Convergence of IRBIT, phosphatidylinositol (4,5) bisphosphate, and WNK/SPAK kinases in regulation of the Na+-HCO3- cotransporters family.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 3593885)

Published in Proc Natl Acad Sci U S A on February 19, 2013

Authors

Jeong Hee Hong1, Dongki Yang, Nikolay Shcheynikov, Ehud Ohana, Dong Min Shin, Shmuel Muallem

Author Affiliations

1: Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

Articles citing this

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology (2013) 1.10

The Ste20 kinases SPAK and OSR1 travel between cells through exosomes. Am J Physiol Cell Physiol (2016) 0.91

Cation-coupled bicarbonate transporters. Compr Physiol (2014) 0.89

cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism. Cell Calcium (2014) 0.88

Proximal renal tubular acidosis mediated by mutations in NBCe1-A: unraveling the transporter's structure-functional properties. Front Physiol (2013) 0.85

Intracellular Cl- as a signaling ion that potently regulates Na+/HCO3- transporters. Proc Natl Acad Sci U S A (2015) 0.84

Structure, function, and regulation of the SLC4 NBCe1 transporter and its role in causing proximal renal tubular acidosis. Curr Opin Nephrol Hypertens (2013) 0.84

Mechanism and synergism in epithelial fluid and electrolyte secretion. Pflugers Arch (2013) 0.80

Molecular mechanisms of renal and extrarenal manifestations caused by inactivation of the electrogenic Na(+)-HCO3 (-) cotransporter NBCe1. Front Physiol (2013) 0.79

NBCe1 as a model carrier for understanding the structure-function properties of Na⁺ -coupled SLC4 transporters in health and disease. Pflugers Arch (2014) 0.79

IRBIT Interacts with the Catalytic Core of Phosphatidylinositol Phosphate Kinase Type Iα and IIα through Conserved Catalytic Aspartate Residues. PLoS One (2015) 0.78

Regulators of Slc4 bicarbonate transporter activity. Front Physiol (2015) 0.77

Phosphatidylinositol 4,5-bisphosphate degradation inhibits the Na+/bicarbonate cotransporter NBCe1-B and -C variants expressed in Xenopus oocytes. J Physiol (2015) 0.77

The ethanol-induced stimulation of rat duodenal mucosal bicarbonate secretion in vivo is critically dependent on luminal Cl-. PLoS One (2014) 0.77

Governing effect of regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity. Channels (Austin) (2015) 0.77

Short-term regulation of murine colonic NBCe1-B (electrogenic Na+/HCO3(-) cotransporter) membrane expression and activity by protein kinase C. PLoS One (2014) 0.77

Hypertension: the missing WNKs. Am J Physiol Renal Physiol (2016) 0.76

Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association. Korean J Physiol Pharmacol (2016) 0.76

A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity. J Biol Chem (2016) 0.75

TGF-β signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes. Glia (2017) 0.75

Articles cited by this

Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol (2003) 18.97

Protein structure prediction and analysis using the Robetta server. Nucleic Acids Res (2004) 7.39

Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43

Automated prediction of CASP-5 structures using the Robetta server. Proteins (2003) 3.41

Homology modeling using parametric alignment ensemble generation with consensus and energy-based model selection. Nucleic Acids Res (2006) 1.96

Prediction of CASP6 structures using automated Robetta protocols. Proteins (2005) 1.94

SLC4 base (HCO3 -, CO3 2-) transporters: classification, function, structure, genetic diseases, and knockout models. Am J Physiol Renal Physiol (2006) 1.84

Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter. J Biol Chem (1998) 1.83

Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71

IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci U S A (2006) 1.61

IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Mol Cell (2006) 1.46

Modular structure of sodium-coupled bicarbonate transporters. J Exp Biol (2009) 1.46

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain. J Biol Chem (2001) 1.43

Electrogenic Na/HCO3 cotransporter (NBCe1) variants expressed in Xenopus oocytes: functional comparison and roles of the amino and carboxy termini. J Gen Physiol (2006) 1.41

Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol (2008) 1.35

Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC). Am J Physiol (1999) 1.34

IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18

cAMP-mediated regulation of murine intestinal/pancreatic Na+/HCO3- cotransporter subtype pNBC1. Am J Physiol Gastrointest Liver Physiol (2002) 1.13

IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium. J Biol Chem (2008) 1.09

The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. J Biol Chem (2002) 1.06

Relief of autoinhibition of the electrogenic Na-HCO(3) [corrected] cotransporter NBCe1-B: role of IRBIT vs.amino-terminal truncation. Am J Physiol Cell Physiol (2011) 1.04

HCO3- salvage mechanisms in the submandibular gland acinar and duct cells. J Biol Chem (2001) 1.00

Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes. Proc Natl Acad Sci U S A (2009) 0.89

Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct. J Clin Invest (2000) 0.89

IRBIT: it is everywhere. Neurochem Res (2010) 0.88

Articles by these authors

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol (2006) 5.68

SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat Cell Biol (2009) 4.73

STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol (2007) 3.47

Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43

Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell (2003) 3.11

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell (2008) 2.30

Mite and cockroach allergens activate protease-activated receptor 2 and delay epidermal permeability barrier recovery. J Invest Dermatol (2008) 2.20

A molecular mechanism for aberrant CFTR-dependent HCO(3)(-) transport in cystic fibrosis. EMBO J (2002) 2.11

TRPC channels as STIM1-regulated store-operated channels. Cell Calcium (2007) 2.04

NaBC1 is a ubiquitous electrogenic Na+ -coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. Mol Cell (2004) 2.02

TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96

Transporter-mediated bile acid uptake causes Ca2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology (2002) 1.91

Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Gastroenterology (2010) 1.86

The solute carrier 26 family of proteins in epithelial ion transport. Physiology (Bethesda) (2008) 1.76

TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J Biol Chem (2005) 1.75

Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6. J Gen Physiol (2006) 1.73

Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology (2004) 1.72

Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev (2012) 1.71

Hypoxia reprograms calcium signaling and regulates myoglobin expression. Am J Physiol Cell Physiol (2008) 1.69

RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis. J Biol Chem (2010) 1.58

Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J (2006) 1.56

Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56

Homer 1 mediates store- and inositol 1,4,5-trisphosphate receptor-dependent translocation and retrieval of TRPC3 to the plasma membrane. J Biol Chem (2006) 1.50

A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO J (2008) 1.47

Homer proteins in Ca2+ signaling by excitable and non-excitable cells. Cell Calcium (2007) 1.45

The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44

TRPC channels as STIM1-regulated SOCs. Channels (Austin) (2009) 1.43

Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3. J Biol Chem (2008) 1.43

Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43

The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct. J Physiol (2008) 1.40

Mitochondria and calcium in health and disease. Cell Calcium (2008) 1.39

An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs. FEBS Lett (2009) 1.39

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels. Proc Natl Acad Sci U S A (2009) 1.38

Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. Gastroenterology (2009) 1.37

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol (2005) 1.36

Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol (2008) 1.35

Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1. J Biol Chem (2009) 1.34

SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (2007) 1.33

TRPC3 channels confer cellular memory of recent neuromuscular activity. Proc Natl Acad Sci U S A (2004) 1.32

IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest (2008) 1.32

Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32

Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice. J Biol Chem (2005) 1.30

Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors. EMBO J (2007) 1.29

Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-). J Biol Chem (2004) 1.28

Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger. J Biol Chem (2004) 1.27

Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system. Cell Calcium (2007) 1.26

Calcium signaling complexes in microdomains of polarized secretory cells. Cell Calcium (2006) 1.24

German cockroach extract activates protease-activated receptor 2 in human airway epithelial cells. J Allergy Clin Immunol (2004) 1.23

Pancreatitis: the neglected duct. Gut (2008) 1.22

SLC26A7 is a Cl- channel regulated by intracellular pH. J Biol Chem (2004) 1.22

Distinct TLR-mediated pathways regulate house dust mite-induced allergic disease in the upper and lower airways. J Allergy Clin Immunol (2012) 1.21

Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. Traffic (2010) 1.20

Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol (2003) 1.20

Signalling specificity in GPCR-dependent Ca2+ signalling. Cell Signal (2003) 1.19

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest (2011) 1.18

Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone. J Biol Chem (2011) 1.17

Borate transport and cell growth and proliferation. Not only in plants. Cell Cycle (2005) 1.15

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology (2013) 1.10

AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct. Am J Physiol Cell Physiol (2002) 1.10

A new mode of Ca2+ signaling by G protein-coupled receptors: gating of IP3 receptor Ca2+ release channels by Gbetagamma. Curr Biol (2003) 1.08

The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function. J Cell Biol (2013) 1.07

The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. J Biol Chem (2002) 1.06

Determinants of coupled transport and uncoupled current by the electrogenic SLC26 transporters. J Gen Physiol (2011) 1.05

Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1. J Biol Chem (2012) 1.04

TRPpathies. J Physiol (2006) 1.04

Regulatory interaction between CFTR and the SLC26 transporters. Novartis Found Symp (2006) 1.04

STIM1-dependent and STIM1-independent function of transient receptor potential canonical (TRPC) channels tunes their store-operated mode. J Biol Chem (2010) 1.03

Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity. Gastroenterology (2011) 1.02