Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects.

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Published in Clin Cancer Res on June 20, 2013

Authors

Marieke F Fransen1, Tetje C van der Sluis, Ferry Ossendorp, Ramon Arens, Cornelis J M Melief

Author Affiliations

1: Authors' Affiliations: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center; and ISA Pharmaceuticals, Leiden, the Netherlands.

Associated clinical trials:

Intra-tumoral Ipilimumab Plus Intravenous Nivolumab Following the Resection of Recurrent Glioblastoma (GlitIpNi) | NCT03233152

Phase I-II Study of Intratumoral Urelumab Combined With Nivolumab in Patients With Solid Tumors (INTRUST) | NCT03792724

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