Safety and efficacy of RNAi therapy for transthyretin amyloidosis.

PubWeight™: 3.97‹?› | Rank: Top 1%

🔗 View Article (PMID 23984729)

Published in N Engl J Med on August 29, 2013

Authors

Teresa Coelho1, David Adams, Ana Silva, Pierre Lozeron, Philip N Hawkins, Timothy Mant, Javier Perez, Joseph Chiesa, Steve Warrington, Elizabeth Tranter, Malathy Munisamy, Rick Falzone, Jamie Harrop, Jeffrey Cehelsky, Brian R Bettencourt, Mary Geissler, James S Butler, Alfica Sehgal, Rachel E Meyers, Qingmin Chen, Todd Borland, Renta M Hutabarat, Valerie A Clausen, Rene Alvarez, Kevin Fitzgerald, Christina Gamba-Vitalo, Saraswathy V Nochur, Akshay K Vaishnaw, Dinah W Y Sah, Jared A Gollob, Ole B Suhr

Author Affiliations

1: Unidade Clinica de Paramiloidose, Hospital de Santo Antonio, Porto, Portugal. tcoelho@netcabo.pt

Associated clinical trials:

Trial to Evaluate Safety and Tolerability of ALN-TTR01 in Transthyretin (TTR) Amyloidosis | NCT01148953

Trial to Evaluate Safety, Tolerability, and Parmacokinetics of ALN-TTR02 in Healthy Volunteer Subjects | NCT01559077

Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C) (ORION) | NCT02597127

The Role of Occult Cardiac Amyloid in the Elderly With Aortic Stenosis. (ATTRact-AS) | NCT03029026

Cardiac Amyloidosis : Diagnostic Using Red Flag Signals (TEAM Red Flags) | NCT04459169

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