Medullary thymic epithelial cell depletion leads to autoimmune hepatitis.

PubWeight™: 1.57‹?› | Rank: Top 4%

🔗 View Article (PMC 3726151)

Published in J Clin Invest on July 15, 2013


Anthony J Bonito1, Costica Aloman, M Isabel Fiel, Nichole M Danzl, Sungwon Cha, Erica G Weinstein, Seihwan Jeong, Yongwon Choi, Matthew C Walsh, Konstantina Alexandropoulos

Author Affiliations

1: Department of Medicine/Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Articles citing this

Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system. Immunol Rev (2015) 0.92

Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus. Nat Commun (2016) 0.82

The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus. Front Immunol (2015) 0.81

Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand. Cell Death Dis (2014) 0.80

Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6. PLoS One (2014) 0.80

Ubiquitin signaling in immune responses. Cell Res (2016) 0.80

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis. Int J Exp Pathol (2014) 0.79

Medullary thymic epithelial cells and central tolerance in autoimmune hepatitis development: novel perspective from a new mouse model. Int J Mol Sci (2015) 0.77

Autoimmune hepatitis: 50 Years of (slow) progress. Hepatology (2014) 0.76

Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease. J Hepatol (2016) 0.76

Control of the thymic medulla and its influence on αβT-cell development. Immunol Rev (2016) 0.76

Thymic NF-κB-inducing kinase regulates CD4(+) T cell-elicited liver injury and fibrosis in mice. J Hepatol (2017) 0.75

Medullary thymic epithelial cells and CD8α(+) dendritic cells coordinately regulate central tolerance but CD8α(+) cells are dispensable for thymic regulatory T cell production. J Autoimmun (2016) 0.75

The thymic medulla: who needs it? Immunol Cell Biol (2013) 0.75

Articles cited by this

Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00

Origin of regulatory T cells with known specificity for antigen. Nat Immunol (2002) 7.49

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol (2001) 7.30

Induction of immunological tolerance by porcine liver allografts. Nature (1969) 5.89

Classification of chronic viral hepatitis: a need for reassessment. J Hepatol (1991) 5.23

The cellular mechanism of Aire control of T cell tolerance. Immunity (2005) 4.74

Aire. Annu Rev Immunol (2009) 4.43

Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology (1994) 4.32

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol (2007) 4.21

Autoimmune hepatitis. N Engl J Med (2006) 4.15

Expression of relB is required for the development of thymic medulla and dendritic cells. Nature (1995) 3.99

FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency. J Hepatol (2012) 3.57

Hepatic T cells and liver tolerance. Nat Rev Immunol (2003) 3.51

Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol (2009) 3.13

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med (2007) 2.91

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 2.84

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity (2008) 2.81

Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology (2004) 2.54

TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med (2006) 2.44

TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36

Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med (2003) 2.12

NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner. J Immunol (2004) 1.92

Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science (2005) 1.91

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc Natl Acad Sci U S A (2008) 1.83

Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of "autoimmune" hepatitis. Hepatology (1988) 1.79

Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease. Hepatology (2002) 1.77

Advances in the diagnosis, pathogenesis, and management of autoimmune hepatitis. Gastroenterology (2010) 1.58

Antibodies to soluble liver antigen: an additional marker in type 1 auto-immune hepatitis. J Hepatol (2000) 1.58

Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells. J Immunol (1985) 1.49

The immunology of experimental liver transplantation in the rat. Immunology (1985) 1.45

Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus. BMC Dev Biol (2007) 1.41

CD4+ CD8+ double positive (DP) T cells in health and disease. Autoimmun Rev (2004) 1.32

Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? J Mol Cell Biol (2011) 1.32

Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines. Eur J Immunol (2006) 1.31

Antibody to liver cytosol (anti-LC1) in patients with autoimmune chronic active hepatitis type 2. Hepatology (1988) 1.21

Establishment of standardised SLA/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence, and clinical characteristics. Gut (2002) 1.16

Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis. Immunol Rev (2000) 1.15

Autoimmune hepatitis. Nat Rev Gastroenterol Hepatol (2011) 1.14

Thymic microenvironments for T-cell repertoire formation. Adv Immunol (2008) 1.11

Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis. Arthritis Rheum (2007) 1.08

The thymus medulla slowly yields its secrets. Ann N Y Acad Sci (2008) 1.08

Control of central self-tolerance induction by autoreactive CD4+ thymocytes. Trends Immunol (2009) 1.05

Clinical significance of autoantibodies to soluble liver antigen in autoimmune hepatitis. J Hepatol (1999) 1.04

Genetics of liver disease: immunogenetics and disease pathogenesis. Gut (2004) 1.04

Aetiopathogenesis of autoimmune hepatitis. J Autoimmun (2009) 1.04

T cell immunity in autoimmune hepatitis. Autoimmun Rev (2005) 1.03

Therapeutic potential of TGF-β-induced CD4(+) Foxp3(+) regulatory T cells in autoimmune diseases. Autoimmunity (2010) 1.02

Autoantibodies as prognostic markers in autoimmune liver disease. Dig Dis Sci (2010) 1.01

Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiation. Prog Mol Biol Transl Sci (2010) 1.01

Genetics in autoimmune hepatitis. Semin Liver Dis (2002) 1.00

The role of AIRE in human autoimmune disease. Nat Rev Endocrinol (2010) 1.00

Frequency and significance of antibodies to soluble liver antigen/liver pancreas in variant autoimmune hepatitis. Autoimmunity (2002) 0.94

Antibodies to soluble liver antigen/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis. Am J Gastroenterol (2002) 0.92

Thymic epithelial cells: antigen presenting cells that regulate T cell repertoire and tolerance development. Immunol Res (2012) 0.90

Plasma cell hepatitis in hepatitis C virus patients post-liver transplantation: case-control study showing poor outcome and predictive features in the liver explant. Liver Transpl (2009) 0.90

Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. J Exp Med (2010) 0.89

Animal models of autoimmune hepatitis. Expert Rev Gastroenterol Hepatol (2010) 0.86

New animal models for autoimmune hepatitis. Semin Liver Dis (2009) 0.86

The autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy or autoimmune polyglandular syndrome type 1. Semin Liver Dis (2009) 0.83

Autoimmune hepatitis. Best Pract Res Clin Gastroenterol (2010) 0.82

Peripheral CD4+CD8+cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1/Th2 cytokines. Cell Immunol (2009) 0.81

Mouse models for experimental autoimmune hepatitis: limits and chances. Dig Dis (2010) 0.81

Discrimination of autoimmune hepatitis: autoantibody typing and beyond. J Gastroenterol (2010) 0.81

Articles by these authors

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol (2003) 8.23

Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 8.09

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16

Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 3.82

v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78

Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol (2006) 3.18

Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol (2004) 2.79

Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood (2007) 2.65

Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat Immunol (2007) 2.61

Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology (2004) 2.54

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. J Cell Biol (2010) 2.47

Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proc Natl Acad Sci U S A (2010) 2.45

TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med (2006) 2.44

Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol (2009) 2.42

TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36

A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis. Gastroenterology (2006) 2.32

Osteoimmunology: interactions of the bone and immune system. Endocr Rev (2008) 2.32

Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity (2002) 2.31

NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP). Mol Endocrinol (2007) 2.25

Liver transplantation for hepatocellular carcinoma: extension of indications based on molecular markers. J Hepatol (2008) 2.22

Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med (2005) 2.21

Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity (2002) 2.20

A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J Exp Med (2002) 2.04

The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04

GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity (2012) 1.98

TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLoS One (2008) 1.86

On the origin of smallpox: correlating variola phylogenics with historical smallpox records. Proc Natl Acad Sci U S A (2007) 1.84

Stimulation by toll-like receptors inhibits osteoclast differentiation. J Immunol (2002) 1.82

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med (2009) 1.81

Liver fibrosis during an outbreak of acute hepatitis C virus infection in HIV-infected men: a prospective cohort study. J Infect Dis (2008) 1.78

Hepatoportal sclerosis as a cause of noncirrhotic portal hypertension in patients with HIV. Am J Gastroenterol (2007) 1.77

Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol (2002) 1.74

Hepatic fibrosis. Curr Opin Gastroenterol (2009) 1.67

Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J Biol Chem (2005) 1.62

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis. J Hepatol (2013) 1.52

Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation. Hepatology (2009) 1.48

GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation (2009) 1.48

Intrahepatic cholangiocarcinoma: new insights in pathology. Semin Liver Dis (2011) 1.46

De novo hepatocellular carcinoma occurring in a transplanted liver: case report and review of the literature. Dig Dis Sci (2006) 1.45

Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors. Hepatology (2005) 1.44

OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol (2012) 1.43

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice. Hepatology (2013) 1.40

Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Blood (2005) 1.38

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest (2011) 1.38

Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN. J Immunol (2006) 1.37

Diffusion-weighted imaging of the liver with multiple b values: effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters--a pilot study. Radiology (2012) 1.31

TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. J Biol Chem (2008) 1.31

Strength of TRAF6 signalling determines osteoclastogenesis. EMBO Rep (2005) 1.30

Regulation of the subcellular localization of tumor necrosis factor receptor-associated factor (TRAF)2 by TRAF1 reveals mechanisms of TRAF2 signaling. J Exp Med (2002) 1.29

The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation. J Biol Chem (2008) 1.29

Biology of the TRANCE axis. Cytokine Growth Factor Rev (2003) 1.29

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis. Aging Cell (2007) 1.29

TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development. J Immunol (2005) 1.27

A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice. Hepatology (2013) 1.27

Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent. J Immunol (2002) 1.26

T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res (2006) 1.26

Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression. Hepatology (2012) 1.24

The role of TRAF6 in signal transduction and the immune response. Microbes Infect (2004) 1.23

Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. J Hepatol (2005) 1.21

TRAF-mediated TNFR-family signaling. Curr Protoc Immunol (2009) 1.19

Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. J Clin Invest (2010) 1.17

Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment. BMC Med Res Methodol (2008) 1.17

IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation. J Exp Med (2005) 1.15

Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. J Clin Invest (2009) 1.15

The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking. Immunity (2006) 1.15

Microphthalmia transcription factor and PU.1 synergistically induce the leukocyte receptor osteoclast-associated receptor gene expression. J Biol Chem (2003) 1.14

Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A (2011) 1.13

The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms. Mol Cell Biol (2012) 1.10

TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice. Proc Natl Acad Sci U S A (2004) 1.09

Osteoimmunology: interactions of the immune and skeletal systems. Mol Cells (2004) 1.09

Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab (2013) 1.09

TNF-related activation-induced cytokine (TRANCE) induces angiogenesis through the activation of Src and phospholipase C (PLC) in human endothelial cells. J Biol Chem (2001) 1.08

Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Aging Cell (2012) 1.07

TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients. Clin Cancer Res (2003) 1.07

Opposing roles for the cyclin-dependent kinase inhibitor p27kip1 in the control of CD4+ T cell proliferation and effector function. J Immunol (2005) 1.05

Hepatitis C infection and alcohol use: A dangerous mix for the liver and antiviral immunity. Alcohol Clin Exp Res (2006) 1.05

Osteoimmunology: cytokines and the skeletal system. BMB Rep (2008) 1.04

Identification and characterization of the precursors committed to osteoclasts induced by TNF-related activation-induced cytokine/receptor activator of NF-kappa B ligand. J Immunol (2006) 1.03

TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol (2003) 1.03

TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood (2010) 1.01

Kupffer cell activation by ambient air particulate matter exposure may exacerbate non-alcoholic fatty liver disease. J Immunotoxicol (2009) 1.01

NHE10, an osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival [corrected]. Biochem Biophys Res Commun (2008) 1.00

Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity (2013) 1.00

Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity. J Immunol (2014) 0.99

Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. J Med Virol (2004) 0.99

Gene expression profiling of osteoclast differentiation by combined suppression subtractive hybridization (SSH) and cDNA microarray analysis. DNA Cell Biol (2002) 0.98

TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii. Infect Immun (2004) 0.97

c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation. J Biol Chem (2002) 0.97

IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner. J Cell Biochem (2012) 0.97