Published in J Enzyme Inhib Med Chem on October 09, 2013
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A (2013) 5.88
Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes (2011) 2.46
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci (2010) 2.37
Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs. Eur J Med Chem (2003) 1.60
Paclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluation. J Control Release (2008) 1.59
Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxel. J Control Release (2009) 1.47
Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue. Front Microbiol (2011) 1.46
Stability of meropenem and doripenem solutions for administration by continuous infusion. J Antimicrob Chemother (2010) 1.33
Insights into the origin of solid-state photochromism and thermochromism of N-salicylideneanils: the intriguing case of aminopyridines. Chemistry (2009) 1.32
Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. J Nutr Biochem (2010) 1.30
Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. FASEB J (2011) 1.29
Functionally selective cannabinoid receptor signalling: therapeutic implications and opportunities. Biochem Pharmacol (2010) 1.25
Gauging a hydrocarbon ruler by an intrinsic exciton probe. Biochemistry (2007) 1.14
PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination. J Control Release (2007) 1.13
Assessment of the efficiency of long-range corrected functionals for some properties of large compounds. J Chem Phys (2007) 1.13
The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. Trends Mol Med (2012) 1.09
Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds. J Nat Prod (2007) 1.07
Accurate simulation of optical properties in dyes. Acc Chem Res (2009) 1.04
Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players. Curr Opin Clin Nutr Metab Care (2007) 1.03
Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets. PLoS One (2011) 1.03
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase. J Biol Chem (2010) 1.03
Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. Proc Natl Acad Sci U S A (2013) 1.00
A phosphonated triarylmethyl radical as a probe for measurement of pH by EPR. Chem Commun (Camb) (2012) 1.00
Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. J Biol Chem (2011) 0.99
Divergent and regioselective synthesis of 1,2,4- and 1,2,5-trisubstituted imidazoles. J Org Chem (2008) 0.98
Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic. Free Radic Biol Med (2011) 0.96
CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. Chembiochem (2008) 0.96
Highly enantioselective synthesis of glycidic amides using camphor-derived sulfonium salts. Mechanism and applications in synthesis. J Am Chem Soc (2006) 0.94
Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus. Antioxid Redox Signal (2010) 0.93
On the importance of leaving group ability in reactions of ammonium, oxonium, phosphonium, and sulfonium ylides. Angew Chem Int Ed Engl (2005) 0.93
Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. Chembiochem (2007) 0.92
Synthesis of two persistent fluorinated tetrathiatriarylmethyl (TAM) radicals for biomedical EPR applications. Bioorg Med Chem Lett (2008) 0.91
Targeting nanoparticles to M cells with non-peptidic ligands for oral vaccination. Eur J Pharm Biopharm (2009) 0.91
Thioindigo dyes: highly accurate visible spectra with TD-DFT. J Am Chem Soc (2006) 0.91
Spectral properties of self-assembled squaraine-tetralactam: a theoretical assessment. Phys Chem Chem Phys (2009) 0.91
Synthesis and biological evaluation of carbon-11- and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging. Nucl Med Biol (2009) 0.90
3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis. Bioorg Med Chem (2013) 0.90
Asymmetric syntheses of three-membered heterocycles using chiral amide-based ammonium ylides. Org Biomol Chem (2015) 0.89
Discovery of novel lipophilic inhibitors of OXA-10 enzyme (class D beta-lactamase) by screening amino analogs and homologs of citrate and isocitrate. Bioorg Med Chem Lett (2009) 0.89
The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. BMC Cancer (2012) 0.89
Design of new triphenylamine-sensitized solar cells: a theoretical approach. Environ Sci Technol (2010) 0.88
Fatty acid amide hydrolase: from characterization to therapeutics. Chem Biodivers (2007) 0.88
Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem (2009) 0.88
Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors. J Med Chem (2002) 0.87
PET imaging of fatty acid amide hydrolase in the brain: synthesis and biological evaluation of an 11C-labelled URB597 analogue. Nucl Med Biol (2010) 0.87
Chiral properties of tetrathiatriarylmethyl spin probes. Chem Commun (Camb) (2011) 0.87
Assessment of long-range corrected functionals performance for n-->pi* transitions in organic dyes. J Chem Phys (2007) 0.87
NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening. Chem Biol (2011) 0.86
First crystal structure of an endo-inulinase, INU2, from Aspergillus ficuum: discovery of an extra-pocket in the catalytic domain responsible for its endo-activity. Biochimie (2012) 0.86
Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS One (2011) 0.86
Assessment of several hybrid DFT functionals for the evaluation of bond length alternation of increasingly long oligomers. J Phys Chem A (2006) 0.86
Theoretical investigation of substituted anthraquinone dyes. J Chem Phys (2004) 0.86
TD-DFT investigation of the UV spectra of pyranone derivatives. J Phys Chem A (2006) 0.85
Targeted nanoparticles with novel non-peptidic ligands for oral delivery. Adv Drug Deliv Rev (2013) 0.85
Aroma extraction dilution analysis of Sauternes wines. Key role of polyfunctional thiols. J Agric Food Chem (2006) 0.85
PCL-PEG-based nanoparticles grafted with GRGDS peptide: preparation and surface analysis by XPS. Biomacromolecules (2007) 0.85
Excited-state properties from ground-state DFT descriptors: A QSPR approach for dyes. J Mol Graph Model (2009) 0.85
Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling. J Med Chem (2006) 0.85
Advantages of cocrystallization in the field of solid-state pharmaceutical chemistry: L-Proline and MnCl(2). Eur J Med Chem (2010) 0.85
Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. J Med Chem (2009) 0.85
Ab initio investigation of the n --> pi* transitions in thiocarbonyl dyes. J Phys Chem A (2006) 0.85
Excitation spectra of nitro-diphenylaniline: accurate time-dependent density functional theory predictions for charge-transfer dyes. J Chem Phys (2006) 0.85
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold. Bioorg Med Chem (2012) 0.84
Inhibitors of the endocannabinoid-degrading enzymes, or how to increase endocannabinoid's activity by preventing their hydrolysis. Recent Pat CNS Drug Discov (2012) 0.84
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis. Bioorg Med Chem (2011) 0.83
Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles. Methods Enzymol (2012) 0.83
Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. Bioorg Med Chem (2011) 0.83
Self-assembling doxorubicin-tocopherol succinate prodrug as a new drug delivery system: synthesis, characterization, and in vitro and in vivo anticancer activity. Bioconjug Chem (2013) 0.83
Ab initio tools for the accurate prediction of the visible spectra of anthraquinones. Spectrochim Acta A Mol Biomol Spectrosc (2006) 0.82
Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia. PLoS One (2013) 0.82
Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis. Int J Pharm (2013) 0.82
Chemistry around imidazopyrazine and ibuprofen: discovery of novel fatty acid amide hydrolase (FAAH) inhibitors. Eur J Med Chem (2010) 0.82
3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett (2008) 0.82
Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice. J Lipid Res (2011) 0.82
Time-dependent density functional theory investigation of the absorption, fluorescence, and phosphorescence spectra of solvated coumarins. J Chem Phys (2006) 0.81
The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB₁- and FAAH-independent mechanisms. Br J Pharmacol (2013) 0.81
First hyperpolarizability of polymethineimine with long-range corrected functionals. J Chem Phys (2007) 0.81
Combined effect of stacking and solvation on the spontaneous mutation in DNA. Phys Chem Chem Phys (2011) 0.81
Synthesis and evaluation of N1/C4-substituted beta-lactams as PPE and HLE inhibitors. Bioorg Med Chem (2004) 0.81
4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands: structural insights into the design of a novel inverse agonist series. J Med Chem (2010) 0.81
Laccase-mediated synthesis of novel substituted phenoxazine chromophores featuring tuneable water solubility. Chemistry (2009) 0.80
Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors. J Med Chem (2009) 0.80
alphavbeta3 Integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers. J Med Chem (2009) 0.80
Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo. Neuropharmacology (2012) 0.80
4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis. J Med Chem (2012) 0.80
Microhydration of protonated glycine: an ab initio family tree. J Phys Chem B (2008) 0.80
Coelenterazine: a two-stage antioxidant in lipid micelles. Free Radic Biol Med (2004) 0.79
Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth. Eur J Pharm Sci (2011) 0.79
beta-Lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase. J Med Chem (2009) 0.79