GPR15-mediated homing controls immune homeostasis in the large intestine mucosa.

PubWeight™: 1.58‹?› | Rank: Top 4%

🔗 View Article (PMC 3762262)

Published in Science on May 09, 2013

Authors

Sangwon V Kim1, Wenkai V Xiang, Changsoo Kwak, Yi Yang, Xiyao W Lin, Mitsuhiko Ota, Umut Sarpel, Daniel B Rifkin, Ruliang Xu, Dan R Littman

Author Affiliations

1: Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

Articles citing this

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53

The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74

TGF-β activation and function in immunity. Annu Rev Immunol (2013) 1.63

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature (2015) 1.60

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis. Nat Immunol (2014) 1.58

Microbiota-mediated inflammation and antimicrobial defense in the intestine. Annu Rev Immunol (2015) 1.23

Regulation of the immune system by the resident intestinal bacteria. Gastroenterology (2014) 1.19

The microbiota in adaptive immune homeostasis and disease. Nature (2016) 1.18

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut. Proc Natl Acad Sci U S A (2014) 1.11

Organ-specific and memory treg cells: specificity, development, function, and maintenance. Front Immunol (2014) 1.11

The importance of regulatory T-cell heterogeneity in maintaining self-tolerance. Immunol Rev (2014) 1.02

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol (2015) 1.00

Control of Regulatory T Cell Migration, Function, and Homeostasis. J Immunol (2015) 1.00

Development and maintenance of intestinal regulatory T cells. Nat Rev Immunol (2016) 0.95

Tissue Tregs. Annu Rev Immunol (2016) 0.94

Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity. Cold Spring Harb Symp Quant Biol (2014) 0.92

T-cell selection and intestinal homeostasis. Immunol Rev (2014) 0.92

The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome. Front Immunol (2015) 0.91

Commensal microbiota regulates T cell fate decision in the gut. Semin Immunopathol (2014) 0.90

The lymph nodes draining the small intestine and colon are anatomically separate and immunologically distinct. Mucosal Immunol (2015) 0.90

The role of commensal bacteria in the regulation of sensitization to food allergens. FEBS Lett (2014) 0.88

Orphan chemoattractant receptor GPR15 mediates dendritic epidermal T-cell recruitment to the skin. Eur J Immunol (2014) 0.86

Leukocyte Trafficking to the Small Intestine and Colon. Gastroenterology (2015) 0.85

Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses. J Exp Med (2015) 0.84

Colonic tolerance develops in the iliac lymph nodes and can be established independent of CD103(+) dendritic cells. Mucosal Immunol (2015) 0.84

Heterogeneity across the murine small and large intestine. World J Gastroenterol (2014) 0.83

The microbiota, the immune system and the allograft. Am J Transplant (2014) 0.83

Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Front Immunol (2016) 0.82

Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand. Br J Pharmacol (2014) 0.82

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo. Gut (2015) 0.81

Toll-like receptor 3 signalling up-regulates expression of the HIV co-receptor G-protein coupled receptor 15 on human CD4+ T cells. PLoS One (2014) 0.81

Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors. J Virol (2015) 0.80

Ethnicity and Smoking-Associated DNA Methylation Changes at HIV Co-Receptor GPR15. Front Psychiatry (2015) 0.80

Mechanisms of T cell organotropism. Cell Mol Life Sci (2016) 0.79

ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation. Elife (2016) 0.79

Harnessing regulatory T cells for the treatment of inflammatory bowel disease. Inflamm Bowel Dis (2015) 0.79

Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge. JCI Insight (2017) 0.78

The Mucosal Immune System and Its Regulation by Autophagy. Front Immunol (2016) 0.78

Polycyclic aromatic hydrocarbons, tobacco smoke, and epigenetic remodeling in asthma. Immunol Res (2014) 0.78

Prospects for therapeutic tolerance in humans. Curr Opin Rheumatol (2014) 0.78

Differential expression of GPR15 on T cells during ulcerative colitis. JCI Insight (2017) 0.78

The Gut Microbiota and Immune System Relationship in Human Graft-versus-Host Disease. Mediterr J Hematol Infect Dis (2016) 0.78

Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis. Cytokine (2014) 0.76

The variable loop 3 in the envelope glycoprotein is critical for the atypical coreceptor usage of an HIV-1 strain. PLoS One (2014) 0.76

The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System. Front Immunol (2017) 0.75

Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4(+) T Cell Differentiation. Eur J Microbiol Immunol (Bp) (2016) 0.75

Roles of the intestinal microbiota in pathogen protection. Clin Transl Immunology (2017) 0.75

Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity. J Autoimmun (2016) 0.75

mTOR is critical for intestinal T-cell homeostasis and resistance to Citrobacter rodentium. Sci Rep (2016) 0.75

Smoking-related general and cause-specific mortality in Estonia. BMC Public Health (2017) 0.75

A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15. Front Immunol (2017) 0.75

Differential phosphorylation signals control endocytosis of GPR15. Mol Biol Cell (2017) 0.75

Articles cited by this

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42

Evolution of mammals and their gut microbes. Science (2008) 21.40

Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell (2005) 15.46

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 14.15

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67

Interactions between the microbiota and the immune system. Science (2012) 10.45

Retinoic acid imprints gut-homing specificity on T cells. Immunity (2004) 9.76

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell (2007) 8.42

Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43

Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature (1997) 6.23

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med (2003) 6.00

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci U S A (2005) 5.96

Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80

Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J Clin Microbiol (1994) 5.68

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity (2006) 5.40

Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol (2008) 5.37

Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science (2006) 5.31

Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity (2011) 4.86

Mucin dynamics and enteric pathogens. Nat Rev Microbiol (2011) 4.23

Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science (2012) 4.17

HIV infection and the gastrointestinal immune system. Mucosal Immunol (2008) 3.14

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat Immunol (2008) 2.83

Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (2009) 2.76

Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat Immunol (2001) 2.76

Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J Exp Med (1997) 2.75

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state. Mol Pharmacol (2006) 2.47

T-cell recruitment to the intestinal mucosa. Trends Immunol (2008) 1.57

Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection. J Virol (2007) 1.47

In vitro Treg suppression assays. Methods Mol Biol (2011) 1.46

Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Proc Natl Acad Sci U S A (2008) 1.40

Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology (2011) 1.34

L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. J Immunol (2005) 1.13

G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. J Immunol (2006) 1.06

Articles by these authors

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94

Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med (2013) 24.88

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26

ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 11.55

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe (2008) 11.08

Interactions between the microbiota and the immune system. Science (2012) 10.45

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (2006) 10.25

The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol (2008) 9.64

A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet (2005) 9.62

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (2005) 8.97

Making sense of latent TGFbeta activation. J Cell Sci (2003) 8.90

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity (2010) 8.90

Regulators of PP2C phosphatase activity function as abscisic acid sensors. Science (2009) 8.84

Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23

Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 8.08

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med (2006) 6.86

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature (2010) 6.44

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science (2004) 5.66

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol (2007) 5.60

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife (2013) 5.49

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature (2010) 5.45

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell (2002) 5.07

Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med (2008) 4.95

A validated regulatory network for Th17 cell specification. Cell (2012) 4.82

Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol (2008) 4.78

DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity (2002) 4.62

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature (2011) 4.56

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol (2005) 4.28

Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A (2009) 4.10

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med (2002) 4.02

Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol (2005) 4.01

Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology (2007) 3.99

Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell (2007) 3.92

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem (2002) 3.92

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature (2011) 3.90

Transcriptional regulation of Th17 cell differentiation. Semin Immunol (2007) 3.86

PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest (2004) 3.86

The microbiome in infectious disease and inflammation. Annu Rev Immunol (2012) 3.76

Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity (2008) 3.64

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature (2011) 3.37

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology (2008) 3.13

Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells. J Virol (2004) 3.12

Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe (2010) 3.08

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature (2013) 2.95

Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat Immunol (2008) 2.93

Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol (2004) 2.90

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84

Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods (2012) 2.79

Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology (2006) 2.78

Mesothelin variant 1 is released from tumor cells as a diagnostic marker. Cancer Epidemiol Biomarkers Prev (2006) 2.77

High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods (2009) 2.75

Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity (2005) 2.72

Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med (2002) 2.68

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma. J Exp Med (2008) 2.60

CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science (2004) 2.54

Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54

Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol (2003) 2.51

Nuclear hormone receptors in T lymphocytes. Cell (2002) 2.51

Relay and control of abscisic acid signaling. Curr Opin Plant Biol (2003) 2.51

RUNX proteins in transcription factor networks that regulate T-cell lineage choice. Nat Rev Immunol (2009) 2.49

Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol (2002) 2.46

Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes. Nature (2002) 2.41

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. J Exp Med (2007) 2.39

The chemokine SDF1 regulates migration of dentate granule cells. Development (2002) 2.34

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32

A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (2012) 2.30

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol (2015) 2.26

Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis Rheum (2012) 2.24

Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet (2009) 2.21

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol (2008) 2.19

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity (2009) 2.15

The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med (2004) 2.14

Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining. Genome Res (2012) 2.12

Transcriptional regulatory networks in Th17 cell differentiation. Curr Opin Immunol (2009) 2.12

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis. Arch Neurol (2011) 2.08

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis. Blood (2009) 2.07

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J (2006) 2.04

Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science (2013) 2.03

Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol (2009) 2.02

Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature (2010) 2.00

Novel plasmid and its variant harboring both a bla(NDM-1) gene and type IV secretion system in clinical isolates of Acinetobacter lwoffii. Antimicrob Agents Chemother (2012) 1.97

The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe (2011) 1.97

Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling. Curr Opin Cell Biol (2009) 1.96

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. Blood (2008) 1.94

Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology (2010) 1.92

Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life (2007) 1.92

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses. J Exp Med (2004) 1.88

Alignment of optical maps. J Comput Biol (2006) 1.88