Published in Nature on September 01, 2013
Sphingolipid metabolites in inflammatory disease. Nature (2014) 2.19
CLEC-2 is required for development and maintenance of lymph nodes. Blood (2014) 1.64
How leukocytes cross the vascular endothelium. Nat Rev Immunol (2015) 1.44
C-type lectins in immunity: recent developments. Curr Opin Immunol (2014) 1.31
Lymph node fibroblastic reticular cells in health and disease. Nat Rev Immunol (2015) 1.31
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest (2015) 1.24
The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol (2014) 1.19
The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation. J Immunol (2014) 1.04
Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. J Clin Invest (2014) 1.03
A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin. Sci Rep (2014) 0.97
Platelet-derived SDF-1 primes the pulmonary capillary vascular niche to drive lung alveolar regeneration. Nat Cell Biol (2015) 0.95
Proteasome function is required for platelet production. J Clin Invest (2014) 0.93
Are Platelets Cells? And if Yes, are They Immune Cells? Front Immunol (2015) 0.92
Secrets of platelet exocytosis - what do we really know about platelet secretion mechanisms? Br J Haematol (2013) 0.90
CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. J Exp Med (2015) 0.89
CLEC-2 expression is maintained on activated platelets and on platelet microparticles. Blood (2014) 0.89
S1P control of endothelial integrity. Curr Top Microbiol Immunol (2014) 0.88
Platelets in inflammation: regulation of leukocyte activities and vascular repair. Front Immunol (2015) 0.87
The role of platelets in the recruitment of leukocytes during vascular disease. Platelets (2015) 0.87
Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells. J Biol Chem (2014) 0.85
Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. Blood (2015) 0.85
Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization. Blood (2015) 0.85
Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. Blood (2014) 0.84
Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications. Front Immunol (2015) 0.83
Granule-mediated release of sphingosine-1-phosphate by activated platelets. Biochim Biophys Acta (2014) 0.83
Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets. J Biol Chem (2015) 0.83
Characterization of monoclonal antibody LpMab-3 recognizing sialylated glycopeptide of podoplanin. Monoclon Antib Immunodiagn Immunother (2015) 0.81
Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle. J Immunol (2015) 0.81
Molecular and cellular mechanisms of lymphatic vascular maturation. Microvasc Res (2014) 0.79
The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state. Eur J Immunol (2015) 0.79
CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP. J Thromb Haemost (2014) 0.79
Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. Annu Rev Physiol (2016) 0.77
Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix. PLoS Genet (2016) 0.77
Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation. Oncotarget (2016) 0.77
Mucin-type O-glycosylation is critical for vascular integrity. Glycobiology (2014) 0.77
Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun (2016) 0.77
Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia. Genes Dis (2015) 0.76
Identification of a novel protein binding motif within the T-synthase for the molecular chaperone Cosmc. J Biol Chem (2014) 0.76
Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin. J Biol Chem (2016) 0.76
Understanding high endothelial venules: Lessons for cancer immunology. Oncoimmunology (2015) 0.76
Platelets as autonomous drones for hemostatic and immune surveillance. J Exp Med (2017) 0.76
Lymph Nodes and Cancer Metastasis: New Perspectives on the Role of Intranodal Lymphatic Sinuses. Int J Mol Sci (2016) 0.75
Imaging S1P1 activation in vivo. Exp Cell Res (2014) 0.75
Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res (2016) 0.75
CollagenVI-Cre mice: A new tool to target stromal cells in secondary lymphoid organs. Sci Rep (2016) 0.75
Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation. J Biol Chem (2015) 0.75
New Concepts and Mechanisms of Platelet Activation Signaling. Physiology (Bethesda) (2017) 0.75
Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis. Blood (2017) 0.75
PDGF upregulates CLEC-2 to induce T regulatory cells. Oncotarget (2015) 0.75
The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis. Cell Mol Gastroenterol Hepatol (2016) 0.75
Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation. Sci Rep (2017) 0.75
Mutation of threonine 34 in mouse podoplanin-Fc reduces CLEC-2 binding and toxicity in vivo while retaining antilymphangiogenic activity. J Biol Chem (2014) 0.75
Self-control of platelets: a new ITIM story. Blood (2014) 0.75
Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies. Thromb J (2016) 0.75
CLEC-2 and podoplanin, partners again. Blood (2016) 0.75
Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells. Proc Natl Acad Sci U S A (2017) 0.75
The molecular cues regulating immune cell trafficking. Proc Jpn Acad Ser B Phys Biol Sci (2017) 0.75
Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney. J Biol Chem (2017) 0.75
Gq pathway regulates proximal C-type lectin-like receptor 2 (CLEC-2) signaling in platelets. J Biol Chem (2017) 0.75
RAG-1-deficient mice have no mature B and T lymphocytes. Cell (1992) 20.97
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87
Lymphocyte homing and homeostasis. Science (1996) 13.26
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol (2001) 10.32
A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature (1983) 8.20
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell (1999) 7.33
Homing and cellular traffic in lymph nodes. Nat Rev Immunol (2003) 7.23
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (2007) 6.04
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J Clin Invest (1999) 5.65
Ligands for L-selectin: homing, inflammation, and beyond. Annu Rev Immunol (2004) 4.35
The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev Cell (2009) 3.87
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell (2006) 3.51
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood (2010) 3.35
Lymphoid organ development: from ontogeny to neogenesis. Nat Immunol (2006) 3.15
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol (2003) 2.92
Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med (2004) 2.91
Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol Rev (1997) 2.89
Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis. Am J Pathol (1997) 2.55
P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest (2002) 2.45
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest (2009) 2.41
The impact of perinatal immune development on mucosal homeostasis and chronic inflammation. Nat Rev Immunol (2011) 2.29
Inflammation induces hemorrhage in thrombocytopenia. Blood (2008) 2.28
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nat Rev Immunol (2012) 2.18
CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. Blood (2009) 2.15
Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J Exp Med (1992) 2.11
Flow-enhanced adhesion regulated by a selectin interdomain hinge. J Cell Biol (2006) 2.02
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest (2008) 2.00
Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest (2002) 1.82
Platelet-mediated lymphocyte delivery to high endothelial venules. Science (1996) 1.78
The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell (2012) 1.66
Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62
Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry (2002) 1.62
Fibroblast-type reticular stromal cells regulate the lymph node vasculature. J Immunol (2008) 1.39
GPVI and CLEC-2 in hemostasis and vascular integrity. J Thromb Haemost (2010) 1.34
Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest (2013) 1.24
Hock immunization: a humane alternative to mouse footpad injections. J Immunol Methods (2007) 1.23
Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation. J Thromb Haemost (2011) 1.11
Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. Clin Sci (Lond) (2011) 1.10
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
Extracellular histones are major mediators of death in sepsis. Nat Med (2009) 6.55
Direct observation of catch bonds involving cell-adhesion molecules. Nature (2003) 6.30
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature (2002) 6.22
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science (2007) 6.04
Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med (2002) 5.10
Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med (2008) 4.55
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet (2008) 3.94
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet (2008) 3.71
Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (2003) 3.60
Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med (2005) 3.59
Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity (2005) 3.39
Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood (2010) 3.35
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med (2007) 3.27
A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med (2008) 3.16
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol (2008) 3.05
CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci U S A (2008) 3.04
Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan. J Biol Chem (2003) 2.96
Maternal exposure to magnetic fields during pregnancy in relation to the risk of asthma in offspring. Arch Pediatr Adolesc Med (2011) 2.90
Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med (2014) 2.90
Anatomical profiling of G protein-coupled receptor expression. Cell (2008) 2.88
A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med (2002) 2.75
piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling. Dev Cell (2011) 2.73
P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation (2008) 2.66
Virologically confirmed population-based burden of hospitalization caused by influenza A and B among children in Hong Kong. Clin Infect Dis (2009) 2.60
Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis. J Exp Med (2006) 2.54
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A (2007) 2.52
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med (2003) 2.49
P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest (2002) 2.45
Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood (2004) 2.45
High-resolution crystal structure of human protease-activated receptor 1. Nature (2012) 2.44
Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest (2008) 2.43
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest (2009) 2.41
Catch bonds govern adhesion through L-selectin at threshold shear. J Cell Biol (2004) 2.36
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med (2009) 2.34
Distinct molecular and cellular contributions to stabilizing selectin-mediated rolling under flow. J Cell Biol (2002) 2.33
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut (2013) 2.32
A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest (2008) 2.26
Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell (2006) 2.26
5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol (2008) 2.24
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell (2012) 2.24
E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling. Blood (2010) 2.24
Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding. Circulation (2007) 2.23
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell (2010) 2.19
Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. Blood (2008) 2.18
Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nat Med (2003) 2.18
Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation. Blood (2010) 2.17
Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood (2011) 2.17
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A (2010) 2.16
Overview of the Alliance for Cellular Signaling. Nature (2002) 2.15
CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. Blood (2009) 2.15
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med (2009) 2.12
Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem (2007) 2.10
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest (2011) 2.09
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab (2011) 2.08
Phospholipase D. Biochem Cell Biol (2004) 2.06
A case-control study of long-term exposure to ambient volatile organic compounds and lung cancer in Toronto, Ontario, Canada. Am J Epidemiol (2013) 2.05
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2002) 2.04
Flow-enhanced adhesion regulated by a selectin interdomain hinge. J Cell Biol (2006) 2.02
Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest (2008) 2.00
Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol (2008) 1.98
Genetic diversity and multiple infections of Plasmodium vivax malaria in Western Thailand. Am J Trop Med Hyg (2003) 1.98
Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A (2006) 1.95
Tumor necrosis factor receptor levels are associated with carotid atherosclerosis. Stroke (2002) 1.94
Critical role for stromal interaction molecule 1 in cardiac hypertrophy. Circulation (2011) 1.91
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood (2011) 1.88
Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem (2002) 1.87
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87
The NOD2 defect in Blau syndrome does not result in excess interleukin-1 activity. Arthritis Rheum (2009) 1.87
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood (2007) 1.86
Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal (2012) 1.86
Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res (2012) 1.85