Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4.

PubWeight™: 0.84‹?›

🔗 View Article (PMC 3763034)

Published in Am J Physiol Lung Cell Mol Physiol on July 19, 2013

Authors

Elizabeth A Townsend1, Charles W Emala

Author Affiliations

1: Department of Anesthesiology, Columbia University, New York, NY, USA. townsend.elizabeth@gmail.com

Articles cited by this

The global burden of asthma. Chest (2006) 5.74

Flavonoid intake and risk of chronic diseases. Am J Clin Nutr (2002) 3.57

Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ Res (2003) 2.39

PDE4 inhibitors: current status. Br J Pharmacol (2008) 2.23

Assessing the safety of adding LABAs to inhaled corticosteroids for treating asthma. N Engl J Med (2011) 1.91

Biochemistry of asthma. Trends Biochem Sci (1991) 1.61

PLC regulation: emerging pictures for molecular mechanisms. Trends Biochem Sci (2010) 1.48

Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. Proc Natl Acad Sci U S A (2000) 1.47

Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. Am J Respir Crit Care Med (2001) 1.26

Quercetin regulates Th1/Th2 balance in a murine model of asthma. Int Immunopharmacol (2008) 1.25

cAMP regulation of airway smooth muscle function. Pulm Pharmacol Ther (2012) 1.24

TNF-alpha upregulates Gialpha and Gqalpha protein expression and function in human airway smooth muscle cells. Am J Physiol (1999) 1.18

The PtdIns-PLC superfamily and signal transduction. Biochim Biophys Acta (1991) 1.16

Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here? Drugs (2000) 1.14

Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. Biochem Pharmacol (2004) 1.12

Medicinal herb use among asthmatic patients attending a specialty care facility in Trinidad. BMC Complement Altern Med (2005) 1.09

Rapid effects of estrogen on intracellular Ca2+ regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2010) 1.08

Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions. J Allergy Clin Immunol (2005) 1.06

Herbals and asthma: usage patterns among a border population. Ann Pharmacother (2003) 1.05

Herbal treatments of asthma: a systematic review. J Asthma (2007) 0.98

The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects. Eur Respir J (1997) 0.98

Inhibition of pulmonary eosinophilia and airway hyperresponsiveness in allergic mice by rolipram: involvement of endogenously released corticosterone and catecholamines. Br J Pharmacol (2000) 0.91

Phosphodiesterase inhibitors: history of pharmacology. Handb Exp Pharmacol (2011) 0.91

The roles of phytochemicals in bronchial asthma. Molecules (2010) 0.90

Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. Am J Respir Cell Mol Biol (2012) 0.89

Airway smooth muscle excitation-contraction coupling and airway hyperresponsiveness. Can J Physiol Pharmacol (2005) 0.86

Mechanisms of relaxant action of 3-O-methylquercetin in isolated guinea pig trachea. Planta Med (2002) 0.85

Anti-virus effect of traditional Chinese medicine Yi-Fu-Qing granule on acute respiratory tract infections. Biosci Trends (2009) 0.85

Acute bronchodilator effect of quercetin in experimental allergic asthma. Bratisl Lek Listy (2011) 0.85

Effects of Ding-Chuan-Tang on bronchoconstriction and airway leucocyte infiltration in sensitized guinea pigs. Immunopharmacol Immunotoxicol (2004) 0.85

Polyphenols and their components in experimental allergic asthma. Adv Exp Med Biol (2013) 0.84

A review on herbal antiasthmatics. Orient Pharm Exp Med (2011) 0.83

Chemokines and their receptors in chronic pulmonary disease. Curr Drug Targets Inflamm Allergy (2005) 0.83

Clinical concerns with inhaled beta2-agonists: adult asthma. Clin Rev Allergy Immunol (2006) 0.82

Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [(3) H]-rolipram binding in guinea pig tissues. Invest New Drugs (2008) 0.82

Inhibitory effect of quercetin on rat trachea contractility in vitro. J Pharm Pharmacol (2009) 0.81

Quercetin inhalation inhibits the asthmatic responses by exposure to aerosolized-ovalbumin in conscious guinea-pigs. Arch Pharm Res (2008) 0.81

Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma. Respir Med (2009) 0.79

Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa 1.1 channels. Acta Physiol (Oxf) (2013) 0.77

New concepts in asthma pathophysiology. Curr Allergy Asthma Rep (2005) 0.77

Articles by these authors

Anaphylaxis and anesthesia: controversies and new insights. Anesthesiology (2009) 2.40

A3 adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis. Am J Physiol Regul Integr Comp Physiol (2006) 1.94

Targeting the restricted α-subunit repertoire of airway smooth muscle GABAA receptors augments airway smooth muscle relaxation. Am J Physiol Lung Cell Mol Physiol (2011) 1.92

Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo. Anesthesiology (2004) 1.65

Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation. Anesthesiology (2009) 1.55

Propofol preferentially relaxes neurokinin receptor-2-induced airway smooth muscle contraction in guinea pig trachea. Anesthesiology (2010) 1.45

GABAA receptors are expressed and facilitate relaxation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2008) 1.43

A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion. Am J Physiol Renal Physiol (2003) 1.38

A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in mice. J Am Soc Nephrol (2004) 1.36

Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways. Am J Physiol Renal Physiol (2007) 1.34

Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis. Shock (2007) 1.32

Isoflurane protects against renal ischemia and reperfusion injury and modulates leukocyte infiltration in mice. Am J Physiol Renal Physiol (2007) 1.30

Adenosine attenuates oxidant injury in human proximal tubular cells via A(1) and A(2a) adenosine receptors. Am J Physiol Renal Physiol (2002) 1.28

Anti-inflammatory and antinecrotic effects of the volatile anesthetic sevoflurane in kidney proximal tubule cells. Am J Physiol Renal Physiol (2006) 1.25

Propofol directly increases tau phosphorylation. PLoS One (2011) 1.25

Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors. Am J Physiol Renal Physiol (2007) 1.20

A1 adenosine receptor knockout mice exhibit increased mortality, renal dysfunction, and hepatic injury in murine septic peritonitis. Am J Physiol Renal Physiol (2005) 1.19

Functional expression of the GABAB receptor in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2006) 1.14

A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure. Am J Physiol Renal Physiol (2002) 1.13

Activation of endogenous GABAA channels on airway smooth muscle potentiates isoproterenol-mediated relaxation. Am J Physiol Lung Cell Mol Physiol (2008) 1.13

TGF-beta1 release by volatile anesthetics mediates protection against renal proximal tubule cell necrosis. Am J Nephrol (2007) 1.12

Preconditioning and adenosine protect human proximal tubule cells in an in vitro model of ischemic injury. J Am Soc Nephrol (2002) 1.07

The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J Appl Physiol (1985) (2009) 1.06

Isoproterenol induces actin depolymerization in human airway smooth muscle cells via activation of an Src kinase and GS. Am J Physiol Lung Cell Mol Physiol (2005) 1.04

Novel expression of a functional glycine receptor chloride channel that attenuates contraction in airway smooth muscle. FASEB J (2011) 1.04

Functional expression of GABAB receptors in airway epithelium. Am J Respir Cell Mol Biol (2008) 1.04

Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle. Anesthesiology (2005) 1.03

Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab (2013) 1.00

Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways. Anesthesiology (2007) 0.99

Leptin repletion restores depressed {beta}-adrenergic contractility in ob/ob mice independently of cardiac hypertrophy. J Physiol (2005) 0.98

beta2-Adrenergic receptor genotype and preterm delivery. Am J Obstet Gynecol (2002) 0.98

Local anesthetics reduce mortality and protect against renal and hepatic dysfunction in murine septic peritonitis. Anesthesiology (2004) 0.96

Characterization of adenosine receptors in human kidney proximal tubule (HK-2) cells. Exp Nephrol (2002) 0.94

Can we find better bronchodilators to relieve asthma symptoms? J Allergy (Cairo) (2012) 0.94

Sevoflurane-mediated TGF-beta1 signaling in renal proximal tubule cells. Am J Physiol Renal Physiol (2007) 0.92

Inhibition of histamine-induced bronchoconstriction in Guinea pig and Swine by pulsed electrical vagus nerve stimulation. Neuromodulation (2009) 0.92

Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2008) 0.91

Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2013) 0.91

Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. Am J Respir Cell Mol Biol (2012) 0.89

Inducible nitric oxide synthase promoter polymorphism affords protection against cognitive dysfunction after carotid endarterectomy. Stroke (2009) 0.88

Intra-arterial drug delivery: a concise review. J Neurosurg Anesthesiol (2007) 0.88

Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle. Am J Respir Cell Mol Biol (2011) 0.88

Oxidant preconditioning protects human proximal tubular cells against lethal oxidant injury via p38 MAPK and heme oxygenase-1. Am J Nephrol (2003) 0.88

Case scenario: bronchospasm during anesthetic induction. Anesthesiology (2011) 0.87

Functional expression of γ-amino butyric acid transporter 2 in human and guinea pig airway epithelium and smooth muscle. Am J Respir Cell Mol Biol (2010) 0.87

Airway epithelium is a predominant source of endogenous airway GABA and contributes to relaxation of airway smooth muscle tone. Am J Physiol Lung Cell Mol Physiol (2012) 0.86

Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. Am J Respir Cell Mol Biol (2014) 0.84

Reverse remodeling and enhanced adrenergic reserve from passive external support in experimental dilated heart failure. J Am Coll Cardiol (2002) 0.82

Expression and muscarinic receptor coupling of Lyn kinase in cultured human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2005) 0.82

Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor. Anesthesiology (2005) 0.81

A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism. Anesthesiology (2003) 0.81

Antagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium. Anesthesiology (2015) 0.81

Chloride channel blockers promote relaxation of TEA-induced contraction in airway smooth muscle. J Smooth Muscle Res (2013) 0.80

Raf-1 kinase mediates adenylyl cyclase sensitization by TNF-alpha in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2007) 0.79

The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. Respir Res (2013) 0.79

The dopamine D(2) receptor is expressed and sensitizes adenylyl cyclase activity in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2011) 0.79

Local anesthetics worsen renal function after ischemia-reperfusion injury in rats. Am J Physiol Renal Physiol (2003) 0.79

Low voltage vagal nerve stimulation reduces bronchoconstriction in guinea pigs through catecholamine release. Neuromodulation (2012) 0.79

Interactive effect of cigarette smoke extract and world trade center dust particles on airway cell cytotoxicity. J Toxicol Environ Health A (2011) 0.79

Chloride in airway smooth muscle: the ignored anion no longer? Am J Physiol Lung Cell Mol Physiol (2012) 0.78

Pre-exposure to vasopressin potentiates the vasoconstrictive effect of epinephrine in rat aorta isolated during late anaphylaxis. Shock (2010) 0.78

Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation. Sci Rep (2013) 0.78

Comparison of cell expression formats for the characterization of GABA(A) channels using a microfluidic patch clamp system. Assay Drug Dev Technol (2012) 0.77

Beta-2 adrenoceptor genotype and progress in term and late preterm active labor. Am J Obstet Gynecol (2011) 0.77

Tumor necrosis factor alpha stimulates adenylyl cyclase activity in human myometrial cells. Biol Reprod (2003) 0.77

Anesthetic effects on γ-aminobutyric acid A receptors: not just on your nerves. Anesthesiology (2013) 0.76

The anti-asthma herbal medicine ASHMI acutely inhibits airway smooth muscle contraction via prostaglandin E2 activation of EP2/EP4 receptors. Am J Physiol Lung Cell Mol Physiol (2013) 0.76

Microvascular blood flow in the airway mucosa modulates bronchoconstriction. J Appl Physiol (1985) (2010) 0.75

Desflurane and neural control of airway tone. Can J Anaesth (2011) 0.75

Gantacurium and CW002 do not potentiate muscarinic receptor-mediated airway smooth muscle constriction in guinea pigs. Anesthesiology (2010) 0.75

Renal protection with isoflurane. Anesth Analg (2006) 0.75