Comparative cytochrome p450 in vitro inhibition by atypical antipsychotic drugs.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 3586484)

Published in ISRN Pharmacol on February 13, 2013

Authors

Guillermo Gervasini1, Maria J Caballero, Juan A Carrillo, Julio Benitez

Author Affiliations

1: Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Av. Elvas s/n, 06071 Badajoz, Spain.

Articles citing this

Evaluation of Herb-Drug Interactions of Hovenia dulcis Fruit Extracts. Pharmacogn Mag (2017) 0.75

Articles cited by this

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol (1998) 3.17

Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy (1998) 2.43

Fluvoxamine-Clozapine drug interaction: inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism. J Clin Psychopharmacol (2000) 2.01

Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. J Chromatogr B Analyt Technol Biomed Life Sci (2006) 1.87

IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding. Nucleic Acids Res (2009) 1.60

Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine. J Clin Psychopharmacol (2003) 1.21

Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos (1999) 1.14

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test. Br J Clin Pharmacol (1994) 1.11

7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem (1998) 1.05

7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. J Med Chem (1996) 0.99

Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients. J Clin Psychopharmacol (1999) 0.86

Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction. J Clin Psychopharmacol (2002) 0.86

Debrisoquine oxidation phenotype during neuroleptic monotherapy. Eur J Clin Pharmacol (1991) 0.85

Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol. Br J Clin Pharmacol (1997) 0.82

Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole. Ther Drug Monit (2009) 0.82

Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline. Pharmacogenetics (2001) 0.82

Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients. J Clin Psychopharmacol (1998) 0.82

Distribution of thioridazine and its metabolites in human tissues and fluids obtained postmortem. Clin Chem (1978) 0.81

Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines. Biochem Pharmacol (2010) 0.80

Thioridazine-fluoxetine interaction at the level of the distribution process in vivo. Pol J Pharmacol (2003) 0.79

Tryptamine: a possible endogenous substrate for CYP2D6. Pharmacogenetics (1997) 0.79

Clinical pharmacokinetics of antipsychotics. J Clin Pharmacol (1994) 0.78

Effect of neurotransmitters on NADPH-cytochrome P450 reductase in vitro activity. Drug Metab Lett (2007) 0.78

Modulation of midazolam 1-hydroxylation activity in vitro by neurotransmitters and precursors. Eur J Clin Pharmacol (2000) 0.78

Pharmacokinetic drug interaction potential of risperidone with cytochrome p450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test. Ther Drug Monit (2001) 0.78

Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine. Pharmacogenetics (1998) 0.78

On the distribution and elimination of haloperidol in cholecystectomized patients. Eur J Drug Metab Pharmacokinet (1981) 0.78

In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes. Pharmacol Biochem Behav (2012) 0.77

Thioridazine inhibits risperidone metabolism: a clinically relevant drug interaction. J Clin Psychopharmacol (2005) 0.77

Influence of antidepressant drugs on chlorpromazine metabolism in human liver--an in vitro study. Pharmacol Rep (2011) 0.77

Atypical antipsychotics--recent findings and new perspectives. Med Res Rev (1989) 0.77

Articles by these authors

GST polymorphisms interact with dietary factors to modulate lung cancer risk: study in a high-incidence area. Nutr Cancer (2010) 1.42

CYP1A1 gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study. BMC Cancer (2010) 0.92

Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds. Clin Pharmacokinet (2004) 0.87

Adenosine triphosphate-binding cassette B1 (ABCB1) (multidrug resistance 1) G2677T/A gene polymorphism is associated with high risk of lung cancer. Cancer (2006) 0.86

Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation. Transpl Int (2012) 0.86

Differences in CYP3A5*3 genotype distribution and combinations with other polymorphisms between Spaniards and Other Caucasian populations. Ther Drug Monit (2005) 0.83

The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study. Br J Clin Pharmacol (2006) 0.81

Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism. Environ Mol Mutagen (2012) 0.80

Effect of neurotransmitters on NADPH-cytochrome P450 reductase in vitro activity. Drug Metab Lett (2007) 0.78

CYP2C8*3 polymorphism and donor age are associated with allograft dysfunction in kidney transplant recipients treated with calcineurin inhibitors. J Clin Pharmacol (2013) 0.77

Evaluation of a drug-drug interaction alert structure through the retrospective analysis of statins-macrolides co-prescriptions. Basic Clin Pharmacol Toxicol (2005) 0.76

SHBG, plasma, and urinary androgens in weight lifters after a strength training. J Physiol Biochem (2010) 0.75

Using a computerized drug prescription screening system to trace drug interactions in an outpatient setting. Ann Pharmacother (2004) 0.75

Melanocortin-4 receptor gene variants are not associated with binge-eating behavior in nonobese patients with eating disorders. Psychiatr Genet (2015) 0.75

Retinal toxic reactions following photopheresis. Arch Dermatol (2007) 0.75

Early detection of drug interactions utilizing a computerized drug prescription handling system-focus on cerivastatin-gemfibrozil. Eur J Clin Pharmacol (2004) 0.75

Determination of urine steroid profile in untrained men to evaluate recovery after a strength training session. J Strength Cond Res (2008) 0.75