Published in Cancer Discov on April 25, 2013
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A (2013) 2.49
Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res (2014) 1.86
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nat Commun (2013) 1.62
Notch1 mutations are drivers of oral tumorigenesis. Cancer Prev Res (Phila) (2014) 1.58
Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res (2014) 1.47
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol (2014) 1.40
Clinical update on cancer: molecular oncology of head and neck cancer. Cell Death Dis (2014) 1.22
A surprising cross-species conservation in the genomic landscape of mouse and human oral cancer identifies a transcriptional signature predicting metastatic disease. Clin Cancer Res (2014) 1.20
Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss. Nat Genet (2014) 1.20
Activation of the NOTCH pathway in head and neck cancer. Cancer Res (2013) 1.15
Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers. Clin Cancer Res (2014) 1.13
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies. Oncotarget (2014) 1.12
mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations. J Natl Cancer Inst (2014) 1.09
Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res (2015) 1.05
Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity. Sci Rep (2015) 1.02
Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer. Cancer (2014) 1.01
Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. Cancer Discov (2013) 1.01
Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene (2014) 0.99
Novel insight into mutational landscape of head and neck squamous cell carcinoma. PLoS One (2014) 0.97
A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma. Mol Cancer Ther (2014) 0.97
Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma. Clin Cancer Res (2013) 0.93
Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature. Oncotarget (2015) 0.93
Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma. Cancer Biol Med (2016) 0.91
Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma. J Clin Invest (2015) 0.90
The negative regulators of Wnt pathway-DACH1, DKK1, and WIF1 are methylated in oral and oropharyngeal cancer and WIF1 methylation predicts shorter survival. Tumour Biol (2014) 0.88
Therapeutic insights from genomic studies of head and neck squamous cell carcinomas. Cancer Discov (2015) 0.88
The roles of HOXD10 in the development and progression of head and neck squamous cell carcinoma (HNSCC). Br J Cancer (2014) 0.87
Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance. Genome Med (2015) 0.87
Senescent cancer-associated fibroblasts secrete active MMP-2 that promotes keratinocyte dis-cohesion and invasion. Br J Cancer (2014) 0.86
Genetic Landscape of Human Papillomavirus-Associated Head and Neck Cancer and Comparison to Tobacco-Related Tumors. J Clin Oncol (2015) 0.86
Somatic copy number alterations detected by ultra-deep targeted sequencing predict prognosis in oral cavity squamous cell carcinoma. Oncotarget (2015) 0.86
Personalizing Medicine in Head and Neck Squamous Cell Carcinoma: The Rationale for Combination Therapies. Med Res Arch (2016) 0.86
Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10. Br J Cancer (2014) 0.84
Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma. Cancer Lett (2015) 0.84
Unraveling the molecular genetics of head and neck cancer through genome-wide approaches. Genes Dis (2014) 0.83
Sequencing the head and neck cancer genome: implications for therapy. Ann N Y Acad Sci (2014) 0.83
Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth. Mol Oncol (2014) 0.83
Role of human papillomavirus in oropharyngeal squamous cell carcinoma: A review. World J Clin Cases (2014) 0.83
The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. Oncogene (2016) 0.83
CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance. Oncotarget (2015) 0.83
Targeting Notch to overcome radiation resistance. Oncotarget (2016) 0.82
Identification of an atypical etiological head and neck squamous carcinoma subtype featuring the CpG island methylator phenotype. EBioMedicine (2017) 0.82
Potential therapeutic targets for oral cancer: ADM, TP53, EGFR, LYN, CTLA4, SKIL, CTGF, CD70. PLoS One (2014) 0.82
Fibroblast growth factor family aberrations as a putative driver of head and neck squamous cell carcinoma in an epidemiologically low-risk patient as defined by targeted sequencing. Head Neck (2016) 0.82
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics. Cancer Cell (2016) 0.81
MDA-9/Syntenin regulates differentiation and angiogenesis programs in head and neck squamous cell carcinoma. Oncoscience (2014) 0.81
Integration of cancer genomics with treatment selection: from the genome to predictive biomarkers. Cancer (2013) 0.81
Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features. Cancer Prev Res (Phila) (2015) 0.81
In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model. J Otolaryngol Head Neck Surg (2016) 0.81
Definitive chemoradiation for primary oral cavity carcinoma: A single institution experience. Oral Oncol (2015) 0.81
Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma. Br J Cancer (2014) 0.80
Notch pathway activation is essential for maintenance of stem-like cells in early tongue cancer. Oncotarget (2016) 0.80
Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin. PLoS One (2013) 0.80
Recurring DNA copy number gain at chromosome 9p13 plays a role in the activation of multiple candidate oncogenes in progressing oral premalignant lesions. Cancer Med (2014) 0.80
Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas. Oncotarget (2016) 0.80
Gene and miRNA expression changes in squamous cell carcinoma of larynx and hypopharynx. Genes Cancer (2015) 0.80
NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell. Sci Rep (2016) 0.80
Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget (2016) 0.79
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Nat Commun (2016) 0.79
The non-coding landscape of head and neck squamous cell carcinoma. Oncotarget (2016) 0.79
Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas. Nat Genet (2017) 0.79
Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma. J Cell Physiol (2014) 0.79
p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia. Oncogene (2013) 0.78
Mutation and Transcriptional Profiling of Formalin-Fixed Paraffin Embedded Specimens as Companion Methods to Immunohistochemistry for Determining Therapeutic Targets in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Pilot of Proof of Principle. Head Neck Pathol (2014) 0.78
Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer (2014) 0.78
Nab-paclitaxel-based compared to docetaxel-based induction chemotherapy regimens for locally advanced squamous cell carcinoma of the head and neck. Cancer Med (2015) 0.78
The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. Oncotarget (2016) 0.78
Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling. Oncogene (2016) 0.78
Integrated genomics approach to identify biologically relevant alterations in fewer samples. BMC Genomics (2015) 0.78
NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma. PLoS One (2016) 0.77
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? Cancer Med (2016) 0.77
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Molecular biology and immunology of head and neck cancer. Surg Oncol Clin N Am (2015) 0.76
Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis. Cancer Res (2015) 0.76
Integrated analysis of oral tongue squamous cell carcinoma identifies key variants and pathways linked to risk habits, HPV, clinical parameters and tumor recurrence. F1000Res (2015) 0.76
Identification of genomic mutations associated with clinical outcomes of induction chemotherapy in patients with head and neck squamous cell carcinoma. J Cancer Res Clin Oncol (2015) 0.76
SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2. Cancer Res (2016) 0.76
Canine spontaneous head and neck squamous cell carcinomas represent their human counterparts at the molecular level. PLoS Genet (2015) 0.76
Prognostic factors, predictive markers and cancer biology: the triad for successful oral cancer chemoprevention. Future Oncol (2016) 0.76
Targeted sequencing reveals TP53 as a potential diagnostic biomarker in the post-treatment surveillance of head and neck cancer. Oncotarget (2016) 0.75
The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. Oncotarget (2016) 0.75
ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell (2016) 0.75
nab-Paclitaxel, cisplatin, and 5-fluorouracil followed by concurrent cisplatin and radiation for head and neck squamous cell carcinoma. Oral Oncol (2016) 0.75
Telomeres and telomerase in head and neck squamous cell carcinoma: from pathogenesis to clinical implications. Cancer Metastasis Rev (2016) 0.75
On Predicting lung cancer subtypes using 'omic' data from tumor and tumor-adjacent histologically-normal tissue. BMC Cancer (2016) 0.75
Prediction of biomarkers of oral squamous cell carcinoma using microarray technology. Sci Rep (2017) 0.75
Prevalence of EGFR Tyrosine Kinase Domain Mutations in Head and Neck Squamous Cell Carcinoma: Cohort Study and Systematic Review. In Vivo (2017) 0.75
Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation. Cancer Lett (2016) 0.75
Neoantigens in immunotherapy and personalized vaccines: Implications for head and neck squamous cell carcinoma. Oral Oncol (2016) 0.75
A network of epigenetic modifiers and DNA repair genes controls tissue-specific copy number alteration preference. Elife (2016) 0.75
Genetic and epigenetic characterization of the tumors in a patient with a tongue primary tumor, a recurrence and a pharyngoesophageal second primary tumor. Mol Cytogenet (2017) 0.75
Current understanding of the tumor microenvironment of laryngeal dysplasia and progression to invasive cancer. Curr Opin Otolaryngol Head Neck Surg (2016) 0.75
Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma. Carcinogenesis (2014) 0.75
Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma. Onco Targets Ther (2016) 0.75
Predictive value of epigenetic alterations in head and neck squamous cell carcinoma. Mol Cell Oncol (2014) 0.75
Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis. Oncotarget (2015) 0.75
DeSigN: connecting gene expression with therapeutics for drug repurposing and development. BMC Genomics (2017) 0.75
Concerning consequences of blocking Notch signaling in satellite muscle stem cells. Front Cell Dev Biol (2015) 0.75
Notch as a tumour suppressor. Nat Rev Cancer (2017) 0.75
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