Targeted therapies in the treatment of advanced hepatocellular carcinoma.

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Published in Clin Med Insights Oncol on May 20, 2013

Authors

Zhengyu Wei1, Cataldo Doria, Yuan Liu

Author Affiliations

1: Division of Surgical Research, Department of Surgery, Cooper University Hospital and Cooper Medical School of Rowan University, Camden, NJ.

Associated clinical trials:

A Study of Ramucirumab (IMC-1121B) Drug Product (DP) and Best Supportive Care (BSC) Versus Placebo and BSC as 2nd-Line Treatment in Participants With Hepatocellular Carcinoma After 1st-Line Therapy With Sorafenib (REACH) | NCT01140347

First Line Hepato Cellular Carcinoma (HCC) (BRISK FL) | NCT00858871

Comparison of Brivanib and Best Supportive Care to Placebo for Treatment of Liver Cancer for Those Subjects Who Have Failed Sorafenib Treatment (BRISK PS) | NCT00825955

Nexavar-Tarceva Combination Therapy for First Line Treatment of Patients Diagnosed With Hepatocellular Carcinoma (SEARCH) | NCT00901901

Study Of Sunitinib Malate Versus Sorafenib In Patients With Inoperable Liver Cancer | NCT00699374

Randomized Phase I/II of RAD001 in Advanced Hepatocellular Carcinoma (HCC) | NCT00390195

Dose Finding Study of AVE1642 in Patients With Advanced or Metastatic Liver Carcinoma | NCT00791544

Safety Study of Foretinib (GSK1363089) in Adults With Liver Cancer | NCT00920192

IMC-A12 in Treating Patients With Advanced Liver Cancer | NCT00639509

Trial of ARQ 197 in Patients With Unresectable Hepatocellular Carcinoma (HCC) Who Have Failed One Prior Systemic Therapy | NCT00988741

Study of IMC-1121B (Ramucirumab) in Participants With Liver Cancer Who Have Not Previously Been Treated With Chemotherapy | NCT00627042

A Study of IMC-A12 in Combination With Sorafenib in Patients With Advanced Cancer of the Liver | NCT00906373

Cixutumumab and Sorafenib Tosylate in Treating Patients With Advanced Liver Cancer | NCT01008566

Bevacizumab in Advanced Hepatocellular Carcinoma | NCT00162669

Phase II Study of Best Support Care (BSC) Plus ZD6474(Vandetanib) in Patients With Inoperable Hepatocellular Carcinoma (HCC) | NCT00508001

A Randomized, Placebo-controlled, Double-blind Phase 2 Study With OSI-906 in Patients With Advanced HCC | NCT01101906

Safety Study of ARQ 197 in Cirrhotic Patients With Hepatocellular Carcinoma (HCC) | NCT00802555

Temsirolimus + Sorafenib in Advanced Hepatocellular Carcinoma (HCC) | NCT01335074

Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma | NCT01008917

Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer | NCT00107536

Belinostat in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery | NCT00321594

Selumetinib in Treating Patients With Locally Advanced or Metastatic Liver Cancer | NCT00604721

A Phase II Trial of OSI-906 and Sorafenib in Advanced Hepatocellular Cancer | NCT01334710

Cetuximab in Patients With Unresectable or Metastatic Hepatocellular Carcinoma | NCT00142428

A Pilot Study of Adjuvant Therapy of Gefitinib (Iressa, ZD1839) in Patients With Resectable Hepatocellular Carcinoma | NCT00282100

Efficacy of Sirolimus In Liver Transplantation for Hepatocellular Carcinoma (HCC) (Sirolimus) | NCT01374750

Phase I Efficacy On Vascular Permeability In Patients With Advanced Colorectal Cancer | NCT00496509

NCT00550719

Gefitinib in Treating Patients With Advanced Unresectable Hepatocellular Carcinoma (Liver Cancer) | NCT00071994

Erlotinib in Treating Patients With Unresectable Liver Cancer and Liver Dysfunction | NCT00047346

Lapatinib in Treating Patients With Locally Advanced or Metastatic Biliary Tract or Liver Cancer That Cannot Be Removed By Surgery | NCT00101036

Erlotinib in Treating Patients With Liver Cancer That Cannot be Surgically Removed | NCT00047333

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