DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise.

PubWeight™: 0.89‹?›

🔗 View Article (PMC 3722167)

Published in PLoS One on July 24, 2013

Authors

Jehad Abubaker1, Ali Tiss, Mohamed Abu-Farha, Fahad Al-Ghimlas, Irina Al-Khairi, Engin Baturcam, Preethi Cherian, Naser Elkum, Maha Hammad, Jeena John, Sina Kavalakatt, Abdelkrim Khadir, Samia Warsame, Said Dermime, Kazem Behbehani, Mohammed Dehbi

Author Affiliations

1: Biomedical Research Department, Dasman Diabetes Institute, Kuwait, Kuwait.

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA (2003) 25.44

The metabolic syndrome. Lancet (2005) 19.47

Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA (2013) 18.86

Molecular chaperones in the cytosol: from nascent chain to folded protein. Science (2002) 15.09

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96

Inflammatory mechanisms in obesity. Annu Rev Immunol (2011) 9.83

Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest (2008) 6.60

Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem (2002) 6.16

The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat Rev Mol Cell Biol (2010) 5.37

Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones (2008) 4.30

Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms. Mol Cell (2010) 3.23

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie (2005) 3.20

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology (2006) 3.12

Heat shock response modulators as therapeutic tools for diseases of protein conformation. J Biol Chem (2005) 2.95

The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol (2011) 2.77

HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 2.52

Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance. J Biol Chem (1997) 2.31

Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab (2008) 2.27

Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res (2010) 2.20

Chaperone regulation of the heat shock protein response. Adv Exp Med Biol (2007) 1.94

The heat shock response: systems biology of proteotoxic stress in aging and disease. Cold Spring Harb Symp Quant Biol (2012) 1.91

A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. Mol Cell (2010) 1.87

Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72. J Leukoc Biol (2005) 1.83

Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. Diabetes (2003) 1.79

Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance. Diabetes (2002) 1.78

The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review. Gerontology (2009) 1.69

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am J Physiol Endocrinol Metab (2008) 1.68

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity. Proc Natl Acad Sci U S A (2002) 1.65

Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol (2011) 1.64

Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells. Int J Cancer (2007) 1.53

Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Diabetes (2008) 1.47

Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis. Exp Oncol (2012) 1.45

Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation. J Biol Chem (2003) 1.42

Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol (2011) 1.41

Exercise training modulates heat shock protein response in diabetic rats. J Appl Physiol (1985) (2004) 1.39

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Biochem J (2011) 1.36

Inflammation, heat shock proteins, and type 2 diabetes. Cell Stress Chaperones (2008) 1.25

Heat shock proteins and exercise: a primer. Appl Physiol Nutr Metab (2008) 1.24

Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling. J Biol Chem (2007) 1.24

Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment: a position paper of The Obesity Society and the American Society of Hypertension. J Clin Hypertens (Greenwich) (2012) 1.23

Age-related differences in skeletal muscle insulin signaling: the role of stress kinases and heat shock proteins. J Appl Physiol (1985) (2008) 1.22

Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats. J Appl Physiol (1985) (2009) 1.11

Improvement of insulin sensitivity by a novel drug, BGP-15, in insulin-resistant patients: a proof of concept randomized double-blind clinical trial. Horm Metab Res (2009) 1.11

Exercise in the metabolic syndrome. Oxid Med Cell Longev (2012) 1.11

The role of JNK proteins in metabolism. Sci Transl Med (2010) 1.09

Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling. PLoS One (2008) 1.08

Lipid chaperones and metabolic inflammation. Int J Inflam (2011) 1.03

Induction of heat shock proteins may combat insulin resistance. Med Hypotheses (2005) 0.97

Acute heat treatment improves insulin-stimulated glucose uptake in aged skeletal muscle. J Appl Physiol (1985) (2010) 0.96

The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell (2012) 0.96

Altered heat stress response following streptozotocin-induced diabetes. Cell Stress Chaperones (2007) 0.93

Heat shock protein 72: release and biological significance during exercise. Front Biosci (2008) 0.93

Liposomal delivery of heat shock protein 72 into renal tubular cells blocks nuclear factor-kappaB activation, tumor necrosis factor-alpha production, and subsequent ischemia-induced apoptosis. Circ Res (2003) 0.91

Doxazosin induces activation of GADD153 and cleavage of focal adhesion kinase in cardiomyocytes en route to apoptosis. Cardiovasc Res (2006) 0.91

Heat shock proteins induction reduces stress kinases activation, potentially improving insulin signalling in monocytes from obese subjects. Cell Stress Chaperones (2012) 0.90

Feedback regulation of the heat shock response. Handb Exp Pharmacol (2006) 0.90

Heat-shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca2+-mediated apoptosis. Biochem J (2012) 0.89

Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance. Diabetes (2012) 0.88

Expression of heat shock protein 70 decreases with age in hepatocytes and splenocytes from female rats. Mech Ageing Dev (1999) 0.87

Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation. PLoS One (2011) 0.84

Plasma adenosine triphosphate and heat shock protein 72 concentrations after aerobic and eccentric exercise. Exerc Immunol Rev (2011) 0.84

Heat shock response regulates insulin sensitivity and glucose homeostasis: pathophysiological impact and therapeutic potential. Curr Diabetes Rev (2011) 0.83

Cell signaling. A new way to burn fat. Science (2006) 0.81

Structure of msj-1 gene in mice and humans: a possible role in the regulation of male reproduction. Gen Comp Endocrinol (2007) 0.81

MSJ-1, a new member of the DNAJ family of proteins, is a male germ cell-specific gene product. Exp Cell Res (1998) 0.80

HSP40 ameliorates impairment of insulin secretion by inhibiting huntingtin aggregation in a HD pancreatic beta cell model. Biosci Biotechnol Biochem (2009) 0.77

Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. J Appl Genet (2007) 0.77

Articles by these authors

Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol (2007) 8.16

Antimicrobial drug discovery through bacteriophage genomics. Nat Biotechnol (2004) 4.17

The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia (2006) 3.54

Prognostic factors in heat wave related deaths: a meta-analysis. Arch Intern Med (2007) 2.33

Cooling and hemodynamic management in heatstroke: practical recommendations. Crit Care (2007) 1.73

FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy. BMC Cancer (2008) 1.63

The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol (2009) 1.60

Expression of B7-H1 in breast cancer patients is strongly associated with high proliferative Ki-67-expressing tumor cells. Int J Cancer (2007) 1.53

Tissue factor/factor VIIa pathway mediates coagulation activation in induced-heat stroke in the baboon. Crit Care Med (2012) 1.48

Enhancement of lytic activity of leukemic cells by CD8+ cytotoxic T lymphocytes generated against a WT1 peptide analogue. Leuk Lymphoma (2009) 1.47

Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes. Cancer Res (2008) 1.45

A new class of small molecule RNA polymerase inhibitors with activity against rifampicin-resistant Staphylococcus aureus. Bioorg Med Chem (2006) 1.23

Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. J Biol Chem (2003) 1.19

Genome annotation and intraviral interactome for the Streptococcus pneumoniae virulent phage Dp-1. J Bacteriol (2010) 1.12

Therapeutic targeting of B7-H1 in breast cancer. Expert Opin Ther Targets (2011) 1.12

Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. Cardiovasc Diabetol (2014) 1.09

Conformational changes and orientation of Humicola lanuginosa lipase on a solid hydrophobic surface: an in situ interface Fourier transform infrared-attenuated total reflection study. Biophys J (2002) 1.09

Being 40 or younger is an independent risk factor for relapse in operable breast cancer patients: the Saudi Arabia experience. BMC Cancer (2007) 1.08

Predictors of sustained virological response to a 48-week course of pegylated interferon alfa-2a and ribavirin in patients infected with hepatitis C virus genotype 4. Ann Saudi Med (2009) 1.06

State of diabetes, hypertension, and comorbidity in Kuwait: showcasing the trends as seen in native versus expatriate populations. Diabetes Care (2013) 1.06

Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells. J Biol Chem (2002) 1.04

Causes of uveitis at a referral center in Saudi Arabia. Ocul Immunol Inflamm (2009) 1.04

Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule. Breast Cancer Res (2010) 1.03

Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J Inflamm (Lond) (2012) 1.03

Mass spectrometry in clinical proteomics - from the present to the future. Proteomics Clin Appl (2008) 1.02

Proteomics analysis of human obesity reveals the epigenetic factor HDAC4 as a potential target for obesity. PLoS One (2013) 0.97

Peptides generated ex vivo from serum proteins by tumor-specific exopeptidases are not useful biomarkers in ovarian cancer. Clin Chem (2010) 0.95

Predictive models to assess risk of type 2 diabetes, hypertension and comorbidity: machine-learning algorithms and validation using national health data from Kuwait--a cohort study. BMJ Open (2013) 0.95

Analytical aspects of proteomics: 2009-2010. Anal Chem (2011) 0.93

Advancements in top-down proteomics. Anal Chem (2011) 0.92

A global benchmark study using affinity-based biosensors. Anal Biochem (2008) 0.91

The Wilms' tumor antigen is a novel target for human CD4+ regulatory T cells: implications for immunotherapy. Cancer Res (2008) 0.91

Extracellular matrix regulates glomerular epithelial cell survival and proliferation. Am J Physiol Renal Physiol (2003) 0.89

Genetic substructure of Kuwaiti population reveals migration history. PLoS One (2013) 0.89

IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects. BMC Immunol (2014) 0.88

Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma. Int J Cancer (2004) 0.87

Complement activates the c-Jun N-terminal kinase/stress-activated protein kinase in glomerular epithelial cells. J Immunol (2002) 0.86

Recombinant activated protein C attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke. Arterioscler Thromb Vasc Biol (2008) 0.86

Purpureocillium lilacinum as a cause of cavitary pulmonary disease: a new clinical presentation and observations on atypical morphologic characteristics of the isolate. J Clin Microbiol (2012) 0.85

Interaction of osteopontin with IL-18 in obese individuals: implications for insulin resistance. PLoS One (2013) 0.85

Toll-like receptor 4 and high-mobility group box 1 are critical mediators of tissue injury and survival in a mouse model for heatstroke. PLoS One (2012) 0.84

CD8 T-cell recognition of human 5T4 oncofetal antigen. Int J Cancer (2006) 0.83

Biomarker discovery and redundancy reduction towards classification using a multi-factorial MALDI-TOF MS T2DM mouse model dataset. BMC Bioinformatics (2011) 0.83

sRAGE in diabetic and non-diabetic critically ill patients: effects of intensive insulin therapy. Crit Care (2011) 0.83

Immunization with a recombinant adenovirus encoding a lymphoma idiotype: induction of tumor-protective immunity and identification of an idiotype-specific T cell epitope. J Immunol (2002) 0.83

FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells. Cell Physiol Biochem (2014) 0.82

Renal expression and activity of the germinal center kinase SK2. Am J Physiol Renal Physiol (2003) 0.82

Enhanced alpha1 adrenergic sensitivity in sensorimotor gating deficits in neonatal ventral hippocampus-lesioned rats. Int J Neuropsychopharmacol (2008) 0.82

Glucocorticoids do not protect against the lethal effects of experimental heatstroke in baboons. Shock (2007) 0.82

Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus. Mol Microbiol (2006) 0.82

Outcome of penile cancer in circumcised men. J Urol (2006) 0.82

Fludarabine-based conditioning chemotherapy for allogeneic hematopoietic stem cell transplantation in acquired severe aplastic anemia. Biol Blood Marrow Transplant (2010) 0.81

Hsp-72, a candidate prognostic indicator of heatstroke. Cell Stress Chaperones (2010) 0.80

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue. Lipids Health Dis (2014) 0.79

Cancer stem cell immunotherapy: the right bullet for the right target. Hematol Oncol Stem Cell Ther (2010) 0.79

Obesity and dental decay: inference on the role of dietary sugar. PLoS One (2013) 0.78

The actin cytoskeleton facilitates complement-mediated activation of cytosolic phospholipase A2. Am J Physiol Renal Physiol (2003) 0.78

The prevalence, clinical characteristics, and prognosis of diastolic heart failure: a clinical study in elderly Saudi patients with up to 5 years follow-up. Congest Heart Fail (2009) 0.77

Microscopic detection of mixed malarial infections: improvement by saponin hemolysis. Med Princ Pract (2008) 0.77

Early detection of ovarian cancer in samples pre-diagnosis using CA125 and MALDI-MS peaks. Cancer Genomics Proteomics (2011) 0.77

Can salivary phosphate levels be an early biomarker to monitor the evolvement of obesity? Contrib Nephrol (2013) 0.77

Adoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma. J Immunother (2004) 0.77

Effects of dehydration on corneal tissue absorption of topical azithromycin in rabbits. Curr Eye Res (2005) 0.77