Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells.

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Published in Nucleic Acids Res on June 26, 2013

Authors

Xiying Qu1, Pengfei Wang, Donglin Ding, Lin Li, Haibo Wang, Li Ma, Xin Zhou, Shaohui Liu, Shiguan Lin, Xiaohui Wang, Gongmin Zhang, Sijie Liu, Lin Liu, Jianhua Wang, Feng Zhang, Daru Lu, Huanzhang Zhu

Author Affiliations

1: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China andKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China.

Associated clinical trials:

Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV (Zinc-Finger) | NCT00842634

Phase 1 Dose Escalation Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Patients | NCT01044654

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