Virol (2005) 1.53
Replication of avian leukosis viruses with mutations at the primer binding site: use of alternative tRNAs as primers. J Virol (1995) 1.52
Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Proc Natl Acad Sci U S A (2002) 1.51
Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways. Proc Natl Acad Sci U S A (2000) 1.51
The thioredoxin binding domain of bacteriophage T7 DNA polymerase confers processivity on Escherichia coli DNA polymerase I. Proc Natl Acad Sci U S A (1997) 1.49
Molecular determinants of HERG channel block. Mol Pharmacol (2006) 1.49
A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir. J Virol (2000) 1.48
Proline isomerases function during heat shock. Proc Natl Acad Sci U S A (1993) 1.48
Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence. Mol Biol Cell (2001) 1.46
The invariant uridine of stop codons contacts the conserved NIKSR loop of human eRF1 in the ribosome. EMBO J (2002) 1.45
Glycine N -methyltransferase deficiency: a new patient with a novel mutation. J Inherit Metab Dis (2003) 1.44
Coreceptor tropism can be influenced by amino acid substitutions in the gp41 transmembrane subunit of human immunodeficiency virus type 1 envelope protein. J Virol (2008) 1.43
Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol (2005) 1.43
Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. Nucleic Acids Res (1997) 1.41
Conversion of omnipotent translation termination factor eRF1 into ciliate-like UGA-only unipotent eRF1. EMBO Rep (2002) 1.40
All four core histone N-termini contain sequences required for the repression of basal transcription in yeast. EMBO J (1996) 1.39
Vertebrate mRNAs with a 5'-terminal pyrimidine tract are candidates for translational repression in quiescent cells: characterization of the translational cis-regulatory element. Mol Cell Biol (1994) 1.39
Effects of charged cluster mutations on the function of herpes simplex virus type 1 UL34 protein. J Virol (2003) 1.38
Analysis of the transmembrane domain of influenza virus neuraminidase, a type II transmembrane glycoprotein, for apical sorting and raft association. J Virol (2000) 1.37
Double-stranded DNA segments can efficiently prime the amplification of human genomic DNA. Nucleic Acids Res (1992) 1.37
The PDE1-encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signaling. Mol Biol Cell (1999) 1.37
Mg(2+) modulates voltage-dependent activation in ether-à-go-go potassium channels by binding between transmembrane segments S2 and S3. J Gen Physiol (2000) 1.36
Tumour necrosis factor-alpha and interferon-gamma synergistically activate the RANTES promoter through nuclear factor kappaB and interferon regulatory factor 1 (IRF-1) transcription factors. Biochem J (2000) 1.36
The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate. J Virol (1999) 1.35
A highly sensitive selection method for directed evolution of homing endonucleases. Nucleic Acids Res (2005) 1.34
Novel computational methods for increasing PCR primer design effectiveness in directed sequencing. BMC Bioinformatics (2008) 1.32
Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies. J Virol (2006) 1.31
The novel Helicobacter pylori CznABC metal efflux pump is required for cadmium, zinc, and nickel resistance, urease modulation, and gastric colonization. Infect Immun (2006) 1.31
Site-directed mutagenesis using Pfu DNA polymerase and T4 DNA ligase. Biotechniques (2005) 1.30
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. PLoS Pathog (2012) 1.30
A base-paired structure in the avian sarcoma virus 5' leader is required for efficient encapsidation of RNA. J Virol (1994) 1.29
K channel subconductance levels result from heteromeric pore conformations. J Gen Physiol (2005) 1.29
Substitutions at amino acid positions 143, 148, and 155 of HIV-1 integrase define distinct genetic barriers to raltegravir resistance in vivo. J Virol (2012) 1.28
Overlapping signals for transcription and replication at the 3' terminus of the vesicular stomatitis virus genome. J Virol (1999) 1.27
A single amino acid change in nsP1 attenuates neurovirulence of the Sindbis-group alphavirus S.A.AR86. J Virol (2000) 1.27
Septal localization of penicillin-binding protein 1 in Bacillus subtilis. J Bacteriol (1999) 1.26
Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother (2002) 1.25
Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo. Mol Cell Biol (1995) 1.25
A procedure for the prediction of temperature-sensitive mutants of a globular protein based solely on the amino acid sequence. Proc Natl Acad Sci U S A (1996) 1.25
The role of casein kinase II in flowering time regulation has diversified during evolution. Plant Physiol (2009) 1.25
Leukotriene A4 hydrolase: determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis. Proc Natl Acad Sci U S A (1991) 1.25
Protein kinase A and mitogen-activated protein kinase pathways antagonistically regulate fission yeast fbp1 transcription by employing different modes of action at two upstream activation sites. Mol Cell Biol (2000) 1.24
Invariant amino acids essential for decoding function of polypeptide release factor eRF1. Nucleic Acids Res (2005) 1.24
Structural and functional roles of the surface-exposed loops of the beta-barrel membrane protein OmpA from Escherichia coli. J Bacteriol (1999) 1.23
Muscle-specific splicing of a heterologous exon mediated by a single muscle-specific splicing enhancer from the cardiac troponin T gene. Mol Cell Biol (1998) 1.22
Helix P4 is a divalent metal ion binding site in the conserved core of the ribonuclease P ribozyme. RNA (2000) 1.22
Genomic amplification with transcript sequencing. Science (1988) 7.52
Shedding light on PCR contamination. Nature (1990) 6.49
Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet (1993) 6.02
Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity. Science (1989) 4.48
Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet (1994) 3.86
Formamide can dramatically improve the specificity of PCR. Nucleic Acids Res (1990) 3.38
Superkiller mutations in Saccharomyces cerevisiae suppress exclusion of M2 double-stranded RNA by L-A-HN and confer cold sensitivity in the presence of M and L-A-HN. Mol Cell Biol (1984) 2.88
The generation of radiolabeled DNA and RNA probes with polymerase chain reaction. Anal Biochem (1989) 2.83
Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients. Mol Psychiatry (2005) 2.78
Yeast KRE genes provide evidence for a pathway of cell wall beta-glucan assembly. J Cell Biol (1990) 2.74
General method for amplifying regions of very high G+C content. Nucleic Acids Res (1993) 2.68
Functionally important regions of the factor IX gene have a low rate of polymorphism and a high rate of mutation in the dinucleotide CpG. Am J Hum Genet (1989) 2.42
Genotypic detection of Mycobacterium tuberculosis rifampin resistance: comparison of single-strand conformation polymorphism and dideoxy fingerprinting. J Clin Microbiol (1995) 2.26
Parameters affecting the yield of DNA from human blood. Anal Biochem (1987) 2.20
Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection. Genomics (1998) 2.19
Screening for mutations by RNA single-strand conformation polymorphism (rSSCP): comparison with DNA-SSCP. Nucleic Acids Res (1992) 2.19
The molecular epidemiology of p53 gene mutations in human breast cancer. Trends Genet (1997) 2.14
Diagnosis of Duchenne dystrophy by enhanced detection of small mutations. Neurology (2001) 2.13
Yeast L dsRNA consists of at least three distinct RNAs; evidence that the non-Mendelian genes [HOK], [NEX] and [EXL] are on one of these dsRNAs. Cell (1982) 2.12
Specific amplification with PCR of a refractory segment of genomic DNA. Nucleic Acids Res (1988) 2.00
The yeast KRE5 gene encodes a probable endoplasmic reticulum protein required for (1----6)-beta-D-glucan synthesis and normal cell growth. Mol Cell Biol (1990) 1.96
Novel association approach for determining the genetic predisposition to schizophrenia: case-control resource and testing of a candidate gene. Am J Med Genet (1993) 1.95
Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility. Genomics (1992) 1.95
Mutations causing hemophilia B: direct estimate of the underlying rates of spontaneous germ-line transitions, transversions, and deletions in a human gene. Am J Hum Genet (1990) 1.78
RNA amplification with transcript sequencing (RAWTS). Nucleic Acids Res (1988) 1.77
Direct sequencing from touch preparations of human carcinomas: analysis of p53 mutations in breast carcinomas. J Natl Cancer Inst (1991) 1.77
Characterization of polymerase chain reaction amplification of specific alleles. Anal Biochem (1990) 1.70
Germ-line origins of mutation in families with hemophilia B: the sex ratio varies with the type of mutation. Am J Hum Genet (1993) 1.66
Overlapping PCR for bidirectional PCR amplification of specific alleles: a rapid one-tube method for simultaneously differentiating homozygotes and heterozygotes. Genome Res (1997) 1.60
Factor VIII gene inversions in severe hemophilia A: results of an international consortium study. Blood (1995) 1.59
Co-curing of plasmids affecting killer double-stranded RNAs of Saccharomyces cerevisiae: [HOK], [NEX], and the abundance of L are related and further evidence that M1 requires L. J Bacteriol (1982) 1.59
Haemophilia B: database of point mutations and short additions and deletions--eighth edition. Nucleic Acids Res (1998) 1.54
Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value. Proc Natl Acad Sci U S A (1996) 1.45
Haemophilia B (sixth edition): a database of point mutations and short additions and deletions. Nucleic Acids Res (1996) 1.44
PCR amplification of specific alleles: rapid detection of known mutations and polymorphisms. Mutat Res (1993) 1.44
Dideoxy fingerprinting (ddE): a rapid and efficient screen for the presence of mutations. Genomics (1992) 1.43
Double-stranded DNA segments can efficiently prime the amplification of human genomic DNA. Nucleic Acids Res (1992) 1.37
Restriction endonuclease fingerprinting (REF): a sensitive method for screening mutations in long, contiguous segments of DNA. Biotechniques (1995) 1.34
Factor IX inhibitors and anaphylaxis in hemophilia B. J Pediatr Hematol Oncol (1997) 1.34
Frequency of recent retrotransposition events in the human factor IX gene. Hum Mutat (2001) 1.33
A past mutation at isoleucine 397 is now a common cause of moderate/mild haemophilia B. Br J Haematol (1990) 1.29
Haemophilia B: database of point mutations and short additions and deletions, fifth edition, 1994. Nucleic Acids Res (1994) 1.21
High frequency of de novo mutations in Li-Fraumeni syndrome. J Med Genet (2009) 1.19
Removal of DNA contamination in polymerase chain reaction reagents by ultraviolet irradiation. Methods Enzymol (1993) 1.16
Parameters affecting the sensitivities of dideoxy fingerprinting and SSCP. PCR Methods Appl (1994) 1.14
A yeast antiviral protein, SKI8, shares a repeated amino acid sequence pattern with beta-subunits of G proteins and several other proteins. Yeast (1993) 1.14
p53 gene mutations inside and outside of exons 5-8: the patterns differ in breast and other cancers. Oncogene (1995) 1.13
Direct sequencing of the activation peptide and the catalytic domain of the factor IX gene in six species. Genomics (1990) 1.13
Single-tube polymerase chain reaction for rapid diagnosis of the inversion hotspot of mutation in hemophilia A. Blood (1998) 1.12
Evidence that proximal multiple mutations in Big Blue transgenic mice are dependent events. Mutat Res (2000) 1.11
Parameters affecting susceptibility of PCR contamination to UV inactivation. Biotechniques (1991) 1.10
Pyrophosphorolysis-activated polymerization (PAP): application to allele-specific amplification. Biotechniques (2000) 1.09
Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epidemiological analyses. Hum Mutat (1996) 1.08
Anaphylactic response to factor IX replacement therapy in haemophilia B patients: complete gene deletions confer the highest risk. Haemophilia (1999) 1.08
NIRCA: a rapid robust method for screening for unknown point mutations. Biotechniques (1996) 1.07
The rates of G:C-->T:A and G:C-->C:G transversions at CpG dinucleotides in the human factor IX gene. Am J Hum Genet (1994) 1.07
p53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis. Oncogene (1994) 1.07
Recurrent nonsense mutations at arginine residues cause severe hemophilia B in unrelated hemophiliacs. Hum Genet (1990) 1.06
Detection of virtually all mutations-SSCP (DOVAM-S): a rapid method for mutation scanning with virtually 100% sensitivity. Biotechniques (1999) 1.05
Reported in vivo splice-site mutations in the factor IX gene: severity of splicing defects and a hypothesis for predicting deleterious splice donor mutations. Hum Mutat (1999) 1.04
Spontaneous microdeletions and microinsertions in a transgenic mouse mutation detection system: analysis of age, tissue, and sequence specificity. Environ Mol Mutagen (2001) 1.04
Segments containing alternating purine and pyrimidine dinucleotides: patterns of polymorphism in humans and prevalence throughout phylogeny. Nucleic Acids Res (1991) 1.02
"Cryptic" repeating triplets of purines and pyrimidines (cRRY(i)) are frequent and polymorphic: analysis of coding cRRY(i) in the proopiomelanocortin (POMC) and TATA-binding protein (TBP) genes. Am J Hum Genet (1993) 1.01
The size distributions of proteins, mRNA, and nuclear RNA. J Mol Evol (1980) 1.00
The pattern of factor IX germ-line mutation in Asians is similar to that of Caucasians. Am J Hum Genet (1990) 1.00
Gene disruption indicates that the only essential function of the SKI8 chromosomal gene is to protect Saccharomyces cerevisiae from viral cytopathology. Virology (1987) 1.00
Polymerase chain reaction amplification of specific alleles: a general method of detection of mutations, polymorphisms, and haplotypes. Methods Enzymol (1993) 0.99
pK-matched running buffers for gel electrophoresis. Anal Biochem (1999) 0.98
Direct carrier testing in 14 families with haemophilia B. Lancet (1989) 0.98
p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain. Oncogene (1995) 0.98
Subcycling-PCR for multiplex long-distance amplification of regions with high and low GC content: application to the inversion hotspot in the factor VIII gene. Biotechniques (1998) 0.96
The rates and patterns of deletions in the human factor IX gene. Am J Hum Genet (1994) 0.96
Risk factors for inhibitor formation in haemophilia: a prevalent case-control study. Haemophilia (2009) 0.96
Missense mutations and evolutionary conservation of amino acids: evidence that many of the amino acids in factor IX function as "spacer" elements. Am J Hum Genet (1991) 0.96
Novel pattern of P53 mutation in breast cancers from Austrian women. J Clin Invest (1995) 0.95
Haplotyping by double PCR amplification of specific alleles. Biotechniques (1991) 0.95
SSCP analysis of long DNA fragments in low pH gel. Hum Mutat (1997) 0.94
Evidence that descendants of three founders constitute about 25% of hemophilia B in the United States. Genomics (1991) 0.94
High frequency of p53 gene mutations in primary breast cancers in Japanese women, a low-incidence population. Br J Cancer (1996) 0.94
Novel pattern of p53 gene mutations in an American black cohort with high mortality from breast cancer. Lancet (1994) 0.94
Simultaneous detection of multiple single-base alleles at a polymorphic site. Biotechniques (1991) 0.93
A postulated mechanism for deletions with inversions. Am J Hum Genet (1993) 0.93
Bi-directional dideoxy fingerprinting (Bi-ddF): a rapid method for quantitative detection of mutations in genomic regions of 300-600 bp. Hum Mol Genet (1996) 0.92
Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics (1991) 0.92
Hemophilia B in a male with a four-base insertion that arose in the germline of his mother. Nucleic Acids Res (1989) 0.92
Germline origins in the human F9 gene: frequent G:C-->A:T mosaicism and increased mutations with advanced maternal age. Hum Genet (1999) 0.91
Prediction of the electrophoretic mobilities of nucleotides on neutral paper. Anal Biochem (1979) 0.91
The incidence of venous thromboembolism among Factor V Leiden carriers: a community-based cohort study. J Thromb Haemost (2005) 0.91
Why does the human factor IX gene have a G + C content of 40%? Am J Hum Genet (1991) 0.91
Spontaneous mutation in Big Blue transgenic mice: analysis of age, gender, and tissue type. Environ Mol Mutagen (1996) 0.90
Overexpression and mutations of p53 in metastatic malignant melanomas. Int J Cancer (1996) 0.90
Spontaneous mutations in the Big Blue transgenic system are primarily mouse derived. Mutat Res (1999) 0.89
Two-tiered DNA-based diagnosis of transthyretin amyloidosis reveals two novel point mutations. Neurology (1991) 0.89
Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G:C to T:A transversions and accumulate with age. Environ Mol Mutagen (1999) 0.88
Characterization of the patterns of polymorphism in a "cryptic repeat" reveals a novel type of hypervariable sequence. Am J Hum Genet (1993) 0.88
A prospective trial of midwest breast cancer patients: a p53 gene mutation is the most important predictor of adverse outcome. Int J Cancer (2000) 0.88
Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/Big Blue double transgenic mice. Oncogene (1996) 0.87
Mutagen test. Nature (1990) 0.87
Mutation frequencies but not mutant frequencies in Big Blue mice fit a Poisson distribution. Environ Mol Mutagen (1996) 0.87