Published in Pflugers Arch on April 21, 2013
PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol (2013) 0.87
A review of the relationships between endogenous sex steroids and incident ischemic stroke and coronary heart disease events. Curr Cardiol Rev (2015) 0.85
Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity. J Vasc Res (2016) 0.75
Sex differences in health and disease: brain and heart connections--a special issue. Pflugers Arch (2013) 0.75
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA (2002) 80.37
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
Function and activation of NF-kappa B in the immune system. Annu Rev Immunol (1994) 17.04
Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation (2008) 15.35
Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A (1996) 10.94
Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci (1999) 10.61
Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA (2007) 10.50
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology (1997) 10.08
Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology (1998) 9.57
The protective effects of estrogen on the cardiovascular system. N Engl J Med (1999) 6.25
The inflammatory response in stroke. J Neuroimmunol (2006) 5.33
Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. JAMA (2003) 5.26
Regulation of arterial tone by activation of calcium-dependent potassium channels. Science (1992) 4.98
An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell (2011) 4.04
EDHF: bringing the concepts together. Trends Pharmacol Sci (2002) 3.69
Gender differences in stroke incidence and poststroke disability in the Framingham heart study. Stroke (2009) 3.23
Cerebral microvessel responses to focal ischemia. J Cereb Blood Flow Metab (2003) 3.14
Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev (1998) 2.98
Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation. J Womens Health (Larchmt) (2006) 2.77
Androgens and cardiovascular disease. Endocr Rev (2003) 2.71
Molecular biology of steroid hormone synthesis. Endocr Rev (1988) 2.68
Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol (2004) 2.58
Vascular actions of estrogens: functional implications. Pharmacol Rev (2008) 2.52
Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol (2000) 2.46
Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab (2004) 2.35
The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab (2004) 2.34
Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium. Am J Physiol (1999) 2.26
Low serum testosterone and increased mortality in men with coronary heart disease. Heart (2010) 2.14
A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Proc Natl Acad Sci U S A (2001) 2.12
The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol (2002) 2.12
Estrogen as a neuroprotectant in stroke. J Cereb Blood Flow Metab (2000) 2.03
Lower testosterone levels predict incident stroke and transient ischemic attack in older men. J Clin Endocrinol Metab (2009) 2.01
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. J Biol Chem (2003) 1.90
Steroid hormone receptors: an update. Hum Reprod Update (2000) 1.90
Influence of sex steroid hormones on cerebrovascular function. J Appl Physiol (1985) (2006) 1.88
Hyperglycemia regulates hypoxia-inducible factor-1alpha protein stability and function. Diabetes (2004) 1.87
Cellular mechanisms involved in the vascular myogenic response. Am J Physiol (1992) 1.86
An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A (2002) 1.82
Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation. Am J Physiol Heart Circ Physiol (2007) 1.80
Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels. Mol Pharmacol (2005) 1.75
Direct agonist/antagonist functions of dehydroepiandrosterone. Endocrinology (2005) 1.68
Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats. Hypertension (1998) 1.66
Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J Neurosci (2003) 1.62
Endothelial influences on cerebrovascular tone. J Appl Physiol (1985) (2006) 1.61
Effect of testosterone on ex vivo vascular reactivity in man. Clin Sci (Lond) (2006) 1.60
Inflammation and infection in clinical stroke. J Cereb Blood Flow Metab (2002) 1.58
Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation (1999) 1.58
Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Proc Natl Acad Sci U S A (1990) 1.57
Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells. Mol Endocrinol (2000) 1.50
Non-genomic actions of androgens. Front Neuroendocrinol (2007) 1.48
Characterization of the potassium channels involved in EDHF-mediated relaxation in cerebral arteries. Br J Pharmacol (1997) 1.47
Neuroscience. Microglia: the enemy within? Science (2003) 1.46
An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol. Horm Behav (2007) 1.43
Testosterone relaxes rabbit coronary arteries and aorta. Circulation (1995) 1.42
Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. Am J Physiol Heart Circ Physiol (2001) 1.42
Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries. Am J Physiol (1998) 1.41
Functional testosterone receptors in plasma membranes of T cells. FASEB J (1999) 1.41
Aromatase: biologic relevance of tissue-specific expression. Semin Reprod Med (2004) 1.38
Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. J Biol Chem (1992) 1.37
Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system. Endocrinology (1985) 1.36
Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. J Clin Endocrinol Metab (2004) 1.36
Testosterone increases neurotoxicity of glutamate in vitro and ischemia-reperfusion injury in an animal model. J Appl Physiol (1985) (2002) 1.35
Deleterious effects of dihydrotestosterone on cerebral ischemic injury. J Cereb Blood Flow Metab (2007) 1.35
Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats. Brain Res (1998) 1.32
Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. Mol Biol Cell (1999) 1.31
Protein kinase C modulates basal myogenic tone in resistance arteries from the cerebral circulation. Circ Res (1991) 1.31
Molecular cell biology of androgen receptor signalling. Int J Biochem Cell Biol (2009) 1.30
Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation (1996) 1.30
Middle cerebral artery function after stroke: the threshold duration of reperfusion for myogenic activity. Stroke (2002) 1.29
Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1. Circulation (1999) 1.27
Pressure-induced myogenic activation of cat cerebral arteries is dependent on intact endothelium. Circ Res (1987) 1.25
Dose-dependent effects of androgens on outcome after focal cerebral ischemia in adult male mice. J Cereb Blood Flow Metab (2009) 1.25
Multiple forms of estrogen receptor-alpha in cerebral blood vessels: regulation by estrogen. Am J Physiol Endocrinol Metab (2002) 1.24
Localized expression of aromatase in human vascular tissues. Circ Res (1999) 1.20
Reactivity of brain parenchymal arterioles after ischemia and reperfusion. Microcirculation (2008) 1.20
Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension (1997) 1.19
Gender differences in long-term functional outcome after first-ever ischemic stroke. Intern Med (2009) 1.18
Dihydrotestosterone promotes vascular cell adhesion molecule-1 expression in male human endothelial cells via a nuclear factor-kappaB-dependent pathway. Endocrinology (2003) 1.18
Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits. Circ Res (1999) 1.18
Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am J Cardiol (1999) 1.17
17beta-estradiol decreases vascular tone in cerebral arteries by shifting COX-dependent vasoconstriction to vasodilation. Am J Physiol Heart Circ Physiol (2003) 1.17
Dihydrotestosterone differentially modulates the mitogen-activated protein kinase and the phosphoinositide 3-kinase/Akt pathways through the nuclear and novel membrane androgen receptor in C6 cells. Endocrinology (2006) 1.15
Myogenic tone, reactivity, and forced dilatation: a three-phase model of in vitro arterial myogenic behavior. Am J Physiol Heart Circ Physiol (2002) 1.15
Testosterone as a protective factor against atherosclerosis--immunomodulation and influence upon plaque development and stability. J Endocrinol (2003) 1.12
Estrogen reduces mouse cerebral artery tone through endothelial NOS- and cyclooxygenase-dependent mechanisms. Am J Physiol Heart Circ Physiol (2000) 1.12
Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men. Arterioscler Thromb Vasc Biol (1997) 1.12
Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels. Stroke (1999) 1.11
Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension. Pharmacol Rep (2008) 1.10
Rapid actions of androgens. Front Neuroendocrinol (2007) 1.09
Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via the MEK/ERK pathway. J Neuroinflammation (2010) 1.09
Testosterone treatment increases thromboxane function in rat cerebral arteries. Am J Physiol Heart Circ Physiol (2005) 1.07
Dihydrotestosterone decreases tumor necrosis factor-alpha and lipopolysaccharide-induced inflammatory response in human endothelial cells. J Clin Endocrinol Metab (2005) 1.07
Effect of testosterone on functional recovery in a castrate male rat stroke model. Brain Res (2005) 1.07
Physiological role of cerebrovascular sympathetic nerves in the autoregulation of cerebral blood flow. Brain Res (1976) 1.04
Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels. Br J Pharmacol (2002) 1.04
Postischemic cerebral blood flow recovery in the female: effect of 17 beta-estradiol. J Cereb Blood Flow Metab (1995) 1.03
Testosterone causes direct relaxation of rat thoracic aorta. J Pharmacol Exp Ther (1996) 1.02
Androgen receptor function is modulated by the tissue-specific AR45 variant. FEBS J (2005) 1.02
Testosterone suppresses endothelium-dependent dilation of rat middle cerebral arteries. Am J Physiol Heart Circ Physiol (2003) 1.01