Published in Hum Mol Genet on August 04, 2013
Obesity accelerates epigenetic aging of human liver. Proc Natl Acad Sci U S A (2014) 2.68
Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biol (2014) 2.40
A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. PLoS Comput Biol (2016) 1.38
EMT and tumor metastasis. Clin Transl Med (2015) 1.29
DNA methylation and healthy human aging. Aging Cell (2015) 1.27
The cerebellum ages slowly according to the epigenetic clock. Aging (Albany NY) (2015) 1.26
Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis. Genes Dev (2015) 1.17
An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging. PLoS Genet (2015) 1.13
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet (2016) 1.07
Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort. Clin Epigenetics (2016) 1.05
Concordant and discordant DNA methylation signatures of aging in human blood and brain. Epigenetics Chromatin (2015) 1.01
From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition? Clin Epigenetics (2015) 0.98
Epigenetic regulation of Keap1-Nrf2 signaling. Free Radic Biol Med (2015) 0.97
New Insights for Oxidative Stress and Diabetes Mellitus. Oxid Med Cell Longev (2015) 0.94
Epigenetic Aging Signatures Are Coherently Modified in Cancer. PLoS Genet (2015) 0.92
An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training. Epigenetics (2014) 0.91
Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites. Clin Epigenetics (2015) 0.91
Emerging issues in public health genomics. Annu Rev Genomics Hum Genet (2014) 0.91
Discordance of DNA methylation variance between two accessible human tissues. Sci Rep (2015) 0.91
Epigenetic clock analyses of cellular senescence and ageing. Oncotarget (2016) 0.90
Longitudinal epigenetic drift in mice perinatally exposed to lead. Epigenetics (2014) 0.88
Genetic and environmental influences interact with age and sex in shaping the human methylome. Nat Commun (2016) 0.88
Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin. Genome Biol (2015) 0.88
Genome-wide methylation patterns provide insight into differences in breast tumor biology between American women of African and European ancestry. Oncotarget (2014) 0.87
Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes. BMC Res Notes (2014) 0.85
SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. World J Stem Cells (2015) 0.84
Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes. Clin Epigenetics (2015) 0.84
A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation. Biol Direct (2015) 0.83
DNA methylation as a dynamic regulator of development and disease processes: spotlight on the prostate. Epigenomics (2015) 0.81
Epigenetic resolution of the 'curse of complexity' in adaptive evolution of complex traits. J Physiol (2014) 0.81
Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases. Neurotherapeutics (2014) 0.80
Biomarkers and ageing: The clock-watcher. Nature (2014) 0.80
Epigenetic Heterogeneity of B-Cell Lymphoma: DNA Methylation, Gene Expression and Chromatin States. Genes (Basel) (2015) 0.80
Reduced DNA methylation patterning and transcriptional connectivity define human skin aging. Aging Cell (2016) 0.79
Longitudinal study of DNA methylation during the first 5 years of life. J Transl Med (2016) 0.78
Comparison of different cell type correction methods for genome-scale epigenetics studies. BMC Bioinformatics (2017) 0.77
Bisphenol A-associated alterations in genome-wide DNA methylation and gene expression patterns reveal sequence-dependent and non-monotonic effects in human fetal liver. Environ Epigenet (2015) 0.77
Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study. Environ Epigenet (2016) 0.77
Impacts of Chromatin States and Long-Range Genomic Segments on Aging and DNA Methylation. PLoS One (2015) 0.77
Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging. Nucleic Acids Res (2015) 0.76
Impact of a folic acid-enriched diet on urinary tract function in mice treated with testosterone and estradiol. Am J Physiol Renal Physiol (2015) 0.76
Testing evolutionary models of senescence: traditional approaches and future directions. Hum Genet (2014) 0.76
Epigenetic assimilation in the aging human brain. Genome Biol (2016) 0.76
Specific premature epigenetic aging of cartilage in osteoarthritis. Aging (Albany NY) (2016) 0.76
Simplified Assay for Epigenetic Age Estimation in Whole Blood of Adults. Front Genet (2016) 0.76
Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases. Epigenomics (2016) 0.76
Age-associated chromatin relaxation is enhanced in Huntington's disease mice. Aging (Albany NY) (2017) 0.75
DNA methylation-based forensic age prediction using artificial neural networks and next generation sequencing. Forensic Sci Int Genet (2017) 0.75
Bistable Epigenetic States Explain Age-Dependent Decline in Mesenchymal Stem Cell Heterogeneity. Stem Cells (2016) 0.75
Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains. Nucleic Acids Res (2016) 0.75
Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study. Aging (Albany NY) (2016) 0.75
Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood. Clin Epigenetics (2016) 0.75
Ischemic stroke patients are biologically older than their chronological age. Aging (Albany NY) (2016) 0.75
Epigenetic Age Acceleration Assessed with Human White-Matter Images. J Neurosci (2017) 0.75
An epigenetic aging clock for dogs and wolves. Aging (Albany NY) (2017) 0.75
Longitudinal effects of developmental bisphenol A and variable diet exposures on epigenetic drift in mice. Reprod Toxicol (2016) 0.75
SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing. Hum Genomics (2015) 0.75
DNA Methylation Assessment from Human Slow- and Fast-Twitch Skeletal Muscle Fibers. J Appl Physiol (1985) (2017) 0.75
Trends in DNA Methylation with Age Replicate Across Diverse Human Populations. Genetics (2017) 0.75
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet (1962) 13.72
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia (1992) 13.20
Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet (2007) 12.08
Tackling the widespread and critical impact of batch effects in high-throughput data. Nat Rev Genet (2010) 11.82
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer (2006) 11.22
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet (2006) 10.47
Epigenetic stem cell signature in cancer. Nat Genet (2006) 9.62
CpG islands and the regulation of transcription. Genes Dev (2011) 9.50
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics (2012) 9.31
Increased methylation variation in epigenetic domains across cancer types. Nat Genet (2011) 8.92
Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res (2008) 8.62
Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet (1994) 8.34
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science (2007) 8.07
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
DNA damage, aging, and cancer. N Engl J Med (2009) 7.56
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome. Epigenetics (2011) 7.38
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07
Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell (2012) 6.50
Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32
Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol (2013) 5.89
Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet (2006) 5.72
Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell (2010) 5.22
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res (2010) 5.08
Telomeres and aging. Physiol Rev (2008) 4.79
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med (2006) 4.61
Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res (1998) 4.39
Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A (2012) 4.26
Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature (2010) 4.04
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet (2011) 3.95
Sirtuins in aging and age-related disease. Cell (2006) 3.95
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene (2007) 3.85
Detectable clonal mosaicism from birth to old age and its relationship to cancer. Nat Genet (2012) 3.68
Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics (2009) 3.50
Epigenetic predictor of age. PLoS One (2011) 3.46
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci U S A (2010) 3.41
An epigenetic signature in peripheral blood predicts active ovarian cancer. PLoS One (2009) 3.33
Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A (2013) 3.15
Telomere length, stem cells and aging. Nat Chem Biol (2007) 3.10
Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol (2012) 3.05
Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res (2001) 3.02
Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res (2010) 2.99
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A (2011) 2.96
Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies. Bioinformatics (2011) 2.91
Bet-hedging and epigenetic inheritance in bacterial cell development. Proc Natl Acad Sci U S A (2008) 2.88
DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells. Aging Cell (2009) 2.84
Age-associated DNA methylation in pediatric populations. Genome Res (2012) 2.53
Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell (2012) 2.15
Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res (2012) 2.10
Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet (2010) 2.03
Age-related DNA methylation changes in normal human prostate tissues. Clin Cancer Res (2007) 2.02
Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci U S A (1996) 1.99
Telomeres and lifestyle factors: roles in cellular aging. Mutat Res (2011) 1.98
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell (2013) 1.97
Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood (2011) 1.92
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev (2013) 1.88
Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Rev (2007) 1.80
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet (2013) 1.72
Epigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation. Genome Med (2012) 1.65
Biological ageing and cardiovascular disease. Heart (2008) 1.64
Parental ages and levels of DNA methylation in the newborn are correlated. BMC Med Genet (2011) 1.64
Estimating human age from T-cell DNA rearrangements. Curr Biol (2010) 1.58
Taking the measure of the methylome. Nat Biotechnol (2010) 1.57
Epigenetic-aging-signature to determine age in different tissues. Aging (Albany NY) (2011) 1.55
A genome-wide methylation study on obesity: differential variability and differential methylation. Epigenetics (2013) 1.51
The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? Bioessays (2008) 1.47
Aging, methylation and cancer. Histol Histopathol (2000) 1.40
The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38
Genome-wide DNA methylation profiling. Wiley Interdiscip Rev Syst Biol Med (2010) 1.37
Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res (2012) 1.37
Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance. Genome Biol (2013) 1.36
Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease. Eur Heart J (2008) 1.35
An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming. PLoS Genet (2012) 1.34
An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways. Sci Rep (2013) 1.26
UTF1 is a chromatin-associated protein involved in ES cell differentiation. J Cell Biol (2007) 1.24
Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma. Genome Med (2013) 1.23
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2. Nat Commun (2013) 1.21
Epigenetic variation and cellular Darwinism. Nat Genet (2011) 1.17
Shared environmental factors associated with telomere length maintenance in elderly male twins. Aging Cell (2007) 1.14
The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics (2011) 1.13
Epigenetics: Stress makes its molecular mark. Nature (2012) 1.11
Computational purification of individual tumor gene expression profiles leads to significant improvements in prognostic prediction. Genome Med (2013) 1.05
Telomeres and adversity: Too toxic to ignore. Nature (2012) 1.04
Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms. Int J Obes (Lond) (2009) 1.03
The role of epigenetics in aging and autoimmunity. Clin Rev Allergy Immunol (2010) 1.03
Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome. Epigenetics (2012) 1.03
DNA methylation studies using twins: what are they telling us? Genome Biol (2012) 0.99
Molecular pathology and age estimation. Forensic Sci Int (2010) 0.98
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature (2009) 18.08
DNA methylation profiling of human chromosomes 6, 20 and 22. Nat Genet (2006) 18.08
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Epigenome-wide association studies for common human diseases. Nat Rev Genet (2011) 7.96
The DNA sequence of the human X chromosome. Nature (2005) 6.97
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
Gene map of the extended human MHC. Nat Rev Genet (2004) 6.01
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer. Nature (2012) 5.84
DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project. PLoS Biol (2004) 4.96
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics (2012) 4.95
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs). Genome Res (2008) 4.84
High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer. Genome Biol (2007) 4.70
Germline rates of de novo meiotic deletions and duplications causing several genomic disorders. Nat Genet (2007) 4.59
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol (2010) 4.25
Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis. PLoS Genet (2011) 3.95
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia. Cell (2007) 3.58
Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol (2008) 3.49
An epigenetic signature in peripheral blood predicts active ovarian cancer. PLoS One (2009) 3.33
BLUEPRINT to decode the epigenetic signature written in blood. Nat Biotechnol (2012) 3.24
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Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
Genome-wide DNA methylation analysis for diabetic nephropathy in type 1 diabetes mellitus. BMC Med Genomics (2010) 2.34
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform. Epigenetics (2013) 2.28
ChAMP: 450k Chip Analysis Methylation Pipeline. Bioinformatics (2013) 2.21
Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet (2012) 2.16
A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer. Breast Cancer Res (2008) 2.09
From genome to epigenome. Hum Mol Genet (2005) 2.03
Single base-resolution methylome of the silkworm reveals a sparse epigenomic map. Nat Biotechnol (2010) 2.03
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99
Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PLoS One (2010) 1.93
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Genes Dev (2013) 1.88
Genome-wide DNA methylation analysis of archival formalin-fixed paraffin-embedded tissue using the Illumina Infinium HumanMethylation27 BeadChip. Methods (2010) 1.71
Methylome analysis using MeDIP-seq with low DNA concentrations. Nat Protoc (2012) 1.70
Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance. Circulation (2012) 1.64
Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors. Genome Res (2011) 1.60
Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J Heart Lung Transplant (2011) 1.58
Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates. Genome Res (2005) 1.56
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Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem (2009) 1.50
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. Hum Mol Genet (2008) 1.47
Sites of differential DNA methylation between placenta and peripheral blood: molecular markers for noninvasive prenatal diagnosis of aneuploidies. Am J Pathol (2009) 1.46
Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle. Am J Physiol Lung Cell Mol Physiol (2007) 1.42
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. Mycopathologia (2011) 1.42
Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics (2006) 1.39
The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer. PLoS Genet (2012) 1.33
ESR1 gene amplification in breast cancer: a common phenomenon? Nat Genet (2008) 1.33
BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines. Cancer Res (2007) 1.33
Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. Breast Cancer Res (2008) 1.28
A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. Genomics (2002) 1.28
Identification of a single killer immunoglobulin-like receptor (KIR) gene in the porcine leukocyte receptor complex on chromosome 6q. Immunogenetics (2006) 1.26
A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform. BMC Bioinformatics (2012) 1.26
An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways. Sci Rep (2013) 1.26
Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. Am J Physiol Lung Cell Mol Physiol (2007) 1.25
Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol (2011) 1.25
Comparative genomic analysis of two avian (quail and chicken) MHC regions. J Immunol (2004) 1.24
The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44. Eur J Immunol (2003) 1.22
Plant and animal endemism in the eastern Andean slope: challenges to conservation. BMC Ecol (2012) 1.22
Resources for methylome analysis suitable for gene knockout studies of potential epigenome modifiers. Gigascience (2012) 1.22
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2. Nat Commun (2013) 1.21
A common variant associated with dyslexia reduces expression of the KIAA0319 gene. PLoS Genet (2009) 1.20
Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circ Res (2005) 1.19
Histone deacetylase inhibitor enhances recovery after AKI. J Am Soc Nephrol (2013) 1.19
Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation. Int J Biochem Cell Biol (2008) 1.18
Future potential of the Human Epigenome Project. Expert Rev Mol Diagn (2004) 1.17
DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta. J Biol Chem (2010) 1.15
Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. Int J Cancer (2009) 1.15
A functional methylome map of ulcerative colitis. Genome Res (2012) 1.15
Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med (2014) 1.14
Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Proc Natl Acad Sci U S A (2011) 1.14
The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells (2011) 1.12
Cellular network entropy as the energy potential in Waddington's differentiation landscape. Sci Rep (2013) 1.12
Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. Age (Dordr) (2014) 1.12
Interferon-beta treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants. Carcinogenesis (2006) 1.11
Using high-density DNA methylation arrays to profile copy number alterations. Genome Biol (2014) 1.11
Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. PLoS Med (2013) 1.10
AutoMeDIP-seq: a high-throughput, whole genome, DNA methylation assay. Methods (2010) 1.10
Murine pulmonary response to chronic hypoxia is strain specific. Exp Lung Res (2008) 1.09
Distribution of breakpoints on chromosome 18 in breast, colorectal, and pancreatic carcinoma cell lines. Cancer Genet Cytogenet (2006) 1.08
Human-specific CpG "beacons" identify loci associated with human-specific traits and disease. Epigenetics (2012) 1.07
Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ (2012) 1.07
Future impact of integrated high-throughput methylome analyses on human health and disease. J Genet Genomics (2008) 1.07
Oxidative injury is a common consequence of BMPR2 mutations. Pulm Circ (2011) 1.06
A genome-wide survey of Major Histocompatibility Complex (MHC) genes and their paralogues in zebrafish. BMC Genomics (2005) 1.06
Functional interpretation of non-coding sequence variation: concepts and challenges. Bioessays (2013) 1.06