Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides.

PubWeight™: 0.84‹?›

🔗 View Article (PMID 23939911)

Published in Eur J Immunol on August 30, 2013

Authors

Hannes Uchtenhagen1, Esam T Abualrous, Evi Stahl, Eva B Allerbring, Marjolein Sluijter, Martin Zacharias, Tatyana Sandalova, Thorbald van Hall, Sebastian Springer, Per-Åke Nygren, Adnane Achour

Author Affiliations

1: Science for Life Laboratory, Center for Infectious Medicine (CIM), Department of Medicine, Karolinska Insitutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Articles by these authors

M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J Immunol (2011) 2.02

A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. J Exp Med (2002) 1.67

Dissecting protein-RNA recognition sites. Nucleic Acids Res (2008) 1.67

Peptide vaccination after T-cell transfer causes massive clonal expansion, tumor eradication, and manageable cytokine storm. Cancer Res (2010) 1.59

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat Struct Mol Biol (2013) 1.47

Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition. J Immunol (2004) 1.46

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res (2007) 1.45

A statistical analysis of random mutagenesis methods used for directed protein evolution. J Mol Biol (2005) 1.40

Community-wide assessment of protein-interface modeling suggests improvements to design methodology. J Mol Biol (2011) 1.40

Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody. Clin Cancer Res (2011) 1.39

Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach. Proc Natl Acad Sci U S A (2011) 1.30

A novel family of human leukocyte antigen class II receptors may have its origin in archaic human species. J Biol Chem (2013) 1.29

Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1. J Biol Chem (2008) 1.28

Design of agonistic altered peptides for the robust induction of CTL directed towards H-2Db in complex with the melanoma-associated epitope gp100. Cancer Res (2009) 1.26

Accounting for global protein deformability during protein-protein and protein-ligand docking. Biochim Biophys Acta (2005) 1.25

Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab. Clin Cancer Res (2011) 1.24

Conformational flexibility of the MHC class I alpha1-alpha2 domain in peptide bound and free states: a molecular dynamics simulation study. Biophys J (2004) 1.24

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity. Proc Natl Acad Sci U S A (2009) 1.24

Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Nat Immunol (2010) 1.24

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells. J Biol Chem (2007) 1.23

Therapeutic cancer vaccines. J Clin Invest (2015) 1.23

Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules. EMBO J (2009) 1.23

Energy minimization in low-frequency normal modes to efficiently allow for global flexibility during systematic protein-protein docking. Proteins (2008) 1.22

EPSVR and EPMeta: prediction of antigenic epitopes using support vector regression and multiple server results. BMC Bioinformatics (2010) 1.21

Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions. Proteins (2013) 1.20

RNA kink-turns as molecular elbows: hydration, cation binding, and large-scale dynamics. Structure (2006) 1.17

HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8⁺ T lymphocytes. Proc Natl Acad Sci U S A (2011) 1.17

Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study. Biopolymers (2009) 1.16

Local and global effects of strong DNA bending induced during molecular dynamics simulations. Nucleic Acids Res (2009) 1.15

Multifunctionalized polymer microcapsules: novel tools for biological and pharmacological applications. Small (2007) 1.15

Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition. J Biol Chem (2007) 1.15

In aged mice, outgrowth of intraocular melanoma depends on proangiogenic M2-type macrophages. J Immunol (2010) 1.15

Protein-ligand docking accounting for receptor side chain and global flexibility in normal modes: evaluation on kinase inhibitor cross docking. J Med Chem (2008) 1.12

Prediction of antigenic epitopes on protein surfaces by consensus scoring. BMC Bioinformatics (2009) 1.12

Effect of the F610A mutation on substrate extrusion in the AcrB transporter: explanation and rationale by molecular dynamics simulations. J Am Chem Soc (2011) 1.12

The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. J Biol Chem (2003) 1.11

Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO). J Biol Chem (2011) 1.11

Enhanced sampling of peptide and protein conformations using replica exchange simulations with a peptide backbone biasing-potential. Proteins (2007) 1.11

Siroheme- and [Fe4-S4]-dependent NirA from Mycobacterium tuberculosis is a sulfite reductase with a covalent Cys-Tyr bond in the active site. J Biol Chem (2005) 1.10

Accounting for loop flexibility during protein-protein docking. Proteins (2006) 1.10

Effective dephosphorylation of Src substrates by SHP-1. J Biol Chem (2003) 1.09

Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid. Eur J Biochem (2003) 1.07

Folding simulations of Trp-cage mini protein in explicit solvent using biasing potential replica-exchange molecular dynamics simulations. Proteins (2009) 1.07

Tapasin and other chaperones: models of the MHC class I loading complex. Biol Chem (2004) 1.07

In silico prediction of binding sites on proteins. Curr Med Chem (2010) 1.06

Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors. Int J Cancer (2010) 1.06

Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 1.05

The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects. J Exp Med (2009) 1.05

Two crystal structures of pneumococcal pilus sortase C provide novel insights into catalysis and substrate specificity. J Mol Biol (2009) 1.05

Maturation of the 5S rRNA 5' end is catalyzed in vitro by the endonuclease tRNase Z in the archaeon H. volcanii. RNA (2008) 1.04

Tapasin edits peptides on MHC class I molecules by accelerating peptide exchange. Eur J Immunol (2010) 1.04

Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge. Virology (2008) 1.04

Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains. Critical roles of residues beyond the pY+3 position. J Biol Chem (2006) 1.04

Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytes. J Biol Chem (2007) 1.03

A coarse-grained force field for Protein-RNA docking. Nucleic Acids Res (2011) 1.02

Crystal structure of the dog lipocalin allergen Can f 2: implications for cross-reactivity to the cat allergen Fel d 4. J Mol Biol (2010) 1.02

A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses. Immunity (2002) 1.02

Strategies to counteract MHC-I defects in tumors. Curr Opin Immunol (2011) 1.02

Differential tapasin dependence of MHC class I molecules correlates with conformational changes upon peptide dissociation: a molecular dynamics simulation study. Mol Immunol (2008) 1.01

Structural flexibility of the nucleosome core particle at atomic resolution studied by molecular dynamics simulation. Biopolymers (2007) 1.00

Protein-protein docking in CAPRI using ATTRACT to account for global and local flexibility. Proteins (2007) 1.00

Comparative molecular dynamics analysis of tapasin-dependent and -independent MHC class I alleles. Protein Sci (2007) 0.99

Hereditary lattice corneal dystrophy is associated with corneal amyloid deposits enclosing C-terminal fragments of keratoepithelin. Invest Ophthalmol Vis Sci (2005) 0.98

Effect of hexafluoroisopropanol alcohol on the structure of melittin: a molecular dynamics simulation study. Protein Sci (2005) 0.97

The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.97

Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer. Semin Immunol (2013) 0.96

Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice. PLoS One (2010) 0.96

ERp29, an unusual redox-inactive member of the thioredoxin family. Antioxid Redox Signal (2006) 0.95

Plasmodium falciparum rosetting epitopes converge in the SD3-loop of PfEMP1-DBL1α. PLoS One (2012) 0.95

A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA. Nucleic Acids Res (2005) 0.94

Folding of a DNA hairpin loop structure in explicit solvent using replica-exchange molecular dynamics simulations. Biophys J (2007) 0.94

Exploiting antigenic diversity for vaccine design: the chlamydia ArtJ paradigm. J Biol Chem (2010) 0.94

Conformational transitions in RNA single uridine and adenosine bulge structures: a molecular dynamics free energy simulation study. Biophys J (2006) 0.94

Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2. Mol Immunol (2012) 0.94

Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation. Eur J Immunol (2013) 0.93

Binding site prediction and improved scoring during flexible protein-protein docking with ATTRACT. Proteins (2010) 0.93

Structural characterization of the tetrameric form of the major cat allergen Fel d 1. J Mol Biol (2007) 0.93

Controlled intracellular release of peptides from microcapsules enhances antigen presentation on MHC class I molecules. Small (2009) 0.92

Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility. FASEB J (2011) 0.92

Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire. Cancer Res (2005) 0.92

Enhanced conformational sampling of nucleic acids by a new Hamiltonian replica exchange molecular dynamics approach. J Chem Phys (2009) 0.91

Malondialdehyde modification of myelin oligodendrocyte glycoprotein leads to increased immunogenicity and encephalitogenicity. Eur J Immunol (2007) 0.91

Blind prediction of interfacial water positions in CAPRI. Proteins (2013) 0.90

Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae. MBio (2014) 0.90

Peptide binding to MHC class I and II proteins: new avenues from new methods. Mol Immunol (2009) 0.90