An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.

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Published in Leukemia on September 25, 2013

Authors

E Clappier1, M F Auclerc2, J Rapion3, M Bakkus4, A Caye5, A Khemiri5, C Giroux5, L Hernandez6, E Kabongo4, S Savola7, T Leblanc8, K Yakouben9, G Plat10, V Costa11, A Ferster12, S Girard13, O Fenneteau14, J M Cayuela15, F Sigaux15, N Dastugue16, S Suciu3, Y Benoit17, Y Bertrand18, J Soulier15, H Cavé19

Author Affiliations

1: 1] U944 INSERM and Hematology laboratory, St-Louis Hospital, APHP, Paris, France [2] Department of Genetics, Robert Debré Hospital, APHP, Paris, France [3] Hematology University Institute, University Paris-Diderot, Paris, France.
2: 1] U944 INSERM and Hematology laboratory, St-Louis Hospital, APHP, Paris, France [2] Department of Pediatric Hematology, St-Louis Hospital, APHP, Paris, France.
3: EORTC Headquarters, Brussels, Belgium.
4: Molecular Hematology Laboratory, UZ Brussels, Brussels, Belgium.
5: Department of Genetics, Robert Debré Hospital, APHP, Paris, France.
6: U944 INSERM and Hematology laboratory, St-Louis Hospital, APHP, Paris, France.
7: MRC-Holland, Amsterdam, The Netherlands.
8: Department of Pediatric Hematology, St-Louis Hospital, APHP, Paris, France.
9: Department of Pediatric Hematology, Robert-Debré Hospital, APHP, Paris, France.
10: Department of Pediatric Onco-Hematology, University Hospital Purpan, Toulouse, France.
11: Department of Pediatrics, Portuguese Oncology Institute, Porto, Portugal.
12: Department of Pediatric Onco-Hematology, Children's University Hospital Reine Fabiola, Brussels, Belgium.
13: Hematology Laboratory, IHOP, Lyon, France.
14: Hematology Laboratory, Robert Debré Hospital, APHP, Paris, France.
15: 1] U944 INSERM and Hematology laboratory, St-Louis Hospital, APHP, Paris, France [2] Hematology University Institute, University Paris-Diderot, Paris, France.
16: Hematology Laboratory, University Hospital Purpan, Toulouse, France.
17: Department of Pediatric Hematology-Oncology, Ghent University Hospital, Ghent, Belgium.
18: Department of Pediatric Hematology, IHOP and Claude Bernard University, Lyon, France.
19: 1] Department of Genetics, Robert Debré Hospital, APHP, Paris, France [2] Hematology University Institute, University Paris-Diderot, Paris, France.

Associated clinical trials:

Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia | NCT00002812

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