Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.

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Published in Lancet Infect Dis on March 01, 2013

Authors

Richard S Hotchkiss1, Guillaume Monneret, Didier Payen

Author Affiliations

1: Department of Anesthesiology, Medicine, and Surgery; Washington University School of Medicine, St Louis, MO, USA. hotch@wustl.edu

Associated clinical trials:

InterLeukin-7 (CYT107) to Improve Clinical Outcomes in Lymphopenic pAtients With COVID-19 Infection UK Cohort (ILIAD-7-UK) | NCT04379076

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Extracranial complications in patients with acute brain injury: a post-hoc analysis of the SOAP study. Intensive Care Med (2008) 1.03

Fluid resuscitation does not improve renal oxygenation during hemorrhagic shock in rats. Anesthesiology (2010) 1.02

Use of the pulmonary artery catheter is not associated with worse outcome in the ICU. Chest (2005) 0.99

Real-time assessment of renal cortical microvascular perfusion heterogeneities using near-infrared laser speckle imaging. Opt Express (2010) 0.99

L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats. Am J Physiol Renal Physiol (2009) 0.98

Clinical review: flow cytometry perspectives in the ICU - from diagnosis of infection to monitoring of injury-induced immune dysfunctions. Crit Care (2011) 0.97

mRNA-based approach to monitor recombinant gamma-interferon restoration of LPS-induced endotoxin tolerance. Crit Care (2011) 0.96

Inter-laboratory assessment of flow cytometric monocyte HLA-DR expression in clinical samples. Cytometry B Clin Cytom (2012) 0.96

Milrinone for the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke (2008) 0.96

Predictive factors of advanced interventional procedures in a multicentre severe postpartum haemorrhage study. Intensive Care Med (2011) 0.96

Use of an inspiratory impedance threshold device on a facemask and endotracheal tube to reduce intrathoracic pressures during the decompression phase of active compression-decompression cardiopulmonary resuscitation. Crit Care Med (2005) 0.96

Human monocytes differentiate into dendritic cells subsets that induce anergic and regulatory T cells in sepsis. PLoS One (2012) 0.96

Efficacy of selective arterial embolisation for the treatment of life-threatening post-partum haemorrhage in a large population. PLoS One (2008) 0.95

Decreased HLA-DR antigen-associated invariant chain (CD74) mRNA expression predicts mortality after septic shock. Crit Care (2013) 0.94

Histocompatibility leukocyte antigen-D related expression is specifically altered and predicts mortality in septic shock but not in other causes of shock. Shock (2004) 0.94

Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock. Clin Immunol (2005) 0.93

Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients. Crit Care (2010) 0.92

Noninvasive techniques for measurements of cardiac output. Curr Opin Crit Care (2005) 0.92

IMMUNE CELL PHENOTYPE AND FUNCTION IN SEPSIS. Shock (2016) 0.91

Adrenal response in patients with septic shock of abdominal origin: relationship to survival. Intensive Care Med (2007) 0.91