Published in Crit Care Med on September 01, 2013
Benefit profile of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis. Crit Care (2015) 1.25
Animal models of sepsis. Virulence (2013) 1.22
Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines. J Intensive Care (2014) 1.11
Use of recombinant human soluble thrombomodulin in patients with sepsis-induced disseminated intravascular coagulation after intestinal perforation. Front Med (Lausanne) (2015) 1.01
Post-marketing surveillance data of thrombomodulin alfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation. J Intensive Care (2014) 1.00
Benefit profile of anticoagulant therapy in sepsis: a nationwide multicentre registry in Japan. Crit Care (2016) 0.93
Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care (2015) 0.89
PAMPs and DAMPs as triggers for DIC. J Intensive Care (2014) 0.86
Platelets and coagulation in infection. Clin Transl Immunology (2016) 0.85
Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85
Sepsis and disseminated intravascular coagulation. J Intensive Care (2016) 0.84
Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO). Ann Hematol (2014) 0.84
Hyperinflammation, rather than hemophagocytosis, is the common link between macrophage activation syndrome and hemophagocytic lymphohistiocytosis. Curr Opin Rheumatol (2014) 0.84
Anticoagulant modulation of inflammation in severe sepsis. World J Crit Care Med (2015) 0.84
The coagulopathy of acute sepsis. Curr Opin Anaesthesiol (2015) 0.82
Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding. J Thromb Haemost (2015) 0.81
Emerging therapeutic targets of sepsis-associated acute kidney injury. Semin Nephrol (2015) 0.81
Assessment of Fibrinolysis in Sepsis Patients with Urokinase Modified Thromboelastography. PLoS One (2015) 0.80
Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity. Crit Care (2016) 0.79
Recombinant soluble thrombomodulin as an adjunctive treatment for sepsis and disseminated intravascular coagulation: relatively safe and possibly effective. Crit Care Med (2013) 0.78
Management of neonatal sepsis in term newborns. F1000Prime Rep (2014) 0.76
Thrombomodulin protects against lung damage created by high level of oxygen with large tidal volume mechanical ventilation in rats. J Intensive Care (2014) 0.76
Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence. MBio (2016) 0.76
A Dormant Microbial Component in the Development of Preeclampsia. Front Med (Lausanne) (2016) 0.76
The efficacy and safety of different anticoagulants on patients with severe sepsis and derangement of coagulation: a protocol for network meta-analysis of randomised controlled trials. BMJ Open (2014) 0.76
The efficacy of recombinant human soluble thrombomodulin for obstetric disseminated intravascular coagulation: a retrospective study. Crit Care (2015) 0.75
Efficacy of recombinant thrombomodulin for DIC after deceased donor liver transplantation: a case report. Surg Case Rep (2016) 0.75
The obstacles that should be overcome to develop new anticoagulants for severe sepsis. Crit Care Med (2014) 0.75
Impact of thrombosis on pulmonary endothelial injury and repair following sepsis. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury. FASEB J (2016) 0.75
Critical care medicine 2013: a review and prospect. J Thorac Dis (2013) 0.75
Pharmacokinetics of Standard- and Reduced-Dose Recombinant Human Soluble Thrombomodulin in Patients with Septic Disseminated Intravascular Coagulation during Continuous Hemodiafiltration. Front Med (Lausanne) (2017) 0.75
New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. BMJ Open (2017) 0.75
The application of anticoagulant therapy to sepsis. J Intensive Care (2017) 0.75
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62
Comparison of two fluid-management strategies in acute lung injury. N Engl J Med (2006) 19.54
International study of the prevalence and outcomes of infection in intensive care units. JAMA (2009) 11.57
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA (2004) 11.27
Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med (2010) 8.58
Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med (2005) 8.55
Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med (2006) 7.97
Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest (2008) 7.94
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood (2011) 6.50
Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation (2011) 6.47
Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA (2003) 6.24
Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet (2007) 6.07
Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 5.88
Systematic overview of warfarin and its drug and food interactions. Arch Intern Med (2005) 5.86
Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med (2005) 5.76
Sepsis definitions: time for change. Lancet (2013) 5.63
Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest (2006) 5.31
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet (2007) 5.23
Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression. Lancet Infect Dis (2012) 5.14
Vital signs after cardiac arrest following withdrawal of life-sustaining therapy: a multicenter prospective observational study. Crit Care Med (2014) 5.07
Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data. Lancet (2011) 4.78
Costs associated with delirium in mechanically ventilated patients. Crit Care Med (2004) 4.75
Prevention and treatment of major blood loss. N Engl J Med (2007) 4.72
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69
Dalteparin versus unfractionated heparin in critically ill patients. N Engl J Med (2011) 4.59
Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest (2009) 4.51
Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA (2010) 4.37
Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis. Clin Infect Dis (2007) 4.23
Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology (2006) 4.03
Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med (2004) 3.89
Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med (2002) 3.87
Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med (2005) 3.85
Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci (2010) 3.84
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
The vexing problem of guidelines and conflict of interest: a potential solution. Ann Intern Med (2010) 3.47
A comparison of three methods to estimate baseline creatinine for RIFLE classification. Nephrol Dial Transplant (2010) 3.45
A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med (2005) 3.44
Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma (2008) 3.40
Aspirin versus low-molecular-weight heparin for extended venous thromboembolism prophylaxis after total hip arthroplasty: a randomized trial. Ann Intern Med (2013) 3.40
Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39
Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial). Kidney Int (2010) 3.37
Family satisfaction with care in the intensive care unit: results of a multiple center study. Crit Care Med (2002) 3.36
Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med (2006) 3.36
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med (2007) 3.35
Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood (2011) 3.25
Thrombomodulin mutations in atypical hemolytic-uremic syndrome. N Engl J Med (2009) 3.24
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study. Crit Care Med (2005) 3.14
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med (2008) 3.14
Acute kidney injury after cardiac surgery: focus on modifiable risk factors. Circulation (2009) 3.10
Attitudes and perceptions of patients towards methods of establishing a DNA biobank. Cell Tissue Bank (2007) 3.05
Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int (2011) 3.05
Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial. Lancet (2003) 2.86
Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med (2010) 2.86
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82
Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med (2009) 2.77
Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit Care Med (2015) 2.77
Findings on the portable chest radiograph correlate with fluid balance in critically ill patients. Chest (2002) 2.77
Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis. Thromb Haemost (2011) 2.75
2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol (2010) 2.75
Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers. Crit Care Med (2005) 2.72
The optimal intensity of vitamin K antagonists in patients with mechanical heart valves: a meta-analysis. J Am Coll Cardiol (2003) 2.71
Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med (2009) 2.68
Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation (2011) 2.65
Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med (2002) 2.62
Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis. Shock (2009) 2.59
Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest (2007) 2.58
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. J Clin Oncol (2002) 2.55
The clinical evaluation committee in a large multicenter phase 3 trial of drotrecogin alfa (activated) in patients with severe sepsis (PROWESS): role, methodology, and results. Crit Care Med (2003) 2.54
Indications, complications, and management of inferior vena cava filters: the experience in 952 patients at an academic hospital with a level I trauma center. JAMA Intern Med (2013) 2.52
Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials. Arch Intern Med (2007) 2.50
Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals. Crit Care Med (2004) 2.50
Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 2.50
Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med (2004) 2.48
Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. Blood (2005) 2.48
Antiphospholipid syndrome. Lancet (2010) 2.47
Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure. Gastroenterology (2012) 2.46
Activation of inflammation and coagulation after infusion of C-reactive protein in humans. Circ Res (2005) 2.46
Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol (2007) 2.46
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med (2011) 2.40
Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium. Acad Med (2010) 2.38
Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med (2011) 2.36
Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects. Crit Care Med (2004) 2.35
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood (2013) 2.35
Utility of history, physical examination, electrocardiogram, and chest radiograph for differentiating normal from decreased systolic function in patients with heart failure. Am J Med (2002) 2.34
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31