What is recent in pancreatic cancer immunotherapy?

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🔗 View Article (PMC 3591222)

Published in Biomed Res Int on December 26, 2012

Authors

Elena Niccolai1, Domenico Prisco, Mario Milco D'Elios, Amedeo Amedei

Author Affiliations

1: Department of Internal Medicine, University of Florence and Patologia Medica Unit, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, Italy.

Associated clinical trials:

Dose Finding Study of a DNA Vaccine Delivered With Intradermal Electroporation in Patients With Prostate Cancer | NCT00859729

Safety and Immunogenicity of a Melanoma DNA Vaccine Delivered by Electroporation | NCT00471133

Mammaglobin-A DNA Vaccine for Metastatic Breast Cancer | NCT00807781

Vaccine Study for Surgically Resected Pancreatic Cancer | NCT00569387

Safety Study of 90Y-hMN14 to Treat Pancreatic Cancer | NCT00041639

Vaccine Treatment for Surgically Resected Pancreatic Cancer | NCT00255827

Low Dose Vaccine Study for Surgically Resected Pancreatic Cancer | NCT00614601

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The dendritic cell system and its role in immunogenicity. Annu Rev Immunol (1991) 23.09

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell (1988) 10.29

Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med (1998) 7.48

Cancer immunology. N Engl J Med (2008) 5.22

Gemcitabine plus bevacizumab compared with gemcitabine plus placebo in patients with advanced pancreatic cancer: phase III trial of the Cancer and Leukemia Group B (CALGB 80303). J Clin Oncol (2010) 5.21

Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol (2005) 5.09

Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205. J Clin Oncol (2010) 4.69

Mesothelin: a new target for immunotherapy. Clin Cancer Res (2004) 4.30

Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res (2001) 4.19

Immune infiltration in human tumors: a prognostic factor that should not be ignored. Oncogene (2009) 3.90

Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol (2005) 3.39

Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med (2004) 3.39

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Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer. J Clin Oncol (2005) 3.28

Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation. J Clin Oncol (2001) 3.27

More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov (2007) 2.68

Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation. Clin Cancer Res (2008) 2.67

Immunotherapy: past, present and future. Nat Med (2003) 2.62

Mesothelin targeted cancer immunotherapy. Eur J Cancer (2007) 2.54

Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res (2000) 2.43

Survivin: a new target for anti-cancer therapy. Cancer Treat Rev (2009) 2.37

The Galalpha1,3Galbeta1,4GlcNAc-R (alpha-Gal) epitope: a carbohydrate of unique evolution and clinical relevance. Biochim Biophys Acta (2007) 2.34

Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nat Med (1997) 2.31

Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines. Nat Rev Cancer (2008) 2.31

Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Am J Clin Pathol (2005) 2.21

Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P. Clin Cancer Res (2009) 2.17

Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res (1993) 2.15

Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. Clin Cancer Res (2005) 2.05

Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res (1994) 1.90

Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther (2008) 1.90

Advances in the assessment and control of the effector functions of therapeutic antibodies. Nat Rev Drug Discov (2011) 1.89

Identification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein survivin in cancer patients. Cancer Res (2001) 1.82

Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol (1993) 1.80

Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcome. J Clin Oncol (2005) 1.75

Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8+ T-cell immunity. J Immunother (2006) 1.75

Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin Cancer Res (1997) 1.74

Potential prophylactic measures against postoperative immunosuppression: could they reduce recurrence rates in oncological patients? Ann Surg Oncol (2003) 1.69

Cancer immunotherapy with mRNA-transfected dendritic cells. Immunol Rev (2004) 1.66

Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. Nat Biotechnol (1998) 1.64

Pathways for aberrant angiogenesis in pancreatic cancer. Mol Cancer (2003) 1.61

Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol Cancer Ther (2002) 1.58

Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity. Cancer Res (2006) 1.57

MUC1 and MUC2 in pancreatic neoplasia. J Clin Pathol (2004) 1.55

Diagnosis of pancreatic adenocarcinoma by detection of human telomerase reverse transcriptase messenger RNA in pancreatic juice with sample qualification. Clin Cancer Res (2001) 1.55

Circulating anti-MUC1 IgG antibodies as a favorable prognostic factor for pancreatic cancer. Int J Cancer (2003) 1.51

The epidermal growth factor receptor in human pancreatic cancer. J Pathol (1992) 1.47

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Distinct mechanisms of immunosuppression as a consequence of major surgery. Infect Immun (1997) 1.44

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Telomerase activity is detected in pancreatic cancer but not in benign tumors. Cancer Res (1997) 1.34

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Pancreatoduodenal carcinoma: a clinicopathologic study of 304 patients and immunohistochemical observation for CEA and CA19-9. J Surg Oncol (1991) 1.31

Poor immunogenicity of a self/tumor antigen derives from peptide-MHC-I instability and is independent of tolerance. J Clin Invest (2004) 1.30

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Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma. Int J Cancer (2001) 1.18

MUC1 expression in primary and metastatic pancreatic cancer cells for in vitro treatment by (213)Bi-C595 radioimmunoconjugate. Br J Cancer (2004) 1.17

Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation. Lancet (1995) 1.17

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