Published in N Engl J Med on May 01, 2013
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Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med (2013) 8.89
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med (2014) 6.89
Clinical and biological implications of driver mutations in myelodysplastic syndromes. Blood (2013) 6.50
Emerging landscape of oncogenic signatures across human cancers. Nat Genet (2013) 6.48
Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12
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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell (2014) 4.17
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Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts. Nature (2014) 2.70
Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. Blood (2014) 2.54
Emerging patterns of somatic mutations in cancer. Nat Rev Genet (2013) 2.50
TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol (2015) 2.44
Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat Genet (2015) 2.44
Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet (2015) 2.43
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature (2014) 2.21
Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser. Sci Rep (2013) 2.19
Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell (2014) 2.15
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet (2013) 2.14
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes Dev (2013) 2.12
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2. Cancer Cell (2016) 2.08
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev (2013) 2.07
MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell (2014) 1.98
The genetic basis of myelodysplasia and its clinical relevance. Blood (2013) 1.95
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Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. Cell (2016) 1.91
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis. Cell Rep (2015) 1.83
Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome. Blood (2014) 1.82
Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas. Nat Genet (2013) 1.80
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell (2015) 1.79
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Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms. Blood (2014) 1.53
Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy. Cancer Discov (2015) 1.52
MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance. Blood (2015) 1.52
Clonal evolution in hematological malignancies and therapeutic implications. Leukemia (2013) 1.50
The landscape and therapeutic relevance of cancer-associated transcript fusions. Oncogene (2014) 1.49
Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China. Proc Natl Acad Sci U S A (2013) 1.49
Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo. Cancer Cell (2015) 1.47
A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing. Nat Commun (2015) 1.47
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Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. Leukemia (2016) 1.45
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DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. Nat Med (2016) 1.42
A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression. J Exp Med (2015) 1.42
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. J Exp Med (2015) 1.41
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. Leukemia (2014) 1.40
A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events. PLoS One (2014) 1.40
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma. Haematologica (2013) 1.40
The mutational landscape of phosphorylation signaling in cancer. Sci Rep (2013) 1.39
Genetic alterations of m(6)A regulators predict poorer survival in acute myeloid leukemia. J Hematol Oncol (2017) 1.39
Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation. Blood (2015) 1.39
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. Leukemia (2014) 1.38
Next-generation sequencing-based multigene mutational screening for acute myeloid leukemia using MiSeq: applicability for diagnostics and disease monitoring. Haematologica (2013) 1.37
Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score. J Clin Oncol (2013) 1.34
Differential DNA mismatch repair underlies mutation rate variation across the human genome. Nature (2015) 1.34
Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia. Nat Commun (2014) 1.33
Notch signaling: switching an oncogene to a tumor suppressor. Blood (2014) 1.32
Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways. Blood (2014) 1.32
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ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Sci Signal (2016) 1.30
Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell (2014) 1.28
The evolving role of FLT3 inhibitors in acute myeloid leukemia: quizartinib and beyond. Ther Adv Hematol (2014) 1.28
Characterizing DNA methylation alterations from The Cancer Genome Atlas. J Clin Invest (2014) 1.27
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miRNA dysregulation in cancer: towards a mechanistic understanding. Front Genet (2014) 1.25
Oncogenic RIT1 mutations in lung adenocarcinoma. Oncogene (2014) 1.24
Proto-oncogenic role of mutant IDH2 in leukemia initiation and maintenance. Cell Stem Cell (2014) 1.23
Genome Modeling System: A Knowledge Management Platform for Genomics. PLoS Comput Biol (2015) 1.21
Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia. Blood (2015) 1.21
Quantifying tumor heterogeneity in whole-genome and whole-exome sequencing data. Bioinformatics (2014) 1.20
IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition. Blood (2014) 1.18
Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. PLoS Genet (2014) 1.18
Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation. Haematologica (2013) 1.17
SYK is a critical regulator of FLT3 in acute myeloid leukemia. Cancer Cell (2014) 1.17
Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm. Leukemia (2013) 1.17
A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet (2014) 1.17
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis. Genes Dev (2015) 1.17
Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance. Blood (2015) 1.16
Emerging research and clinical development trends of liposome and lipid nanoparticle drug delivery systems. J Pharm Sci (2013) 1.16
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Nat Genet (2016) 1.15
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33
DNMT3A mutations in acute myeloid leukemia. N Engl J Med (2010) 14.07
Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med (2004) 11.61
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters. Proc Natl Acad Sci U S A (2006) 10.63
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med (2012) 10.20
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De novo assembly and analysis of RNA-seq data. Nat Methods (2010) 9.69
The origin and evolution of mutations in acute myeloid leukemia. Cell (2012) 9.66
Increased methylation variation in epigenetic domains across cancer types. Nat Genet (2011) 8.92
Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor. Science (2002) 6.05
MuSiC: identifying mutational significance in cancer genomes. Genome Res (2012) 4.73
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes. Science (2010) 4.60
Prognostic significance of the European LeukemiaNet standardized system for reporting cytogenetic and molecular alterations in adults with acute myeloid leukemia. J Clin Oncol (2012) 4.34
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Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol (2008) 3.47
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. Blood (2011) 3.41
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High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. J Clin Invest (2009) 2.66
The prognostic and functional role of microRNAs in acute myeloid leukemia. Blood (2010) 2.33
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood (2003) 2.26
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Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell (2006) 1.88
Chromosomal translocations: revisited yet again. Blood (2008) 1.86
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MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood (2012) 1.75
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MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. J Hematol Oncol (2012) 1.42
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miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death. Mol Cancer (2012) 1.21
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