Published in Crit Care on March 12, 2013
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Standard subcutaneous dosing of unfractionated heparin for venous thromboembolism prophylaxis in surgical ICU patients leads to subtherapeutic factor Xa inhibition. Intensive Care Med (2012) 3.68
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High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest (2005) 3.58
The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med (2006) 3.53
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The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med (2009) 3.30
Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med (2012) 3.24
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Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
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Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet (2002) 3.17
Management of bleeding following major trauma: an updated European guideline. Crit Care (2010) 3.09
Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med (2007) 3.06
Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. Am J Respir Crit Care Med (2008) 2.99
C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest (2003) 2.95
Anatomical and functional intrapulmonary shunt in acute respiratory distress syndrome. Crit Care Med (2008) 2.93
Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal. Anesthesiology (2009) 2.91
Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest (2008) 2.90
Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med (2010) 2.88
Let us use the pulmonary artery catheter correctly and only when we need it. Crit Care Med (2005) 2.83
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82
Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med (2007) 2.79
Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients. Am J Respir Crit Care Med (2014) 2.78
Albumin administration improves organ function in critically ill hypoalbuminemic patients: A prospective, randomized, controlled, pilot study. Crit Care Med (2006) 2.74
Do all nonsurvivors of cardiogenic shock die with a low cardiac index? Chest (2003) 2.73
Has mortality from acute renal failure decreased? A systematic review of the literature. Am J Med (2005) 2.73
Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit Care Med (2013) 2.72
Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med (2009) 2.68
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Statin use and mortality in the bacteremic critically ill patient. Crit Care Med (2006) 2.57
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ECMO criteria for influenza A (H1N1)-associated ARDS: role of transpulmonary pressure. Intensive Care Med (2012) 2.50
Survival in critical illness is associated with early activation of mitochondrial biogenesis. Am J Respir Crit Care Med (2010) 2.48
Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med (2004) 2.48
Lung opening and closing during ventilation of acute respiratory distress syndrome. Am J Respir Crit Care Med (2009) 2.47
Does dopamine administration in shock influence outcome? Results of the Sepsis Occurrence in Acutely Ill Patients (SOAP) Study. Crit Care Med (2006) 2.47
Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care (2005) 2.47
The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis. Crit Care Med (2007) 2.45
Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med (2006) 2.40
Management of bleeding following major trauma: a European guideline. Crit Care (2007) 2.40
Ethics and end-of-life care for adults in the intensive care unit. Lancet (2010) 2.40
Antibiotic strategies in severe nosocomial sepsis: why do we not de-escalate more often? Crit Care Med (2012) 2.39
The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients. Crit Care Med (2011) 2.37
Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections. Crit Care Med (2015) 2.37
Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Crit Care Med (2007) 2.36
Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock. Crit Care Med (2012) 2.36
Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med (2004) 2.33
Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients. Intensive Care Med (2012) 2.33
Severe sepsis in cirrhosis. Hepatology (2009) 2.33
Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care (2009) 2.32
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31
Mechanisms of sepsis-induced organ dysfunction. Crit Care Med (2007) 2.30
The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks. Intensive Care Med (2011) 2.28
Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med (2008) 2.27
The prognostic value of muscle StO2 in septic patients. Intensive Care Med (2007) 2.25
Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best? Crit Care Med (2003) 2.23
The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals. Crit Care Med (2011) 2.23
Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. Crit Care Med (2010) 2.23
Gamma-globulin levels in patients with community-acquired septic shock. Shock (2009) 2.21
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17
A large-bolus injection, but not continuous infusion of sodium selenite improves outcome in peritonitis. Shock (2009) 2.17
The application of esophageal pressure measurement in patients with respiratory failure. Am J Respir Crit Care Med (2014) 2.16