Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial.

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Published in Lancet on October 26, 2013


Colin P Derdeyn1, Marc I Chimowitz2, Michael J Lynn3, David Fiorella4, Tanya N Turan2, L Scott Janis5, Jean Montgomery3, Azhar Nizam3, Bethany F Lane3, Helmi L Lutsep6, Stanley L Barnwell7, Michael F Waters8, Brian L Hoh9, J Maurice Hourihane10, Elad I Levy11, Andrei V Alexandrov12, Mark R Harrigan13, David Chiu14, Richard P Klucznik15, Joni M Clark16, Cameron G McDougall17, Mark D Johnson18, G Lee Pride19, John R Lynch20, Osama O Zaidat21, Zoran Rumboldt22, Harry J Cloft23, Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators

Author Affiliations

1: Mallinckrodt Institute of Radiology and the Departments of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO, USA. Electronic address:
2: Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.
3: Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public, Health, Atlanta, GA, USA.
4: Department of Neurosurgery, State University of New York, Stony Brook, NY, USA.
5: National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD, USA.
6: Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
7: Department of Neurological Surgery and the Dotter Interventional Institute, Oregon Health Sciences University, Portland, OR, USA.
8: Departments of Neurology and Neuroscience, University of Florida, Gainesville, FL, USA.
9: Department of Neurosurgery, University of Florida, Gainesville, FL, USA.
10: Dent Neurological Institute, Buffalo, NY, USA.
11: Department of Neurosurgery, University of Buffalo, NY, USA.
12: Department of Neurology, University of Alabama, Birmingham, AL, USA.
13: Department of Neurosurgery, University of Alabama, Birmingham, AL, USA.
14: Department of Neurology, Houston Methodist Hospital, Houston, TX, USA.
15: Department of Radiology, Houston Methodist Hospital, Houston, TX, USA.
16: Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
17: Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
18: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
19: Departments of Radiology and Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
20: Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
21: Departments of Neurology, Radiology, and Neurosurgery, Medical College of Wisconsin, Milwaukee, WI.
22: Department of Radiology, Medical University of South Carolina, Charleston, SC, USA.
23: Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Associated clinical trials:

Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) | NCT00004732

Secondary Prevention of Small Subcortical Strokes Trial (SPS3) | NCT00059306

Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) | NCT00576693

NCT 00576693

Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS ) (SIPS-ICAS) | NCT03719820

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