Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals.

PubWeight™: 1.21‹?› | Rank: Top 10%

🔗 View Article (PMC 3595218)

Published in PLoS Biol on March 12, 2013

Authors

Wilhelm Palm1, Marta M Swierczynska, Veena Kumari, Monika Ehrhart-Bornstein, Stefan R Bornstein, Suzanne Eaton

Author Affiliations

1: Max-Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Articles citing this

The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol (2013) 3.84

Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development. Genes Dev (2014) 1.57

Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling. Genes Dev (2014) 1.06

Pathogenesis of Nonalcoholic Steatohepatitis. Gastroenterology (2016) 1.02

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog. Nature (2014) 0.94

Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89

Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties. Cell Rep (2015) 0.89

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish. Chem Sci (2014) 0.88

Metabolic insights from zebrafish genetics, physiology, and chemical biology. Cell Mol Life Sci (2015) 0.88

The Hedgehog pathway: role in cell differentiation, polarity and proliferation. Arch Toxicol (2015) 0.88

Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties. Sci Rep (2014) 0.85

Endocannabinoids are conserved inhibitors of the Hedgehog pathway. Proc Natl Acad Sci U S A (2015) 0.85

Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress. Front Cell Infect Microbiol (2013) 0.82

Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep (2016) 0.79

Smoothened Regulation: A Tale of Two Signals. Trends Pharmacol Sci (2015) 0.78

Changes in morphology and function of adrenal cortex in mice fed a high-fat diet. Int J Obes (Lond) (2014) 0.77

Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling. Cancers (Basel) (2015) 0.77

Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidase. PLoS Comput Biol (2014) 0.76

Cholesterol-free and cholesterol-bound Hedgehog: Two sparring-partners working hand in hand in the Drosophila wing disc? Fly (Austin) (2013) 0.75

Sonic Hedgehog: a lipid speciated hormone? Oncotarget (2015) 0.75

Suzanne Eaton: the beautiful logic of development. J Cell Biol (2013) 0.75

Essential basal cytonemes take up Hedgehog in the Drosophila wing imaginal disc. Development (2017) 0.75

Articles cited by this

Phase separation of integral membrane proteins in Triton X-114 solution. J Biol Chem (1981) 26.33

The metabolic syndrome. Lancet (2005) 19.47

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell (1992) 10.97

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature (2000) 10.04

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14

Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55

Cholesterol modification of hedgehog signaling proteins in animal development. Science (1996) 5.66

Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell (2009) 5.57

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet (2008) 5.50

Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol (2003) 5.40

The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development (1997) 5.09

Patched acts catalytically to suppress the activity of Smoothened. Nature (2002) 4.69

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell (1997) 4.43

Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature (2005) 4.38

Separation of plasma lipoproteins by density-gradient ultracentrifugation. Anal Biochem (1975) 3.97

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol (2002) 3.85

FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature (2005) 3.50

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development (2006) 3.39

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development (2008) 3.30

Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem (1998) 2.95

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell (1994) 2.94

Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet (2011) 2.93

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell (2010) 2.91

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell (2001) 2.84

Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab (2006) 2.72

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell (1999) 2.70

A freely diffusible form of Sonic hedgehog mediates long-range signalling. Nature (2001) 2.50

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A (2009) 2.47

Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell (1996) 2.39

Novel lipid modifications of secreted protein signals. Annu Rev Biochem (2004) 2.37

Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell (1999) 2.33

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev (2004) 2.16

A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development (1997) 1.88

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev (2012) 1.84

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med (2010) 1.82

Animal lipoproteins: chemistry, structure, and comparative aspects. J Lipid Res (1980) 1.65

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell (2012) 1.65

Characterization of plasma lipoproteins separated and purified by agarose-column chromatography. Biochem J (1974) 1.61

Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev (2010) 1.54

Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes. Proc Natl Acad Sci U S A (1998) 1.53

Lipoprotein-heparan sulfate interactions in the Hh pathway. Dev Cell (2007) 1.51

The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels. Development (1999) 1.47

ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes. J Lipid Res (1997) 1.39

Incredible journey: how do developmental signals travel through tissue? Genes Dev (2004) 1.38

Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog. Dev Cell (2003) 1.37

A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form. J Biol Chem (2005) 1.37

Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. Development (2006) 1.34

Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition. PLoS Genet (2012) 1.32

Cholesterol modification restricts the spread of Shh gradient in the limb bud. Proc Natl Acad Sci U S A (2006) 1.30

Interstitial fluid lipoproteins. J Lipid Res (1987) 1.23

Drosophila NPC1b promotes an early step in sterol absorption from the midgut epithelium. Cell Metab (2007) 1.21

Cholesterol metabolism and embryogenesis. Trends Genet (1998) 1.19

LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals. Dev Cell (2012) 1.14

Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids. Development (2004) 1.12

Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep (2012) 1.11

Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling. Differentiation (2002) 1.10

Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells. J Biol Chem (2009) 1.10

Hedgehog signaling and the Gli code in stem cells, cancer, and metastases. Sci Signal (2011) 1.09

Patched regulates Smoothened trafficking using lipoprotein-derived lipids. Development (2009) 1.08

Collier transcription in a single Drosophila muscle lineage: the combinatorial control of muscle identity. Development (2007) 1.05

Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes. Traffic (2012) 1.03

Release and trafficking of lipid-linked morphogens. Curr Opin Genet Dev (2005) 1.01

Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev Cell (2011) 0.97

Metabolic diseases and cancer risk. Curr Opin Oncol (2012) 0.94

Lipoproteins of human peripheral lymph. Eur Heart J (1990) 0.92

Lipoprotein particles cross the blood-brain barrier in Drosophila. J Neurosci (2010) 0.91

Purifying the hedgehog protein and its variants. Methods Mol Biol (2007) 0.83

Articles by these authors

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing. Curr Biol (2007) 5.17

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature (2005) 4.38

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila. Cell (2010) 3.57

Myosin II dynamics are regulated by tension in intercalating cells. Dev Cell (2009) 3.49

Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell (2005) 3.26

Pheochromocytoma: recommendations for clinical practice from the First International Symposium. October 2005. Nat Clin Pract Endocrinol Metab (2007) 3.25

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions. Clin Endocrinol (Oxf) (2013) 3.12

Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83

The clinically inapparent adrenal mass: update in diagnosis and management. Endocr Rev (2004) 2.73

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab (2013) 2.49

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J (2002) 2.26

Clinical outcomes and genome-wide association for a brain methylation site in an antidepressant pharmacogenetics study in Mexican Americans. Am J Psychiatry (2014) 2.26

Brain anatomy and sensorimotor gating in Asperger's syndrome. Brain (2002) 2.26

Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. Clin Chem (2011) 2.24

Congenital adrenal hyperplasia. Lancet (2005) 2.21

Malignant pheochromocytoma: current status and initiatives for future progress. Endocr Relat Cancer (2004) 2.20

Seasonal variation in plasma free normetanephrine concentrations: implications for biochemical diagnosis of pheochromocytoma. Eur J Endocrinol (2014) 2.13

Evaluation of a diabetes management system based on practice guidelines, integrated care, and continuous quality management in a Federal State of Germany: a population-based approach to health care research. Diabetes Care (2008) 2.00

The endocytic pathway and formation of the Wingless morphogen gradient. Development (2005) 1.93

The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophr Res (2004) 1.87

Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes. Development (2004) 1.80

Identical, but not the same: intra-site and inter-site reproducibility of fractional anisotropy measures on two 3.0T scanners. Neuroimage (2010) 1.75

A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72

Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients. PLoS One (2009) 1.71

Dissociation of ACTH and glucocorticoids. Trends Endocrinol Metab (2008) 1.68

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet (2009) 1.61

A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language. Genome Biol (2011) 1.58

Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease. Circ Res (2009) 1.58

Motor system hyperconnectivity in juvenile myoclonic epilepsy: a cognitive functional magnetic resonance imaging study. Brain (2011) 1.55

Lipoprotein-heparan sulfate interactions in the Hh pathway. Dev Cell (2007) 1.51

Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status. Eur J Cancer (2011) 1.49

Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. Development (2002) 1.48

The Janus faces of allopurinol-allopurinol hypersensitivity syndrome. Am J Med (2008) 1.47

Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. Crit Care Med (2005) 1.47

Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion. Crit Care Med (2010) 1.45

Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets. Proc Natl Acad Sci U S A (2010) 1.42

Effects of diet and development on the Drosophila lipidome. Mol Syst Biol (2012) 1.41

Predicting kala-azar disease manifestations in asymptomatic patients with latent Leishmania donovani infection by detection of antibody against recombinant K39 antigen. Clin Diagn Lab Immunol (2002) 1.41

Effects of oral procyclidine administration on cognitive functions in healthy subjects: implications for schizophrenia. J Clin Psychopharmacol (2002) 1.39

Neural response to pleasant stimuli in anhedonia: an fMRI study. Neuroreport (2003) 1.33

Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition. PLoS Genet (2012) 1.32

Shotgun lipidomics on a LTQ Orbitrap mass spectrometer by successive switching between acquisition polarity modes. J Mass Spectrom (2012) 1.28

Establishment of global patterns of planar polarity during growth of the Drosophila wing epithelium. Curr Biol (2012) 1.28

Insight, distress and coping styles in schizophrenia. Schizophr Res (2007) 1.26

Development of a diabetes prevention management program for clinical practice. Public Health Rep (2007) 1.25

Volumetric structural brain abnormalities in men with schizophrenia or antisocial personality disorder. Behav Brain Res (2006) 1.25

Shotgun lipidomics on high resolution mass spectrometers. Cold Spring Harb Perspect Biol (2011) 1.24

Decomposing the neural correlates of antisaccade eye movements using event-related FMRI. Cereb Cortex (2007) 1.22

Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: potential clinical implications. J Clin Endocrinol Metab (2002) 1.22

Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Proc Natl Acad Sci U S A (2002) 1.22

Cognitive generation of affect in bipolar depression: an fMRI study. Eur J Neurosci (2004) 1.21

Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma. Endocr Relat Cancer (2010) 1.21

Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11beta-hydroxysteroid dehydrogenase. Proc Natl Acad Sci U S A (2011) 1.20

Schizoaffective disorder: diagnostic issues and future recommendations. Bipolar Disord (2008) 1.19

Survival strategies of a sterol auxotroph. Development (2010) 1.16

Regional cortical thinning in subjects with violent antisocial personality disorder or schizophrenia. Am J Psychiatry (2007) 1.15

miR-125b regulates calcification of vascular smooth muscle cells. Am J Pathol (2011) 1.15

The schizophrenia risk allele C of the TCF4 rs9960767 polymorphism disrupts sensorimotor gating in schizophrenia spectrum and healthy volunteers. J Neurosci (2011) 1.14

Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A (2012) 1.14

Longitudinal study of symptoms and cognitive function in chronic schizophrenia. Schizophr Res (2003) 1.14

The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biol Psychiatry (2005) 1.14

Gout--current diagnosis and treatment. Dtsch Arztebl Int (2009) 1.14

LipidXplorer: a software for consensual cross-platform lipidomics. PLoS One (2012) 1.13

The Finnish Diabetes Risk Score is associated with insulin resistance and progression towards type 2 diabetes. J Clin Endocrinol Metab (2008) 1.13

Prefrontal cortex and insight in schizophrenia: a volumetric MRI study. Schizophr Res (2006) 1.12

Primary human CD34+ hematopoietic stem and progenitor cells express functionally active receptors of neuromediators. Blood (2004) 1.12

Evidence for deficit in tasks of ventral, but not dorsal, prefrontal executive function as an endophenotypic marker for bipolar disorder. Biol Psychiatry (2005) 1.11

Transplantation of human islets without immunosuppression. Proc Natl Acad Sci U S A (2013) 1.10

A behavioural and functional neuroimaging investigation into the effects of nicotine on sensorimotor gating in healthy subjects and persons with schizophrenia. Psychopharmacology (Berl) (2006) 1.10

Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy. Proc Natl Acad Sci U S A (2002) 1.10

Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr Res (2004) 1.08

Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A (2006) 1.08

Gene expression profiling of benign and malignant pheochromocytoma. Ann N Y Acad Sci (2006) 1.08

Patched regulates Smoothened trafficking using lipoprotein-derived lipids. Development (2009) 1.08

Isolation of neural crest derived chromaffin progenitors from adult adrenal medulla. Stem Cells (2009) 1.07

Prevalence of parvovirus B19 and human bocavirus DNA in the heart of patients with no evidence of dilated cardiomyopathy or myocarditis. Clin Infect Dis (2009) 1.05

Isolation, characterization, and differentiation of progenitor cells from human adult adrenal medulla. Stem Cells Transl Med (2012) 1.05

Neuroticism influences brain activity during the experience of visceral pain. Gastroenterology (2011) 1.04

Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy. Brain (2012) 1.04

Reliability of smooth pursuit, fixation, and saccadic eye movements. Psychophysiology (2003) 1.04

Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant (2012) 1.03

NIH conference. Future directions in the study and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Ann Intern Med (2002) 1.03

Neurological basis of poor insight in psychosis: a voxel-based MRI study. Schizophr Res (2008) 1.02