Published in Nat Biotechnol on March 01, 2013
Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol (2013) 3.84
Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease. Nat Biotechnol (2013) 3.20
Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system. Plant Methods (2013) 2.04
Targeted mutagenesis using CRISPR/Cas system in medaka. Biol Open (2014) 1.18
TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity. Nucleic Acids Res (2014) 1.16
Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine. Pharmacol Ther (2014) 1.12
Gene therapy on the move. EMBO Mol Med (2013) 1.10
Pol III Promoters to Express Small RNAs: Delineation of Transcription Initiation. Mol Ther Nucleic Acids (2014) 0.99
Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases. Hum Genet (2016) 0.88
Disruption of HPV16-E7 by CRISPR/Cas system induces apoptosis and growth inhibition in HPV16 positive human cervical cancer cells. Biomed Res Int (2014) 0.87
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome. Mol Ther (2015) 0.84
Retracted Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells. Onco Targets Ther (2014) 0.84
Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection. PLoS One (2015) 0.82
TALE-PvuII fusion proteins--novel tools for gene targeting. PLoS One (2013) 0.80
Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras. PLoS One (2016) 0.78
Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells. Nucleic Acids Res (2014) 0.77
Site-Directed Genome Knockout in Chicken Cell Line and Embryos Can Use CRISPR/Cas Gene Editing Technology. G3 (Bethesda) (2016) 0.76
Meiotic chromosome synapsis and recombination in Arabidopsis thaliana: new ways of integrating cytological and molecular approaches. Chromosome Res (2014) 0.76
Transcription Activator-Like Effector Nucleases (TALEN)-Mediated Targeted DNA Insertion in Potato Plants. Front Plant Sci (2016) 0.75
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (2012) 48.17
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat Biotechnol (2013) 21.32
A simple cipher governs DNA recognition by TAL effectors. Science (2009) 19.99
RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol (2013) 15.51
RNA-programmed genome editing in human cells. Elife (2013) 14.82
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat Biotechnol (2013) 14.28
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res (2011) 7.93
An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol (2011) 6.44
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nat Biotechnol (2007) 8.88
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res (2011) 7.93
Unexpected failure rates for modular assembly of engineered zinc fingers. Nat Methods (2008) 6.51
DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. Mol Ther (2007) 3.94
Custom zinc-finger nucleases for use in human cells. Mol Ther (2005) 3.04
Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivity. Mol Ther (2008) 3.02
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Res (2012) 2.26
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res (2012) 2.14
Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors. J Virol (2007) 2.05
Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Mol Cell Biol (2003) 2.01
TALE nucleases: tailored genome engineering made easy. Curr Opin Biotechnol (2012) 1.96
Zinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modifications. Mol Ther (2010) 1.95
Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion. Nucleic Acids Res (2010) 1.92
Targeted genome modifications using integrase-deficient lentiviral vectors. Mol Ther (2007) 1.60
Zinc-finger nuclease based genome surgery: it's all about specificity. Curr Gene Ther (2011) 1.56
Targeted genome editing in pluripotent stem cells using zinc-finger nucleases. Methods (2010) 1.48
MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration. Hepatology (2013) 1.32
Inactivation of hepatitis B virus replication in cultured cells and in vivo with engineered transcription activator-like effector nucleases. Mol Ther (2013) 1.26
Quantification of zinc finger nuclease-associated toxicity. Methods Mol Biol (2010) 1.24
Adding fingers to an engineered zinc finger nuclease can reduce activity. Biochemistry (2011) 1.17
Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases. Mol Ther (2013) 1.16
Targeted chromosomal gene modification in human cells by single-stranded oligodeoxynucleotides in the presence of a DNA double-strand break. Mol Ther (2006) 1.16
Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome. PLoS Pathog (2010) 1.12
Zinc-finger nucleases for somatic gene therapy: the next frontier. Hum Gene Ther (2011) 1.11
Genotoxicity in gene therapy: an account of vector integration and designer nucleases. Curr Opin Mol Ther (2008) 1.04
Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors. Hum Gene Ther (2011) 1.04
MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology (2011) 1.01
Ultramicroscopy reveals axonal transport impairments in cortical motor neurons at prion disease. Biophys J (2009) 1.00
Retargeting sleeping beauty transposon insertions by engineered zinc finger DNA-binding domains. Mol Ther (2012) 0.97
Fate of recombinant adeno-associated viral vector genomes during DNA double-strand break-induced gene targeting in human cells. Hum Gene Ther (2010) 0.94
Inhibition of ocular neovascularization by hedgehog blockade. Mol Ther (2005) 0.94
Retargeting transposon insertions by the adeno-associated virus Rep protein. Nucleic Acids Res (2012) 0.92
A novel zinc-finger nuclease platform with a sequence-specific cleavage module. Nucleic Acids Res (2011) 0.92
Generation and genetic modification of induced pluripotent stem cells. Expert Opin Biol Ther (2010) 0.91
Matricellular signaling molecule CCN1 attenuates experimental autoimmune myocarditis by acting as a novel immune cell migration modulator. Circulation (2010) 0.91
The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting. Hum Gene Ther (2012) 0.86
Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases. PLoS One (2011) 0.85
Highly efficient zinc-finger nuclease-mediated disruption of an eGFP transgene in keratinocyte stem cells without impairment of stem cell properties. Stem Cell Rev (2012) 0.84
On target? Tracing zinc-finger-nuclease specificity. Nat Methods (2011) 0.84
Histone deacetylase inhibition rescues gene knockout levels achieved with integrase-defective lentiviral vectors encoding zinc-finger nucleases. Hum Gene Ther Methods (2013) 0.84
Impaired axonal transport in motor neurons correlates with clinical prion disease. PLoS Pathog (2009) 0.83
Translating the genomic revolution - targeted genome editing in primates. N Engl J Med (2014) 0.79
Editing CCR5: a novel approach to HIV gene therapy. Adv Exp Med Biol (2015) 0.76
Targeted integration by adeno-associated virus. Methods Mol Med (2003) 0.76
Deciphering the impact of parameters influencing transgene expression kinetics after repeated cell transduction with integration-deficient retroviral vectors. Cytometry A (2015) 0.76
Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines. Methods Mol Biol (2012) 0.76
DNA-binding activity of adeno-associated virus Rep is required for inverted terminal repeat-dependent complex formation with herpes simplex virus ICP8. J Virol (2011) 0.75