Published in Chemistry on August 28, 2013
A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu. J Chem Phys (2010) 11.76
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Development of a decarboxylative palladation reaction and its use in a Heck-type olefination of arene carboxylates. J Am Chem Soc (2002) 1.37
Synthesis of biaryls via catalytic decarboxylative coupling. Science (2006) 1.37
Addition of amines to nitriles catalyzed by ytterbium amides: an efficient one-step synthesis of monosubstituted N-arylamidines. Org Lett (2008) 1.35
Decarboxylative coupling reactions: a modern strategy for C-C-bond formation. Chem Soc Rev (2011) 1.24
Carboxylic acids as substrates in homogeneous catalysis. Angew Chem Int Ed Engl (2008) 1.17
Biaryl synthesis via Pd-catalyzed decarboxylative coupling of aromatic carboxylates with aryl halides. J Am Chem Soc (2007) 1.15
Synthesis of aryl ketones or ketimines by palladium-catalyzed arene C-H addition to nitriles. J Org Chem (2006) 1.04
Synthesis of quinazolin-4(3H)-ones via Pd(II)-catalyzed intramolecular C(sp2)-H carboxamidation of N-arylamidines. J Org Chem (2011) 0.99
N-allyl-N-sulfonyl ynamides as synthetic precursors to amidines and vinylogous amidines. An unexpected N-to-C 1,3-sulfonyl shift in nitrile synthesis. J Org Chem (2011) 0.97
Inverse electron demand Diels-Alder reactions of 1,2,3-triazines: pronounced substituent effects on reactivity and cycloaddition scope. J Am Chem Soc (2011) 0.95
Synthesis of aryl ketones by the PD-catalyzed C-H activation of arenes and intermolecular carbopalladation of nitriles. J Am Chem Soc (2004) 0.94
Insertion of arynes into thioureas: a new amidine synthesis. Org Lett (2011) 0.93
Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders. Eur J Pharmacol (2010) 0.93
ESI-MS detection of proposed reaction intermediates in the air-promoted and ligand-modulated oxidative Heck reaction. J Org Chem (2006) 0.93
Scope of the inverse electron demand Diels-Alder reactions of 1,2,3-triazine. Org Lett (2011) 0.93
Direct synthesis of quinazolines through copper-catalyzed reaction of aniline-derived benzamidines. Org Lett (2010) 0.90
Palladium-catalyzed decarboxylative coupling of aromatic acids with aryl halides or unactivated arenes using microwave heating. Chem Commun (Camb) (2008) 0.88
Pd(O2CCF3)2/benzoquinone: a versatile catalyst system for the decarboxylative olefination of arene carboxylic acids. Org Lett (2009) 0.85
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Copper-catalyzed intramolecular C-N bond formation: a straightforward synthesis of benzimidazole derivatives in water. J Org Chem (2010) 0.84
PdII-catalyzed cyclization of alkynes containing aldehyde, ketone, or nitrile groups initiated by the acetoxypalladation of alkynes. Angew Chem Int Ed Engl (2002) 0.83
Oral platelet glycoprotein IIb/IIIa receptor inhibitors--part II. Clin Cardiol (2003) 0.82
Synthesis and biochemical activity of novel amidine derivatives as m1 muscarinic receptor agonists. Bioorg Med Chem (1996) 0.81
Analysis of highly potent amidine containing inhibitors of serine proteases and their N-hydroxylated prodrugs (amidoximes). J Enzyme Inhib Med Chem (2010) 0.80
Synthesis of aryl ketones by palladium(II)-catalyzed decarboxylative addition of benzoic acids to nitriles. Angew Chem Int Ed Engl (2010) 0.80
Cationic palladium(II)-catalyzed addition of arylboronic acids to nitriles. One-step synthesis of benzofurans from phenoxyacetonitriles. Org Lett (2006) 0.79
Palladium-catalyzed N-monoarylation of amidines and a one-pot synthesis of quinazoline derivatives. Org Lett (2012) 0.79
Rapid synthesis of 1,3,5-substituted 1,2,4-triazoles from carboxylic acids, amidines, and hydrazines. J Org Chem (2011) 0.79
Palladium-catalyzed decarboxylative 1,2-addition of carboxylic acids to aldehydes or imines. Chem Commun (Camb) (2010) 0.78
Synthesis of aryl sulfides by decarboxylative C-S cross-couplings. Chemistry (2009) 0.77
In vitro and in vivo antimalarial activities of T-2307, a novel arylamidine. Antimicrob Agents Chemother (2012) 0.77
Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates. Org Lett (2012) 0.77
Pd-catalysed decarboxylative Suzuki reactions and orthogonal Cu-based O-arylation of aromatic carboxylic acids. Chem Commun (Camb) (2010) 0.76
Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem (2009) 1.30
Dioxygen-promoted regioselective oxidative heck arylations of electron-rich olefins with arylboronic acids. J Org Chem (2004) 1.21
Non-peptide AT2-receptor agonists. Curr Opin Pharmacol (2010) 1.15
Pressurized Hot Water Extraction of anthocyanins from red onion: A study on extraction and degradation rates. Anal Chim Acta (2010) 1.11
Efficient palladium(II) catalysis under air. Base-free oxidative heck reactions at room temperature or with microwave heating. J Org Chem (2007) 1.07
The first ligand-modulated oxidative Heck vinylation. Efficient catalysis with molecular oxygen as palladium(0) oxidant. Chem Commun (Camb) (2003) 1.04
A new highly asymmetric chelation-controlled heck arylation. J Am Chem Soc (2003) 0.99
Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors. Bioorg Med Chem Lett (2009) 0.99
Formamide as a combined ammonia synthon and carbon monoxide source in fast palladium-catalyzed aminocarbonylations of aryl halides. J Comb Chem (2003) 0.99
Structural basis for the inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors. J Mol Biol (2009) 0.96
Palladium(II)-catalyzed coupling reactions with a chelating vinyl ether and arylboronic acids: a new Heck/Suzuki domino diarylation reaction. Chem Commun (Camb) (2009) 0.95
Microwave-promoted aminocarbonylations of aryl chlorides using Mo(CO)(6) as a solid carbon monoxide source. J Comb Chem (2006) 0.95
Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorg Med Chem Lett (2004) 0.95
Microwave-enhanced and metal-catalyzed functionalizations of the 4-aryl-dihydropyrimidone template. J Comb Chem (2005) 0.94
ESI-MS detection of proposed reaction intermediates in the air-promoted and ligand-modulated oxidative Heck reaction. J Org Chem (2006) 0.93
Microwave-assisted high-speed PCR. Eur J Pharm Sci (2003) 0.92
Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase. J Med Chem (2011) 0.92
A selective AT2 receptor ligand with a gamma-turn-like mimetic replacing the amino acid residues 4-5 of angiotensin II. J Med Chem (2004) 0.92
Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor. J Med Chem (2007) 0.91
Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins. J Med Chem (2005) 0.91
Synthesis of styrenes by palladium(II)-catalyzed vinylation of arylboronic acids and aryltrifluoroborates by using vinyl acetate. Chemistry (2009) 0.91
DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. J Med Chem (2013) 0.91
Dimethylformamide as a carbon monoxide source in fast palladium-catalyzed aminocarbonylations of aryl bromides. J Org Chem (2002) 0.90
Ultrafast chemistry: cobalt carbonyl-mediated synthesis of diaryl ketones under microwave irradiation. Org Lett (2003) 0.90
High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II. J Comb Chem (2003) 0.89
Virtual screening data fusion using both structure- and ligand-based methods. J Chem Inf Model (2011) 0.89
Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic. J Med Chem (2008) 0.88
Analysis of catecholamines and related substances using porous graphitic carbon as separation media in liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2004) 0.87
Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C. Org Biomol Chem (2012) 0.87
Chelation-mediated palladium(II)-catalyzed domino Heck-Mizoroki/Suzuki-Miyaura reactions using arylboronic acids: increasing scope and mechanistic understanding. J Org Chem (2011) 0.86
Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J Med Chem (2010) 0.86
Discovery of dipeptides with high affinity to the specific binding site for substance P1-7. J Med Chem (2010) 0.86
One-pot, two-step, microwave-assisted palladium-catalyzed conversion of aryl alcohols to aryl fluorides via aryl nonaflates. J Org Chem (2013) 0.85
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors. J Med Chem (2008) 0.84
Identification and characterization of polyphenolic antioxidants using on-line liquid chromatography, electrochemistry, and electrospray ionization tandem mass spectrometry. Anal Chem (2009) 0.84
Selective terminal heck arylation of vinyl ethers with aryl chlorides: a combined experimental-computational approach including synthesis of betaxolol. J Org Chem (2006) 0.83
A new regioselective Heck vinylation with enamides. Synthesis and investigation of fluorous-tagged bidentate ligands for fast separation. J Org Chem (2003) 0.83
In vitro and in vivo evaluation of a (18)F-labeled high affinity NOTA conjugated bombesin antagonist as a PET ligand for GRPR-targeted tumor imaging. PLoS One (2013) 0.82
Microwave-enhanced aminocarbonylations in water. Org Lett (2005) 0.82
Palladium(II)-catalyzed desulfitative synthesis of aryl ketones from sodium arylsulfinates and nitriles: scope, limitations, and mechanistic studies. J Org Chem (2014) 0.82
An efficient method to perform milliliter-scale PCR utilizing highly controlled microwave thermocycling. Chem Commun (Camb) (2004) 0.82
Microwave-assisted synthesis of Weinreb and MAP aryl amides via Pd-catalyzed Heck aminocarbonylation using Mo(CO)6 or W(CO)6. J Org Chem (2011) 0.81
From the first selective non-peptide AT(2) receptor agonist to structurally related antagonists. J Med Chem (2012) 0.81
HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells. J Med Chem (2010) 0.81
Easy-to-execute carbonylations: microwave synthesis of acyl sulfonamides using Mo(CO)(6) as a solid carbon monoxide source. J Org Chem (2005) 0.81
A new structural theme in C2-symmetric HIV-1 protease inhibitors: ortho-substituted P1/P1' side chains. Bioorg Med Chem (2006) 0.81
New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists. J Med Chem (2005) 0.81
A rapid microwave protocol for Heck vinylation of aryl chlorides under air. Mol Divers (2003) 0.80
Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors. Bioorg Med Chem (2010) 0.80
Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery. Bioorg Med Chem (2008) 0.80
Synthesis of P1'-functionalized macrocyclic transition-state mimicking HIV-1 protease inhibitors encompassing a tertiary alcohol. J Med Chem (2014) 0.80
Synthesis of aryl ketones by palladium(II)-catalyzed decarboxylative addition of benzoic acids to nitriles. Angew Chem Int Ed Engl (2010) 0.80
Microwave-accelerated spiro-cyclizations of o-halobenzyl cyclohexenyl ethers by palladium(0) catalysis. J Org Chem (2007) 0.80
Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT1 and AT2 receptors. J Med Chem (2006) 0.80
Synthesis and characterization of a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging. Bioconjug Chem (2013) 0.79
Microwave-enhanced copper-catalyzed N-arylation of free and protected amino acids in water. J Comb Chem (2007) 0.79
Trisubstituted imidazoles as Mycobacterium tuberculosis glutamine synthetase inhibitors. J Med Chem (2012) 0.79
Arylboronic acids as versatile coupling partners in fast microwave promoted oxidative Heck chemistry. Mol Divers (2003) 0.79
Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic. Bioorg Med Chem Lett (2009) 0.79
Rapid palladium-catalyzed synthesis of esters from aryl halides utilizing Mo(CO)(6) as a solid carbon monoxide source. J Comb Chem (2003) 0.79
A novel p53 mutant found in iatrogenic urothelial cancers is dysfunctional and can be rescued by a second-site global suppressor mutation. J Biol Chem (2013) 0.79
Transmetallation versus β-hydride elimination: the role of 1,4-benzoquinone in chelation-controlled arylation reactions with arylboronic acids. Chemistry (2012) 0.79
An investigation of peak-broadening effects arising when combining CE with MS. Electrophoresis (2007) 0.79
Microwave-promoted palladium(II)-catalyzed C-P bond formation by using arylboronic acids or aryltrifluoroborates. Chemistry (2009) 0.79
Meniscus body position and its change over four years in asymptomatic adults: a cohort study using data from the Osteoarthritis Initiative (OAI). BMC Musculoskelet Disord (2014) 0.79
Angiotensin II pseudopeptides containing 1,3,5-trisubstituted benzene scaffolds with high AT2 receptor affinity. J Med Chem (2005) 0.78
Toward a benchmarking data set able to evaluate ligand- and structure-based virtual screening using public HTS data. J Chem Inf Model (2015) 0.78
Microwave-promoted and chelation-controlled double arylations of terminal olefinic carbon of vinyl ethers. J Org Chem (2004) 0.78
Fast synthesis of aryl triflates with controlled microwave heating. Org Lett (2002) 0.78
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett (2011) 0.78
Synthesis, X-ray analysis, and biological evaluation of a new class of stereopure lactam-based HIV-1 protease inhibitors. J Med Chem (2012) 0.78
Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold. Org Biomol Chem (2006) 0.78
In situ generation of carbon monoxide from solid molybdenum hexacarbonyl. A convenient and fast route to palladium-catalyzed carbonylation reactions. J Comb Chem (2002) 0.77
Masked 3-aminoindan-1-ones by a palladium-catalyzed three-component annulation reaction. J Org Chem (2005) 0.77