Published in Lancet on February 22, 2013
The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol (2013) 2.60
Familial hypercholesterolemia: developments in diagnosis and treatment. Dtsch Arztebl Int (2014) 2.12
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol (2016) 1.68
Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet (2015) 1.51
Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction. PLoS Genet (2015) 1.47
Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. Eur Heart J (2015) 1.28
Genetics of CHD in 2016: Common and rare genetic variants and risk of CHD. Nat Rev Cardiol (2017) 1.07
Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations. J Med Genet (2014) 1.00
Analysis of the frequency and spectrum of mutations recognised to cause familial hypercholesterolaemia in routine clinical practice in a UK specialist hospital lipid clinic. Atherosclerosis (2013) 0.96
LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias. J Lipid Res (2014) 0.93
Familial hypercholesterolemia: A review. Ann Pediatr Cardiol (2014) 0.91
Using genetic prediction from known complex disease Loci to guide the design of next-generation sequencing experiments. PLoS One (2013) 0.88
A review on the traditional Chinese medicinal herbs and formulae with hypolipidemic effect. Biomed Res Int (2014) 0.87
Cardiovascular risk assessment of dyslipidemic children: analysis of biomarkers to identify monogenic dyslipidemia. J Lipid Res (2014) 0.82
Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study. BMC Med Genet (2014) 0.82
Whole-exome sequencing in an extended family with myocardial infarction unmasks familial hypercholesterolemia. BMC Cardiovasc Disord (2014) 0.80
Genetic testing of Korean familial hypercholesterolemia using whole-exome sequencing. PLoS One (2015) 0.79
Systematic analysis of variants related to familial hypercholesterolemia in families with premature myocardial infarction. Eur J Hum Genet (2015) 0.78
A genetic variant in the LDLR promoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia. BMC Med Genomics (2014) 0.78
Polygenic familial hypercholesterolaemia: does it matter? Lancet (2013) 0.78
My Approach to the Patient With Familial Hypercholesterolemia. Mayo Clin Proc (2016) 0.78
Variable expressivity and co-occurrence of LDLR and LDLRAP1 mutations in familial hypercholesterolemia: failure of the dominant and recessive dichotomy. Mol Genet Genomic Med (2016) 0.77
Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL-C levels in a latvian population. BMC Med Genet (2015) 0.77
Would raising the total cholesterol diagnostic cut-off from 7.5 mmol/L to 9.3 mmol/L improve detection rate of patients with monogenic familial hypercholesterolaemia? Atherosclerosis (2015) 0.77
Improving the cost-effectiveness equation of cascade testing for familial hypercholesterolaemia. Curr Opin Lipidol (2015) 0.77
Improving detection of familial hypercholesterolaemia in primary care using electronic audit and nurse-led clinics. J Eval Clin Pract (2015) 0.77
Mutational analysis of a cohort with clinical diagnosis of familial hypercholesterolemia: considerations for genetic diagnosis improvement. Genet Med (2015) 0.77
Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet (2017) 0.76
Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II. Lipids Health Dis (2016) 0.76
Premature coronary heart disease and autosomal dominant hypercholesterolemia: Increased risk in women with LDLR mutations. J Clin Lipidol (2015) 0.76
What matters most in pediatric familial hypercholesterolemia, genotype or phenotype? J Lipid Res (2014) 0.76
Genetics of Lipid and Lipoprotein Disorders and Traits. Curr Genet Med Rep (2016) 0.76
The genetics and screening of familial hypercholesterolaemia. J Biomed Sci (2016) 0.76
The genetic spectrum of familial hypercholesterolemia in south-eastern Poland. Metabolism (2015) 0.75
The use of targeted exome sequencing in genetic diagnosis of young patients with severe hypercholesterolemia. Sci Rep (2016) 0.75
The UK Paediatric Familial Hypercholesterolaemia Register: preliminary data. Arch Dis Child (2016) 0.75
Update on Familial Hypercholesterolemia: Diagnosis, Cardiovascular Risk, and Novel Therapeutics. Endocrinol Metab (Seoul) (2017) 0.75
Cardiovascular risk stratification in familial hypercholesterolaemia. Heart (2016) 0.75
Lipids: Targeting cascade screening in familial hypercholesterolaemia. Nat Rev Cardiol (2013) 0.75
Type 1 Diabetes Genetic Risk Score: A Novel Tool to Discriminate Monogenic and Type 1 Diabetes. Diabetes (2016) 0.75
Targeting cascade screening in familial hypercholesterolaemia. Nat Rev Endocrinol (2013) 0.75
Screening for Familial Hypercholesterolemia in Children: What Can We Learn From Adult Screening Programs? Healthcare (Basel) (2015) 0.75
Identification of the Functional Variant(s) that Explain the Low-Density Lipoprotein Receptor (LDLR) GWAS SNP rs6511720 Association with Lower LDL-C and Risk of CHD. PLoS One (2016) 0.75
The Contribution of GWAS Loci in Familial Dyslipidemias. PLoS Genet (2016) 0.75
The distribution and characteristics of LDL receptor mutations in China: A systematic review. Sci Rep (2015) 0.75
New Approaches in Detection and Treatment of Familial Hypercholesterolemia. Curr Cardiol Rep (2015) 0.75
Quality assessment of the genetic test for familial hypercholesterolemia in the Netherlands. Cholesterol (2013) 0.75
Familial hypercholesterolemia. Cardiol Clin (2015) 0.75
Atypical Presentation and Treatment Response in a Child with Familial Hypercholesterolemia Having a Novel LDLR Mutation. JIMD Rep (2016) 0.75
Almanac 2013: stable coronary artery disease. Wien Klin Wochenschr (2013) 0.75
[Congenital disorders of lipoprotein metabolism]. Herz (2017) 0.75
Body Mass Index and Risk of Alzheimer Disease: a Mendelian Randomization Study of 399,536 Individuals J Clin Endocrinol Metab (2017) 0.75
10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med (2008) 35.49
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet (2009) 9.90
Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet (2012) 9.43
Long-term follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med (2008) 8.82
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat Genet (2005) 7.82
Association of socioeconomic position with health behaviors and mortality. JAMA (2010) 7.64
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ (2007) 6.73
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet (2005) 6.59
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysis. JAMA (2011) 5.93
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet (2010) 5.31
Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. BMJ (2012) 5.26
Gender-specific associations of short sleep duration with prevalent and incident hypertension: the Whitehall II Study. Hypertension (2007) 5.20
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Treatment of periodontitis and endothelial function. N Engl J Med (2007) 4.83
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ (2014) 4.69
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J (2010) 4.31
A prospective study of change in sleep duration: associations with mortality in the Whitehall II cohort. Sleep (2007) 4.25
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91
The UK10K project identifies rare variants in health and disease. Nature (2015) 3.89
Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. BMJ (2011) 3.65
Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet (2005) 3.60
Invasive dental treatment and risk for vascular events: a self-controlled case series. Ann Intern Med (2010) 3.59
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J (2013) 3.58
Work stress and coronary heart disease: what are the mechanisms? Eur Heart J (2008) 3.56
Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care (2012) 3.53
Metabolically healthy obesity and risk of mortality: does the definition of metabolic health matter? Diabetes Care (2013) 3.43
Assessing salivary cortisol in large-scale, epidemiological research. Psychoneuroendocrinology (2009) 3.33
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood. Int J Epidemiol (2007) 3.15
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J (2011) 3.00
A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. Atherosclerosis (2003) 2.97
Mortality in adults aged 26-54 years related to socioeconomic conditions in childhood and adulthood: post war birth cohort study. BMJ (2002) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs. BMJ (2012) 2.88
SLC2A9 is a high-capacity urate transporter in humans. PLoS Med (2008) 2.87
Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol (2002) 2.84
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83