Mechanisms and function of substrate recruitment by F-box proteins.

PubWeight™: 2.56‹?› | Rank: Top 1%

🔗 View Article (PMC 3827686)

Published in Nat Rev Mol Cell Biol on May 09, 2013

Authors

Jeffrey R Skaar1, Julia K Pagan, Michele Pagano

Author Affiliations

1: Department of Pathology, New York University Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA. skaarlab@gmail.com

Articles citing this

(truncated to the top 100)

Classification of intrinsically disordered regions and proteins. Chem Rev (2014) 2.48

Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature (2014) 2.11

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. Nat Genet (2014) 2.01

New insights into ubiquitin E3 ligase mechanism. Nat Struct Mol Biol (2014) 1.82

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol (2013) 1.62

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nat Cell Biol (2014) 1.55

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1. Am J Physiol Endocrinol Metab (2014) 1.55

Cell-fate determination by ubiquitin-dependent regulation of translation. Nature (2015) 1.55

Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities. Cancer Cell (2014) 1.51

Roles of F-box proteins in cancer. Nat Rev Cancer (2014) 1.51

Building and remodelling Cullin-RING E3 ubiquitin ligases. EMBO Rep (2013) 1.47

SCFTIR1/AFB-based auxin perception: mechanism and role in plant growth and development. Plant Cell (2015) 1.35

SCF ubiquitin ligase-targeted therapies. Nat Rev Drug Discov (2014) 1.25

Ubiquitin-mediated response to microsporidia and virus infection in C. elegans. PLoS Pathog (2014) 1.20

Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. Mol Cell (2013) 1.05

Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes Dev (2013) 1.05

Quantifying ubiquitin signaling. Mol Cell (2015) 1.02

The oncogenic microRNA-21 inhibits the tumor suppressive activity of FBXO11 to promote tumorigenesis. J Biol Chem (2015) 0.98

Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. J Virol (2014) 0.96

Nutrient salvaging and metabolism by the intracellular pathogen Legionella pneumophila. Front Cell Infect Microbiol (2014) 0.96

Untethering the TIR1 auxin receptor from the SCF complex increases its stability and inhibits auxin response. Nat Plants (2015) 0.93

Targeting the ubiquitin pathway for cancer treatment. Biochim Biophys Acta (2014) 0.93

DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation. Dev Cell (2014) 0.92

Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and potential roles in post-transcriptional regulatory networks. Nucleic Acids Res (2014) 0.92

Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression. EMBO J (2014) 0.92

ERAD and how viruses exploit it. Front Microbiol (2014) 0.91

Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System. J Biol Chem (2016) 0.91

Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. Open Biol (2013) 0.91

Regulation of the protein stability of EMT transcription factors. Cell Adh Migr (2014) 0.88

MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. Oncogene (2015) 0.87

Glycosylation of Skp1 affects its conformation and promotes binding to a model f-box protein. Biochemistry (2014) 0.87

The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling. Elife (2014) 0.86

Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. Biochem J (2015) 0.85

Recent advances in SCF ubiquitin ligase complex: Clinical implications. Biochim Biophys Acta (2016) 0.85

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism. J Biol Chem (2014) 0.84

FEM1 proteins are ancient regulators of SLBP degradation. Cell Cycle (2017) 0.84

Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms. J Cancer (2015) 0.84

The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA. Elife (2016) 0.83

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma. EMBO J (2016) 0.83

F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proc Natl Acad Sci U S A (2015) 0.83

Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. J Biol Chem (2013) 0.83

The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol (2017) 0.83

SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties. J Cell Sci (2015) 0.83

Cullin E3 ligases and their rewiring by viral factors. Biomolecules (2014) 0.82

Targeting ubiquitination for cancer therapies. Future Med Chem (2015) 0.82

Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. Biomed Res Int (2014) 0.81

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle. Elife (2016) 0.81

Plant ubiquitin ligases as signaling hubs. Nat Struct Mol Biol (2014) 0.81

FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification. Nat Cell Biol (2015) 0.81

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. J Biol Chem (2015) 0.81

The COP9 signalosome and cullin-RING ligases in the heart. Am J Cardiovasc Dis (2015) 0.81

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase. Proc Natl Acad Sci U S A (2014) 0.81

Glycosylation of Skp1 promotes formation of Skp1-cullin-1-F-box protein complexes in dictyostelium. Mol Cell Proteomics (2014) 0.81

FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Cancer Lett (2015) 0.81

Ubiquitin-Dependent Regulation of Stem Cell Biology. Trends Cell Biol (2017) 0.81

F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. Cell Death Dis (2015) 0.80

FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Genes Dev (2015) 0.80

The IRAK homolog Pelle is the functional counterpart of IκB kinase in the Drosophila Toll pathway. PLoS One (2013) 0.80

FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. Nucleic Acids Res (2014) 0.79

DNA Damage Regulates Translation through β-TRCP Targeting of CReP. PLoS Genet (2015) 0.79

Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression. J Pathol (2015) 0.79

Oligomerization of SCFTIR1 Is Essential for Aux/IAA Degradation and Auxin Signaling in Arabidopsis. PLoS Genet (2016) 0.79

Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis. Semin Cancer Biol (2015) 0.78

Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1. PLoS Genet (2014) 0.78

Skp2 is over-expressed in breast cancer and promotes breast cancer cell proliferation. Cell Cycle (2016) 0.78

Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. Elife (2016) 0.78

Oxygen sensing by protozoans: how they catch their breath. Curr Opin Microbiol (2015) 0.78

Proteasome-dependent degradation of replisome components regulates faithful DNA replication. Cell Cycle (2013) 0.78

SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability. Oncotarget (2014) 0.78

NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR. J Virol (2016) 0.78

An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat Commun (2017) 0.77

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin. J Biol Chem (2015) 0.77

Small molecule therapeutics targeting F-box proteins in cancer. Semin Cancer Biol (2015) 0.77

Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson's disease (PD). Mol Brain (2016) 0.77

PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation. PLoS One (2014) 0.77

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Biochem J (2016) 0.77

Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis. Mol Cancer (2016) 0.77

Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets. Mol Biol Cell (2015) 0.77

Two-way communication between the metabolic and cell cycle machineries: the molecular basis. Cell Cycle (2015) 0.77

A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation. J Immunol (2016) 0.77

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition. Sci Rep (2015) 0.77

FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). J Biol Chem (2016) 0.76

The E3 Ubiquitin Ligase Adaptor Protein Skp1 Is Glycosylated by an Evolutionarily Conserved Pathway That Regulates Protist Growth and Development. J Biol Chem (2015) 0.76

Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors. Oncogene (2014) 0.76

Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun (2016) 0.76

Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery. J Biol Chem (2016) 0.76

TRIB1 Is Regulated Post-Transcriptionally by Proteasomal and Non-Proteasomal Pathways. PLoS One (2016) 0.76

DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet (2016) 0.76

AtMYB93 is an endodermis-specific transcriptional regulator of lateral root development in arabidopsis. Plant Signal Behav (2014) 0.76

The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs. Elife (2016) 0.76

Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins. Int J Biochem Cell Biol (2016) 0.76

The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation. Mol Cell Biol (2015) 0.76

Glycan-binding F-box protein from Arabidopsis thaliana protects plants from Pseudomonas syringae infection. BMC Plant Biol (2016) 0.76

Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors. Oncotarget (2015) 0.76

The COP9 signalosome and vascular function: intriguing possibilities? Am J Cardiovasc Dis (2015) 0.76

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. EMBO J (2016) 0.76

Phytochrome Signaling Is Mediated by PHYTOCHROME INTERACTING FACTOR in the Liverwort Marchantia polymorpha. Plant Cell (2016) 0.76

PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth. Nature (2017) 0.76

Chemical Synthesis of a Glycopeptide Derived from Skp1 for Probing Protein Specific Glycosylation. Chemistry (2015) 0.75

SCFFBXO17 E3 ligase modulates inflammation by regulating proteasomal degradation of glycogen synthase kinase-3β in lung epithelia. J Biol Chem (2017) 0.75

Articles cited by this

(truncated to the top 100)

The ubiquitin system. Annu Rev Biochem (1998) 43.36

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84

Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88

Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol (2005) 14.42

Frequent pathway mutations of splicing machinery in myelodysplasia. Nature (2011) 11.44

Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92

Mechanism of auxin perception by the TIR1 ubiquitin ligase. Nature (2007) 8.21

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer (2008) 7.93

The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet (2008) 7.65

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature (2001) 7.31

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell (2007) 7.24

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell (2007) 7.10

The ubiquitin code. Annu Rev Biochem (2012) 7.08

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep (2008) 6.21

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer (2008) 6.10

An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (2001) 6.07

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell (2009) 5.97

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature (2007) 5.65

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature (2011) 5.32

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells. Nat Cell Biol (1999) 4.98

Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev (2004) 4.68

An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat Methods (2009) 4.46

Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med (2007) 4.04

Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell (2007) 3.99

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol Cell (2007) 3.97

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol Cell (2003) 3.91

Global protein stability profiling in mammalian cells. Science (2008) 3.91

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol (2001) 3.87

Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature (2010) 3.87

FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res (2007) 3.79

Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev (2006) 3.78

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature (2004) 3.73

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature (2011) 3.69

A family of mammalian F-box proteins. Curr Biol (1999) 3.68

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature (2004) 3.63

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science (2007) 3.59

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev Cell (2003) 3.53

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell (2005) 3.47

Identification of a family of human F-box proteins. Curr Biol (1999) 3.31

Proline hydroxylation and gene expression. Annu Rev Biochem (2005) 3.23

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell (2006) 3.08

The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science (2007) 3.05

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells. Mol Cell Biol (2000) 2.96

Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication. Mol Cell (2005) 2.78

The cryptochromes: blue light photoreceptors in plants and animals. Annu Rev Plant Biol (2011) 2.76

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell (2007) 2.69

SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem (2005) 2.68

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med (2010) 2.65

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1. Mol Cell (2001) 2.61

Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science (2009) 2.60

Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science (2008) 2.53

An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Science (2009) 2.49

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proc Natl Acad Sci U S A (2001) 2.39

Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem Biol (2012) 2.34

The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4. Curr Biol (2008) 2.33

Tel2 regulates the stability of PI3K-related protein kinases. Cell (2007) 2.30

E3 ubiquitin ligase that recognizes sugar chains. Nature (2002) 2.17

Structural assembly of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2010) 2.17

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature (2010) 2.15

Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell (2013) 2.14

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover. Blood (2000) 2.08

Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet (2012) 2.07

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. Proc Natl Acad Sci U S A (2004) 2.05

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell (2011) 2.03

The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol (2011) 1.99

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med (2007) 1.99

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell (2012) 1.98

Identification of small molecule activators of cryptochrome. Science (2012) 1.95

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage. Nature (2009) 1.93

SnapShot: F Box Proteins II. Cell (2009) 1.88

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat Biotechnol (2010) 1.88

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature (2011) 1.86

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Mol Cell (2011) 1.85

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature (2012) 1.79

Roles of BCL6 in normal and transformed germinal center B cells. Immunol Rev (2012) 1.78

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR. Mol Cell (2011) 1.78

Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation. J Cell Sci (2010) 1.74

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. J Biol Chem (2000) 1.73

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol (2010) 1.71

The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B. J Biol Chem (2001) 1.69

Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev Cell (2010) 1.68

Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa. PLoS Pathog (2009) 1.68

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol Cell (2009) 1.64

Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div (2007) 1.64

SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell (2007) 1.60

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell (2013) 1.56

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. J Biol Chem (2010) 1.56

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc Natl Acad Sci U S A (2010) 1.49

EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell (2012) 1.48

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol (2012) 1.47

Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther (2009) 1.46

FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome. Neurology (2008) 1.45

FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. Cell (2013) 1.42

SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature (2013) 1.41

Articles by these authors

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96

The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol (2004) 8.21

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer (2008) 6.10

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science (2006) 5.94

Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev (2004) 4.68

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell (2008) 4.04

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature (2004) 3.73

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem (2003) 3.68

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo. Dev Cell (2003) 3.62

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science (2007) 3.59

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature (2003) 3.54

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev (2008) 3.49

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest (2002) 3.36

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Nature (2006) 3.31

The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science (2007) 3.05

American Idol and NIH Grant Review. Cell (2006) 3.01

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Mol Cell (2006) 2.75

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell (2005) 2.75

Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation. Cell (2003) 2.54

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis. Nature (2008) 2.46

APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell (2007) 2.35

Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem Biol (2012) 2.34

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol (2008) 2.32

Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol (2003) 2.27

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature (2007) 2.20

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature (2010) 2.15

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. J Cell Biol (2008) 2.08

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. Proc Natl Acad Sci U S A (2004) 2.05

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell (2012) 1.98

Dual mode of degradation of Cdc25 A phosphatase. EMBO J (2002) 1.95

APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation. Cell Cycle (2009) 1.94

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature (2013) 1.94

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle (2008) 1.90

SnapShot: F Box Proteins II. Cell (2009) 1.88

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol (2003) 1.85

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature (2012) 1.79

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR. Mol Cell (2011) 1.78

Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Am J Pathol (2007) 1.77

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. Mol Cell (2009) 1.77

Control of cell growth by the SCF and APC/C ubiquitin ligases. Curr Opin Cell Biol (2009) 1.55

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol Cell (2004) 1.55

Oncogenic aberrations of cullin-dependent ubiquitin ligases. Oncogene (2004) 1.51

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol (2012) 1.47

Stabilizers and destabilizers controlling cell cycle oscillators. Mol Cell (2006) 1.42

SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature (2013) 1.41

The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer. Biochim Biophys Acta (2013) 1.34

Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis. Mol Cell Biol (2004) 1.33

Involvement of the SCF complex in the control of Cdh1 degradation in S-phase. Cell Cycle (2005) 1.32

INTS3 controls the hSSB1-mediated DNA damage response. J Cell Biol (2009) 1.31

FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress. J Cell Biol (2013) 1.28

Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. J Biol Chem (2006) 1.27

SnapShot: F box proteins I. Cell (2009) 1.27

Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med (2004) 1.24

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress. Sci Signal (2012) 1.23

DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age. Dev Cell (2007) 1.22

Cell cycle, proteolysis and cancer. Curr Opin Cell Biol (2004) 1.22

Experimental tests to definitively determine ubiquitylation of a substrate. Methods Enzymol (2005) 1.21

SCF ubiquitin ligases in the maintenance of genome stability. Trends Biochem Sci (2011) 1.21

Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J Biol Chem (2002) 1.20

Altered expression of p27 and Skp2 proteins in prostate cancer of African-American patients. Clin Cancer Res (2003) 1.19

S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase. Am J Pathol (2002) 1.17

Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. Am J Pathol (2004) 1.17

Cdh1: a master G0/G1 regulator. Nat Cell Biol (2008) 1.16

In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation. Mol Cell Biol (2002) 1.13

Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. J Biol Chem (2006) 1.12

Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle (2010) 1.10

Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222. Cancer Res (2009) 1.09

Constitutive phosphorylation of aurora-a on ser51 induces its stabilization and consequent overexpression in cancer. PLoS One (2007) 1.07

Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma. Cancer (2004) 1.07

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. J Cell Biol (2011) 1.06

Cdk1: the dominant sibling of Cdk2. Nat Cell Biol (2005) 1.06

FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nat Cell Biol (2013) 1.04

Tumor suppressor function of androgen receptor coactivator ARA70alpha in prostate cancer. Am J Pathol (2010) 1.02

Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes. BMC Biochem (2007) 0.99

SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nat Cell Biol (2013) 0.98

Multisite phosphorylation of nuclear interaction partner of ALK (NIPA) at G2/M involves cyclin B1/Cdk1. J Biol Chem (2007) 0.94

The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain. Cell Cycle (2005) 0.93

Don't skip the G1 phase: how APC/CCdh1 keeps SCFSKP2 in check. Cell Cycle (2004) 0.93

Role of the ubiquitin proteasome system in the heart. Circ Res (2013) 0.93

Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. Mol Cell (2013) 0.92

Clinical relevance of SKP2 alterations in metastatic melanoma. Pigment Cell Melanoma Res (2010) 0.92

To be or not to be ubiquitinated? Cell Cycle (2004) 0.92

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis. Trends Cell Biol (2012) 0.92

The atrial natriuretic peptide genetic variant rs5068 is associated with a favorable cardiometabolic phenotype in a Mediterranean population. Diabetes Care (2013) 0.91

A peptidomimetic siRNA transfection reagent for highly effective gene silencing. Mol Biosyst (2006) 0.91

Fenton's pre-treatment of mature landfill leachate. Chemosphere (2004) 0.90

Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis. Adv Cancer Res (2003) 0.89

MCL1 meets its end during mitotic arrest. EMBO Rep (2011) 0.89

Skp2, the FoxO1 hunter. Cancer Cell (2005) 0.88

Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion. Genes Dev (2010) 0.87

FBH1 protects melanocytes from transformation and is deregulated in melanomas. Cell Cycle (2013) 0.86

Wnt signaling in mitosis. Dev Cell (2009) 0.86

The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy. Urol Oncol (2009) 0.84

Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase. J Biol Chem (2007) 0.84

BubR1 is modified by sumoylation during mitotic progression. J Biol Chem (2011) 0.84

The metabolic syndrome predicts cardiovascular events in subjects with normal fasting glucose: results of a 15 years follow-up in a Mediterranean population. Atherosclerosis (2007) 0.83