Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMC 4122282)

Published in Pulm Pharmacol Ther on March 27, 2013

Authors

Juanita H J Vernooy1, Niki D J Ubags, Guy G Brusselle, Jan Tavernier, Benjamin T Suratt, Guy F Joos, Emiel F M Wouters, Ken R Bracke

Author Affiliations

1: Department of Respiratory Medicine, Maastricht University Medical Center+, PO Box 5800, 6202 AZ Maastricht, The Netherlands. j.vernooy@maastrichtuniversity.nl

Articles cited by this

(truncated to the top 100)

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86

Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85

The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med (2004) 18.60

Identification and expression cloning of a leptin receptor, OB-R. Cell (1995) 9.74

Adipose tissue, inflammation, and cardiovascular disease. Circ Res (2005) 8.72

Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol (2005) 8.39

Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax (2004) 8.09

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature (1998) 7.36

Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med (1999) 6.21

Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes (2006) 5.25

Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet (2004) 5.16

Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol (2008) 4.89

Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation (2003) 4.63

Leptin regulates proinflammatory immune responses. FASEB J (1998) 4.31

Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. PLoS Med (2011) 4.02

The leptin receptor. J Biol Chem (1997) 3.76

PTP1B regulates leptin signal transduction in vivo. Dev Cell (2002) 3.61

Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med (1997) 3.35

The weight of leptin in immunity. Nat Rev Immunol (2004) 3.24

Molecular and anatomical determinants of central leptin resistance. Nat Neurosci (2005) 2.98

The epidemiology of obesity and asthma. J Allergy Clin Immunol (2005) 2.87

Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res (2004) 2.67

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature (1998) 2.66

Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord (2000) 2.59

Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med (1997) 2.48

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem (2000) 2.41

Retracted Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype. Am J Respir Crit Care Med (2012) 2.39

Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J Biol Chem (2000) 2.36

Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med (2001) 2.31

Obesity and asthma: possible mechanisms. J Allergy Clin Immunol (2008) 2.30

Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus. J Nutr (2007) 2.28

Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia. J Immunol (2002) 2.27

Body mass index and asthma severity in the National Asthma Survey. Thorax (2008) 2.26

Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol (2000) 2.25

Obesity and respiratory hospitalizations during influenza seasons in Ontario, Canada: a cohort study. Clin Infect Dis (2011) 2.17

Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol (1999) 2.15

Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res (2001) 2.15

A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch Intern Med (2000) 2.14

Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med (1999) 2.08

Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol (2005) 2.08

Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med (2005) 1.97

Regulatory T cells in allergy and asthma. Chest (2007) 1.80

Responses to ozone are increased in obese mice. J Appl Physiol (1985) (2003) 1.79

Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol (2005) 1.60

Association between leptin and asthma in adults. Thorax (2006) 1.59

Diet-induced obesity impairs the T cell memory response to influenza virus infection. J Immunol (2010) 1.58

Leptin gene expression in the brain and pituitary gland. Endocrinology (1999) 1.58

Colonic leptin: source of a novel proinflammatory cytokine involved in IBD. FASEB J (2004) 1.58

Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med (2006) 1.57

Pulmonary physiologic changes of morbid obesity. Am J Med Sci (1999) 1.57

Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir Med (2005) 1.54

A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res (2002) 1.50

Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology (Oxford) (2006) 1.49

Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. J Appl Physiol (1985) (2008) 1.47

Prospective study of pneumonia hospitalizations and mortality of U.S. older people: the role of chronic conditions, health behaviors, and nutritional status. Public Health Rep (1989) 1.46

Expression of leptin receptor in lung: leptin as a growth factor. Eur J Pharmacol (1999) 1.41

Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol (2004) 1.40

Selective impairment in dendritic cell function and altered antigen-specific CD8+ T-cell responses in diet-induced obese mice infected with influenza virus. Immunology (2008) 1.38

Circulating leptin in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1999) 1.38

Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia. Clin Exp Immunol (2007) 1.37

Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis. Ann Rheum Dis (2005) 1.35

Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab (1998) 1.35

Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. Am J Physiol Lung Cell Mol Physiol (2002) 1.34

Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ. Am J Respir Crit Care Med (2011) 1.34

Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes (1996) 1.33

Obesity increases the risk of incident asthma among adults. Eur Respir J (2005) 1.33

Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice. Int Immunol (2005) 1.30

Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches? J Allergy Clin Immunol (2011) 1.28

Leptin inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol (2002) 1.28

Animal model of Mycobacterium abscessus lung infection. J Leukoc Biol (2008) 1.27

Leptin receptor signaling: pathways to leptin resistance. Front Biosci (Landmark Ed) (2011) 1.26

Associations of obesity, sleep-disordered breathing, and wheezing in children. Am J Respir Crit Care Med (2004) 1.26

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation. Diabetes (1999) 1.26

Are overweight asthmatics more difficult to control? Allergy (2006) 1.22

Expression of leptin and leptin receptor isoforms in the human stomach. Gut (2000) 1.22

In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes: evidence for a regional specific regulation by sex steroid hormones. Endocrinology (1999) 1.22

Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1999) 1.22

Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol (2005) 1.21

Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. J Appl Physiol (1985) (2007) 1.18

Leptin and leptin receptor expression in asthma. J Allergy Clin Immunol (2009) 1.16

Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury. Am J Respir Cell Mol Biol (2012) 1.13

Obesity, adipokines and asthma. Allergy (2009) 1.10

Leptin regulates functional capacities of polymorphonuclear neutrophils. Free Radic Res (2003) 1.10

Identification of leptin receptors in lung and isolated fetal type II cells. Am J Respir Cell Mol Biol (2002) 1.10

Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci (2000) 1.09

Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun (2003) 1.06

Leptin attenuates respiratory complications associated with the obese phenotype. J Appl Physiol (1985) (1998) 1.06

Predisposition to acute respiratory infections among overweight preadolescent children: an epidemiologic study in Poland. Public Health (1998) 1.06

Diet-induced obesity in mice reduces the maintenance of influenza-specific CD8+ memory T cells. J Nutr (2010) 1.04

Estrogens and glucocorticoid hormones in adipose tissue metabolism. Curr Med Chem (2007) 1.04

Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice. J Immunol (2010) 1.03

Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues. Biochem Biophys Res Commun (1997) 1.03

Gender differences in the adipose secretome system in chronic obstructive pulmonary disease (COPD): a pivotal role of leptin. Respir Med (2011) 1.03

Leptin enhances lung maturity in the fetal rat. Pediatr Res (2006) 1.03

Leptin receptor polymorphisms and lung function decline in COPD. Eur Respir J (2009) 1.00

Does leptin play a cytokine-like role within the airways of COPD patients? Eur Respir J (2005) 0.99

The effect of leptin on Lep expression is tissue-specific and nutritionally regulated. Nat Med (1999) 0.99

Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation. Eur J Immunol (2007) 0.99

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity. Dev Cell (2002) 0.97

Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers. Thorax (2008) 0.97

Articles by these authors

Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med (2010) 15.07

High-quality binary protein interaction map of the yeast interactome network. Science (2008) 10.65

An empirical framework for binary interactome mapping. Nat Methods (2008) 6.59

Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med (2014) 6.29

An experimentally derived confidence score for binary protein-protein interactions. Nat Methods (2008) 5.27

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56

An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med (2013) 4.49

Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19

Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70

Systemic effects of smoking. Chest (2007) 3.63

Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 3.54

Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med (2014) 3.50

Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44

Corticosteroids and the risk of atrial fibrillation. Arch Intern Med (2006) 3.28

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03

Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD. Chest (2003) 2.90

Determinants of depression in the ECLIPSE chronic obstructive pulmonary disease cohort. Am J Respir Crit Care Med (2010) 2.80

Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci U S A (2006) 2.51

Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Nat Methods (2009) 2.50

Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res (2006) 2.40

Disturbed intestinal integrity in patients with COPD: effects of activities of daily living. Chest (2014) 2.27

Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 2.26

A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23

New insights into the immunology of chronic obstructive pulmonary disease. Lancet (2011) 2.23

Differences in content and organisational aspects of pulmonary rehabilitation programmes. Eur Respir J (2013) 2.20

Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation. Proc Natl Acad Sci U S A (2004) 2.19

Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD. Chest (2004) 2.08

Exercise capacity before and after an 8-week multidisciplinary inpatient rehabilitation program in lung cancer patients: a pilot study. Lung Cancer (2006) 2.07

Arterial stiffness in patients with COPD: the role of systemic inflammation and the effects of pulmonary rehabilitation. Eur Respir J (2013) 2.05

Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells. Am J Respir Crit Care Med (2005) 2.01

Inaccuracy of estimating peak work rate from six-minute walk distance in patients with COPD. COPD (2012) 1.98

Activation of the WNT/β-catenin pathway attenuates experimental emphysema. Am J Respir Crit Care Med (2010) 1.94

Extreme obesity and outcomes in critically ill patients. Chest (2011) 1.92

Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88

Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study. Am J Respir Crit Care Med (2012) 1.87

Severe asthma in adults: what are the important questions? J Allergy Clin Immunol (2007) 1.85

Effects of neuromuscular electrical stimulation of muscles of ambulation in patients with chronic heart failure or COPD: a systematic review of the English-language literature. Chest (2009) 1.81

Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.79

Increased granzyme A expression in type II pneumocytes of patients with severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.76

The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest (2010) 1.75

Identification of five chronic obstructive pulmonary disease subgroups with different prognoses in the ECLIPSE cohort using cluster analysis. Ann Am Thorac Soc (2015) 1.72

Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology. Am J Respir Cell Mol Biol (2002) 1.71

Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells. Am J Respir Crit Care Med (2007) 1.67

Identification and characterization of human pulmonary dendritic cells. Am J Respir Cell Mol Biol (2004) 1.66

Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice. J Immunol (2011) 1.65

An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63

Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.63

Efficacy of nutritional supplementation therapy in depleted patients with chronic obstructive pulmonary disease. Nutrition (2003) 1.60

Chronic obstructive pulmonary disease and cerebral microbleeds. The Rotterdam Study. Am J Respir Crit Care Med (2013) 1.57

Risk factors for osteoporosis in Caucasian patients with moderate chronic obstructive pulmonary disease: a case control study. Bone (2012) 1.56

Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. J Immunol (2006) 1.55

Proposal for a multidimensional staging system for chronic obstructive pulmonary disease. Respir Med (2005) 1.54

Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. FASEB J (2004) 1.53

Role of activin-A in cigarette smoke-induced inflammation and COPD. Eur Respir J (2013) 1.52

Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet (2012) 1.52

Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. J Immunol (2007) 1.51

The many faces of the SOCS box. Cytokine Growth Factor Rev (2008) 1.50

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells. Nat Methods (2005) 1.50

The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med (2014) 1.49

Critical view on diagnosing muscle wasting by single-frequency bio-electrical impedance in COPD. Respir Med (2009) 1.49

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med (2012) 1.49

MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.42

The last wish of a patient with end stage chronic obstructive pulmonary disease. BMJ (2008) 1.41

Glutaredoxin-1 attenuates S-glutathionylation of the death receptor fas and decreases resolution of Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med (2014) 1.40

Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol (2006) 1.38

Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis. Thorax (2007) 1.32

Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort. Respir Med (2010) 1.30

How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering. Mol Cell Endocrinol (2012) 1.30

Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms. Am J Respir Cell Mol Biol (2006) 1.30

Predicting outcomes from 6-minute walk distance in chronic obstructive pulmonary disease. J Am Med Dir Assoc (2011) 1.28

Obesity and asthma: an inflammatory disease of adipose tissue not the airway. Am J Respir Crit Care Med (2012) 1.28

In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization. Biochim Biophys Acta (2006) 1.27

Matrix metalloproteinases in asthma and COPD. Curr Opin Pharmacol (2005) 1.27

Leptin receptor signaling: pathways to leptin resistance. Front Biosci (Landmark Ed) (2011) 1.26

Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease. Am J Respir Cell Mol Biol (2006) 1.25

Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required? Respir Res (2005) 1.25

The in vitro production and characterization of neutrophils from embryonic stem cells. Blood (2003) 1.23

Physical activity monitoring in COPD: compliance and associations with clinical characteristics in a multicenter study. Respir Med (2011) 1.23