Published in J Virol on October 02, 2013
Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation. PLoS One (2014) 0.82
P-TEFb goes viral. Inside Cell (2015) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
A generalized technique for deletion of specific genes in large genomes: alpha gene 22 of herpes simplex virus 1 is not essential for growth. Cell (1981) 8.56
Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity. EMBO J (1984) 7.33
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J Virol (1989) 5.77
Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice. J Virol (1985) 4.17
Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component on infected cells. Nature (1984) 3.80
Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells. Proc Natl Acad Sci U S A (1993) 3.77
Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants. J Virol (1990) 3.05
The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein alpha 22. Proc Natl Acad Sci U S A (1992) 2.97
Chromatin control of herpes simplex virus lytic and latent infection. Nat Rev Microbiol (2008) 2.86
Regulation of herpesvirus macromolecular synthesis: evidence for multilevel regulation of herpes simplex 1 RNA and protein synthesis. Cold Spring Harb Symp Quant Biol (1975) 2.77
Regulation of the interferon system: evidence that Vero cells have a genetic defect in interferon production. J Gen Virol (1979) 2.69
Herpes simplex virus ICP0 mutants are hypersensitive to interferon. J Virol (2000) 2.66
Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide. J Virol (1993) 2.45
Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program. J Virol (1995) 2.13
ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II. J Virol (1999) 1.73
Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection. J Virol (2004) 1.63
Functional anatomy of herpes simplex virus 1 overlapping genes encoding infected-cell protein 22 and US1.5 protein. J Virol (1999) 1.52
Optimized viral dose and transient immunosuppression enable herpes simplex virus ICP0-null mutants To establish wild-type levels of latency in vivo. J Virol (2000) 1.45
In vitro characterization of a herpes simplex virus type 1 ICP22 deletion mutant. Virus Genes (1993) 1.41
Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus. J Virol (2005) 1.40
Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell (2006) 1.37
Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites. J Virol (2004) 1.34
The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1. J Virol (2005) 1.30
Mechanism of complement inactivation by glycoprotein C of herpes simplex virus. J Immunol (1997) 1.22
A herpes simplex virus type 1 ICP22 deletion mutant is altered for virulence and latency in vivo. Arch Virol (1994) 1.18
Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural immunoglobulin M antibody. J Virol (2006) 1.17
Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase II. J Virol (2007) 1.16
Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection. PLoS Pathog (2009) 1.11
Plasma membrane-targeted Raf kinase activates NF-kappaB and human immunodeficiency virus type 1 replication in T lymphocytes. J Virol (1998) 1.10
The interaction of glycoprotein C of herpes simplex virus types 1 and 2 with the alternative complement pathway. Virology (1994) 1.06
E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}. J Exp Med (2011) 1.05
The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J Biol Chem (2005) 1.05
ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions. J Virol (2006) 1.02
Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesis. J Virol (2004) 0.96
Herpes simplex virus type 1 immediate-early protein ICP22 is required for VICE domain formation during productive viral infection. J Virol (2009) 0.95
Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression. J Virol (2008) 0.93
Role of nuclear factor Y in stress-induced activation of the herpes simplex virus type 1 ICP0 promoter. J Virol (2010) 0.89
Transient expression of herpes simplex virus type 1 ICP22 represses viral promoter activity and complements the replication of an ICP22 null virus. J Virol (2009) 0.89
Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb. PLoS One (2012) 0.84
Defining herpes simplex genes involved in neurovirulence and neuroinvasiveness. Curr Eye Res (1987) 0.83
Herpes simplex virus 1 ICP0 phosphorylation site mutants are attenuated for viral replication and impaired for explant-induced reactivation. J Virol (2011) 0.83
B7 costimulation molecules encoded by replication-defective, vhs-deficient HSV-1 improve vaccine-induced protection against corneal disease. PLoS One (2011) 0.81
Origin of expression of the herpes simplex virus type 1 protein U(S)1.5. J Virol (2009) 0.81
HSV-1 ICP22: hijacking host nuclear functions to enhance viral infection. Future Microbiol (2013) 0.80
Transcriptional regulation of the Herpes Simplex Virus 1alpha-gene by the viral immediate-early protein ICP22 in association with VP16. Sci China C Life Sci (2009) 0.79
Genome sequence of herpes simplex virus 1 strain KOS. J Virol (2012) 1.12
HSV-1 ICP0: paving the way for viral replication. Future Virol (2011) 0.94
Role of nuclear factor Y in stress-induced activation of the herpes simplex virus type 1 ICP0 promoter. J Virol (2010) 0.89
Transient expression of herpes simplex virus type 1 ICP22 represses viral promoter activity and complements the replication of an ICP22 null virus. J Virol (2009) 0.89
Genome sequence of herpes simplex virus 1 strain McKrae. J Virol (2012) 0.88
N-terminal phosphorylation sites of herpes simplex virus 1 ICP0 differentially regulate its activities and enhance viral replication. J Virol (2012) 0.86
hTERT extends the life of human fibroblasts without compromising type I interferon signaling. PLoS One (2013) 0.84
Herpes simplex virus 1 ICP0 phosphorylation site mutants are attenuated for viral replication and impaired for explant-induced reactivation. J Virol (2011) 0.83
CK2 inhibitors increase the sensitivity of HSV-1 to interferon-β. Antiviral Res (2011) 0.82
HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in mice. Virus Res (2013) 0.82
HSV-1 ICP22: hijacking host nuclear functions to enhance viral infection. Future Microbiol (2013) 0.80
Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replication in vivo. J Neurovirol (2010) 0.78
Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons. J Virol (2015) 0.76
A flow cytometric assay for the study of E3 ubiquitin ligase activity. Cytometry A (2009) 0.75