Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γ.

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DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity. Proc Natl Acad Sci U S A (2005) 1.67

Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. Mol Cell Biol (2004) 1.64

1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage. J Biol Chem (2002) 1.57

Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches. J Biol Chem (1994) 1.52

NMR characterization of a DNA duplex containing the major acrolein-derived deoxyguanosine adduct gamma -OH-1,-N2-propano-2'-deoxyguanosine. J Biol Chem (2000) 1.51

Fidelity of nucleotide incorporation by human mitochondrial DNA polymerase. J Biol Chem (2001) 1.47

Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta. Mol Cell Biol (2004) 1.47

Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells. J Biol Chem (2002) 1.46

Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta. J Biol Chem (2002) 1.40

Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal. Chem Res Toxicol (2009) 1.38

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The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta. Nucleic Acids Res (2009) 1.31

Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase. J Biol Chem (2006) 1.29

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs. J Mol Biol (2003) 1.29

Responses to the major acrolein-derived deoxyguanosine adduct in Escherichia coli. J Biol Chem (2000) 1.29

Endogenous formation and significance of 1,N2-propanodeoxyguanosine adducts. Mutat Res (1999) 1.26

Evaluation of the mutagenic potential of the principal DNA adduct of acrolein. J Biol Chem (2000) 1.25

Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. Chem Res Toxicol (2002) 1.25

Detection of an interchain carbinolamine cross-link formed in a CpG sequence by the acrolein DNA adduct gamma-OH-1,N( 2)-propano-2'-deoxyguanosine. J Am Chem Soc (2002) 1.24

The efficiency and fidelity of translesion synthesis past cisplatin and oxaliplatin GpG adducts by human DNA polymerase beta. J Biol Chem (2000) 1.20

The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine. Hum Mol Genet (2007) 1.19

Role of 1,N2-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans. IARC Sci Publ (1999) 1.19

Action of mitochondrial DNA polymerase gamma at sites of base loss or oxidative damage. J Biol Chem (1995) 1.16

Acrolein induces oxidative stress in brain mitochondria. Neurochem Int (2004) 1.15

Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts. Mutat Res (2007) 1.14

Mitochondrial DNA damage and its consequences for mitochondrial gene expression. Biochim Biophys Acta (2012) 1.12

Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family. Chem Res Toxicol (2008) 1.12

Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity. J Biol Chem (2009) 1.12

Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links. Chem Res Toxicol (2010) 1.12

Human DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA. Mol Cell Biol (2005) 1.06

The effect of DNA mismatches on the ATPase activity of MSH1, a protein in yeast mitochondria that recognizes DNA mismatches. J Biol Chem (1994) 1.02

Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion (2006) 1.01

Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activity. Nucleic Acids Res (2010) 1.00

Lesion bypass by S. cerevisiae Pol ζ alone. DNA Repair (Amst) (2011) 0.95

Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations. Methods (2010) 0.95

Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers. J Biol Chem (2011) 0.94

Analysis of Rev1p and Pol zeta in mitochondrial mutagenesis suggests an alternative pathway of damage tolerance. DNA Repair (Amst) (2007) 0.94

Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine. Nucleic Acids Res (2004) 0.93

Saccharomyces cerevisiae polymerase zeta functions in mitochondria. Genetics (2006) 0.91

Role of high-fidelity Escherichia coli DNA polymerase I in replication bypass of a deoxyadenosine DNA-peptide cross-link. J Bacteriol (2011) 0.89

Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase. J Biol Chem (2004) 0.86

Mass spectrometry-based quantification of myocardial protein adducts with acrolein in an in vivo model of oxidative stress. Mol Nutr Food Res (2011) 0.82

1,N(2)-propanodeoxyguanosine adduct formation in aortic DNA following inhalation of acrolein. Environ Health Perspect (2001) 0.81

Acrolein-induced toxicity--defective mitochondrial function as a possible mechanism. Arch Environ Contam Toxicol (1999) 0.79

Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. Nat Rev Drug Discov (2003) 2.20

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci U S A (2006) 2.17

Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest (2006) 2.14

DNA polymerase gamma in mitochondrial DNA replication and repair. Chem Rev (2006) 2.12

Molecular and clinical genetics of mitochondrial diseases due to POLG mutations. Hum Mutat (2008) 2.04

Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia. Am J Hum Genet (2006) 1.99

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia. Nat Struct Mol Biol (2004) 1.87

The common A467T mutation in the human mitochondrial DNA polymerase (POLG) compromises catalytic efficiency and interaction with the accessory subunit. J Biol Chem (2005) 1.81

DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity. Proc Natl Acad Sci U S A (2005) 1.67

Consequences of mutations in human DNA polymerase gamma. Gene (2005) 1.65

Role for DNA polymerase kappa in the processing of N2-N2-guanine interstrand cross-links. J Biol Chem (2008) 1.64

Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa. Mol Cell Biol (2004) 1.64

Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources. Acc Chem Res (2008) 1.60

Site-specific somatic mitochondrial DNA point mutations in patients with thymidine phosphorylase deficiency. J Clin Invest (2003) 1.60

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations. Cell Mol Life Sci (2010) 1.58

1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage. J Biol Chem (2002) 1.57

Modulation of the W748S mutation in DNA polymerase gamma by the E1143G polymorphismin mitochondrial disorders. Hum Mol Genet (2006) 1.54

Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta. Mol Cell Biol (2004) 1.47

Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells. J Biol Chem (2002) 1.46

Long patch base excision repair in mammalian mitochondrial genomes. J Biol Chem (2008) 1.44

Alpers-Huttenlocher syndrome. Pediatr Neurol (2013) 1.44

DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations. Biochim Biophys Acta (2008) 1.43

Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis. AIDS (2006) 1.43

Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta. J Biol Chem (2002) 1.40

Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal. Chem Res Toxicol (2009) 1.38

Molecular diagnosis of Alpers syndrome. J Hepatol (2006) 1.38

The mitochondrial DNA polymerase as a target of oxidative damage. Nucleic Acids Res (2002) 1.35

Active site mutation in DNA polymerase gamma associated with progressive external ophthalmoplegia causes error-prone DNA synthesis. J Biol Chem (2002) 1.34

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic Acids Res (2009) 1.34

Incision of DNA-protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair. Proc Natl Acad Sci U S A (2002) 1.31

Comparative evaluation of the bioreactivity and mutagenic spectra of acrolein-derived alpha-HOPdG and gamma-HOPdG regioisomeric deoxyguanosine adducts. Chem Res Toxicol (2003) 1.31

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs. J Mol Biol (2003) 1.29

Reduction in frataxin causes progressive accumulation of mitochondrial damage. Hum Mol Genet (2003) 1.24

Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. DNA Repair (Amst) (2009) 1.24

The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine. Hum Mol Genet (2007) 1.19

Mono-allelic POLG expression resulting from nonsense-mediated decay and alternative splicing in a patient with Alpers syndrome. DNA Repair (Amst) (2005) 1.19

Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance. Nucleic Acids Res (2005) 1.19

Initiation of repair of DNA-polypeptide cross-links by the UvrABC nuclease. Biochemistry (2005) 1.19

Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors. Mutat Res (2006) 1.18

Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia. Hum Mol Genet (2005) 1.16

POS5 gene of Saccharomyces cerevisiae encodes a mitochondrial NADH kinase required for stability of mitochondrial DNA. Eukaryot Cell (2003) 1.14

Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts. Mutat Res (2007) 1.14

Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family. Chem Res Toxicol (2008) 1.12

Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links. Chem Res Toxicol (2010) 1.12

Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication. J Biol Chem (2009) 1.11

Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence. Chem Res Toxicol (2006) 1.11

Human polymorphic variants of the NEIL1 DNA glycosylase. J Biol Chem (2007) 1.10

Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination. Environ Mol Mutagen (2007) 1.10

Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV. J Biol Chem (2008) 1.09

Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5'-CpG-3' sequence by the acrolein-derived gamma-OH-1,N2-propano-2'-deoxyguanosine DNA adduct. J Am Chem Soc (2005) 1.08

Replication past a trans-4-hydroxynonenal minor-groove adduct by the sequential action of human DNA polymerases iota and kappa. Mol Cell Biol (2006) 1.08

Human DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA. Mol Cell Biol (2005) 1.06

Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines. Biochemistry (2010) 1.05

Progressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1. Arch Neurol (2008) 1.04

Biochemical analysis of human POLG2 variants associated with mitochondrial disease. Hum Mol Genet (2011) 1.04

mip1 containing mutations associated with mitochondrial disease causes mutagenesis and depletion of mtDNA in Saccharomyces cerevisiae. Hum Mol Genet (2010) 1.04

Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect (2014) 1.03

Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity. J Biol Chem (2010) 1.00

Ribonucleotide discrimination and reverse transcription by the human mitochondrial DNA polymerase. J Biol Chem (2011) 1.00

RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity. Aging Cell (2012) 0.99

8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction. PLoS One (2012) 0.98

Mammalian cell mutagenesis of the DNA adducts of vinyl chloride and crotonaldehyde. Environ Mol Mutagen (2005) 0.98

R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity. Antimicrob Agents Chemother (2009) 0.98

Site-specific DNA cleavage by Chlorella virus topoisomerase II. Biochemistry (2002) 0.97

Determination of active site residues in Escherichia coli endonuclease VIII. J Biol Chem (2001) 0.96

Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations. Methods (2010) 0.95

Site-specific mutagenicity of stereochemically defined 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal in mammalian cells. Environ Mol Mutagen (2003) 0.94

Human mitochondrial DNA polymerase γ exhibits potential for bypass and mutagenesis at UV-induced cyclobutane thymine dimers. J Biol Chem (2011) 0.94

Clinical and molecular features of POLG-related mitochondrial disease. Cold Spring Harb Perspect Biol (2013) 0.94

Formation of inter- and intrastrand imine type DNA-DNA cross-links through secondary reactions of aldehydic adducts. Chem Res Toxicol (2005) 0.93

Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase. J Biol Chem (2004) 0.93

Nucleotide incorporation by human DNA polymerase gamma opposite benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyguanosine and deoxyadenosine. Nucleic Acids Res (2004) 0.93

Biochemical analysis of the G517V POLG variant reveals wild-type like activity. Mitochondrion (2011) 0.92

DNA damage recognition of mutated forms of UvrB proteins in nucleotide excision repair. Biochemistry (2004) 0.92

Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence. Chem Res Toxicol (2006) 0.92

Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance. Hum Mol Genet (2012) 0.91

Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity. Antimicrob Agents Chemother (2011) 0.91

DNA cross-link induced by trans-4-hydroxynonenal. Environ Mol Mutagen (2010) 0.90

Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells. Chem Res Toxicol (2002) 0.89

Role of high-fidelity Escherichia coli DNA polymerase I in replication bypass of a deoxyadenosine DNA-peptide cross-link. J Bacteriol (2011) 0.89

Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase. Mol Pharmacol (2012) 0.88

The interface of transcription and DNA replication in the mitochondria. Biochim Biophys Acta (2011) 0.88

Structure of T4 pyrimidine dimer glycosylase in a reduced imine covalent complex with abasic site-containing DNA. J Mol Biol (2006) 0.88

Evidence for Escherichia coli polymerase II mutagenic bypass of intrastrand DNA crosslinks. DNA Repair (Amst) (2005) 0.88

A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits. Mitochondrion (2011) 0.87

Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion. DNA Repair (Amst) (2009) 0.87

A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene. Environ Mol Mutagen (2003) 0.87