Molecular changes induced by the curcumin analogue D6 in human melanoma cells.

PubWeight™: 0.79‹?›

🔗 View Article (PMC 3651720)

Published in Mol Cancer on May 04, 2013

Authors

Carla Rozzo1, Manuela Fanciulli, Cristina Fraumene, Antonio Corrias, Tiziana Cubeddu, Ilaria Sassu, Sara Cossu, Valentina Nieddu, Grazia Galleri, Emanuela Azara, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri, Marina Pisano

Author Affiliations

1: Biomolecular Chemistry Institute, National Research Council of Italy, Traversa La Crucca, 3. 07100, Sassari, Italy. carla.rozzo@icb.cnr.it

Articles cited by this

Cancer statistics, 2010. CA Cancer J Clin (2010) 103.28

NIH Image to ImageJ: 25 years of image analysis. Nat Methods (2012) 84.41

Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med (2010) 67.34

Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med (2011) 45.46

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell (1996) 11.22

Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proc Natl Acad Sci U S A (1990) 11.10

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature (1999) 10.48

Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ (2004) 9.96

p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer (2009) 9.21

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science (2000) 8.74

The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol (2004) 8.21

Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol (2006) 7.76

BH3-Only proteins-essential initiators of apoptotic cell death. Cell (2000) 7.04

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov (2009) 6.36

A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics (2003) 6.31

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif (2003) 4.68

Treatment of metastatic melanoma: an overview. Oncology (Williston Park) (2009) 4.58

Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev (2006) 4.24

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett (2008) 3.61

Transcriptional cross talk between NF-kappaB and p53. Mol Cell Biol (1999) 3.40

Curcumin and cancer: an "old-age" disease with an "age-old" solution. Cancer Lett (2008) 3.14

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. Apoptosis (2002) 2.69

Living with p53, dying of p53. Cell (2007) 2.62

Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. J Cell Sci (2002) 2.58

The biology of stem cell factor and its receptor C-kit. Int J Biochem Cell Biol (1999) 2.57

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature (2010) 2.15

BRAF targeted therapy changes the treatment paradigm in melanoma. Nat Rev Clin Oncol (2011) 2.10

ASPP: a new family of oncogenes and tumour suppressor genes. Br J Cancer (2007) 1.94

Main roads to melanoma. J Transl Med (2009) 1.67

Multitargeting by curcumin as revealed by molecular interaction studies. Nat Prod Rep (2011) 1.62

p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Proc Natl Acad Sci U S A (2004) 1.53

Transport of liposomal and albumin loaded curcumin to living cells: an absorption and fluorescence spectroscopic study. Biochim Biophys Acta (2006) 1.40

Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim Biophys Acta (2007) 1.35

Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer (2005) 1.31

DNA microarray analyses of melanoma gene expression: a decade in the mines. Pigment Cell Res (2007) 1.30

The role of the PI3K-AKT pathway in melanoma. Cancer J (2012) 1.30

GADD45 proteins: central players in tumorigenesis. Curr Mol Med (2012) 1.26

mE10, a novel caspase recruitment domain-containing proapoptotic molecule. J Biol Chem (1999) 1.22

Cell cycle control as a basis for cancer drug development (Review). Int J Oncol (2000) 1.16

Inhibition of nuclear factor-kappaB and nitric oxide by curcumin induces G2/M cell cycle arrest and apoptosis in human melanoma cells. Melanoma Res (2004) 1.12

Antitumor, anti-invasion, and antimetastatic effects of curcumin. Adv Exp Med Biol (2007) 1.10

Stress sensor Gadd45 genes as therapeutic targets in cancer. Cancer Ther (2009) 1.09

Targeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancer. Nutr Cancer (2011) 1.06

Curcumin enhances the efficacy of chemotherapy by tailoring p65NFκB-p300 cross-talk in favor of p53-p300 in breast cancer. J Biol Chem (2011) 1.04

Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Mol Cancer Ther (2009) 1.04

Gene-expression profiling in human cutaneous melanoma. Oncogene (2003) 1.02

Curcumin-induced GADD153 gene up-regulation in human colon cancer cells. Carcinogenesis (2004) 1.01

Melanoma epidemiology and public health. Dermatol Clin (2009) 0.99

Antiproliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells. Mol Cancer (2007) 0.98

Analysis of candidate genes through a proteomics-based approach in primary cell lines from malignant melanomas and their metastases. Melanoma Res (2005) 0.97

Hsp70B' regulation and function. Cell Stress Chaperones (2007) 0.91

Multifocal signal modulation therapy of cancer: ancient weapon, modern targets. Mol Cell Biochem (2009) 0.91

Deciphering the intricate regulatory mechanisms for the cellular choice between cell repair, apoptosis or senescence in response to damaging signals. Cell Signal (2010) 0.90

Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011". J Transl Med (2012) 0.87

Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. Mol Cancer (2010) 0.85

Nutrition and melanoma prevention. Clin Dermatol (2010) 0.84

Increased expression of inducible HSP70 in apoptotic cells is correlated with their efficacy for antitumor vaccine therapy. Int J Cancer (2004) 0.80

Articles by these authors

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer. Cancer Res (2004) 2.82

BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J Clin Oncol (2012) 2.41

The role of BRAF V600 mutation in melanoma. J Transl Med (2012) 2.00

The Rel/NF-κB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J Leukoc Biol (2012) 1.74

Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue. J Pathol (2004) 1.41

HCV-related hepatocellular carcinoma: From chronic inflammation to cancer. Clin Immunol (2009) 1.35

Association of variation in Fcgamma receptor 3B gene copy number with rheumatoid arthritis in Caucasian samples. Ann Rheum Dis (2010) 1.31

X-inactivation patch size in human female tissue confounds the assessment of tumor clonality. Proc Natl Acad Sci U S A (2003) 1.30

Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. Cancer Cell (2004) 1.27

Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma. Cancer Immunol Immunother (2014) 1.23

A new essential hypertension susceptibility locus on chromosome 2p24-p25, detected by genomewide search. Am J Hum Genet (2002) 1.20

BRCA1 and BRCA2 point mutations and large rearrangements in breast and ovarian cancer families in Northern Poland. Oncol Rep (2008) 1.16

Equine and canine Anaplasma phagocytophilum strains isolated on the island of Sardinia (Italy) are phylogenetically related to pathogenic strains from the United States. Appl Environ Microbiol (2005) 1.15

NF-κB as potential target in the treatment of melanoma. J Transl Med (2012) 1.14

MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project. Int J Cancer (2014) 1.10

Neoplastic leptomeningitis presenting in a melanoma patient treated with dabrafenib (a V600EBRAF inhibitor): a case report. J Med Case Rep (2012) 1.09

Ocular refraction: heritability and genome-wide search for eye morphometry traits in an isolated Sardinian population. Hum Genet (2004) 1.07

High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis. PLoS One (2009) 1.06

Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010". J Transl Med (2011) 1.02

Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy. BMC Cancer (2009) 1.02

Different molecular signatures in magnetic resonance imaging-staged facioscapulohumeral muscular dystrophy muscles. PLoS One (2012) 1.00

Altered trichothecene biosynthesis in TRI6-silenced transformants of Fusarium culmorum influences the severity of crown and foot rot on durum wheat seedlings. Mol Plant Pathol (2011) 1.00

Antiproliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells. Mol Cancer (2007) 0.98

Analysis of candidate genes through a proteomics-based approach in primary cell lines from malignant melanomas and their metastases. Melanoma Res (2005) 0.97

Spectrum and prevalence of BRCA1 and BRCA2 germline mutations in Sardinian patients with breast carcinoma through hospital-based screening. Cancer (2005) 0.97

Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia. J Transl Med (2012) 0.97

Factors predicting the occurrence of germline mutations in candidate genes among patients with cutaneous malignant melanoma from South Italy. Eur J Cancer (2006) 0.96

AurkA inhibitors enhance the effects of B-RAF and MEK inhibitors in melanoma treatment. J Transl Med (2014) 0.95

Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012". J Transl Med (2013) 0.95

Electroactive C(2) symmetry receptors based on the biphenyl scaffold and tetrathiafulvalene units. J Org Chem (2006) 0.94

Seasonal variation in occurrence of pulmonary embolism: analysis of the database of the Emilia-Romagna region, Italy. Chronobiol Int (2007) 0.93

Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-alpha 2b treatment. J Transl Med (2010) 0.93

NEMO-binding domain peptide inhibits proliferation of human melanoma cells. Cancer Lett (2008) 0.93

Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma. J Transl Med (2013) 0.92

Overexpression of h-prune in breast cancer is correlated with advanced disease status. Clin Cancer Res (2005) 0.90

Anaplasma phagocytophilum, Sardinia, Italy. Emerg Infect Dis (2005) 0.90

A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population. BMC Cancer (2009) 0.90

FCGR3B copy number variation is associated with systemic lupus erythematosus risk in Afro-Caribbeans. Rheumatology (Oxford) (2011) 0.90

CASC2a gene is down-regulated in endometrial cancer. Anticancer Res (2007) 0.90

High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas. Cancer (2003) 0.89

Synchronous interdigitating dendritic cell sarcoma and B-cell small lymphocytic lymphoma in a lymph node. Arch Pathol Lab Med (2006) 0.89

Presence of Jaagsiekte sheep retrovirus in tissue sections from human bronchioloalveolar carcinoma depends on patients' geographical origin. Hum Pathol (2008) 0.89

Space flight affects motility and cytoskeletal structures in human monocyte cell line J-111. Cytoskeleton (Hoboken) (2011) 0.89

Epidemiology of thyroid cancer in an area of epidemic thyroid goiter. J Cancer Epidemiol (2013) 0.88

Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia. BMC Cancer (2009) 0.88

Future perspectives in melanoma research. Meeting report from the "Melanoma research: a bridge from Naples to the World. Napoli, December 5th-6th 2011". J Transl Med (2012) 0.87

Exposure of human lymphocytes and lymphoblastoid cells to simulated microgravity strongly affects energy metabolism and DNA repair. J Cell Biochem (2005) 0.87

Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties. Amino Acids (2013) 0.87

Ceftriaxone blocks the polymerization of α-synuclein and exerts neuroprotective effects in vitro. ACS Chem Neurosci (2013) 0.87

BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study. J Clin Oncol (2004) 0.87

Reproductive aging-associated common genetic variants and the risk of breast cancer. Breast Cancer Res (2012) 0.87

Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer. Hum Mutat (2004) 0.86

Low penetrance of autosomal dominant lateral temporal epilepsy in Italian families without LGI1 mutations. Epilepsia (2013) 0.85

Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. Mol Cancer (2010) 0.85

Adjuvant treatment of malignant melanoma: where are we? Crit Rev Oncol Hematol (2005) 0.85

Seasonal variation in occurrence of aortic diseases: the database of hospital discharge data of the Emilia-Romagna region, Italy. J Thorac Cardiovasc Surg (2008) 0.85

Induction of arginosuccinate synthetase (ASS) expression affects the antiproliferative activity of arginine deiminase (ADI) in melanoma cells. Oncol Rep (2011) 0.84

Seasonal pattern of peptic ulcer hospitalizations: analysis of the hospital discharge data of the Emilia-Romagna region of Italy. BMC Gastroenterol (2010) 0.84

Proteomic profiling of human melanoma metastatic cell line secretomes. J Proteome Res (2011) 0.84

5-Lipoxygenase-dependent apoptosis of human lymphocytes in the International Space Station: data from the ROALD experiment. FASEB J (2012) 0.84

Natural and natural-like phenolic inhibitors of type B trichothecene in vitro production by the wheat (Triticum sp.) pathogen Fusarium culmorum. J Agric Food Chem (2014) 0.84

Do BRAF inhibitors select for populations with different disease progression kinetics? J Transl Med (2013) 0.83

Ovis aries Papillomavirus 3: a prototype of a novel genus in the family Papillomaviridae associated with ovine squamous cell carcinoma. Virology (2010) 0.83

Origin and distribution of the BRCA2-8765delAG mutation in breast cancer. BMC Cancer (2007) 0.83

CDKN2A and MC1R analysis in amelanotic and pigmented melanoma. Melanoma Res (2009) 0.83

Molecular alterations in key-regulator genes among patients with T4 breast carcinoma. BMC Cancer (2010) 0.82

Surgical management of suspicious melanocytic lesions in Italy. Dermatology (2013) 0.82

Molecular and antigenic characterization of a Mycoplasma bovis strain causing an outbreak of infectious keratoconjunctivitis. J Vet Diagn Invest (2006) 0.82

Exposure to modeled microgravity induces metabolic idleness in malignant human MCF-7 and normal murine VSMC cells. FEBS Lett (2006) 0.82

Caveolae and caveolae constituents in mechanosensing: effect of modeled microgravity on cultured human endothelial cells. Cell Biochem Biophys (2006) 0.81

Identification of a PKP2 gene deletion in a family with arrhythmogenic right ventricular cardiomyopathy. Eur J Hum Genet (2013) 0.81

Microsatellite instability and mutation analysis of candidate genes in unselected sardinian patients with endometrial carcinoma. Cancer (2002) 0.81

Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies. BMC Med Res Methodol (2012) 0.81

A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration. Cell Cycle (2009) 0.81

Characterisation of Mycoplasma capricolum P60 surface lipoprotein and its evaluation in a recombinant ELISA. Vet Microbiol (2007) 0.80

Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release. J Leukoc Biol (2003) 0.80

Ring-closing olefin metathesis of 2,2'-divinylbiphenyls: a novel and general approach to phenanthrenes. Org Lett (2004) 0.80

NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug. J Transl Med (2012) 0.80

Future perspectives in melanoma research: meeting report from the "Melanoma Bridge", Napoli, December 5th-8th 2013. J Transl Med (2014) 0.80

In vitro activity of the αvβ3 integrin antagonist RGDechi-hCit on malignant melanoma cells. Anticancer Res (2013) 0.79

Mutation analysis of candidate genes in melanoma-prone families: evidence of different pathogenetic mechanisms at chromosome 9P21. Melanoma Res (2003) 0.79

Effect of dabrafenib on melanoma cell lines harbouring the BRAF(V600D/R) mutations. BMC Cancer (2013) 0.79

Identification of predictive factors for the occurrence of predisposing MLH1 and MSH2 germline mutations among Sardinian patients with colorectal carcinoma. Eur J Cancer (2005) 0.79