Gamma secretase inhibitors of Notch signaling.

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Published in Onco Targets Ther on July 23, 2013

Authors

Roma Olsauskas-Kuprys1, Andrei Zlobin, Clodia Osipo

Author Affiliations

1: The Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Chicago, Chicago, IL, USA.

Associated clinical trials:

A Notch Signalling Pathway Inhibitor for Patients With Advanced Breast Cancer (0752-014) | NCT00106145

RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or Cannot Be Removed By Surgery | NCT01071564

A Trial In Patients With Advanced Cancer And Leukemia | NCT00878189

Safety and Tolerability of Different Dose Combinations of Ridaforolimus With MK-2206 or MK-0752 for Participants With Advanced Cancer (MK-8669-049) | NCT01295632

Phase I/II Study of MK-0752 Followed by Docetaxel in Advanced or Metastatic Breast Cancer | NCT00645333

Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors | NCT01131234

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097, Paclitaxel, and Carboplatin Before Surgery in Treating Patients With Stage II or Stage III Triple-Negative Breast Cancer | NCT01238133

Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced, Metastatic, or Recurrent Triple Negative Invasive Breast Cancer | NCT01151449

RO4929097 and Letrozole in Treating Post-Menopausal Women With Hormone Receptor-Positive Stage II or Stage III Breast Cancer | NCT01208441

Study Of MK-0752 In Combination With Tamoxifen Or Letrozole to Treat Early Stage Breast Cancer (MK-0752) | NCT00756717

RO4929097 and Capecitabine in Treating Patients With Refractory Solid Tumors | NCT01158274

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