Published in Curr Genomics on December 01, 2012
The transcriptional landscape of age in human peripheral blood. Nat Commun (2015) 1.20
The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat Commun (2014) 1.00
CD28 negative T cells: is their loss our gain? Am J Transplant (2014) 0.90
Pathogenesis of idiopathic pulmonary fibrosis: review of recent findings. F1000Prime Rep (2014) 0.83
The effect of ageing of the immune system on vaccination responses. Hum Vaccin Immunother (2013) 0.80
Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction. Oncotarget (2016) 0.79
Aging of immune system: Immune signature from peripheral blood lymphocyte subsets in 1068 healthy adults. Aging (Albany NY) (2016) 0.78
Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms. Clin Mol Allergy (2017) 0.77
Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis. Mem Inst Oswaldo Cruz (2013) 0.76
The influences of age on T lymphocyte subsets in C57BL/6 mice. Saudi J Biol Sci (2016) 0.75
Levels of CMV-reactive antibodies correlate with the induction of CD28(null) T cells and systemic inflammation in chronic obstructive pulmonary disease (COPD). Cell Mol Immunol (2015) 0.75
pERK-dependent defective TCR-mediated activation of CD4(+) T cells in end-stage renal disease patients. Immun Ageing (2017) 0.75
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 34.47
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57
Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55
Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol (2008) 10.42
Changes in thymic function with age and during the treatment of HIV infection. Nature (1998) 10.27
Positive and negative selection of T cells. Annu Rev Immunol (2002) 8.32
Homeostasis of naive and memory T cells. Immunity (2008) 7.48
Age-related changes in lymphocyte development and function. Nat Immunol (2004) 6.16
A role for Dicer in immune regulation. J Exp Med (2006) 5.81
Maintaining the norm: T-cell homeostasis. Nat Rev Immunol (2002) 5.63
The aging immune system: primer and prospectus. Science (1996) 4.86
Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy". J Exp Med (1994) 4.41
Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol (2002) 4.25
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett (2005) 4.04
Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell (2005) 4.02
Ageing and infection. Lancet Infect Dis (2002) 3.79
Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat Med (2000) 3.70
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol (2002) 3.35
Cancer and ageing: rival demons? Nat Rev Cancer (2003) 3.25
HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation. Immunity (2004) 2.86
Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. Blood (2002) 2.83
Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol (2001) 2.78
Telomeres in T and B cells. Nat Rev Immunol (2002) 2.76
Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years. Arch Intern Med (2008) 2.67
Cytokines and T-cell homeostasis. Curr Opin Immunol (2007) 2.58
Impact of aging on DNA methylation. Ageing Res Rev (2003) 2.50
Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J Immunol (2004) 2.49
Is immunosenescence infectious? Trends Immunol (2004) 2.47
MicroRNAs and epigenetics. FEBS J (2011) 2.44
T cell subset-specific susceptibility to aging. Clin Immunol (2008) 2.42
Accelerated immune senescence and HIV-1 infection. Exp Gerontol (2007) 2.41
The aging of the immune system. Transpl Int (2009) 2.32
miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell (2010) 2.31
Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells. Blood (2003) 2.27
The immunology of exceptional individuals: the lesson of centenarians. Immunol Today (1995) 2.26
Human CD8(+) T-cell differentiation in response to viruses. Nat Rev Immunol (2003) 2.23
Exceptional longevity does not result in excessive levels of disability. Proc Natl Acad Sci U S A (2008) 2.19
CD28 extinction in human T cells: altered functions and the program of T-cell senescence. Immunol Rev (2005) 2.16
Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell (2012) 2.15
Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1). Exp Gerontol (2003) 2.11
Immunosenescence: what does it mean to health outcomes in older adults? Curr Opin Immunol (2009) 2.09
Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLoS One (2010) 2.03
Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. J Exp Med (2003) 2.01
Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27. J Immunol (2005) 2.01
Multiparameter evaluation of human thymic function: interpretations and caveats. Clin Immunol (2005) 1.97
Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin Immunol (2002) 1.97
The aging of the immune system. Adv Immunol (2002) 1.96
Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells. AIDS (1994) 1.93
Thymic involution and immune reconstitution. Trends Immunol (2009) 1.91
Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J Immunol (2004) 1.89
Mechanism for down-regulation of CD28 by Nef. EMBO J (2001) 1.87
Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J Immunol (2005) 1.85
Rapid turnover of effector-memory CD4(+) T cells in healthy humans. J Exp Med (2004) 1.85
Reduced telomerase activity in human T lymphocytes exposed to cortisol. Brain Behav Immun (2008) 1.82
Evidence of premature immune aging in patients thymectomized during early childhood. J Clin Invest (2009) 1.81
Why aging T cells fail: implications for vaccination. Immunity (2006) 1.78
KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells. Blood (2009) 1.73
Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. J Exp Med (2004) 1.71
Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function. Aging Cell (2012) 1.71
DNA methylation maintains allele-specific KIR gene expression in human natural killer cells. J Exp Med (2003) 1.70
Direct evidence for thymic function in adult humans. J Exp Med (1999) 1.70
Identification of a human recent thymic emigrant phenotype. Proc Natl Acad Sci U S A (2000) 1.69
Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells. Mech Ageing Dev (2000) 1.68
The immunological synapse: a focal point for endocytosis and exocytosis. J Cell Biol (2010) 1.68
Effects of aging on T cell function. Curr Opin Immunol (2009) 1.67
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood (2005) 1.65
Human NK cells display major phenotypic and functional changes over the life span. Aging Cell (2010) 1.65
Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Proc Natl Acad Sci U S A (2003) 1.65
Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+ CD28- cytotoxic effector clones. Int Immunol (1999) 1.65
Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection. J Virol (2012) 1.61
Cutting edge: identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1. J Immunol (2006) 1.59
CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J Immunol (2002) 1.58
Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization. J Immunol (2004) 1.58
Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people. Immun Ageing (2008) 1.57
DNA methylation and chromatin structure regulate T cell perforin gene expression. J Immunol (2003) 1.54
Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology (2001) 1.53
Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity. J Biol Chem (1998) 1.52
Immune dysregulation and chronic stress among older adults: a review. Neuroimmunomodulation (2008) 1.51
Functional properties of CD4+ CD28- T cells in the aging immune system. Mech Ageing Dev (1998) 1.41
Effects of exogenous interleukin-7 on human thymus function. Blood (2002) 1.38
The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation. J Immunol (2007) 1.38
CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation. J Immunol (2007) 1.37
Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. J Clin Invest (1996) 1.36
Role of CMV in immune senescence. Virus Res (2010) 1.35
Postthymic development of CD28-CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype. J Immunol (1999) 1.34
IL-15 activates telomerase and minimizes telomere loss and may preserve the replicative life span of memory CD8+ T cells in vitro. J Immunol (2005) 1.33
Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol (1999) 1.32
Short telomeres in depression and the general population are associated with a hypocortisolemic state. Biol Psychiatry (2011) 1.31
Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses. Proc Natl Acad Sci U S A (2004) 1.27
Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol (2003) 1.25
Organization of proximal signal initiation at the TCR:CD3 complex. Immunol Rev (2009) 1.25
Quantitative changes in T cell DNA methylation occur during differentiation and ageing. Eur J Immunol (1990) 1.25
Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways. J Immunol (2000) 1.25
Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, phosphatidylinositol 3-kinase, Akt, NF-kappaB, and p300 pathway in microglia. J Immunol (2007) 1.24
Telomere/telomerase dynamics within the human immune system: effect of chronic infection and stress. Exp Gerontol (2010) 1.23
IL-7 and IL-15: biology and roles in T-Cell immunity in health and disease. Crit Rev Immunol (2008) 1.22
Telomeres and immunological diseases of aging. Gerontology (2009) 1.22
Long-term retention of older adults in the Cardiovascular Health Study: implications for studies of the oldest old. J Am Geriatr Soc (2010) 1.22
The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09. Rheumatology (Oxford) (2013) 2.14
NKG2D ligands: key targets of the immune response. Trends Immunol (2008) 1.71
HLA antigens may influence the age of onset of psoriasis and psoriatic arthritis. J Rheumatol (2003) 1.62
Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Proc Natl Acad Sci U S A (2010) 1.48
Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection. J Infect Dis (2005) 1.30
TNF-alpha -308A promoter polymorphism is associated with enhanced TNF-alpha production and inflammatory activity in Crohn's patients with fistulizing disease. Am J Gastroenterol (2003) 1.11
Epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells. PLoS One (2010) 1.11
The amino acid at position 97 is involved in folding and surface expression of HLA-B27. Int Immunol (2005) 1.07
Relationship between functional ability in older people, immune system status, and intensity of response to CMV. Age (Dordr) (2011) 1.05
Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor. J Biol Chem (2006) 1.04
When Aging Reaches CD4+ T-Cells: Phenotypic and Functional Changes. Front Immunol (2013) 1.03
Transcriptional regulation of MICA and MICB: a novel polymorphism in MICB promoter alters transcriptional regulation by Sp1. Eur J Immunol (2007) 1.02
Mobilization and homing of hematopoietic stem cells. Adv Exp Med Biol (2012) 0.99
Association of the KIR3DS1*013 and KIR3DL1*004 alleles with susceptibility to ankylosing spondylitis. Arthritis Rheum (2010) 0.97
DNA methylation: a promising landscape for immune system-related diseases. Trends Genet (2012) 0.97
Extended human leukocyte antigen haplotype EH18.1 influences progression to hepatocellular carcinoma in patients with hepatitis C virus infection. J Infect Dis (2004) 0.95
High serum tumor necrosis factor-alpha levels are associated with lack of response to infliximab in fistulizing Crohn's disease. Am J Gastroenterol (2002) 0.95
MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis. J Rheumatol (2002) 0.94
Activating KIR genes are associated with ankylosing spondylitis in Asian populations. Hum Immunol (2008) 0.93
Pharmacogenetics of tacrolimus after renal transplantation: analysis of polymorphisms in genes encoding 16 drug metabolizing enzymes. Clin Chem Lab Med (2011) 0.93
The predictive value of soluble major histocompatibility complex class I chain-related molecule A (MICA) levels on heart allograft rejection. Transplantation (2006) 0.92
Differences between pediatric and adult celiac disease. Rev Esp Enferm Dig (2011) 0.91
Epigenetic modulation of the immune function: a potential target for tolerance. Epigenetics (2013) 0.90
NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system. Age (Dordr) (2011) 0.90
DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8+ T and NK cells. Epigenetics (2012) 0.89
HFE gene mutations in alcoholic and virus-related cirrhotic patients with hepatocellular carcinoma. Am J Gastroenterol (2002) 0.89
IL-15 preferentially enhances functional properties and antigen-specific responses of CD4+CD28(null) compared to CD4+CD28+ T cells. Aging Cell (2011) 0.89
Mitochondrial DNA and TFAM gene variation in early-onset myocardial infarction: evidence for an association to haplogroup H. Mitochondrion (2010) 0.88
High variability of HLA-B27 alleles in ankylosing spondylitis and related spondyloarthropathies in the population of northern Spain. Hum Immunol (2002) 0.88
Autophagy and self-defense. Adv Exp Med Biol (2012) 0.87
Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects. Age (Dordr) (2012) 0.86
MHC class I chain-related gene A transmembrane polymorphism modulates the extension of ulcerative colitis. Hum Immunol (2003) 0.86
The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population. J Invest Dermatol (2005) 0.86
A predictive model of treatment outcome in patients with chronic HCV infection using IL28B and PD-1 genotyping. J Hepatol (2012) 0.85
KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients. Clin Transplant (2011) 0.85
Soluble MHC class I chain-related protein B serum levels correlate with disease activity in relapsing-remitting multiple sclerosis. Hum Immunol (2008) 0.84
CD8dim and NKG2D expression defines related subsets of CD4+ T cells in HIV-infected patients with worse prognostic factors. J Acquir Immune Defic Syndr (2009) 0.84
Comparison of six human anti-transglutaminase ELISA-tests in the diagnosis of celiac disease in the Saharawi population. World J Gastroenterol (2005) 0.84
A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-transplanted patients. Pharmacogenet Genomics (2013) 0.84
Influence of HLA-B*5703 and HLA-B*1403 on susceptibility to spondyloarthropathies in the Zambian population. J Rheumatol (2008) 0.84
HLA-DR17 is associated with enthesitis in psoriatic arthritis. Joint Bone Spine (2011) 0.83
KIR genes and their role in spondyloarthropathies. Adv Exp Med Biol (2009) 0.83
HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis. Arthritis Res Ther (2006) 0.82
MICB typing by PCR amplification with sequence specific primers. Immunogenetics (2003) 0.82
Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus. Mol Genet Metab (2012) 0.82
Fine mapping of a major histocompatibility complex in ankylosing spondylitis: association of the HLA-DPA1 and HLA-DPB1 regions. Arthritis Rheum (2011) 0.82
Immune systems evolution. Adv Exp Med Biol (2012) 0.81
Identification of epitopes and immunodominant regions on the MICA protein defined by alloantibodies from kidney transplant patients. Transplantation (2009) 0.81
A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis. Ann Rheum Dis (2012) 0.81
Post-transplant soluble MICA and MICA antibodies predict subsequent heart graft outcome. Transpl Immunol (2006) 0.81
Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function. BMC Neurosci (2014) 0.81
MHC class I region plays a role in the development of diverse clinical forms of celiac disease in a Saharawi population. Am J Gastroenterol (2004) 0.80
Functional polymorphisms in the CYP3A4, CYP3A5, and CYP21A2 genes in the risk for hypertension in pregnancy. Biochem Biophys Res Commun (2010) 0.80
CD127(low) expression in CD4+CD25(high) T cells as immune biomarker of renal function in transplant patients. Transplantation (2009) 0.80
NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp. J Leukoc Biol (2013) 0.79
Association of MHC class I related gene B (MICB) to celiac disease. Am J Gastroenterol (2004) 0.79
Clinical differences between men and women with psoriatic arthritis: relevance of the analysis of genes and polymorphisms in the major histocompatibility complex region and of the age at onset of psoriasis. Clin Dev Immunol (2013) 0.78
Patients with psoriatic arthritis may show differences in their clinical and genetic profiles depending on their age at psoriasis onset. Clin Exp Rheumatol (2012) 0.78
Genetic study confirms association of HLA-DPA1(∗)01:03 subtype with ankylosing spondylitis in HLA-B27-positive populations. Hum Immunol (2013) 0.78
The origin of the bacterial immune response. Adv Exp Med Biol (2012) 0.77
The emergence of the major histocompatilibility complex. Adv Exp Med Biol (2012) 0.77
Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation. Eur J Immunol (2012) 0.77
Immunology and the challenge of transplantation. Adv Exp Med Biol (2012) 0.76
Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients. BMC Med (2014) 0.75
The allele MICB 0050204, over-represented in the Caucasian population, has an additional exon resulting from a new splice junction sequence. Hum Immunol (2007) 0.75
ABCB1 (MDR-1) pharmacogenetics of tacrolimus in renal transplanted patients: a Next Generation Sequencing approach. Clin Chem Lab Med (2015) 0.75
Molecular mechanism of spondyloarthropathies. Preface. Adv Exp Med Biol (2009) 0.75
Could the clinical differences between men and women with psoriatic arthritis be explained in part by genetic factors? Clin Exp Rheumatol (2013) 0.75